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anti-varicella zoster immunoglobulins

✓ Approved

Kedrion · Polyclonal Antibodies · Polyclonal Antibodies

What is anti-varicella zoster immunoglobulins?

anti-varicella zoster immunoglobulins is a polyclonal antibodies developed by Kedrion. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

CompanyKedrion
Drug ClassPolyclonal Antibodies, Antibody
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, Kedrion

Therapeutic Indications

anti-varicella zoster immunoglobulins is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsVaricella zoster virus infection✓ Approved

Related Research Articles

PubMedFrontiers in microbiology2026-10-15

Effects of long-term application of traditional compost and bio-compost on soil microbial community structure and life-history strategies.

Liu Lizhan L, Yang Tao T, Wu Xiaofang X, Fan Yang Y et al.

Long-term compost application is an important strategy for improving soil fertility and regulating soil microbial communities, but the comparative effects of traditional compost and bio-compost on microbial life-history strategies remain unclear, which is a valuable framework for linking community shifts to soil carbon and nutrient cycling. In this study, a long-term (30-year) field experiment established in 1993 under a winter wheat-summer maize cropping system was used to evaluate the effects of high-rate bio-compost, high-rate traditional compost, low-rate bio-compost, low-rate traditional compost, and an unfertilized control on soil properties, enzyme activities, microbial community structure, and oligotrophic/copiotrophic groups. Compost application significantly increased soil organic carbon, total nitrogen, total phosphorus, and soil moisture, with soil organic carbon content in the high-rate bio-compost treatment being 33.8% higher than that of the control. Soil oxidative enzyme activities, including catalase, lignin peroxidase, manganese peroxidase, and laccase, were also enhanced by compost addition. Bacterial diversity was highest under low-rate bio-compost, whereas fungal diversity and trophic strategies showed stronger responses to fertilization. Principal coordinate analysis and permutational multivariate analysis of variance indicated that both bacterial and fungal community compositions were significantly altered by 30 years of compost application. The bacterial oligotroph/copiotroph ratio remained relatively stable among treatments, while the fungal oligotroph/copiotroph ratio decreased significantly under low-rate bio-compost. Specifically, this treatment significantly decreased the relative abundance of the oligotrophic fungal phylum Basidiomycota while increasing the copiotrophic phylum Ascomycota, indicating a shift toward copiotrophic fungal groups. Co-occurrence network analysis showed that the high-rate bio-compost significantly enhanced microbial network complexity, increasing the number of nodes from 419 (control) to 753 and edges from 828 to 1841 in the bacterial network, suggesting enhanced microbial connectivity under high-rate bio-compost application. Correlation, Mantel, and redundancy analyses further identified soil total phosphorus and oxidative enzyme activities, especially manganese peroxidase, lignin peroxidase, and laccase, as key factors associated with microbial community variation and trophic group distribution. Overall, long-term bio-compost application improved soil fertility, stimulated oxidative enzyme activities, enhanced microbial network complexity, and regulated microbial life-history strategies, with different responses between bacterial and fungal communities.

PMID 42876575
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PubMedChemical Society reviews2026-10-15

New approach methodologies in nanomedicine: bridging the gap between in silico, in vitro, and in vivo systems.

Radwan Yasmine Y, Rebolledo Laura P LP, Skelly Elizabeth E, Grabarnik Emma E et al.

The rise of nanomedicine has led to the regulatory approval of more than 80 nanoparticle (NP)-based therapeutics over the past two decades. Further advancement in the field requires a deeper understanding of the nano-bio interface of NPs, including their uptake, delivery, efficacy, toxicity, and adverse effects. Despite the heavy reliance on conventional cell cultures for NP screening, these models do not recapitulate the in vivo microenvironment, complexity, and physiological responses; hence, follow-up animal studies are required. Nonetheless, because of species-specific differences and ethical concerns around animal studies, developing alternative platforms has become critical. To address these issues, 3D cell culture models such as organoids, spheroids, and organ-on-chip systems have emerged to bridge the gap between in vitro and in vivo systems. Because they better represent cell interactions, gene expression, nutrient gradients, and tissue-specific functions, 3D models also align with the U.S. FDA's promotion of new approach methodologies (NAMs) to reduce animal testing. This review covers examples of organic and inorganic NPs tested in 3D models and discusses organ-specific NAMs, considering their advantages and limitations. The review also highlights how 3D models improve NP evaluation for drug delivery, toxicity, and targeted therapy, and provides a coherent NAMs toolbox for developing in silico methods for NP assessment. Future perspectives are introduced to underscore the importance of integrating in silico NAMs and 3D models to complement in vivo models for advancing precision medicine and improving the translational potential of complex drug products containing nanotechnology.

PMID 42876279
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PubMedPakistan journal of biological sciences : PJBS2026-10-15

Molecular Engineering of the Thioredoxin (trxA) Gene in Chryseobacterium proteolyticum Enhanced its Keratinase Bioconversion of Chicken Feathers.

Mpaka Lindelwa L, Nnolim Nonso E NE, Nwodo Uchechukwu U UU

<b>Background and Objective:</b> Keratinases are gaining traction in green technology and the bio-economy due to their ability to convert keratinous biomass into valuable products, such as animal feed. However, improving their output remains challenging. This study investigated genetic engineering approaches to increase keratinase production. <b>Materials and Methods:</b> The genome of the keratinolytic bacterium, <i>C. proteolyticum,</i> was sequenced using the Ion GeneStudio<sup>™</sup> S5 Prime System, covering 2,484,843 reads, and sequence reads generated were assembled using SPAdes 3.13.0. The quality of the reads was assessed with QUAST V4.1, and the obtained sequences were annotated with Prokka 1.14.6, which revealed that trxA is associated with keratinolytic activity. The nucleotide sequence obtained was uploaded to the NCBI database and was assigned the accession number JBJLWK000000000. The <i>trxA</i> gene was amplified with primers from NCBI Primer-BLAST, cloned into a p-GEM<sup>®</sup>-T Easy vector, and transformed into <i>E. coli</i> JM109, and expressed using IPTG and SDS-PAGE analysis. The effects of pH and temperature on enzyme production were studied, and the recombinant strain's thermostability and tolerance to commercial laundry detergents were assessed. <b>Results:</b> The gene was successfully cloned and expressed, with SDS-PAGE showing a clear band at 11 kDa, matching trxA's molecular weight. The pGEM-trxA construct demonstrated high keratinase activity across various pH and temperature conditions. Additionally, the recombinant strain showed excellent thermostability and detergent tolerance. <b>Conclusion:</b> These findings highlight the potential of recombinant technology to boost keratinase yields and support the sustainable recycling of keratinous waste.

PMID 42876176
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PubMedRespirology case reports2026-10-15

The Bird's Nest Sign as an Initial Presentation of Primary Pulmonary B-Cell Non-Hodgkin Lymphoma With Plasmacytic Differentiation.

Dinh-Van Luong L, Nguyen-Cong Hoang-Anh HA, Duong-Minh Phuong P, Tran-Ngoc Nguyen N et al.

The bird's nest sign (BNS) has been described as a sign on chest computed tomography (CT) in various pulmonary diseases. We report a rare case of primary pulmonary B-cell non-Hodgkin lymphoma with plasmacytic differentiation presenting with BNS, mimicking an invasive fungal disease at first. A 61-year-old Vietnamese man with a history of idiopathic thrombocytopenia and splenectomy 3 years prior to admission presented with prolonged dry cough, mild dyspnoea on exertion and chest discomfort for 3 weeks. His laboratory tests were unremarkable, but his chest CT showed bilateral consolidation with the BNS. After an unfavourable response to anti-fungal therapy, the second transthoracic lung biopsy confirmed the diagnosis of primary pulmonary B-cell non-Hodgkin lymphoma with plasmacytic differentiation. This case highlights the importance of considering lymphoma in the differential diagnosis of BNS when infection is excluded and concurrently seeking a confirmatory diagnosis with repeated diagnostic procedures when necessary.

PMID 42876532
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PubMedChemical communications (Cambridge, England)2026-10-15

Electrocatalytic valorization of methane: strategies and pathways toward value-added chemicals.

Lv Mingyang M, Zhou Yida Y, Wang Chen C, Li Qingyi Q et al.

Methane (CH4), as the principal component of natural gas, shale gas, and combustible ice, serves as a strategic resource crucial for optimizing carbon utilization and reducing reliance on petroleum. Electrocatalytic methane conversion, driven by clean electrical energy, enables the selective transformation of methane under mild conditions, offering a promising alternative to conventional energy-intensive and high-emission processes. This review systematically summarizes recent advances in the electrocatalytic conversion of methane into high-value-added products. The article begins by explaining the fundamental principles of electrocatalytic methane conversion and highlighting its distinct advantages over conventional methods. Subsequently, we focus on a variety of target products, including C1 products, C2+ products, and other high-value products, offering a detailed discussion of the latest developments in diverse electrocatalytic systems and providing an in-depth analysis of their respective reaction mechanisms. Finally, the review will conclude by identifying the key scientific and technological challenges currently faced by this field and by proposing perspectives on future research directions and development opportunities, with the aim of serving as a valuable resource for advancing this emerging area even further.

PMID 42876336
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PubMedNatural product reports2026-10-15

γ-Amino acid-containing natural products of bacterial origin: structure, biosynthesis, and bioactivity.

Götze Sebastian S, Decker Tanya T, Balluff Sven S, Beemelmanns Christine C

Covering: 1966 to 2026γ-Amino acids are structurally diverse non-proteinogenic building blocks that endow bacterial natural products with unique conformational, physicochemical, and biological properties. Although individual γ-amino acid-containing metabolites have been extensively investigated, their structural diversity, biosynthetic origins, and functional significance have rarely been considered from a unified perspective. Here, we review nearly six decades of research on bacterial γ-amino acid-containing natural products, covering from 1966 and the discovery of bleomycin to genome-guided discoveries in 2026. We discuss the major structural classes of γ-amino acids, including GABA-derived, β-keto, statine-type, vinylogous, fully reduced, and masked amino acid-derived motifs, and highlight how these building blocks are generated through primary metabolism, hybrid NRPS-PKS assembly lines, and specialized tailoring reactions. Particular emphasis is placed on the relationships between γ-amino acid structure, biosynthetic logic, and biological function, including their roles in protease inhibition, covalent target engagement, metallophore activity, and microbial ecology. Finally, we discuss emerging opportunities for genome mining and biosynthetic engineering that are expected to accelerate the discovery and exploitation of γ-amino acid-containing natural products.

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