Drug Database
RA

rabies immunoglobulin (human) (HyperRAB S/D)

✓ Approved

Grifols, S.A. · Polyclonal Antibodies · Polyclonal Antibodies

What is rabies immunoglobulin (human)?

rabies immunoglobulin (human) is a polyclonal antibodies developed by Grifols, S.A.. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

Brand NamesHyperRAB S/D
CompanyGrifols, S.A.
Drug ClassPolyclonal Antibodies, Antibody
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, Grifols, S.A.

Therapeutic Indications

rabies immunoglobulin (human) is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsRabies✓ Approved

Related Research Articles

PubMedBMC public health2026-10-15

Rabies and rabies prophylaxis in Egypt: a nationwide cross-sectional study that calls for action.

Helal Mohamed Basyouni MB, Saeda Mohamed Ahmed MA, Elshaar Ahmed Gamal AG, Zayed Mohamed Elsayed ME et al.

Rabies is a fatal but preventable viral disease that poses a global health threat, especially in developing countries. Despite the high incidence of animal bites reported annually in Egypt, limited data exist regarding the knowledge, attitudes, and practices (KAP) of the general population toward rabies and rabies prophylaxis. We conducted a nationwide cross-sectional study using a structured interview-based survey targeting individuals aged 18 years or older who attended outpatient clinics at nine university hospitals across Egypt. The survey assessed participants' KAP toward rabies and rabies prophylaxis and identified barriers to prophylaxis uptake. Among 1,777 participants who responded to the survey, only 42.8% (n = 760) had good knowledge about rabies and rabies prophylaxis, while the majority, 88.5% (n = 1,572), exhibited a positive attitude toward rabies prophylaxis. Knowledge was higher among those who reported awareness of rabies campaigns in their geographic areas (69.1% vs. 40.5%, p < 0.001) and those who had previously been bitten or attacked by animals (56.1% vs. 41.3%, p < 0.001). Overall, 9.7% (n = 173) of participants reported a history of animal bites or attacks; however, 18.5% (n = 32) of these participants did not receive post-exposure prophylaxis (PEP), and 17% (n = 24) did not complete the vaccine schedule. Pre-exposure prophylaxis (PrEP) uptake was low, with only 4.3% (n = 23) of high-risk individuals receiving it. Key barriers to rabies prophylaxis included lack of knowledge about the rabies vaccine, reported by 82.4% of participants, lack of knowledge about rabies, reported by 81.7%, and inadequate hospital facilities, reported by 43.1%. Despite a generally positive attitude toward rabies prophylaxis, knowledge and adherence to prophylactic measures, including pre-exposure and post-exposure prophylaxis, remain relatively inadequate in Egypt. Public health interventions, such as educational campaigns and improved accessibility to vaccination services, are needed to address these gaps and mitigate the public health burden of rabies.

PMID 42875760
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PubMedFrontiers in immunology2026-10-15

Mycophenolate mofetil as salvage therapy for refractory acute-onset CIDP associated with rheumatoid arthritis: a case report.

Tan Jinhui J, Huang Hai H, Tan Linghua L, Li Bo B

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated neuropathy that rarely co-occurs with rheumatoid arthritis (RA). When CIDP proves refractory to first-line therapies, management becomes particularly challenging, especially in patients with multiple autoimmune conditions. A 43-year-old Chinese male with a 3-year history of seropositive RA in sustained remission presented with acute progressive quadriparesis, bilateral ptosis, and facial diplegia. Cerebrospinal fluid analysis revealed albuminocytologic dissociation, and nerve conduction studies demonstrated evolving demyelinating features, consistent with a diagnosis of acute-onset CIDP (A-CIDP). The patient responded inadequately to sequential treatment with intravenous immunoglobulin, high-dose corticosteroids, and the neonatal Fc receptor (FcRn) antagonist efgartigimod, experiencing repeated relapses during corticosteroid tapering. Mycophenolate mofetil (MMF) was subsequently introduced as a steroid-sparing agent at 0.75 g twice daily, enabling further prednisone tapering from 20 mg to 10 mg daily without relapse; MMF was later up-titrated to 1 g twice daily. Under a combined, multi-target immunosuppressive regimen of MMF, prednisone, methotrexate, iguratimod, and hydroxychloroquine, the patient achieved sustained neurological improvement, with prednisone successfully tapered to 10 mg daily by October 2025 and maintained thereafter. By April 2026, only residual mild ptosis persisted, and no infectious complications occurred. This case suggests that MMF-based multi-target immunosuppression may be a therapeutic option for RA-associated, treatment-refractory A-CIDP, potentially enabling successful glucocorticoid tapering even after an inadequate response to a short course of FcRn-targeted therapy.

PMID 42876587
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PubMedBehavior research methods2026-10-15

The samplr package: A tool for modeling human cognition with sampling algorithms.

Castillo Lucas L, Li Yun-Xiao YX, Sanborn Adam N AN

Many models of cognition have sampling as a central component. Researchers have used them to explain human performance across a wide range of tasks involving perception, probability reasoning, and choice. One family of these models takes inspiration from sampling approaches developed in statistics, either by adjusting samples with prior beliefs or by implementing a sampling algorithm that overcomes the difficulty of independent samples at the expense of autocorrelation. While these models have been successful in modeling human behavior, their adoption has been slowed by the technical difficulties in applying them. Here, we introduce the samplr package, which includes a variety of these algorithms and cognitive models built upon them. We show how models in this package can match qualitative patterns found in human data, and walk readers through examples of how to compare these models quantitatively to human data. This tool aims to make these methods accessible to many more researchers.

PMID 42875719
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PubMedBreastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine2026-10-15

LGBTQ+ Parents and Infant Feeding: An Analysis of the Household Pulse Survey Dataset.

Bahorski Jessica S JS, Pena Hidalgo Jairo J, Sabuncu Crim C, Xavier Hall Casey D CD

Human milk is the optimal food for newborns; however, infant feeding practices of parents who are lesbian, gay, bisexual, trans, queer, or sexual and gender minorities (LGBTQ+) are largely unknown. The purpose of this study was to describe infant feeding practices in LGBTQ+ families and compare to heterosexual or cisgender families. Secondary analyses of parents with an infant less than 12 months from the Household Pulse Survey (April-July 2024) were conducted. Demographic characteristics to include sexual orientation and gender identification were extracted. Infant feeding practices were classified as: (1) human milk only; (2) a mix of human milk and formula; or (3) formula only. The chi square test and multinomial regression were used in these analyses. Data from 1,598 parents were analyzed, 7.63% identified as not heterosexual and 1.4% as gender diverse. There were no significant differences in feeding practices between cisgender and gender-diverse parents: human milk only 41.7% versus 47.8% (p = 0.71), mixed feeding 25.0% versus 26.1% (p = 1.0), formula only 33.3% versus 26.7% (p = 0.61). Nor any significant differences in heterosexual parents compared to lesbian, gay, and bisexual parents: human milk only 42.3% vs 36.1% (p = 0.22), mixed feeding 24.8% versus 27.1% (p = 0.66), formula only 32.9% versus 36.9% (p = 0.43). Results remained nonsignificant using regression models and controlling for covariates, along with analyses of men and women separately. These data provide preliminary insight into infant feeding practices of LGBTQ+ parents, demonstrating no differences compared to heterosexual or cisgender parents. Clinicians should continue to support human milk as the optimal choice for all families.

PMID 42876241
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PubMedXenotransplantation2026-10-15

Expression of Human Thrombomodulin by Porcine Endothelium Attenuates Thrombus Formation and Platelet Activation in a Dynamic Shear Flow Model.

Dufault Megan M, Sanatkar Sayed-Amir SA, Habibabady Zahra Z, Diaz Victoria V et al.

Long term xenografts often fail in association with evidence of coagulation pathway dysregulation, which may be caused in part by the inefficient binding of inactivated protein C (PC) to porcine thrombomodulin (TBM). This study evaluates the effect of human TBM (hTBM) expression by genetically modified pig endothelium on human platelet activation, adhesion, and aggregation within a dynamic in vitro xenoperfusion model. Porcine aortic endothelial cells (PAECs) with a variety of genetic modifications and immortalized human coronary endothelial cells (HCECs) (n = 9) were cultured to confluence in microfluidic channels and perfused for one hour with human whole blood stained with 0.5 mM Calcein to visualize thrombosis formation. After one hour of perfusion, platelet adhesion (as percent surface area coverage) and aggregation (fluorescence intensity) were significantly reduced in association with human APC (hAPC) pretreatment of GTKO, and with DKO.hCD55.hTBM or 10-GE ECs relative to GT/DKO ± hCD55 ECs. Fold change in frequency of activated (CD62P+) platelets in channel effluent was significantly decreased in association with GTKO+hAPC (1.5 ± 0.03 p = 0.01, n = 6), and DKO.hCD55.hTBM (1.6 ± 0.03 p = 0.02, n = 12) or 10-GE ECs (1.3 ± 0.04 p < 0.0001, n = 9) relative to GT/DKO ± hCD55 ECs (1.8 ± 0.07, n = 8). No significant difference was observed between DKO.hCD55.hTBM and GTKO+hAPC. We conclude that, under conditions mimicking microcirculatory flow, hTBM expression confers anti-thrombotic effects comparable to those with hAPC pretreatment of GTKO ECs. Consequently, hTBM expression is a promising method to inhibit platelet dysregulation in xenotransplant models.

PMID 42876424
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PubMedStem cells (Dayton, Ohio)2026-10-15

Bridging the Translational Gap in Sex-Specific Alzheimer's Disease Using Human iPSC-Based Neural Cell Models.

Supakul Sopak S, Phisalaphong Romruedee R, Changchai Makalin M, Okano Hideyuki H

Alzheimer's disease (AD) exhibits marked sex differences in disease prevalence, progression, and therapeutic responsiveness, with women disproportionately affected by both cognitive decline and neuropathological burden. Although sex hormones such as estrogen, progesterone, and testosterone have demonstrated neuroprotective effects in experimental systems, clinical outcomes of hormone-based interventions remain inconsistent. Emerging evidence further indicates that sex-specific molecular programs extend beyond endocrine signaling alone and include cell type-specific transcriptional architectures established across the lifespan. Recent single-cell transcriptomic studies have suggested that biological sex fundamentally shapes multicellular brain vulnerability. However, prevailing preclinical systems incompletely model human endocrine aging, sex chromosome biology, and patient-specific genetic heterogeneity, thereby limiting translational relevance. Human induced pluripotent stem cell (iPSC)-derived neural systems provide a new platform for mechanistically interrogating sex-specific pathways within human genetic backgrounds. By preserving donor-specific genetic backgrounds and sex chromosome complement, iPSC-derived neurons, astrocytes, microglia, and multicellular systems enable controlled investigation of hormone-responsive phenotypes, APOE-associated mechanisms, and cell type-specific transcriptional programs. However, their developmental immaturity and incomplete representation of systemic aging, vascular, immune, and endocrine physiology limit direct extrapolation to patients. Integration of these cellular systems with human omics datasets, neuropathological observations, and clinical studies may therefore help address specific components of the translational gap in AD.

PMID 42876052
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