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miconazole + benzoyl peroxide (Acnidazil / Acne Creme Plus)

✓ Approved

Teva Pharmaceutical Industries Ltd. · Small Molecule · Small Molecule

What is miconazole + benzoyl peroxide?

miconazole + benzoyl peroxide is a small molecule developed by Teva Pharmaceutical Industries Ltd.. It is approved for therapeutic indications.

Drug Profile

Brand NamesAcnidazil, Acne Creme Plus
CompanyTeva Pharmaceutical Industries Ltd.
Drug ClassSmall Molecule
StatusApproved
Sources: ClinicalTrials.gov, Teva Pharmaceutical Industries Ltd.

Therapeutic Indications

miconazole + benzoyl peroxide is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersAcne✓ Approved

Related Research Articles

PubMedMolecules (Basel, Switzerland)2026-10-16

Peroxidase Sensor Based on Electroactive Ce3+-Phytic Acid-Cu2+@Cu Composite.

Dou Boxin B, Li Minrong M, Li Mingyu M, Wang Yan Y et al.

Peroxide is a vital oxidant that can quickly kill bacteria, viruses, and fungi in food and ensure food safety. However, excessive intake will stimulate the gastrointestinal tract, cause abdominal pain and vomiting, and its strong oxidation will also destroy the vitamin and protein structure in food. Cerium-based nanomaterials exhibit good biocompatibility and strong chemical stability, and have significant application value in biological detection. Cu nanoparticles were deposited on the surface of a glassy carbon electrode (GCE) by potentiostatic deposition. The Ce3+/PA-Cu2+@Cu/GCE sensor was constructed by etching and complexing Cu2+ with phytic acid (PA) to form a PA-Cu3+ coordination film. By X-ray diffraction (XRD) and Fourier Transform Infrared (FT-IR), the structure of composite material on the electrode surface was characterized. Electrochemical test results: Cu time of electrodeposition 700 s, PA embellishment 60 min, Ce3+ coordination 60 min, and H2O2 Reaction 15 min. The detection linearity range of the sensor for hydrogen peroxide is 0.1-100 μmol/L, detection limit is 0.89 μmol/L, and there was good selectivity, sensitivity and reproducibility (RSD = 1.013%) and stability (retention of 84% response at 28 days).

PMID 42883214
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PubMedMolecules (Basel, Switzerland)2026-10-16

Dynamic Coordination Microenvironments of Fe Single-Atom Catalysts in Advanced Oxidation Processes: From Working-State Evolution to Pathway-Selective Regulation.

Li Shuqi S, Li Shun S, Zheng Haobin H, Lou Xinyi X

Iron single-atom catalysts (Fe-SACs) offer an atomically defined platform for peroxide-based advanced oxidation, yet their reactivity is still frequently rationalized using coordination structures measured only before or after catalysis. Such static descriptors identify precursor sites but do not necessarily resolve the Fe configurations that carry turnover. This Review establishes a dynamic coordination framework that distinguishes resting structures, reaction-induced working states, and irreversible deactivation products. It examines how first-shell coordination, axial ligation, extended microenvironments, neighboring sites, and interfacial solvation govern the formation and interconversion of peroxide-bound, hydroxy, Fe-oxo, and electronically coupled Fe-oxidant states. Radical, high-valent Fe-oxo, singlet-oxygen, and interfacial electron-transfer pathways are treated as competing catalytic fluxes emerging from a shared working-state landscape rather than as fixed attributes of individual Fe-Nx motifs. Particular emphasis is placed on the evidence required to identify kinetically competent intermediates, distinguish reversible coordination adaptation from structural escape, and connect working-state populations with regeneration and lifetime. Coordination and microenvironment engineering strategies are then evaluated according to their ability to control pathway selectivity without compromising site recoverability. Covalent organic frameworks are discussed as molecularly programmable platforms that can integrate Fe-site definition, charge transport, solvation, and oxidant supply. The resulting structure-state-pathway-lifetime framework advances Fe-SAC design from static activity correlations toward predictive control of catalytic trajectories under realistic operating conditions.

PMID 42883262
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PubMedMaterials (Basel, Switzerland)2026-10-16

Octavinyl-POSS as a Modifier of Thermoplastic Polyolefin Elastomers Based on Ethylene-Propylene-Diene and Ethylene-1-Octene EPDM/POEs Blends.

Lipińska Magdalena M, Marek Patrycja P, Gałęziewska Monika M

Thermoplastic polyolefin elastomers (TPOs) were developed from ethylene-propylene-diene (EPDM) rubber and ethylene-1-octene copolymers (POEs) differing in melt viscosity and crystallinity. EPDM/POE blends were prepared at a fixed composition by a melt-mixing process readily applicable to industrial manufacturing. To enhance interfacial interactions and network formation, the blends were modified with octavinyl-polyhedral oligomeric silsesquioxane (POSS) and subsequently crosslinked using dicumyl peroxide (DCP). The rheological behavior of the uncured blends was strongly influenced by the viscosity of the POE phase. POSS incorporation, together with peroxide curing, improved viscoelastic response, as evidenced by Cole-Cole analysis, and promoted curing, resulting in higher cure rate index CRI values and shorter optimum cure times τ90. The introduction of the POE phase increased the storage modulus G' of the blends, indicating a reinforcing effect. Furthermore, curing and POSS modification enhanced the tensile properties, leading to a pronounced increase in tensile strength and an approximately fourfold improvement in elongation at break. Crosslinking in the presence of POSS reduced the crystallinity of the POE phase and altered the viscoelastic response by restricting polymer chain mobility, thereby reducing stress relaxation and improving creep-recovery performance. Enhanced interfacial interactions were further confirmed by glass transition behavior. As a result, the EPDM/POE/POSS systems exhibited thermo-responsive shape-memory performance, characterized by higher shape fixity F and shape recovery RR ratios.

PMID 42882714
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PubMedFoods (Basel, Switzerland)2026-10-16

Prevalence of Aflatoxin B1 and Other Quality Indicators in Artisanal Peanut Oil from Small-Scale Workshops in Nanning, China.

Qi Zihao Z, Qiao Fan F, Xie Yu Y, Li Huishuai H et al.

To characterize aflatoxin B1 (AFB1) contamination, oil-quality variation, workshop hygiene, and modeled dietary risk associated with artisanal peanut oil produced by small-scale workshops in Nanning, China. A cross-sectional study was conducted in 144 workshops across all 12 county-level administrative areas of Nanning, with one peanut-oil sample collected from each workshop. On-site hygiene practices were assessed using a structured 13-item instrument. AFB1 concentration, acid value, and peroxide value were measured using national standard methods. Regional differences were evaluated using non-parametric tests, and K-means clustering was applied to characterize multivariate quality profiles. Dietary exposure was assessed using estimated daily intake (EDI), margin of exposure (MOE), and modeled AFB1-attributable hepatocellular carcinoma (HCC) risk. AFB1 was detected in 88.2% of samples, while 3.5% exceeded the Chinese maximum level of 20 μg/kg. Samples from counties had significantly higher AFB1 concentrations, acid values, and peroxide values than those from municipal districts (all p < 0.001). Compliance was relatively high for basic hygiene and spatial separation, whereas routine contaminant testing was reported by only 18% of workshops and aflatoxin-degradation equipment was available in 35%. The primary clustering analysis identified overall-low (81.2%), AFB1-dominant (9.7%), and rancidity-dominant (9.0%) profiles, whereas sensitivity analysis after log10 transformation favored a broader two-cluster structure. Estimated AFB1 intake was higher under the rural than the urban scenario (2.6436 vs. 0.6890 ng/kg bw/day), with corresponding MOE values of 151.31 and 580.55. Modeled HCC risk was also higher under the rural scenario and under the hepatitis B surface antigen-positive scenario. Artisanal peanut oil from small-scale workshops in Nanning showed frequent AFB1 detection, marked regional variation in multiple quality indicators, and limited implementation of contaminant-specific control practices. These findings support closer attention to routine AFB1 monitoring, storage management, and broader quality control, particularly in county settings.

PMID 42883600
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PubMedMaterials (Basel, Switzerland)2026-10-16

Valorisation of Pre- and Post-Consumer Cotton, Viscose and Bast-Fibre Textile Waste into Sodium Carboxymethyl Cellulose: A Comprehensive Study of Feedstock Type, Synthesis Route and Product Quality.

Małek Marcin M, Lipka Norbert N, Szeliga Marcin M, Tabor Monika M

Sodium carboxymethyl cellulose (Na-CMC) is among the most widely used water-soluble cellulose ethers, yet its industrial production still relies largely on virgin cotton linters and wood pulp. In this work, we systematically converted a broad panel of cellulose-bearing textile wastes-reference fabrics, pre-consumer sewing-room clippings and post-consumer garments made of cotton, viscose, flax, jute and their blends-into Na-CMC through heterogeneous alkalisation and etherification in an isopropanol-water medium. Five synthesis routes were compared, including single-step, stepwise-reagent, hydrogen peroxide (H2O2) bleaching/degrading, cross-linking (dichloroacetic acid) and sodium monochloroacetate (MCA-Na) variants. Fifty-five separate batch syntheses were characterised for degree of substitution (DS), 2% apparent viscosity, active-substance purity, pH and residual moisture. The mean DS was 0.48 ± 0.07 and did not differ significantly among feedstock classes; used garments yielded similar mean substitution levels to reference fabrics in the statistical comparison. Product purity, in contrast, was lower on average for post-consumer material (71.9%) than for reference fabrics (75.9%), with a broader post-consumer distribution. scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM/EDS) examination of the feedstocks matched this trend, showing frayed, contaminated post-consumer fibres with sulfur signals and locally elevated aluminium on the fibre surface, which were not observed on the smooth pre-consumer cotton. DS showed moderate positive correlations with purity and log-viscosity. Apparent viscosities spanned four orders of magnitude (2.5-23,100 mPa·s), enabling a single, tunable process to deliver both low- and high-viscosity grades. The moderate DS (reagent efficiency ≈ 42%) is consistent with the monochloroacetate charge and reagent losses to hydrolysis rather than with the textile origin of the cellulose, and hydrogen peroxide lowered viscosity to 2.5-30 mPa·s without a significant loss of substitution. The results demonstrate laboratory-scale conversion of mechanically shredded textile waste into technical-grade CMC spanning a broad viscosity range.

PMID 42882600
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PubMedMolecules (Basel, Switzerland)2026-10-16

A Green Lindqvist-Type POM/TEMPO/H2O2 Ternary Catalytic System for the Selective Oxidation of Hantzsch 1,4-Dihydropyridines (1,4-DHPs) to Pyridines.

Zeng Qiang Q, Yan Xiaoxiao X, Hou Shaohong S, Zhang Yutong Y et al.

Pyridine derivatives are prepared via the dehydrogenative aromatization of 1,4-dihydropyridines (1,4-DHPs). Among these methods, stoichiometric catalysis with high waste and electrochemical oxidation with less productivity are limited in their use. Notably, methyl groups and nitrogen atoms may impose limitations on oxidation. We revealed the efficient strategy via recyclable Lindqvist-type polyoxometalate (POM) (n-Bu4N)2[Mo6O19] and 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) as co-catalysts using the green and economical oxidant hydrogen peroxide. The method applied to the aromatization of a large amount of 1,4-dihydropyridines (1,4-DHPs) incorporating multiple oxidation-prone groups to pyridines with a high conversation rate and selectivity. The Lindqvist-type POM/TEMPO/H2O2 ternary catalytic system was verified on a larger scale; meanwhile, after being recycled for six times, the Lindqvist-type POM catalyst could be used for the oxidation without obvious loss in reaction time and isolated yield (up to 90%). The mechanism of the ternary catalytic system was proposed by the control experiments.

PMID 42883293
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