Drug Database
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doxycycline hyclate (Targadox)

✓ Approved

Fortress Biotech, Inc. · Small Molecule · Small Molecule

What is doxycycline hyclate?

doxycycline hyclate is a small molecule developed by Fortress Biotech, Inc.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesTargadox
CompanyFortress Biotech, Inc.
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Fortress Biotech, Inc.

Therapeutic Indications

doxycycline hyclate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersAcne✓ Approved

Related Research Articles

PubMedJournal of oral biology and craniofacial research2026-08-30

Influence of matrix metalloproteinase inhibitors on resin-dentin bond strength and hybrid-layer characteristics of caries-affected dentin using a universal adhesive system.

Dhatavkar Prasanna P, Aggarwal Shalini S, Kesharani Pooja P, Borkar Anamika A

Matrix metalloproteinase-mediated collagen degradation compromises the durability of resin-dentin bonds, particularly in caries-affected dentin. Natural matrix metalloproteinase (MMP) inhibitors have gained attention as biocompatible alternatives to conventional synthetic agents for improving adhesive stability. To evaluate the effects of natural and synthetic MMP inhibitors on microtensile bond strength and failure patterns in caries-affected dentin bonded with a universal adhesive using etch-and-rinse and self-etch modes. A total of 240 extracted human permanent molars with artificially induced caries-affected dentin were allocated to 16 subgroups according to pretreatment agent and bonding mode. The pretreatment agents included grape seed extract, green tea extract, riboflavin, cranberry extract, chlorhexidine, doxycycline, sodium fluoride, and no inhibitor. A universal adhesive and nanohybrid composite resin were applied according to the assigned etch-and-rinse or self-etch protocol. Microtensile bond strength was measured using a universal testing machine. Data were analyzed using one-way analysis of variance, chi-square test, and Pearson correlation coefficient at a significance level of 0.05. Etch-and-rinse bonding produced significantly greater bond strength than self-etch bonding. Grape seed extract and green tea extract showed the highest bond-strength values, followed by riboflavin and cranberry extract. Chlorhexidine, doxycycline, and sodium fluoride showed limited improvement. Adhesive failure predominated the association with bond strength. Etch-and-rinse application of a universal adhesive combined with natural matrix metalloproteinase inhibitors, especially grape seed and green tea extracts, enhanced resin-dentin bond strength in caries-affected dentin.

PMID 42668588
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PubMedJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2026-08-30

Dual-Layer vs. Closed-Cell Devices in Carotid Artery Stenting: The Role of Plaque Morphology on Short-Term Outcomes.

M Lodato L, R Pini P, A Bramucci B, N Tusini T et al.

Carotid artery stenting (CAS) is an alternative revascularization method for patients with internal carotid stenosis in whom an endovascular approach is selected instead of carotid endarterectomy. In recent years, dual-layer stents have increasingly been employed due to their better plaque coverage compared to closed-cell stents. The aim of this study was to report the outcomes of these two stent types in a real-world clinical setting. Patients with internal carotid artery stenosis who underwent CAS between 2004 and 2023 at two high-volume centers were retrospectively analyzed. Plaques were classified as: type 1(lipid-rich), type 2(fibro lipid) and type 3(calcified). Primary endpoints included technical success (defined as residual stenosis <30% on completion angiography), and the incidence of stroke/death and TIA/stroke within 30 days comparing period of procedures and clinical manifestation (symptomatic and asymptomatic) comparing type of stent and type of plaque. A total of 944 CAS procedures were performed. Most of patients were male (68%) and younger than 80 years (72%). Symptomatic stenosis was present in 236(25%) patients, while 708(75%) were asymptomatic, with calcified plaques being most common (60%). Technical success was achieved in 94% procedures. In 6%, CAS procedure was abandoned due to excessive arch/carotid tortuosity. Before and after 2014 technical success rates were 9.7% and 3.6% (p<0.001). The overall 30-day TIA/stroke and stroke/death rates were 6.4% and 2.4%, 10% and 4% in symptomatic and 5% and 2% in asymptomatic. Closed-cell stents (Wallstent, Boston Scientific Corporation, Massachusetts, USA) and dual-layer stents (Roadsaver, Terumo Corporation, Tokyo, Japan) were used in 64% and 36% of cases. Stroke/death and TIA/stroke occurred in 2.8%vs.0.8% (p=0.20) in asymptomatic, and in 14.2%vs.5.4%(p=0.05) in symptomatic. The 30-day stroke/death rate was 0.7%vs.0.8% (p=0.80) in asymptomatic, while the 30-day TIA/stroke rate was higher, but not statistically significant, in the Wallstent group (5.9%vs.4.2%p=0.30) in symptomatic. Patients with type 0-2 plaques treated with dual-layer stents had a significantly lower 30-day TIA/stroke rate (10%vs.3.7%, p=0.02). Asymptomatic status (OR:0.4,95%CI:0.2-0.8, p=0.008) and use of dual-layer stents (OR:0.5,95%CI:0.3-1, p=0.05) are independent protective factors for 30-day TIA/stroke. Dual layer devices are associated with a significantly lower 30-day TIA/stroke rate in patients with vulnerable plaque types (1-2). Symptomatic status and stent design both influenced periprocedural outcomes, underscoring the value of tailoring device choice to plaque morphology.

PMID 42669335
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PubMedCureus2026-08-30

Treatment of Persistent Gastrocutaneous Fistula After Percutaneous Endoscopic Gastrostomy Using Endoscopic Suturing With Argon Plasma Coagulation: A Report of Two Cases.

Washington Miles J MJ, Washington Morris J MJ, Biswas Saptarshi S

Persistent gastrocutaneous fistula (PGCF) is an uncommon but often challenging complication following removal of a percutaneous endoscopic gastrostomy (PEG) tube. Prolonged PEG tube requirement leads to epithelialization of the PEG tube tract, resulting in a PGCF when the tube is removed. Several management options have been described for this complication, many of which demonstrate variable success rates. However, no definitive treatment for PGCF has been established. We report two adult male patients, aged 63 and 30 years, who developed PGCF after PEG tube removal following prolonged PEG placement. The first patient had persistent low-volume drainage for approximately one year after removal of the PEG tube, despite an attempt at external purse-string suture closure with simultaneous endoscopic clip placement. The second patient developed persistent high-volume drainage with peristomal skin breakdown despite local wound care and ostomy appliance placement for 3 months after removal of the PEG tube. Both patients underwent argon plasma coagulation of the fistula tract followed by endoscopic suture closure using the Boston Scientific OverStitch device (Boston Scientific Corporation, Marlborough, USA). In both cases, fistula drainage resolved within one week, with no documented recurrence during available follow-up. These cases are reported to highlight the technical feasibility of combined argon plasma coagulation and endoscopic suturing for selected chronic post-PEG PGCFs and to add to the limited published experience with this approach.

PMID 42668957
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PubMedIDCases2026-08-30

Emergence of a novel NDM-4-producing Citrobacter freundii complex species in a complicated urinary tract infection treated with cefiderocol.

Boehm Cheyanne C, Dingle Tanis C TC, Croxen Matthew A MA, Lynch Tarah T et al.

Multidrug-resistant (MDR) Gram-negative infections represent a growing global health threat with increasingly limited therapeutic options. We report a case of complicated urinary tract infection in a 70-year-old woman with underlying renal cysts complicated by rupture and subsequent formation of left infrarenal and paracolic pelvic abscesses. The initial infection was caused by Escherichia coli; however, following initial prolonged broad-spectrum antimicrobial therapy, a novel New Delhi metallo-β-lactamase (NDM type carbapenemase)-producing Citrobacter species was subsequently isolated from urine cultures. Whole-genome sequencing confirmed identification as a novel Citrobacter species and identified the presence of a blaNDM-4 gene. Antimicrobial susceptibility testing demonstrated resistance to most tested agents, with susceptibility limited to nitrofurantoin, cefiderocol, aztreonam, doxycycline, and tigecycline. Repeat abscess drainage and treatment with cefiderocol resulted in clinical and microbiological resolution of infection. This case underscores the critical role of drainage and access to newer antibiotic agents in management of complex intra-abdominal infections. Genome sequencing aids the detection of novel reservoirs of antibiotic resistance genes in carbapenemase-producing Enterobacterales that may emerge during prolonged antimicrobial exposure.

PMID 42668689
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PubMedClinical & experimental optometry2026-08-30

Repeatability of near point of fixation disparity test.

Alhassan Mosaad M, Alrehaili Rathath R, Alnifai Lena L, Alrashed Muhamad M et al.

Vergence assessment is a fundamental component of binocular vision evaluation, enabling clinicians to detect and monitor conditions such as convergence insufficiency. Accurate and repeatable clinical tests are essential for reliable diagnosis and for tracking patient progress over time. The Near Point of Fixation Disparity (NPFD), associated positive fusional vergence (APFV) range, and associated negative fusional vergence (ANFV) range are polarised Nonius-based tests designed to evaluate vergence system integrity. However, their repeatability remains uninvestigated, limiting clinical utility. This study is the first to assess intraexaminer and interexaminer repeatability of these tests in symptomatic and asymptomatic participants. The NPFD test is commercially available from Vision Assessment Corporation, Rolling Meadows, IL, USA. This prospective, cross-sectional study enrolled 64 university students (32 symptomatic, 32 asymptomatic; aged 18-27 years) from King Saud University, Riyadh, Saudi Arabia. Symptom status was classified using the Convergence Insufficiency Symptom Survey (CISS; score ≥21 = symptomatic). Two trained optometrists performed all measurements across two sessions separated by two weeks. Repeatability was assessed using mean difference, 95% confidence intervals, intraclass correlation coefficient, coefficient of repeatability, and Bland-Altman analysis. Intraexaminer repeatability of the NPFD test ranged from moderate to good with intraclass correlation coefficient 0.47-0.86, with the strongest agreement observed in asymptomatic participants. The APFV and ANFV ranges demonstrated poor intraexaminer repeatability, with limits of agreement frequently exceeding 10-15 prism dioptres. Interexaminer repeatability was poor across all three tests in both groups, with negative intraclass correlation coefficient values in several comparisons and limits of agreement exceeding 20 prism dioptres. Although the NPFD test can achieve acceptable intraexaminer repeatability, its interexaminer reliability remains poor, raising concerns about its use as a diagnostic tool across different examiners. Vergence assessments should be performed by the same examiner, and changes of less than 10-15 prism dioptres should be interpreted with caution. Standardisation of testing protocols is strongly recommended to improve the clinical applicability of these tests.

PMID 42669425
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PubMedPakistan journal of medical sciences2026-08-30

Impact of ChatGPT-assisted personalized learning on teaching acute abdomen to undergraduate medical students: A randomized crossover study.

Ilyas Maria M, Khan Rehan Ahmed RA, Yasmeen Rahila R, Kamal Zainab Z et al.

The application of Artificial Intelligence (AI) in medical education has emerged as a promising avenue for personalized learning experiences to the individual needs of medical students. This study investigated the impact of AI-driven personalized learning pathways on the academic performance of medical students in acute abdomen topic, comparing against traditional learning method. This study used a randomized controlled crossover trial conducted from February 2024 to July 2024 among fourth year one hundred undergraduate medical students at Islamic International Medical College, Riphah International University, Pakistan. In this study, students enrolled in a general surgery course were randomly assigned to experimental group and control group following a pre-test. The experimental group engaged with AI-driven personalized learning pathways, powered by ChatGPT-4, the control group utilized conventional educational resources. Both groups completed a post-test to assess the effects of their respective learning interventions. Statistical analyses, including descriptive statistics, independent-samples t-tests and paired-samples t-tests were conducted using SPSS. The pre-test scores of the experimental (M = 17.12, SD = 6.99) and control groups (M = 18.64, SD = 6.91) did not differ significantly (p = 0.277). Post-intervention, the experimental group showed a statistically significant improvement (M = 22.8, SD = 5.11) compared to the control group (M = 19.24, SD = 7.11), with a p-value of .005 and a moderate effect size (Cohen's d = 0.58). This suggests that AI-driven personalized learning pathways had a positive and measurable impact on the students' academic performance in the experimental group. AI-driven personalized learning pathways can enhance the academic performance of medical students, particularly in subject of surgery. Future research should explore the long-term effects of personalized AI-powered educational interventions.

PMID 42668909
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