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Uralyt-K

✓ Approved

Rottapharm Madaus · Small Molecule · Small Molecule

What is Uralyt-K?

Uralyt-K is a small molecule developed by Rottapharm Madaus. It is approved for therapeutic indications via oral (po).

Drug Profile

CompanyRottapharm Madaus
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Rottapharm Madaus

Therapeutic Indications

Uralyt-K is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Renal and urinary disordersCalculus urinary✓ Approved

Related Research Articles

PubMedMolecules (Basel, Switzerland)2026-10-16

Gd3+-Driven Microstructure Regulation of Tm3+, Yb3+: GdxBi2-xWO6 for High-Sensitivity Temperature Sensing and Magnetism.

Feng Xin X, Wang Linxiang L, Shi Jiachen J, Jiang Mengliang M et al.

Tm3+, Yb3+: GdxBi2-xWO6 series upconversion luminescent materials were synthesized via a solid-state method. Calculations and XRD analysis reveal that Gd3+ in the lattice exhibits both substitutional and interstitial doping. Compared with the NaYF4 matrix, the Bi2WO6 material doped with Gd3+ has a lower Debye temperature (392.45 K), and the maximum phonon energy is low; thus, the probability of nonradiative transitions decreases. SEM images and EDS results reveal that the powder particle size ranges from 0.5 to 3 μm and that the elements are evenly distributed on the surface. The diffuse reflectance absorption spectra indicate that moderate Tm3+, Yb3+ and Gd3+ doping shifts the absorption band of the material towards longer wavelengths and decreases the band gaps. Under 980 nm laser excitation and a Gd3+ doping concentration of x = 0.2, the emission intensities of Tm3+ at 476 nm, 683 nm, 703 nm, and 804 nm increase by 1.8, 1.24, 1.35, and 81.9 times, respectively. Calculations reveal that these emissions in the range of 450 to 850 nm originate from three-photon or two-photon absorption. Gd3+ codoping can prolong the lifetime of the Tm3+ energy levels. When this sample was excited at 980 nm (518 mW), the temperature was characterized by FIR703nm/476nm from 298 K to 573 K, and the obtained maximum relative sensitivity was 3.4907 K-1 (298 K). The minimum temperature resolution was 0.0083 K (298 K). Compared with that of the undoped Gd3+ sample, the temperature sensitivity of the Gd3+-codoped sample increased by 92.35 times. Under an external magnetic field of 20 kOe and a temperature of 300 K, the magnetization of the sample doped with Gd3+ increased fourfold to 0.08174 emu/g. This material has potential applications in temperature sensing and magnetic resonance imaging.

PMID 42883321
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PubMedInternational journal of molecular sciences2026-10-16

Activation of KCa3.1 K+ Channel Suppresses COX2- and ARG1-Dependent Immunosuppressive Metabolic Programs in THP-1-Derived M2-like Macrophages.

Kajikuri Junko J, Kitahara Ayano A, Matsui Miki M, Maeda Yasuhiro Y et al.

M2-like macrophages contribute to the establishment of immunosuppressive microenvironments through coordinated activation of inflammatory and metabolic programs. Cyclooxygenase-2 (COX2) catalyzes prostaglandin E2 (PGE2) production, whereas arginase-1 (ARG1) hydrolyzes L-arginine (ARG) to ornithine (ORN) and urea. However, the ion channel-dependent mechanisms governing these immunometabolic pathways remain poorly defined. Here, we examined the role of the Ca2+-activated K+ channel KCa3.1 in regulating COX2 and ARG1 in THP-1-derived M2-like macrophages. COX2 and ARG1 were markedly upregulated during M2-like differentiation, whereas pharmacological activation of KCa3.1 with SKA-121 significantly reduced their mRNA and protein expression. KCa3.1 activation also decreased PGE2 production, increased extracellular ARG, and reduced ORN accumulation. Exposure to elevated extracellular K+ concentration ([K+]e) further enhanced COX2 and ARG1 expression, increased PGE2 production, and shifted ARG metabolism toward ORN formation; each of these responses was attenuated by KCa3.1 activation. Pharmacological inhibition of ERK or CREB signaling suppressed both COX2 and ARG1 expression, whereas inhibition of JNK, AP-1, NOX2, or NRF2 had limited effects. CREB2 knockdown similarly reduced COX2 and ARG1 under both basal and elevated [K+]e conditions. These findings demonstrate that KCa3.1 activation negatively regulates COX2- and ARG1-associated immunometabolic programs in THP-1-derived M2-like macrophages and suggest a potential role for KCa3.1 in modulating macrophage-associated inflammatory and metabolic responses.

PMID 42883725
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PubMedArchiv der Pharmazie2026-10-16

K+ Channels in Membrane Potential Dynamics and Migration of Neutrophil Granulocytes.

Ulu Tahir T, Siemer Henrik H, Heuer Alexa A, Schimmelpfennig Sandra S et al.

Neutrophil granulocytes exhibit dynamic changes in membrane potential upon stimulation with the complement component C5a. It is not well-defined which ion channels are responsible for membrane potential dynamics in neutrophils, although ion channel signaling has been linked to neutrophil behavior. Here, we investigated the contribution of K+ channels that are important players in different immune cells: KCa3.1, Kir2.1, and KV1.3. We studied their roles in membrane potential regulation, chemotaxis, and LTB4 secretion using live-cell imaging, analytical methods, and mathematical modeling. We identify membrane potential dynamics as an important regulatory axis in neutrophil migration. Kir2.1 is a key regulator of resting membrane potential. Kir2.1 blockade depolarizes the membrane potential of neutrophils by ~30 mV to -41.9 mV, and it delays and attenuates the C5a-induced depolarization. In contrast, KCa3.1 and KV1.3 inhibition neither modifies the resting membrane potential nor the C5a-induced depolarization. Nonetheless, the inhibition of all three K+ channels impairs chemotaxis toward C5a, in part by a reduced LTB4 secretion and/or possibly by non-conductive properties related to the interactome of the three K+ channels. Together, these findings demonstrate that KCa3.1, KV1.3 and Kir2.1 channels play distinct but critical roles in neutrophil function and inflammatory signalling.

PMID 42885434
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-16

Interfacial Reconstruction Enables Enhanced Thermoelectric Performance in Bismuth Telluride-Based Alloys.

Chen Wenyi W, Shi Xiao-Lei XL, Li Meng M, Zhang Chao C et al.

Bismuth telluride-based alloys are the benchmark thermoelectric materials for near-room-temperature power generation and solid-state cooling, yet further performance improvements through conventional optimization strategies remain challenging. Here, we introduce an interfacial reconstruction strategy by incorporating SnSe into Bi0.4Sb1.6Te3. Interdiffusion and chemical reconstruction at the Bi0.4Sb1.6Te3/SnSe heterointerfaces synergistically regulate charge-carrier transport and phonon scattering. As a result, the optimized composite achieves a peak dimensionless figure of merit (ZT) of ∼1.38 at 363 K and an average ZT of ∼1.25 across 303-423 K. Moreover, a single-leg thermoelectric device fabricated from this material delivers an energy conversion efficiency of ∼6.47% under a temperature difference of 200 K. These results establish interfacial reconstruction as a simple and effective approach to improving the thermoelectric performance of bismuth telluride-based alloys.

PMID 42881362
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PubMedMolecules (Basel, Switzerland)2026-10-16

Wide-Color-Span: Blue-Shifted Thermochromic D-A-D Fluorophores for Ratiometric Temperature Sensing.

Qin Zheng-Kun ZK, Feng Chi C, Tang Meiqi M, Li Yanfei Y et al.

Thermochromic fluorescent materials have significant application prospects in the field of temperature sensing. In this study, based on the donor-acceptor-donor (D-A-D) strategy, two fluorescent molecules, MPT-1 and MPT-2, with fluorenyl cores and methoxy phenothiazine as donors, were synthesized via the Buchwald-Hartwig C-N cross-coupling reaction, and their structures were confirmed by 1H NMR, 13C NMR and HRMS. Thermogravimetric analysis indicated that both compounds exhibited excellent thermal stability (Td = 377 °C, 413 °C). Aggregation-induced emission (AIE) experiments showed that the emission peak blue-shifted by approximately 42-44 nm with increasing aggregation. Temperature-dependent fluorescence studies indicated that from 80 K to 300 K, the emission peaks of both molecules shifted continuously from the yellow region to the blue region. The relative sensitivities of MPT-1 and MPT-2 were 2.5% K-1 and 2.19% K-1, respectively, with CIE ΔE shifts of 0.19 and 0.18. This study elucidates the thermochromic mechanism of D-A-D-type fluorescent molecules, confirms the tunability of their emission colour in response to temperature, and provides theoretical guidance and experimental reference for the design of novel thermochromic fluorescent materials and their applications in temperature sensing.

PMID 42883267
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PubMedJournal of clinical medicine2026-10-16

Clinical Outcomes of Single Intramedullary K-Wire Fixation with Figure-of-Eight Suture Augmentation for Ulnar Styloid Base and Distal Ulnar Metaphyseal Fractures.

Lee Jaeheon J, Ha Cheungsoo C, Kang Jae Hoon JH, Jeong Chanho C et al.

Background/Objectives: The optimal fixation method for ulnar styloid base fractures remains controversial. Conventional dual K-wire fixation may be technically challenging in certain fracture configurations, whereas hook plate fixation provides rigid fixation but requires additional implant placement and surgical exposure. The purpose of this study was to evaluate the clinical and radiographic outcomes of single intramedullary K-wire fixation combined with figure-of-eight suture augmentation for ulnar styloid base and distal ulnar metaphyseal fractures. Methods: We retrospectively reviewed 60 patients who underwent fixation of ulnar styloid base or distal ulnar metaphyseal fractures associated with distal radius fractures between 2021 and 2024. The construct consisted of a single intramedullary K-wire augmented with a figure-of-eight Ethibond suture. Radiographic union, functional outcomes, pain, range of motion, and complications were assessed at final follow-up. Results: The median follow-up was 14 months (range, 12-60). Radiographic union was achieved in 58 of 60 patients (96.7%) at a mean of 9.6 ± 1.9 weeks. The median QuickDASH score was 4.5 (range, 0-18.2), the Modified Mayo Wrist Score was 91.7 ± 8.1, and the visual analogue scale score for ulnar-sided wrist pain was 1.7 ± 1.0. Two patients (3.3%) developed radiographic nonunion, but neither required revision surgery. No fixation failure, loss of reduction, deep infection, or revision fixation occurred. Conclusions: Single intramedullary K-wire fixation with figure-of-eight suture augmentation was associated with a high rate of radiographic union and favorable functional outcomes in ulnar styloid base and distal ulnar metaphyseal fractures. These findings support the clinical feasibility of this fixation construct.

PMID 42881936
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