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miconazole + benzoyl peroxide (Acnidazil / Acne Creme Plus)

✓ Approved

Teva Pharmaceutical Industries Ltd. · Small Molecule · Small Molecule

What is miconazole + benzoyl peroxide?

miconazole + benzoyl peroxide is a small molecule developed by Teva Pharmaceutical Industries Ltd.. It is approved for therapeutic indications.

Drug Profile

Brand NamesAcnidazil, Acne Creme Plus
CompanyTeva Pharmaceutical Industries Ltd.
Drug ClassSmall Molecule
StatusApproved

Therapeutic Indications

miconazole + benzoyl peroxide is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersAcne✓ Approved

Related Research Articles

PubMedMacromolecules2026-07-17

Solid State Cross-Linked Polypropylene via Reactive Extrusion: A Scalable Approach.

Perez-Bravo Jonas J JJ, González-Benito Javier J, Harings Jules A W JAW

Solid-state reactive extrusion provides a promising route for modifying semicrystalline polymers while minimizing degradation associated with conventional melt processing. Here, isotactic polypropylene was modified using benzoyl peroxide at 110 °C, below the polymer melting temperature. Under these conditions, radical reactions occur within the amorphous regions of the semicrystalline matrix while crystalline lamellae remain intact and restrict large-scale chain motion. FTIR and 13C CP-MAS NMR analyses indicate that the polypropylene backbone is largely preserved after processing. Differential scanning calorimetry shows increased crystallization temperatures and reduced crystallinity, consistent with restricted chain mobility and network-induced nucleation. Rheological measurements reveal a progressive increase in the storage modulus with increasing peroxide concentration and a transition toward predominantly elastic behavior with the absence of G'/G" crossover, indicating increased molecular connectivity and network formation. Compared with conventional melt-state peroxide modification, the solid-state approach promotes intermolecular connectivity while limiting degradation pathways, providing an energy-efficient and scalable strategy for tailoring polypropylene properties.

PubMedChemistry & biodiversity2026-07-17

Reassignment of a Biaryl Peroxide Natural Product as an Industrial Antioxidant.

Elyashberg Mikhail M, Su Chuyi C, Williams Craig M CM, Bates Roderick W RW

A biaryl peroxide natural product is reassigned to an industrial antioxidant following inspection of the original data, calculation of 13C NMR chemical shifts, and comparison to an authentic sample.

PubMedScientific reports2026-07-17

Silver nanoparticle hydrogen peroxide composite mitigates resistant Escherichia coli dissemination driven by poultry waste biosecurity failures.

Badawy Basma B, Sayed-Ahmed Mohamed Z MZ, Elsayed Mona M MM, Al-Rasheed Mohammed M et al.

This two-phase study evaluated biosecurity vulnerabilities across 100 commercial poultry farms via a field survey and an in vitro assessment of hydrogen peroxide (H2O2) versus a silver nanoparticle-hydrogen peroxide (AgNPs- H2O2) composite. Survey metrics revealed critical baseline deficiencies: 80% of farmers lacked antimicrobial resistance (AMR) awareness, 90% practiced no litter treatment, and 70% of untreated waste was sold directly to aquaculture. Molecular analysis of 192 litter samples verified a 72.4% E. coli prevalence, with Multiple Antibiotic Resistance (MAR) indices peaking at 0.90. Phenotypic profiling showed high resistance to ampicillin (89.9%) and amoxicillin-clavulanic acid (61.2%), whereas colistin demonstrated 100% susceptibility. A significant co-resistance was identified between imipenem and tetracycline (φ = 0.65, p_adj < 0.001) and between cefotaxime and ceftazidime (φ = 0.58, p_adj < 0.001), P < 0.01) after Benjamini-Hochberg FDR correction. Concurrently, the AgNPs- H2O2 composite exhibited superior efficacy with a Minimum Inhibitory Concentration (MIC) of 3.125 µg/mL, proving four-fold more potent than standalone H2O2. Time-kill kinetics demonstrated complete bacterial reduction within 24 h (P < 0.001), successfully suppressing the post-6-hour regrowth observed with H2O2 alone. While this study is limited by its regional geographical scope and the lack of molecular characterization for specific resistance genes, it conclusively identifies veterinary supervision deficits (P < 0.0001) as a driver of extensively drug-resistant (XDR) transmission. Ultimately, the AgNPs- H2O2 composite offers a promising in vitro One Health biosecurity strategy, achieving complete bacterial reduction under controlled conditions at a 75% lower concentration than standalone H2O2, pending field validation.

PubMedRSC advances2026-07-17

Eco-friendly silver nanoparticle-based dual sensors for environmental toxicants: Hg2+ and H2O2.

Mahamud Nahim Md Ahad MA, Islam Md Toufiqul MT, Das Saurav Kumar SK, Islam A B M Nazmul ABMN et al.

Monitoring mercury ions (Hg2+) and hydrogen peroxide (H2O2) in aquatic environments is essential due to their environmental persistence and ability to induce severe health disorders. This study highlights the potential of biogenically synthesized silver nanoparticles (AgNPs) as an efficient probe for Hg2+ and H2O2 detection in water. The AgNP nanoprobes are highly selective for Hg2+, as evidenced by the surface plasmon resonance (SPR) band and a visible color shift from brown to colorless; interference studies confirmed minimal responses to competing ions. The nanoprobe exhibited a limit of detection (LOD) of 1.65 µM and a limit of quantification (LOQ) of 5.50 µM, with excellent linearity (R 2 = 0.9919). The nanoprobe was tested for Hg2+ in real water samples and showed excellent recovery rates. Analysis using synchrotron radiation X-ray photoelectron spectroscopy (SR-XPS) showed that the formation of an amalgam during detection alters the SPR. Additionally, the AgNP probe efficiently detected hydrogen peroxide (H2O2) in aqueous solution, with an LOD of 5.46 µM and an LOQ of 18.20 µM, respectively. The study emphasizes that a rapid, eco-friendly colorimetric sensor was developed to reliably detect hazardous pollutants in water.

PubMedFacial plastic surgery & aesthetic medicine2026-07-17

Costal Cartilage Allograft Processing and User Patterns in Rhinoplasty.

Vasudev Milind M, Liu Lauren L, Lonergan Ashley A, Torabi Sina J SJ et al.

Specific allograft processing methods may contribute to high failure rates. To characterize commonly used proprietary costal cartilage allograft processing techniques among tissue banks and assess surgeon preferences for graft sterilization methods in rhinoplasty. A comprehensive review of American Association of Tissue Banks (AATB)-certified cartilage providers was performed using public databases, United States Patent and Trademark Office records, PubMed, and consultation with research scientists. An international survey of rhinoplasty surgeons in the Evidence-Based Rhinoplasty Reading Group assessed allograft preferences for rhinoplasty. Among 41 AATB-certified cartilage providers, 12 distinct proprietary processing protocols were identified. Gamma irradiation (1.0-5.0 Mrad) was used in 63.6% of methods. Peroxide-based detergents, including hydrogen peroxide, were used in 36.4%, and alcohol-based detergents, including isopropyl alcohol, in 36.4%. Antibiotic or aseptic solutions (bacitracin, polymyxin B, gentamicin) were incorporated in 45.4% of protocols. Survey respondents favored fresh-frozen costal cartilage allograft, although most surgeons (74.6%) reported exclusive use of autologous costal cartilage. Substantial heterogeneity exists in costal cartilage allograft processing methods and surgeon selection preferences. Variability in processing may contribute to differences in reported clinical outcomes. Greater understanding of these methods may guide future research and support evidence-based graft selection.

PubMedJournal of hazardous materials2026-07-17

Revisiting furfuryl alcohol as a probe for singlet oxygen formation mechanism in chlorine-hydrogen peroxide system.

Li Lan L, Chen Hui H, Chen Yuheng Y, Chen Baiyang B

Singlet oxygen (1O2) is a key reactive species in environmental, chemical, and biological systems. For decades, furfuryl alcohol (FFA) has been used as a probe for quantifying 1O2 based on the assumption that it reacts selectively with 1O2 but is inert toward other oxidants. However, we demonstrate that this assumption is fundamentally flawed in the chlorine-hydrogen peroxide (H2O2) system-one of the most common contexts for 1O2 generation. Results demonstrate that chlorine alone can degrade FFA significantly, implying that previous studies may have systematically overestimated 1O2 yields. Specifically, raising pH facilitated the decay of chlorine but hindered FFA degradation, suggesting that 1O2 formation is unfavorable under alkaline conditions. Increasing the dosage of chlorine enhanced FFA degradation, but decreased the relative contribution of 1O2 to FFA degradation. More strangely, increasing the FFA dosage unexpectedly reduced the kinetics of FFA degradation, implying that the concentration of 1O2 was not constant under fixed chlorine-H2O2 condition. Maintaining low dissolved oxygen enhanced FFA decay, suggesting that superoxide is not an intermediate for 1O2 formation. Furthermore, pyranone was not formed during FFA degradation processes, invalidating it as a characteristic product. These evidences together challenge the accountability regarding FFA selectivity, pyranone formation, and 1O2 formation mechanisms before using FFA for 1O2 quantification in chlorine-involved systems.

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