Drug Database
DO

doxycycline hyclate (Targadox)

✓ Approved

Fortress Biotech, Inc. · Small Molecule · Small Molecule

What is doxycycline hyclate?

doxycycline hyclate is a small molecule developed by Fortress Biotech, Inc.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesTargadox
CompanyFortress Biotech, Inc.
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Fortress Biotech, Inc.

Therapeutic Indications

doxycycline hyclate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersAcne✓ Approved

Related Research Articles

PubMedChronic respiratory disease2026-07-17

Construction of a patient health management patient journey map based on health action process approach theory for patients with chronic obstructive pulmonary disease.

Chen Shengxi S, Li Yinlong Y, Zhang Yan Y, Chen Xinxin X et al.

BackgroundSelf-management ability for patients with chronic obstructive pulmonary disease (COPD) in China urgently needs to be strengthened. The Health Action Process Approach (HAPA) promotes health-oriented behaviour change by tailoring interventions to each stage of the individual's disease. This approach has been applied across a wide range of fields. However, its application among patients with COPD remains relatively limited.ObjectiveTo construct a patient health management journey map based on the HAPA theory.MethodsUsing the HAPA theory as a framework, a patient health management patient journey map was developed through literature review, reference to standardised guidelines, phenomenological research and expert consultation.ResultsFrom the literature review, 12 relevant articles were included to form the preliminary framework. Semi-structured interviews with 5 respiratory medical staff identified the core stages of the patient journey. In a separate subsequent process, the 8 experts selected for consultation had an average work experience of 19.13 ± 3.27 years. Education levels included 2 with a bachelor's degree and 6 with a master's degree or above; professional titles included 3 associate senior doctors, 3 senior doctors and 2 intermediate doctors; and research specialties included 5 in respiratory medicine and 3 in internal medicine nursing. As for the consultation involvement, 3 experts participated once and 5 experts participated twice or more. The familiarity coefficient with consultation content was 0.851, the judgment basis coefficient was 0.916 and the authority coefficient of the experts was 0.889. The coordination of expert opinions was measured by Kendall's W and was 0.429 (χ2 = 42.452, P < 0.001). Finally, a proof-of-concept test with 5 patients refined the patient journey map's usability by simplifying terminology and adjusting adherence strategies.DiscussionThe patient health management journey map constructed in this study, based on the HAPA theory, is scientific, comprehensive and usable, covering key stages such as disease diagnosis, acute exacerbation management, stable period maintenance and rehabilitation support. It provides patients with comprehensive scientific guidance and promotes the establishment of healthy behaviours.

PMID 42467075
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PubMedBiomacromolecules2026-07-17

Injectable Thermoresponsive PIB/PDA/Doxycycline Hydrogels with Antibacterial, Antioxidant, and Temperature-Triggered Hemostatic Functions for Wound Healing.

Zhang Yuanjing Y, Chen Zheng Z, Guo Jiaxuan J, Yang Xueqing X et al.

Injectable and thermoresponsive hydrogels integrating hemostasis, infection suppression, and oxidative stress mitigation are highly desirable for complex wound management and intravascular intervention scenarios. Herein, we developed a biocompatible and thermoresponsive hydrogel based on a poly(N-isopropylacrylamide-co-butyl methacrylate) (PIB) matrix modified with polydopamine (PDA) and loaded with doxycycline (PIB/PDA/Doxycycline). PDA endowed efficient 808 nm photothermal conversion with robust cycling stability, as well as broad-spectrum radical scavenging activity. The hydrogel enables controlled and sustained release of doxycycline over 300 h, and in vitro assays confirmed synergistic chemo-photothermal antibacterial activity against Staphylococcus aureus and Escherichia coli. In a murine full-thickness wound model, the PIB/PDA/Doxycycline achieved nearly complete wound closure with improved tissue regeneration. In a murine tail-transection bleeding model, the hydrogel rapidly formed a physical gel barrier at 37 °C, leading to a significant reduction in blood loss. This integrated hydrogel system holds promise for wound repair, antibacterial treatment, antioxidant microenvironment regulation, and temperature-triggered hemostatic applications.

PMID 42464024
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PubMedActa ophthalmologica2026-07-17

Efficacy and safety of topical macrolides versus systemic tetracyclines for meibomian gland dysfunction-a systematic review and meta-analysis.

Safir Margarita M, Chan Clara C CC, Teichman Joshua C JC, Arbel Itamar I et al.

To review the efficacy and safety of oral doxycycline antibiotics versus topical macrolides in the treatment of meibomian gland dysfunction (MGD). Systematic review and meta-analysis. A comprehensive search of PubMed, Scopus, Embase, and ClinicalTrials.gov through December 2024 identified randomised controlled trials (RCTs) comparing oral tetracyclines with topical macrolides for MGD. Eligible studies reported outcomes related to tear film stability, meibomian gland function, ocular surface health, or symptom severity. Data extraction followed PRISMA guidelines and risk of bias was assessed using Cochrane methods. Among 3699 publications (1964-2024), six RCTs from distinct locations (374 patients) met inclusion criteria, describing only topical azithromycin and oral doxycycline. Treatment regimens were comparable: one month of topical azithromycin (1-1.5%, once to four times daily) versus three to 8 weeks of oral doxycycline (100-200 mg daily). Both treatments significantly improved MGD signs and symptoms. In pooled analyses, topical azithromycin showed superiority in reducing tear debris (odds ratio [OR], 0.33; 95% confidence interval [CI], 0.15-0.74); however, while the total symptoms score favoured azithromycin, the result was borderline (OR, 0.62; 95% CI, 0.38-1.00) and sensitivity-dependent. Subgroup analysis showed doxycycline was superior for corneal fluorescein staining (standardised mean difference [SMD], 0.64; 95% CI, 0.22-1.05), whereas 1% azithromycin was superior for tear breakup time (mean difference [MD], -1.40; 95% CI, -2.20 to -0.60) and dropout-causing adverse events (risk ratio [RR], 0.07; 95% CI, 0.01-0.49). Both topical azithromycin and oral doxycycline are effective for MGD management. Topical azithromycin demonstrated a more favourable safety profile and may represent a useful therapeutic option, particularly for patients with low tolerance to systemic medications. However, further high-quality studies are needed to strengthen the evidence base.

PMID 42464955
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PubMedJournal of hazardous materials2026-07-17

Environmental residue-level doxycycline accelerates compensatory evolution and persistence of tet(X4)-mediated tigecycline resistance in Escherichia coli.

Chen Tao T, Yuan Xingyun X, Chen Majian M, Wen Xin X et al.

Environmental residues of tetracycline antibiotics are widespread in livestock and poultry environments and represent an important but underexplored driver of antibiotic resistance (AR) persistence. Here, we investigated how residue-level doxycycline influences the compensatory evolution of E. coli carrying the clinically critical tigecycline resistance gene tet(X4). Using long-term experimental evolution (∼500 generations) under antibiotic-free and environmentally relevant doxycycline conditions, combined with phenotypic assays, gene expression analysis, and whole-genome sequencing, we found that tet(X4) imposed a significant initial fitness cost, which was largely alleviated by ∼300 generations. Notably, fitness recovery occurred without observable plasmid loss or downregulation of tet(X4) under the tested conditions. Instead, adaptive evolution was associated with high-frequency mutations in chromosomal global regulators crp and arcA, which coincided with coordinated phenotypic remodeling, including enhanced motility, reduced reactive oxygen species accumulation, and decreased outer membrane permeability. Importantly, residue-level doxycycline exposure further stabilized plasmid maintenance and resistance levels, indicating that environmental antibiotic residues may contribute to the persistence of high-priority resistance genes during compensatory evolution. These findings suggest that low-level environmental antibiotic exposure may create a selective landscape associated with the stabilization of tet(X4), highlighting a previously underappreciated pathway by which environmental contamination may influence antibiotic resistance and pose potential risks to environmental and public health.

PMID 42462607
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PubMedEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery2026-07-17

My journey of internal thoracic artery grafting.

Lytle Bruce B

PMID 42466993
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PubMedAdvances in medical education and practice2026-07-17

Narrative Mentorship and Professional Identity Formation: Reflections from a National Educational Event in Qatar.

Al-Mohammed Fatima F, Al-Thani Hessa H, Peralta Ruben R

Professional identity formation is a central goal of medical education, shaping how learners understand the meaning and values of clinical practice. During a national educational event in Qatar, an experienced surgeon shared his personal professional journey with more than 700 students, focusing on uncertainty, failure, mentorship, and resilience rather than technical achievement. This manuscript presents a reflective perspective on that educational encounter rather than a formal empirical study. The narrative prompted open student reflections on fear, belonging, and the realities of a medical career, revealing the strong emotional and educational impact of narrative mentorship. This experience highlights how authentic clinician stories can strengthen professional identity, address the hidden curriculum, and support whole-person development within educational settings. As healthcare continues to advance technologically, intentional integration of narrative mentorship into health professions education remains essential for cultivating reflective and resilient future clinicians.

PMID 42465711
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