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fluvoxamine (Favoxil CR / Favoxile CR / fluvoxamine CR)

✓ Approved

Astellas Pharma · SLC6A4 · Small Molecule

What is fluvoxamine?

fluvoxamine is a small molecule developed by Astellas Pharma. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesFavoxil CR, Favoxile CR, fluvoxamine CR
CompanyAstellas Pharma
Drug ClassSmall Molecule
Molecular TargetSLC6A4
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Astellas Pharma

Mechanism of Action

Molecular Targets

fluvoxamine acts on 1 molecular target:

SLC6A4solute carrier family 6 member 4 (5HTT, 5-HTT)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

fluvoxamine is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Psychiatric disordersObsessive-compulsive disorder✓ Approved
Psychiatric disordersSocial anxiety disorder✓ Approved

Related Research Articles

PubMedJournal of the American Heart Association2026-07-17

Sex Differences in Exercise Capacity and Outcomes Following Outpatient Cardiac Rehabilitation.

Smith Joshua R JR, Medina-Inojosa Jose R JR, Chacin Suarez Audry S AS, Taylor Jenna L JL et al.

Cardiac rehabilitation (CR) leads to increased exercise capacity (VO2peak) and risk reduction of major adverse cardiovascular events (MACEs). Women exhibit blunted VO2peak improvements following CR. The purpose was to examine sex differences in the clinical predictors of VO2peak improvement and odds of MACEs following CR. From 1999 to 2017, all consecutive patients undergoing cardiopulmonary exercise testing before and after CR were included. Sex differences in peak exercise metrics in response to CR were compared. Multiple logistic regression models were fit to assess clinical predictors of VO2peak improvement (defined as >0% from pre-CR) and MACEs following CR for men and women. A total of 513 men and 158 women were included. Men had greater increases in VO2peak than women following CR (P=0.001). For men, independent predictors of VO2peak improvement following CR included higher CR session attendance (odds ratio [OR], 1.04 [95% CI, 1.02-1.06]), peripheral artery disease (OR, 0.47 [95% CI, 0.25-0.86]), and pre-CR VO2peak (OR, 0.98 [95% CI, 0.97-0.99]) (all, P<0.02). Independent predictors of lower odds of MACEs following CR in men included higher number of CR sessions (OR, 0.97 [95% CI, 0.95-0.99]), pre-CR VO2peak (OR, 0.98 [95% CI, 0.97-0.99]), surgical CR indication (OR, 0.34 [95% CI, 0.18-0.68]), and no history of peripheral artery disease (OR, 2.94 [95% CI, 1.60-5.38]) (all, P<0.02). For women, the selected clinical characteristics were not statistically significant independent predictors of VO2peak improvement or odds of MACEs (except for diabetes) following CR. These findings suggest that clinical predictors of VO2peak improvement and odds of MACEs following CR are sex specific.

PMID 42466484
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PubMedOrganic letters2026-07-17

Light-Promoted Dearomative Amination of Nonactivated Arenes via Redox-Neutral Chromium-Nitrenoid Transfer.

Xie Hui H, Zeng Wei-Long WL, Li Chu-Qiao CQ, Wang Ming-Yang MY et al.

A light-driven dearomative amination of nonactivated arenes via redox-neutral Cr-nitrenoid transfer is reported. We designed a novel Cr(0) redox-neutral mode that overcomes traditional Cr(0)/Cr(II) redox pathways in dearomatization chemistry using (η6-arene)Cr(CO)3, thereby shifting the electrophile scope from obligatory cationic species to neutral nitrenes for the first time. This strategy enables both dearomative 1,2-hydroamination and 1,2-carboamination with exclusive regio- and stereocontrol, broad functional-group tolerance, and preferential site-selectivity for benzene rings over heteroarenes.

PMID 42464821
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PubMedWater research2026-07-17

Double macrocyclic cationic crosslinked network enabling ultrafast and efficient aqueous Cr(Ⅵ) remediation.

Deng Xinyi X, Cheng Haonan H, Yang Xinyu X, Ye Jinhong J et al.

The efficient Cr(VI) remediation from industrial wastewater is of critical importance in water purification. Herein, we rationally constructed a dual-macrocyclic cationic cross-linked network (P1) through a quaternization-driven nucleophilic substitution strategy. The incorporation of calixarene units suppresses excessive aggregation of porphyrin macrocycles, thereby improving the accessibility of adsorption sites, while the cross-linked network provides mesoporous features and interparticle voids that facilitate the diffusion of chromium species. In addition, the porphyrin and calixarene building blocks offer abundant functional sites, including hydroxyl groups, NH groups, nitrogen atoms, and cationic N⁺ centers, which interact with Cr(VI) through electrostatic attraction, ion exchange, and hydrogen-bonding interactions. As a result, P1 enables ultrafast and efficient Cr(VI) capture over a wide pH range (3-11) with good resistance toward coexisting anions. P1 exhibits a Cr(VI) adsorption capacity of 265.96 mg g-1 and a high pseudo-second-order kinetic constant (k2 = 2.016 g mg-1 min-1), reaching adsorption equilibrium within 4 min. Additionally, P1 treatment substantially reduced the toxicity of chromium-containing wastewater, enabling its potential reuse for agricultural irrigation, including wheat and mung bean cultivation. Mechanistic investigations reveal that Cr(VI) removal by P1 proceeds through synergistic electrostatic attraction, ion exchange, hydrogen bonding, and partial reduction to Cr(III), accompanied by the retention of a fraction of the generated Cr(III) species through surface complexation and coordination interactions.

PMID 42462651
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PubMedScientific reports2026-07-17

Adsorption behavior of lead and chromium onto MgO impregnated biochar derived from banana peels and rice husk in binary environment.

Kanwal Tayyaba T, Iftikhar Rashid R, Ernst Mathias M, Lee Kang Hoon KH et al.

In current research, raw- and MgO-impregnated biochar derived via (co)pyrolysis of rice husk (RH) and banana peel (BP) in mass ratios (0:1, 1:0 and 1:1) were synthesized and examined for their physiochemical properties and adsorption performance for Cr(VI) and Pb(II) ions removal from synthetic solutions. Owing to excellent removal capability (Cr(VI): 94% at pH 2; Pb(II): 100% at pH 4) of 2 g/L MgO-impregnated biochar with mass ratio 1:1 (MgO@CBC) for 20 mg/L metals ions loading in single solute system with 120 min contact time, removal performance of MgO@CBC was examined under binary environment. Interestingly, binary solute system showed significant MgO@CBC adsorption performance for Pb(II) removal (99%) with slight decrease in Cr(VI) removal (88.5%) at pH 2 under similar boundary conditions. Moreover, increasing metal ions concentration showed improved MgO@CBC adsorption potential for Cr(VI) at pH 4 and Pb(II) at pH 2, due to porous matrix Mg2+-mediated compounds and unique surface characteristics. Furthermore, the underlying removal mechanism using MgO@CBC was identified as (Cr(VI): reduction/complexation coupled with electrostatic attraction) and (Pb(II): ligand exchange followed by surface complexation) and in binary system as (Cr(VI) and Pb(II): ligand exchange, electrostatic attraction, bimetallic bonding (Pb-O-Cr) and surface complexation). In addition, MgO@CBC displayed promising recyclability potential for metal ions removal up to five cycles. In general, these experimental and mechanistic insights may provide feasible and ecofriendly solutions to tanneries, when dealing with toxic metal ions from their effluents.

PMID 42463736
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PubMedJournal of the American Heart Association2026-07-17

Metacognitive Therapy in Cardiac Rehabilitation: Staff Barriers and Enablers to Training in an Evidence-Based Psychological Treatment for Anxiety and Depression.

Wells Adrian A, Belcher Andrew A, Reeves David D, Doherty Patrick P et al.

This study was designed to explore cardiac rehabilitation (CR) practitioners' experiences and perceptions of group metacognitive therapy training, identifying the facilitators and barriers encountered. A nested qualitative study using reflexive thematic analysis was conducted as part of PATHWAY-Beacons (National Institute for Health and Care Research 202956), a mixed-methods study evaluating the implementation of group metacognitive therapy as part of routine care in CR services. Practitioners from 6 CR services in England enrolled in interviews at 3 stages: before training, after training, and after delivering all group sessions. Nine practitioners participated in the study, with 7 completing all 4 interviews, 1 completing 2 interviews (pre- and posttraining), and another completing just 1 (pretraining). Key enablers for effective training emerged in 3 subthemes: training delivery style, essential training components, and the online training format. These aspects contributed positively to the practitioners' training experiences and improved their understanding of group metacognitive therapy. Conversely, barriers included issues related to training structure, staff skepticism, and specific additional training needs. The findings support the positive value of training CR staff in group metacognitive therapy and offer important insights for enhancing the delivery and uptake of training within the National Health Service. Although the study findings represent views of a predominantly female sample, this reflects the composition of the current CR workforce.

PMID 42466501
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PubMedJournal of insect physiology2026-07-17

Establishment of a new germ-free Spodoptera frugiperda model to explore the gut microbiota on larval, pupal development and adult reproduction.

Bin-Li, Sun Hai-Dong HD, Liu Mei M, He Xin X et al.

Symbiotic microbiota of insects play crucial roles in host development, metabolism, and immunity, but the molecular mechanisms underlying these interactions remain poorly understood, particularly in non-model lepidopteran pests. Traditional germ-free (GF) insect models are primarily generated using antibiotics, which may introduce confounding effects and fail to completely eliminate microbiota. Here, we present an antibiotic-free method to generate GF Spodoptera frugiperda larvae by rearing them on axenically cultured maize. The 3rd to 6th instar GF larvae exhibited significantly reduced weight and length compared to the conventionally reared (CR) larvae, and the developmental period was prolonged. Transcriptomic analysis of 3rd instar larvae revealed significant differences in gene expression between the two groups, especially in pathways related to total carbohydrate, protein, triglycerides metabolism, as well as juvenile hormone (JH) signaling pathway. In addition, three nutritional content and JH titer were tested between GF and CR larvae. Furthermore, GF groups showed lower pupation rate and eclosion rate, reduced pupal weight, and prolonged developmental period, while pupal length was not affected compare to CR groups. Additionally, the ovarian and testes sizes of GF adults were smaller than those of CR adults. Consistently, GF females laid fewer eggs with significantly lower hatching rate compared to the CR females. These findings demonstrate that microbiota profoundly influence egg, larval, pupal development and adult reproduction in S. frugiperda. This study provides a robust framework for microbiota-function research in agricultural pests and expands our understanding of lepidopteran insects and microbiota interactions.

PMID 42462808
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