Drug Database
MO

moxisylyte hydrochloride (Erecnos / Icavex)

✓ Approved

Medea Research · Small Molecule · Small Molecule

What is moxisylyte hydrochloride?

moxisylyte hydrochloride is a small molecule developed by Medea Research. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesErecnos, Icavex
CompanyMedea Research
Drug ClassSmall Molecule
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Medea Research

Therapeutic Indications

moxisylyte hydrochloride is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Reproductive system and breast disordersErectile dysfunction✓ Approved

Related Research Articles

PubMedMolecules (Basel, Switzerland)2026-10-16

A Robust AQbD-Based RP-HPLC Method for Simultaneous Quantification of Acyclovir and Doxepin Hydrochloride in Bulk and Topical Cream Formulation.

Kumar Akshay A, Kumar Mohit M, Saini Abhishek A, Agrawal Mohit M et al.

The present study describes the development and validation of a simple, rapid, and reliable RP-HPLC method for the simultaneous estimation of acyclovir and doxepin hydrochloride in bulk and topical cream formulation using an Analytical Quality by Design (AQbD) approach. The combination of acyclovir, an antiviral agent, and doxepin, an antipruritic and anti-inflammatory drug, offers a combined topical approach for the management of herpes-associated skin conditions. The method development was guided by a predefined Analytical Target Profile (ATP), followed by systematic risk assessment to identify critical quality attributes (CQAs) and critical method parameters (CMPs). The central composite design (CCD) was employed to optimize key chromatographic variables, including mobile phase composition and flow rate. The chromatographic separation was achieved on a C18 column using an isocratic mobile phase of acetonitrile and water (40:60 v/v) at a flow rate of 1.0 mL/min, with UV detection at 240 nm. The retention times were found to be 2.58 min for acyclovir and 4.64 min for doxepin hydrochloride, indicating efficient separation with good peak symmetry. The method was validated according to ICH Q2(R2) guidelines and demonstrated excellent linearity over the concentration ranges of 2-10 µg/mL (acyclovir) and 12-28 µg/mL (doxepin hydrochloride), with correlation coefficients greater than 0.997. The method exhibited high precision (%RSD < 2%), accuracy (recovery within 99-101%), and good sensitivity with low LOD and LOQ values. The robustness studies confirmed the reliability of the method under small, deliberate variations in chromatographic conditions. The developed cream formulation showed uniform drug content and satisfactory in vitro drug release, with a sustained release profile reaching approximately 96% over 24 h. In conclusion, the proposed AQbD-based RP-HPLC method is suitable for routine quantitative analysis and quality control of acyclovir and doxepin hydrochloride in combined topical formulations.

PMID 42883330
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PubMedInternational journal of molecular sciences2026-10-16

Development and Application of a Dual-Fluorescent Reporter Assay for Feline Infectious Peritonitis Virus RNA-Dependent RNA Polymerase Inhibitor Screening.

Semkum Ploypailin P, Lueangaramkul Varanya V, Jiwattanasap Supichaya S, Mana Natjira N et al.

Feline infectious peritonitis virus (FIPV) causes a fatal disease in cats that remains challenging to treat due to the absence of effective vaccines and limited antiviral therapies. Given its central role in viral replication and transcription, RNA-dependent RNA polymerase (RdRp) represents a highly promising and strategic target for antiviral drug development. To enable live-cell monitoring of RdRp activity without external substrates or cell disruption, we developed a biologically validated, cell-based dual-fluorescent reporter assay using green fluorescent protein and red fluorescent protein to evaluate RdRp-dependent reporter activity. Following validation with the well-characterized RdRp inhibitor ribavirin, the dual-reporter platform achieved a Z-factor of 0.54 and a Z'-factor of 0.61. The system was further utilized to assess the antiviral potential of fifteen alkaloid compounds. Among compounds evaluated, lycorine and lycorine hydrochloride exhibited potent inhibition of RdRp-dependent reporter activity and yielded IC50 values of 2.83 ± 0.45 μM and 1.58 ± 0.20 μM, respectively. Further evaluation revealed that both compounds significantly reduced FIPV replication in infected cell. These findings identify lycorine and lycorine hydrochloride as promising anti-FIPV candidates and support further investigation of lycorine-class alkaloids as anti-coronaviral scaffolds. Together, the validated cell-based screening platform and whole-virus antiviral activity provide a foundation for advancing RdRp-targeted antiviral discovery against FIPV.

PMID 42883927
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PubMedAnimals : an open access journal from MDPI2026-10-16

Chromium Propionate and Zilpaterol Hydrochloride Supplementation in Finishing Lambs: Growth Performance, Body Composition, Carcass Characteristics, and Meat Quality.

Hernández-Tovar Anselmo A, Hernández-García Esaúl E, Lazalde-Cruz Rosalba R, Rodríguez-Cordero Daniel D et al.

The objective of this study was to evaluate the effects of chromium propionate (Cr-Pr) and zilpaterol hydrochloride (ZH) supplementation on growth performance, performance-derived estimates of dietary energy utilization, body composition, carcass traits, wholesale cut distribution, and meat quality of finishing lambs. Forty intact male Dorper × Katahdin lambs were blocked by initial body weight (38.21 ± 1.72 kg) and assigned to a 2 × 2 factorial arrangement (n = 10/treatment): Control (0 Cr-Pr + 0 ZH), ZH (0 Cr-Pr + 7.2 mg ZH/lamb/d), Cr-Pr (1.2 mg elemental Cr/lamb/d + 0 ZH), and Cr-Pr + ZH (1.2 mg elemental Cr/lamb/d + 7.2 mg ZH/lamb/d). The experimental period lasted 45 d; Cr-Pr was supplemented throughout d 1-45, whereas ZH was administered during d 15-42, followed by a 3 d withdrawal period (d 43-45). Under the conditions evaluated, Cr-Pr, ZH, and their interaction did not affect growth performance or performance-derived estimates of dietary energy utilization (p > 0.05); however, both compounds produced specific changes in body composition and carcass traits. Supplementation with Cr-Pr reduced omental, visceral, and perirenal fat by 21.8, 18.6, and 18.7%, respectively (p ≤ 0.044), and increased longissimus muscle area (LMA) by 5.3% (p = 0.013). An interaction between Cr-Pr and ZH was detected for rib fat thickness (FAT) (p = 0.050), with the ZH and Cr-Pr individual treatments showing lower FAT than Control and Cr-Pr + ZH. Supplementation with ZH increased dressing percentage by 7.2% (p = 0.048). Regarding wholesale cuts, classified according to Institutional Meat Purchase Specifications (IMPS), Cr-Pr increased shoulder (IMPS 206) and loin (IMPS 231) proportions by 10.3 and 10.6%, respectively, and reduced shoulder (IMPS 207) by 3.3% (p = 0.043), whereas ZH increased breast (IMPS 209) weight by 15.0% and its proportion of cold carcass weight (CCW) by 9.7% (p ≤ 0.042). Interactions between Cr-Pr and ZH were also detected for ribs (IMPS 209A) and flank (IMPS 232) weights (p ≤ 0.047). Supplementation did not affect meat quality traits (p ≥ 0.217). Overall, Cr-Pr was associated with reduced internal fat deposition and increased LMA and loin (IMPS 231) proportion, whereas ZH modified dressing percentage and breast (IMPS 209) weight and proportion of CCW. These responses occurred without changes in growth performance or performance-derived estimates of dietary energy utilization and without detectable changes in the evaluated meat quality traits. The interactions observed for FAT, ribs (IMPS 209A), and flank (IMPS 232) were trait-specific and did not indicate a consistent benefit of the combination.

PMID 42883037
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PubMedFoods (Basel, Switzerland)2026-10-16

Theabrownin from Pu-erh Tea Restores Intestinal Immunity via Gut Microbiota-Metabolite Network in Immunosuppressed Mice.

Zhao Lei L, Zhu Anding A, Chen Jinping J, Shao Minglong M et al.

Theabrownin (TB), a polymeric pigment derived from ripened Pu-erh tea, demonstrates beneficial effects on lipid reduction, weight management, and mitigation of metabolic syndrome. However, the role of TB in restoring immune function in vivo has not been studied. This study evaluated the therapeutic effects and underlying mechanisms of TB in cyclophosphamide (CTX)-induced immunosuppressed mice. TB was administered at doses of 1.215, 0.608, and 0.304 mg/kg body weight, with levamisole hydrochloride (40 mg/kg) serving as a positive drug control. Each experimental group comprised eight mice. Evaluations primarily consisted of histopathological examination, enzyme-linked immunosorbent assay, Western blotting, flow cytometry, 16S rRNA sequencing, and ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)-based untargeted metabolomics. The results demonstrate that high- and medium-dose TB treatment significantly alleviated immunosuppression, as evidenced by restored body and organ weights, colon length, splenic and colonic histoarchitecture, blood cell counts, and immunoglobulin levels. These improvements correlated with upregulated colonic cytokines, claudin-1, occludin, toll-like receptor 2/4, and reduced regulatory T cell populations. High- and medium-dose TB treatment also enriched beneficial gut microbiota, including Lactobacillus and Candidatus saccharimonas, accompanied by strong microbiota-metabolite correlations (M2 = 0.725, p = 0.003). Metabolic KEGG pathway enrichment analysis revealed that moderate-dose TB significantly activated caffeine metabolism and histidine metabolism, accompanied by the enrichment of multiple immune signaling pathways driven by diacylglycerol series lipid metabolites, whereas high-dose TB induced a greater number of immune signaling pathways. Overall, TB may reverse CTX-induced immunosuppression by integrating gut microbiota-metabolite reprogramming, highlighting TB's potential as an immunomodulatory functional component of medicine-food homologous products.

PMID 42883488
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PubMedAmerican journal of veterinary research2026-10-15

Liposomal bupivacaine does not prolong neuraxial blockade and produces less consistent motor blockade than bupivacaine hydrochloride in inland bearded dragons (Pogona vitticeps).

Ferreira Tatiana H TH, Uelmen Johnny A JA, Fink Dustin M DM, Mans Christoph C

To compare the effects of liposomal bupivacaine (LB) to standard bupivacaine hydrochloride (B) formulation following neuraxial injection in inland bearded dragons (Pogona vitticeps). 12 adult bearded dragons (0.35 ± 0.13 kg) were sedated with alfaxalone (15 mg/kg SC), and neuraxial injections were performed with B treatment (1.5 mg/kg to 0.3 mL/kg) and LB treatment (4 mg/kg to 0.3 mL/kg) in all animals in a randomized, crossover, blinded experimental design with a 7-day interval. Motor/sensory block was assessed by mechanical stimulation of limbs; 25%, 50%, and 75% of the trunk's length; and cloacal vent tone. Heart rate, respiratory rate, righting reflex, and head position were evaluated. Overall success was 100% for B treatment and 92% for LB treatment. Median onset was 5 minutes for both B and LB treatments. Duration and extent of blockade were similar between treatments; however, pelvic limb motor blockade was less consistent in the LB treatment (7 of 12 animals), with 3 animals showing unilateral blockade. Apnea requiring manual ventilation occurred in 2 animals in the B treatment and in 2 animals in the LB treatment. Bupivacaine hydrochloride at 1.5 mg/kg (0.3 mL/kg) produced reliable motor and sensory blockade but resulted in respiratory complications. Liposomal bupivacaine at 4 mg/kg (0.3 mL/kg) resulted in a similar onset, extent and duration of blockade but less consistent motor blockade and was also associated with respiratory complications. Neuraxial injection continues to show promise as a regional anesthetic technique in healthy bearded dragons, providing extensive motor and sensory blockade. However, respiratory complications occurred with both bupivacaine formulations at the doses evaluated, indicating that lower doses should be used. Further studies are needed to establish the safety profile and clinical advantages of lipossomal bupivacaine before clinical use.

PMID 42880342
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PubMedJournal of ophthalmic & vision research2026-10-15

Comparison Between Mohindra Retinoscopy and Wet Retinoscopy in Refraction of Infants and Children.

Ghafoor Mousffa Abdul MA, Tahir Afia A, Noor Shahid S, Hassan Zaneera Z et al.

The purpose of this study was to compare the results of Mohindra near retinoscopy and wet retinoscopy in the refraction of infants and children. This comparative cross-sectional analytical study included 56 participants, comprising two equal groups of 28 infants and 28 children with refractive errors. Both Mohindra near retinoscopy and wet retinoscopy were performed on each infant and child. Mohindra near retinoscopy was performed first in a dark room at a distance of 50 cm with one eye occluded. Wet retinoscopy was performed after Mohindra near retinoscopy using 1% cyclopentolate hydrochloride eye drops. The Wilcoxon signed-rank test was used for comparison between the two techniques. The mean spherical values obtained by Mohindra near retinoscopy were 0.14 ± 2.97 D and 0.20 ± 3.04 D for the right and left eyes, respectively, whereas wet retinoscopy demonstrated higher spherical means of 0.52 ± 3.28 D and 0.58 ± 3.17 D. Statistically significant differences were observed between Mohindra near retinoscopy and wet retinoscopy for spherical measurements in the right (Z = -3.665, P < 0.001) and left (Z = -3.600, P < 0.001) eyes. Significant differences were also found in cylindrical measurements for the right (Z = -2.380, P = 0.017) and left (Z = -3.355, P = 0.001) eyes. Wet retinoscopy yielded statistically significant differences in refractive measurements compared to Mohindra near retinoscopy in infants and children. Mohindra near retinoscopy underestimated hyperopic and astigmatic refractive errors. These findings suggest that wet retinoscopy remains the fundamental method for pediatric refractive assessment, particularly in infants and in cases of latent hyperopia.

PMID 42877002
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