Drug Database
CE

cefaclor (Raniclor / Raniclor)

✓ Approved

Ranbaxy Laboratories Limited · Small Molecule · Small Molecule

What is cefaclor?

cefaclor is a small molecule developed by Ranbaxy Laboratories Limited. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesRaniclor, Raniclor
CompanyRanbaxy Laboratories Limited
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Ranbaxy Laboratories Limited

Therapeutic Indications

cefaclor is developed for 6 unique indications across 3 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsLower respiratory tract infection✓ Approved
Infections and infestationsOtitis media✓ Approved
Infections and infestationsTonsillitis✓ Approved
Infections and infestationsUrinary tract infection✓ Approved
Respiratory, thoracic and mediastinal disordersTonsillar inflammation✓ Approved

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Related Research Articles

PubMedBJGP open2026-07-16

Understandability of statin patient information leaflets in the UK: a mixed-methods cross-sectional evaluation.

Rao Diya D, Dickson Jon M JM, Sudbury Mia M, Dixon William W et al.

Statins are the UK's most prescribed medicine and are used more in deprived populations. Patient Information Leaflets (PILs) included in medication packaging may support safe, effective use, but only if they are understandable. Guidance states PILs should have a reading age of ≤13-years, and regulators require that ≥80% of patients answer comprehension questions correctly on them when 'user tested'. To provide the first independent evaluation of the readability and comprehension of UK statin PILs. Study 1: Cross-sectional analysis of the reading age of 39/40 of the UK's approved statin PILs. Study 2: Cross-sectional survey with a representative sample of 517 UK adults aged 40-74. Study 1: Reading age was assessed using four readability formulas, with additional scores calculated after adjusting for potentially familiar technical terms. Study 2: Two PILs (atorvastatin [MSN] and rosuvastatin [Ranbaxy]) were randomly selected and user tested with participants. They answered eight comprehension questions per PIL; responses were double-scored. Study 1: No PIL met the recommended reading age. Median reading age was 15.9 years (15.0 after adjustment). Atorvastatin PILs were least readable. Study 2: Key messages were poorly understood; for atorvastatin, 5/8 items met the≥80% criterion; for rosuvastatin, 2/8 met it. Key safety and use messages were frequently misunderstood. UK statin PILs do not meet recommended readability or comprehension standards and are likely to be difficult to understand for many users. Improving clarity and usability is essential to support equitable understanding and safe, informed long-term statin use.

PMID 42457226
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PubMedFrontiers in dental medicine2026-07-16

Clinical and enzymatic evaluation of the effect of dietary vitamin C on orthodontic tooth movement.

Pulikkottil Sunny Naveen N, Ravi M S MS

To evaluate the effect of dietary vitamin C supplementation on the rate of orthodontic tooth movement during canine retraction by comparing individuals receiving supplementation with those who are not. Additionally, to analyze changes in selected enzymatic biomarkers in the gingival crevicular fluid (GCF). This study included 28 patients who underwent orthodontic treatment followed by first premolar extraction and levelling. Participants were divided into two groups: Group I received dietary vitamin C supplementation (500 mg chewable tablets), while Group II served as controls without supplementation. Canine retraction was carried out using NiTi closed coil springs delivering 150 g force with absolute anchorage provided by mini-implants, and digital scans were recorded at R0(before retraction) and R1(75 days). The rate of canine retraction was calculated as the distance moved per time. GCF was collected at baseline (T0), before retraction (T1), and after 75 days (T2) and analyzed for alkaline phosphatase and acid phosphatase levels using ELISA. The vitamin C group demonstrated significantly greater maxillary canine retraction compared to controls, with mean values of (3.20 ± 0.84 mm) vs. (1.96 ± 0.60 mm) in males and (2.86 ± 0.38 mm) vs. (1.73 ± 0.31 mm) in females. Alkaline phosphatase and Acid phosphatase levels increased significantly over time in both groups, with a greater rise in the vitamin C group. Dietary vitamin C supplementation significantly accelerated canine retraction and enhanced bone remodeling enzyme activity during orthodontic treatment.

PMID 42459823
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PubMedThe American journal of case reports2026-07-09

Anterior ST-Segment Elevation Myocardial Infarction Shortly After Cefaclor Exposure: A Case Report Highlighting Kounis Syndrome as a Differential Diagnosis.

Zuo Quan Q, Zhu Yue Y, Wang Zhiwei Z, Ge Tao T

BACKGROUND Kounis syndrome is an acute coronary syndrome associated with allergic or hypersensitivity reactions, but establishment of causality is difficult when objective allergy-related tests are unavailable during emergency treatment. This report describes anterior ST-segment elevation myocardial infarction (STEMI) occurring shortly after cefaclor exposure and highlights the diagnostic limitations of attributing the event to hypersensitivity in routine emergency clinical practice. CASE REPORT A 61-year-old man with a history of positive penicillin skin testing, but no prior penicillin administration, developed severe chest pain approximately 1 hour after self-administration of oral cefaclor for respiratory symptoms. He had no rash, urticaria, wheezing, angioedema, oropharyngeal edema, hypotension, or dyspnea; no prehospital antihistamines, corticosteroids, or epinephrine were administered. Electrocardiography showed ST-segment elevation in V2 to V6, and emergency coronary angiography demonstrated 90% proximal left anterior descending artery stenosis with Thrombolysis in Myocardial Infarction grade II flow. Primary percutaneous coronary intervention restored grade III flow and relieved symptoms. High-sensitivity cardiac troponin I increased from 0.57 to 1.10 ng/mL and peaked at 3.92 ng/mL at 15 hours. Serum tryptase, histamine, total and specific IgE, and intracoronary imaging were not obtained. The Naranjo score was 2, indicating a possible adverse drug reaction. CONCLUSIONS The temporal association prompted consideration of Kounis syndrome, but severe fixed coronary stenosis makes coincidental plaque-related STEMI a major alternative diagnosis. Early allergy biomarker sampling and careful causal assessment are important in similar cases.

PMID 42421293
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PubMedNaunyn-Schmiedeberg's archives of pharmacology2026-07-07

Formulation, evaluation, and optimisation of soft chewable lozenges using Box-Behnken design for the treatment of schizophrenia.

Chauhan Neha N, Patel Amit Ambalal AA, Patel Ravish R, Patel Samir S et al.

Schizophrenia is a long-term psychiatric disorder that generally requires long-term pharmacotherapy, where poor medication adherence and delayed therapeutic onset remain major challenges. The present study is focused on formulating, optimising, and evaluating soft chewable patient-friendly lozenges of brexpiprazole to improve dissolution, patient compliance, and drug absorption in individuals with schizophrenia. Soft chewable lozenges were prepared by a melt-pour method and optimised using a three-factor, three-level Box-Behnken design. PEG 1000, acacia, and colloidal silica were selected as formulation variables, while hardness and the time required for 80% drug release were considered as responses. The prepared formulations were subjected to physicochemical evaluation, dissolution testing, and stability assessment. All batches underwent physicochemical evaluation parameters, including in vitro dissolution and stability. The optimised formulation (S8) underwent in vivo pharmacokinetic evaluation on rabbits. Hardness values ranged between 2.2 and 5.6 kg/cm2 and drug release times (80% release) of 18.55-26.23 min. The optimum results were observed for batch S8 with 96.12% drug release and low hardness (2.2 kg/cm2). In vivo studies confirmed improvement in drug absorption with reduced Tmax (2 h) and increased Cmax (34.86 ng/mL) in comparison with the reference standard. Stability testing confirmed the stability of the optimised formulation throughout the study period. The optimised soft chewable brexpiprazole lozenges are a potential dosage form with improved patient acceptability, increased adherence, and improved systemic absorption, thus supporting its potential in the management of schizophrenia.

PMID 42410223
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PubMedFrontiers in pharmacology2026-07-03

The effectiveness and safety of commercial Chinese polyherbal preparation in treating infantile anorexia: a systematic review and Bayesian network meta-analysis.

Liu Rongchen R, Liu Jiahui J, Li Linrong L

Commercial Chinese polyherbal preparations (CCPPs) are increasingly used for infantile anorexia (IA), but comparative effectiveness and safety differences among them remain unclear. This Bayesian network meta-analysis compares various CCPPs for IA to inform clinical practice. We systematically searched CNKI, Wanfang, VIP, China Biology Medicine, PubMed, Web of Science, Embase, and Cochrane Library for RCTs on CCPPs for IA up to 9 April 2024. Study quality was assessed using the Cochrane RoB tool. Primary outcomes were overall effective rate, weight change, hemoglobin (Hb) levels, and adverse reactions. This research implemented Bayesian network meta-regression to ascertain the impact of different CCPPs and durations of treatment on the effectiveness and safety to treat IA. 141 RCTs (n = 16,963 patients; 49 CCPPs) were included. For overall effective rate, Huaji Oral Solution (HJKFY), Jianpi Pills + Reference Drug (JPW + RD), and Erkangning (EKN) showed significant superiority vs. control (all RR > 1.54, P < 0.05). Regarding weight change, Erpixing Granules (EPXKL) and Xiaoer Fufang Jineijin Chewable Tablets + RD (XEFFJNJJJP + RD) demonstrated significant benefits (MD = 2.26 and 2.10, P < 0.05 for XEFFJNJJJP + RD). For Hb levels, Jianbaoling Granules (JBLKL), Erbao Granules + RD (EBKL + RD), and Shenqu Xiaoshi Oral Solution + RD (SQXSKFY + RD) showed significant advantages (all MD > 10.72, P < 0.05). CCPPs exhibited a favorable safety profile, with mostly mild adverse reactions. CCPPs are significantly more effective and safer than control treatments for IA. Different CCPPs excelled on specific outcomes: HJKFY for overall efficacy, EPXKL for weight gain, and JBLKL for Hb improvement. These findings require confirmation via larger, high-quality, multi-center RCTs. https://www.crd.york.ac.uk/prospero/, identifier CRD42024535550.

PMID 42394975
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PubMedMicrobiology spectrum2026-07-01

Association between phenotypes and genotypes of antimicrobial resistance in E. coli and Salmonella isolates from retail chicken meat and live bird market sewage in Bangladesh.

Parvin Mst Sonia MS, Talukder Sudipta S, Sharmy Sayra Tasnin ST, Hasan Md Mehedi MM et al.

Retail chicken meat contaminated with Escherichia coli and Salmonella represents a significant global public health concern, particularly in developing countries like Bangladesh. The presence of antimicrobial-resistant (AMR) strains in retail chicken meat poses a serious health threat to consumers. Therefore, a cross-sectional live bird market (LBM) survey was conducted to determine the spectrum of AMR and association among AMR phenotypes, as well as between phenotypes and resistance genes in E. coli and Salmonella isolated from retail chicken meat (n = 320) and LBM sewage (n = 64) samples collected from 64 LBMs of 32 upazilas in 16 districts spanning 8 administrative divisions of Bangladesh. E. coli and Salmonella were identified using culture-based and molecular methods and were subsequently subjected to antimicrobial susceptibility testing. Genes encoding β-lactamases and plasmid-mediated quinolone resistance were detected by multiplex PCR and confirmed by sequencing. Multidrug resistance (MDR) was observed in 99.1% and 92.2% of E. coli and in 99.4% and 100% of Salmonella from retail chicken meat and LBM sewage samples, respectively. The most frequently detected resistance genes were bla_TEM, bla_CTX-M-1, qnrA, qnrB, and qnrS. Strong associations between phenotypic resistance and corresponding resistance genes were observed for cefepime/bla_CTX-M-1, ceftazidime/bla_CTX-M-1, aztreonam/bla_CTX-M-1, cefuroxime/qnrA, ceftriaxone/qnrA, cefoxitin/qnrB, cefixime/qnrB, cefaclor/qnrB, trimethoprim-sulfamethoxazole/qnrS, ampicillin/qnrS, and amoxicillin-clavulanic acid/qnrS (P < 0.05). Overall, these findings indicate that retail chicken meat serves as a potential source of MDR E. coli and Salmonella harboring clinically relevant AMR genes. Urgent attention is needed, including strengthening antimicrobial stewardship and surveillance programs in poultry production systems in Bangladesh. Retail chicken meat is a potential reservoir of antimicrobial-resistant (AMR) Escherichia coli and Salmonella, which pose a major public health concern due to their ability to harbor a wide range of AMR genes. Given the high consumption of chicken meat and the increasing prevalence and invasiveness of multidrug-resistant E. coli and Salmonella, continuous monitoring of their prevalence and AMR patterns in retail chicken meat and sewage samples is essential. Understanding the associations among resistance genes may provide critical insights for developing effective antimicrobial stewardship and prudent-use guidelines. Moreover, these findings could serve as a foundation for future research addressing public health and food safety challenges associated with AMR foodborne bacteria.

PMID 42379817
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