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miconazole + benzoyl peroxide (Acnidazil / Acne Creme Plus)

✓ Approved

Teva Pharmaceutical Industries Ltd. · Small Molecule · Small Molecule

What is miconazole + benzoyl peroxide?

miconazole + benzoyl peroxide is a small molecule developed by Teva Pharmaceutical Industries Ltd.. It is approved for therapeutic indications.

Drug Profile

Brand NamesAcnidazil, Acne Creme Plus
CompanyTeva Pharmaceutical Industries Ltd.
Drug ClassSmall Molecule
StatusApproved
Sources: ClinicalTrials.gov, Teva Pharmaceutical Industries Ltd.

Therapeutic Indications

miconazole + benzoyl peroxide is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersAcne✓ Approved

Related Research Articles

PubMedDalton transactions (Cambridge, England : 2003)2026-08-30

A triphenylphosphine-coordinated copper(I) complex with aggregation-induced emission characteristics for chemodynamic therapy.

Hong Zhaoguo Z, Lai Xinjie X, Liu Fangyi F, He Ming M et al.

Cu(I)-mediated Fenton-like catalytic performance has been extensively explored in chemodynamic therapy (CDT) due to its excellent reactive oxygen species (ROS) production. Integration of its specific Cu(I)-mediated CDT functions with customized aggregation-induced emission (AIE) luminogens to achieve efficient therapeutics and specific bioimaging of tumors is highly desirable but rarely studied. Herein, a novel triphenylamine (TPA)-modified AIE-active ligand and triphenylphosphine (TPP)-coordinated copper(I) complex (denoted as DPB-OD-Cu) was fabricated and accurately characterized. Owing to the restriction of the two rotatable parts of TPA and TPP units to motion in poor and high viscosity solvents, DPB-OD-Cu exhibits strong AIE behavior. Besides, the obtained DPB-OD-Cu exhibited high cytotoxicity and tumor suppression effect due to the conversion of intracellular hydrogen peroxide (H2O2) into cytotoxic hydroxyl radicals (˙OH) in the presence of Cu(I), thereby increasing oxidative stress, leading to the apoptosis of cancer cells. Furthermore, DPB-OD-Cu has shown specific mitochondrial imaging performance in NCI-H460 cancer cells. Therefore, the integration of Cu(I)'s Fenton-like reaction with functional AIEgens will advance the development of cell/subcellular-targeted CDT agents for image-guided therapy, opening new therapeutic opportunities.

PMID 42669408
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-08-30

An Injectable ROS-Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions.

Cheng Peixian P, Song Jian J, Li Yuxin Y, Chen Ming M et al.

Intrauterine injury triggers a self-reinforcing cycle of inflammation, oxidative stress, and fibrosis that culminates in intrauterine adhesions (IUA), severely impairing women's reproductive health. Current treatments, including hysteroscopic adhesiolysis combined with hormonal therapy or physical barriers, show high recurrence and cannot simultaneously target these interconnected pathways. Here, we developed an injectable ROS-responsive hydrogel (GPP) loaded with cerium-tannic acid metal-phenolic nanozymes (CeTA) that exhibit superoxide dismutase (SOD)- and catalase (CAT)-mimetic activities. Unlike passive barriers, its boronate ester-crosslinked network remains stable under physiological conditions but is selectively cleaved in ROS-rich inflammatory microenvironments, enabling on-demand, lesion-localized CeTA delivery. In vitro, by scavenging excess superoxide and hydrogen peroxide, CeTA alleviated oxidative stress, restored mitochondrial membrane potential, promoted macrophage repolarization from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype, and reversed TGF-β1-induced fibrosis in endometrial stromal cells. In a rat IUA model, CeTA@GPP hydrogel restored uterine antioxidant enzyme activity, suppressed TGF-β1 expression and myofibroblast activation, and enhanced cell proliferation and angiogenesis; transcriptomic profiling confirmed coordinated down-regulation of the inflammation, oxidative stress, and fibrosis pathways. Accordingly, CeTA@GPP hydrogel promoted structural and functional endometrial regeneration and improved endometrial receptivity. By integrating minimally invasive injectability, physical barrier protection, and intelligent ROS-responsive multi-target bioactivity, CeTA@GPP hydrogel provides a promising strategy for IUA.

PMID 42669616
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PubMedJournal of materials chemistry. B2026-08-30

Design of Fenton reaction-based poly(γ-glutamic acid)-grafted tyramine hydrogels with intrinsic photothermal properties.

Muppuri Supritha S, Hsu Yu-I YI, Uyama Hiroshi H

Temperature regulates biochemical reactions, and controlled hyperthermia has been widely investigated for therapeutic applications. However, conventional hyperthermia is limited by non-specific heat distribution, which can damage surrounding healthy tissues. Photothermal therapy (PTT) enables localized heat generation under near-infrared (NIR) irradiation, although most reported PTT systems involve exogenous nanomaterials that require complex synthesis, surface functionalization, or integration with carrier systems to improve dispersion and retention at the target site. These modifications increase material complexity and may introduce toxicity concerns. Herein, poly(γ-glutamic acid)-tyramine (PGA-Tyr) hydrogels were prepared via Fenton reaction-mediated crosslinking, in which dityramine bonds formed the hydrogel network and in situ-generated ferric ions facilitated NIR-to-thermal energy conversion. The effects of iron(II) chloride (FeCl2), hydrogen peroxide (H2O2), and the degree of substitution (DS) of PGA-Tyr on gelation kinetics, mechanical properties, swelling behavior, and pore structure were systematically investigated. Ferric ion-containing hydrogels demonstrated efficient photothermal conversion, and the temperature increased to approximately 52.5-53.1 °C under NIR irradiation. Futhermore, optimization of the hydrogel formulation increased the photothermal conversion efficiency from ∼16% to 36.52%, with stable performance over repeated irradiation cycles. Hydrogel network density and ferric ion content regulated light penetration and heat retention, thereby enabling efficient thermal regulation. Increasing the network density improved hydrogel stability, whereas enzymatic treatment accelerated degradation. Overall, Fenton-mediated PGA-Tyr hydrogels exhibit tunable mechanical, swelling, and photothermal properties and provide a material platform for further biological evaluation in photothermal biomedical applications.

PMID 42669215
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PubMediScience2026-08-29

Mycoplasma mycoides subsp. capri encodes multiple pathways for hydrogen peroxide production.

Chandran Suchismita S, Gonzalez-Juarbe Norberto N, Assad-Garcia Nacyra N, Yimthin Thatcha T et al.

Several Mollicutes species import glycerol and related molecules as carbon sources, resulting in the release of hydrogen peroxide (H2O2), which has been suggested as a pathogenicity mechanism. We systematically deleted genes encoding components of the H2O2 pathways in Mycoplasma mycoides subsp. capri GM12 to get insight into the role of candidate factors constituting the pathways. As expected, glycerol metabolism in GM12 is associated with the highest H2O2 production compared with glycerophosphocholine. The absence of either L-alpha-glycerophosphate oxidase (GlpO) or the glycerol uptake facilitator GlpF, which is the main glycerol importer in GM12, ceased H2O2 production. However, our data did not support any role for the presumed glycerol transport system, GtsABC in glycerol- or glycerophosphocholine-dependent H2O2 production. Caprine peripheral blood mononuclear cells (PBMCs) did not show increased cytotoxic effects upon incubation with GM12 in the presence of glycerol, which does not support H2O2 to be a primary pathogenicity mechanism in GM12.

PMID 42667075
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PubMedFood microbiology2026-08-29

Physicochemical properties of plasma activated water and artificial plasma activated water and their bactericidal efficacy against Salmonella spp. over 21 days of storage.

Měřínská Tereza T, Walker Mitchell M, Keener Kevin K

This study builds upon the authors' previous research by evaluating the ability of plasma-activated water (PAW), generated using high-voltage atmospheric cold plasma, to remove Salmonella from common surfaces found in poultry houses. It investigates the physicochemical properties, stability, and antimicrobial efficacy of PAW against Salmonella over a 21-day storage period and compares it to artificially prepared PAW (APAW). PAW was generated by exposing deionized and distilled water to atmospheric cold plasma in 80% humid air at 90 kV and 60 Hz for 30 min, while APAW was prepared as a mixture of hydrogen peroxide and nitric acid. The resulting PAW and APAW both contained approximately 1100 ppm of nitrate, 1400 ppm of peroxide, and had a pH of 1.9. These solutions were applied to stainless-steel coupons contaminated with an approximately 8 log10 CFU Salmonella cocktail (S. Typhimurium, S. Newport, S. Montevideo, and S. Enteritidis). Despite minor chemical changes during storage, PAW retained strong bactericidal activity over the full 21-day period, achieving up to 99.76% reduction of Salmonella within 30 s of treatment. APAW showed comparable performance, achieving up to 99.67% reduction under the same conditions, suggesting that chemically matched solution can reproduce the antimicrobial efficacy of freshly generated PAW.

PMID 42668187
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PubMedVascular pharmacology2026-08-29

Aquaporin-1 facilitates the transport of hydrogen peroxide and nitric oxide during endothelium-dependent vasorelaxation.

Rodríguez Omar Echeverría OE, Rodríguez Sebastián Ramírez SR, Torres Sara Daniela Hernández SDH, Rosas Héctor Riveros HR et al.

Aquaporins (AQPs) are transmembrane proteins that primarily transport water, but certain isoforms also facilitate the diffusion of small neutral signaling molecules, such as hydrogen peroxide (H2O2) and nitric oxide (NO). However, whether AQPs mediate vascular H2O2 and NO transport remains poorly understood. We investigated whether AQPs facilitate the transport of these endothelium-derived relaxing factors using relaxation assays in isolated male Wistar rat aortas. Incubation with diphenyleneiodonium (non-specific NADPH oxidase inhibitor), VAS2870 (pan-NADPH oxidase inhibitor), diethyldithiocarbamate (superoxide dismutase inhibitor), exogenous peroxidase, AgNO3 (non-selective AQP inhibitor), or bacopaside II (selective AQP1 inhibitor) significantly attenuated carbachol-stimulated endothelium-dependent relaxation. Vasorelaxation induced by exogenous H2O2 was reduced by AgNO3 or bacopaside II; however, in endothelium-denuded rings, AgNO3 - but not bacopaside II- attenuated this response. Furthermore, both AgNO3 and bacopaside II decreased relaxation mediated by the intracellular NO donor sodium nitroprusside. Concomitantly, in endothelium-denuded segments, vasorelaxation induced by the extracellular NO donor spermine NONOate was diminished by AgNO3, but was slightly increased by bacopaside II. Collectively, these findings suggest that during endothelium-dependent vasorelaxation, AQP1 facilitates endothelial H2O2 influx and subsequent NO efflux, rather than promoting their entry into vascular smooth muscle cells. Thus, our work uncovers a coordinated H2O2-NO signaling cascade that drives endothelium-dependent relaxation in the rat aorta via AQP1-mediated transport, providing novel insights into the biophysical mechanisms governing endothelial function.

PMID 42668030
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