prothrombin complex (Kanokad / Kaskadil)

Difunctionalization of unsaturated hydrocarbons via EDA complexes to access pentafluorosulfanyl thioethers.

Zhang Xiaofeng X, Jiang Yuanyang Y, Yang Hui-Yi HY, Ma Yifan Y et al.

Recently, the pentafluorosulfanyl (SF5) group has attracted considerable interest from medicinal chemists owing to its capacity to significantly enhance the pharmaceutical properties of small-molecule drug candidates. However, a general method for three-component pentafluorosulfanylation of electron-deficient alkenes remains elusive. Herein, we present an electron donor-acceptor (EDA) complex photoactivation strategy for the thiopentafluorosulfanylation of unsaturated hydrocarbons, including electron-deficient alkenes, alkynes, 1,6-enynes, and even acetylene gas. The utility of this approach is demonstrated through the synthesis of a diverse array of pentafluorosulfanyl thioethers and the late-stage functionalization of complex molecules, including pharmaceuticals, natural products, and amino acid derivatives. This work establishes a framework for designing atom-economical difunctionalization reactions that employ green LEDs under mild conditions. Moreover, mechanistic studies support an EDA complex-mediated pathway and identify ArSCl as a key intermediate formed upon generation of the thiyl radical.

Real-World Outcomes of Iptacopan in C3 Glomerulopathy and Primary Immune Complex-Mediated Membranoproliferative Glomerulonephritis.

Bassanese Giulia G, Weingarten Ariel Martje AM, Marasà Maddalena M, Mancuso Maria Cristina MC et al.

Computational modelling of host-guest interactions between a Ni(II) coordination complex and persistent organic pollutants.

Hasan Md Nur MN, Dutta Basudeb B, Mahapatra Manas M, Halder Shibashis S

Regulatory restrictions and controlled experimental access to numerous hazardous agrochemicals pose a growing challenge to the strategic design of advanced sensing materials for persistent organic pollutants (POPs). This study presents a comprehensive theoretical analysis of a well-characterized Ni(II)-based coordination complex, prepared by a slow diffusion process, as a possible sensing platform for the identification of several POPs. Density functional theory (DFT), time-dependent DFT, reduced density gradient, and electron localization function analyses were utilized to systematically investigate the Ni complex's interaction with representative POPs, their optical responses, non-covalent interactions, and electron localization. Depending on the molecular structure of the POPs, optimized host-guest geometries exhibit favourable binding affinities driven by a combination of van der Waals interactions, electrostatic interactions, π-interactions, etc. The recognition mechanism and relative selectivity of the Ni(II) complex towards different POPs can be observed at the molecular level through binding energies, charge transfer characteristics, frontier molecular orbital analyses, independent gradient model and non-covalent interaction studies. The outcome highlights the Ni(II) complex's potential as a sensing material via alterations in optical responses. Its electronic structure is found to be sensitively modulated upon guest binding. This study establishes a predictive computational sensing strategy for hazardous POPs that are difficult to access experimentally (sometimes banned), providing useful guidelines for the future design of coordination complex-based sensors targeting hazardous and highly regulated contaminants.

Metronomic decitabine with venetoclax offers a patient-centered frontline therapeutic approach for TP53-mutated complex-karyotype myeloid neoplasms.

Walsh Laura Frances LF, Lee Royce P RP, Pan Joanathan J, Dutta Arun B AB et al.

Not available.