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HO

Hoe-285 (Hoe 285 / Brainorm / Albex 285)

✓ Approved

Sanofi S.A · Small Molecule · Small Molecule

What is Hoe-285?

Hoe-285 is a small molecule developed by Sanofi S.A. It is approved for therapeutic indications via injectable (others) or intravenous (iv) or oral (po).

Drug Profile

Brand NamesHoe 285, Brainorm, Albex 285
CompanySanofi S.A
Drug ClassSmall Molecule
RouteInjectable (Others), Intravenous (IV), Oral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Sanofi S.A

Therapeutic Indications

Hoe-285 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Nervous system disordersDelayed ischaemic neurological deficit✓ Approved

Related Research Articles

PubMedInternational journal of molecular sciences2026-10-16

Nonlinear Dose-Response Association Between Exercise Intensity and Urinary Liver-Type Fatty Acid-Binding Protein in Young Men: A Piecewise Threshold Analysis.

Thanh Hoa Do HD, Le Duan Duc DD, Anh Tuan Nguyen TN, Thai Cuong Nguyen CN et al.

High-intensity physical exercise can induce temporary renal hemodynamic strain and subclinical tubular injury, yet the exact dose-response relationship remains poorly defined. This study investigated the relationship between exercise intensity and urinary liver-type fatty acid-binding protein (L-FABP) concentrations, a sensitive marker of proximal tubular stress, to identify an exploratory intensity threshold. We conducted an observational cohort study of 285 healthy young men undergoing a routine 20 min physical training session. Exercise intensity was quantified as metabolic equivalents of task (METs) using wearable accelerometers, and urinary L-FABP was measured pre-exercise and 30 min post-exercise. Post-exercise urinary L-FABP concentrations increased significantly from baseline (median, 1.89 vs. 0.90 µg/gCr; p < 0.001). Restricted cubic splines confirmed a nonlinear dose-response relationship (p for nonlinearity < 0.001) with an estimated breakpoint at 6.76 METs (95% CI, 5.67 to 7.12). Below 6.76 METs, exercise intensity was not significantly associated with post-exercise L-FABP (β = 0.068, p = 0.358), whereas above this threshold, L-FABP escalated rapidly (β = 0.491, p < 0.001). In conclusion, exercise intensity nonlinearly correlates with proximal renal tubular stress in young men. The 6.76 MET threshold represents an exploratory breakpoint marking an inflection zone beyond which exercise-associated subclinical renal tubular stress accelerates.

PMID 42883787
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PubMedJournal of clinical medicine2026-10-16

Contemporary Clinical Spectrum and Factors Associated with Mortality in Infective Endocarditis: A Multicenter Cohort Study (COSMO-IE).

Kış Mehmet M, Şenöz Oktay O, İnan Duygu D, Akhan Onur O et al.

Background: Despite continuous advancements in diagnostic imaging and targeted antimicrobial protocols for infective endocarditis (IE), global epidemiological data show that both disease burden and incidence continue to rise. This study aimed to evaluate real-world diagnostic and treatment approaches in accordance with the 2023 European Society of Cardiology (ESC) IE Guidelines and to identify independent predictors of mortality in a contemporary patient cohort. Methods: This multicenter, retrospective cohort study analyzed data from 470 consecutive adult patients diagnosed with IE across 27 academic reference centers between 1 September 2023 and 1 June 2025. Patients were managed and adjudicated according to the 2023 ESC diagnostic criteria. Demographic data, clinical characteristics, microbiological profiles, imaging findings, empirical antibiotic therapy patterns, and clinical outcomes were analyzed. Independent predictors of mortality were determined using multivariable Cox proportional hazards regression models. Results: The mean age of the overall study population was 58.08 ± 16.81 years, with a male predominance (60.6%, n = 285). Staphylococcus aureus was the most frequently isolated pathogen (27.9%), with a high proportion of methicillin resistance (38.9%). Hospital-acquired IE was identified in 41.1% of cases. Surgical treatment was performed in 40.6% (n = 191) of the cohort. The 28-day mortality rate was 11.9%, and the overall mortality during follow-up reached 26.4%. Multivariable Cox regression analysis identified hospital-acquired IE (HR = 2.247; 95% CI: 1.216-4.167; p = 0.010) and the presence of major clinical complications (HR = 4.207; 95% CI: 1.556-11.378; p = 0.005) as the strongest independent predictors of mortality. Conclusions: Contemporary infective endocarditis is a highly complex and fatal disease characterized by a prominent healthcare-associated burden and a predominant staphylococcal etiology. The occurrence of major clinical complications and hospital-acquired infections were the primary independent predictors of mortality.

PMID 42882221
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PubMedJournal of clinical medicine2026-10-16

Short-Term Safety of Gastric Endoscopic Submucosal Dissection in Patients Aged 80 Years or Older Under a Standardized Inpatient Post-Procedural Surveillance Pathway: Data from a 13-Year Real-World Cohort Study.

Choi Youn I YI, Won Sun Young SY, Cho Yong Suk YS, Park Byung Kyu BK et al.

Background/Objectives: Gastric endoscopic submucosal dissection (ESD) is an established organ-preserving treatment for gastric neoplasia, but the short-term safety of ESD in patients aged 80 years or older remains clinically important. We evaluated the efficacy and short-term safety of gastric ESD in patients aged ≥80 years treated under a standardized inpatient post-procedural surveillance pathway. Methods: This retrospective cohort study included 2021 consecutive unique patients who underwent gastric ESD for gastric adenoma or gastric cancer at a single institution between April 2013 and March 2026. Patients were classified as <80 years or ≥80 years. Standard hospitalization was 3 nights/4 days for patients not receiving antithrombotic agents and 5 nights/6 days for those receiving antithrombotic agents. The primary safety outcomes were post-ESD bleeding, perforation, pneumonia, and delirium. Absolute risk differences with 95% confidence intervals (CIs) were calculated, and multivariable logistic regression was performed to evaluate the association between age ≥ 80 years and selected efficacy and safety outcomes. Results: Among the 2021 patients, 285 were aged ≥80 years and 1736 were aged <80 years. Non-curative resection was more frequent in patients aged ≥80 years (7.7% vs. 4.6%; p = 0.026), but this difference was not significant after lesion-adjusted analysis. Post-ESD bleeding (2.5% vs. 2.4%), perforation (0.4% vs. 0.7%), and pneumonia (0% vs. 0.1%) were comparable between groups, while delirium occurred in one patient aged ≥80 years. No 30-day mortality occurred in either group. In multivariable analysis, age ≥ 80 years was not independently associated with post-ESD bleeding or perforation, and the primary safety findings were similar after propensity-score matching. Conclusions: In this single-center cohort, gastric ESD in selected patients aged ≥80 years was not independently associated with non-curative resection or increased short-term adverse outcomes. Chronological age alone should not preclude gastric ESD when standardized monitoring and individualized risk assessment are applied.

PMID 42881835
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PubMedJournal of clinical medicine2026-10-16

Neutrophil-to-Lymphocyte Ratio Is Associated with Disease Progression in a Surveillance Cohort of Patients with Branch-Duct IPMN.

Hansen Frederik J FJ, Ewald Peter P, Sorncharoen Luis L, Quast Daniel R DR et al.

Background: A Branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) are common pancreatic precursor lesions requiring varying duration of surveillance because of their potential for malignant transformation. Current risk stratification relies predominantly on imaging-based criteria defined by the Kyoto guidelines, while reliable blood-based biomarkers are lacking. The neutrophil-to-lymphocyte ratio (NLR) has been associated with invasive IPMN in surgical resected cases, but its role in routine BD-IPMN surveillance has not been investigated. This study investigated the association between NLR and disease progression in a large surveillance cohort of patients with BD-IPMN. Methods: This retrospective two-center study included patients with image-based diagnosis of BD-IPMN who underwent at least one further follow-up endoscopic ultrasound (EUS) examination between 2006 and 2026 and had an available differential blood count. Disease progression was defined as the development of new worrisome features (WFs), high-risk stigmata (HRS), pancreatic resection for progressive disease, or IPMN-associated carcinoma. Results: A total of 285 patients undergoing 2207 EUS examinations were included, with a mean EUS surveillance duration of 4.8 years. During follow-up, 63 patients (22.1%) developed at least one WF, 4 (1.4%) developed HRS, 11 (3.9%) underwent pancreatic resection, and 2 (0.7%) developed IPMN-associated carcinoma. NLR was significantly elevated in patients who developed WFs (p = 0.0023), HRS (p < 0.0001), underwent pancreatic resection (p = 0.0006), or had high-grade dysplasia (p = 0.0002). Baseline continuous NLR showed no significant discriminatory ability for subsequent disease progression (AUC, 0.563; 95% CI, 0.482-0.635; p = 0.136). Patients with an NLR above the cohort median (>2.36) had approximately twofold higher odds of subsequent disease progression (OR, 2.02; 95% CI, 1.02-3.98). Longitudinal analyses demonstrated significant increases in NLR preceding the development of WFs (p < 0.0001), HRS (p = 0.0265), and pancreatic resection (p = 0.0272). Rising NLR was particularly associated with cyst growth, cyst size ≥30 mm, and main pancreatic duct dilation. Conclusions: Elevated and increasing NLR was associated with BD-IPMN progression and correlated with established markers of higher-risk disease. Longitudinal NLR assessment may represent a simple and widely available complementary biomarker for surveillance; however, its modest discriminatory performance warrants prospective validation before clinical implementation.

PMID 42882217
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PubMedJournal of primary care & community health2026-10-15

Development of a Competency Scale for Nurses Supporting the Lives of Older Adults in Japanese Community-Based Integrated Care.

Hoshi Misuzu M, Minamizaki Maya M, Doi Mana M, Kanoya Yuka Y

ObjectivesThe study aimed to evaluate the reliability and validity of a Competency Scale for Nurses Supporting the Lives of Older Adults in Japanese Community-Based Integrated Care.MethodsThis cross-sectional study used a preliminary 36-item scale administered to 296 nurses working in community-based integrated care. Construct validity was examined using exploratory and confirmatory factor analyses. Criterion-related validity was assessed by examining correlations with existing scales. Reliability was evaluated using Cronbach's α and test-retest reliability.ResultsA total of 285 valid responses were obtained. Item analysis excluded 15 items, leaving 21 items. Exploratory factor analysis identified three factors comprising 12 items. Confirmatory factor analysis demonstrated acceptable model fit (goodness-of-fit index [GFI] = 0.931, adjusted GFI = 0.886, comparative fit index = 0.969, root mean square error of approximation = 0.054). Correlations with external scales ranged from r = 0.252 to 0.750. The overall Cronbach's α was 0.852, and test-retest reliability was confirmed (r = 0.814, p < 0.01).ConclusionThe findings support the developed scale's reliability and validity. This scale may be useful for assessing nurses' competencies in community-based integrated care and identifying areas for professional development.

PMID 42878152
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PubMedPlastic and reconstructive surgery2026-10-15

Diagnostic Accuracy of Ultrasound for Localizing Lymphovenous Anastomosis Sites in Lymphedema Surgery.

Jaklin Florian J FJ, Oberreiter Maxim L ML, Weninger Wolfgang J WJ, Tzou Chieh-Han J CJ et al.

Preoperative vessel mapping is critical for successful lymphovenous anastomosis (LVA) in supermicrosurgical lymphedema treatment. Indocyanine green lymphography is common but limited by poor depth penetration and reduced visibility in advanced disease. This study aimed to evaluate the diagnostic accuracy, measurement agreement with intraoperative findings, and procedural efficiency of preoperative ultrasound in identifying surgically compatible LVA sites. This study retrospectively analyzed prospectively collected data between April 2019 and January 2024 at a secondary care center. Consecutive patients with scintigraphically confirmed limb lymphedema underwent preoperative ultrasound to localize LVA sites, with intraoperative findings as the reference standard. Diagnostic accuracy was assessed using positive predictive value (PPV), Bland-Altman analysis, multivariable logistic regression, and subgroup testing. Eighty-seven patients (mean age, 55.8 ± 12.8 years; 75 women) underwent 109 ultrasound examinations. Of 470 ultrasound-localized sites, 285 were selected for surgery; 272 were intraoperatively confirmed (PPV, 95.4%; 95% CI: 92.3, 97.5%). The 13 false positives were independent of tissue thickness, vessel size, depth, and distance (all p > 0.17). Ultrasound diameters showed minimal bias compared with intraoperative measurements [+0.13 mm (95% CI: 0.09, 0.17) for lymphatics; -0.10 mm (95% CI: -0.17, -0.04) for veins]. Mean total examination time was 34.7 ± 9.6 minutes; per-image analysis averaged 7.2 ± 2.3 minutes and was unrelated to diagnostic accuracy (p = 0.74). Preoperative ultrasound enabled accurate, reproducible localization of LVA sites with strong anatomical agreement and consistent performance across participant and anatomical variables.

PMID 42878748
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