Drug Database
TH

thiamine-cobaltichlorophyllate (Midoriamin)

✓ Approved

Nisshin Pharma · Small Molecule · Small Molecule

What is thiamine-cobaltichlorophyllate?

thiamine-cobaltichlorophyllate is a small molecule developed by Nisshin Pharma. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesMidoriamin
CompanyNisshin Pharma
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Nisshin Pharma

Therapeutic Indications

thiamine-cobaltichlorophyllate is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Gastrointestinal disordersDuodenal ulcer✓ Approved
Gastrointestinal disordersGastric ulcer✓ Approved

Related Research Articles

PubMedEnvironmental microbiology2026-10-16

Functional Metagenomics Reveals Gut Microbial Biosynthetic Potential for Essential Nutrients in Juvenile Chum Salmon.

Ghosh Subrata Kumar SK, Wassel Mai A MA, Wong Marty Kwok-Shing MK, Hyodo Susumu S et al.

The fish gut microbiota contributes to host nutrition, immunity and homeostasis, yet how its metabolic capacity relates to gaps in the host genome remains poorly characterized. Here we used shotgun metagenomic sequencing and KEGG module completion analysis to compare the biosynthetic potential of the gut microbiome with that of the host genome in juvenile chum salmon (Oncorhynchus keta) at 35 days posthatching, when exogenous feeding begins. Because small juvenile guts yield low microbial biomass and a high proportion of host DNA, we first optimized a protocol combining enzymatic lysis with NEBNext-based host DNA depletion. This raised the bacterial sequence fraction from 11.3% to 41.2% and increased the number of KEGG Orthology identifiers mapped to modules from 1128 to 1532. Module Completion Ratio analysis revealed complementation in functional potential: the chum salmon genome was incomplete for de novo biosynthesis of essential amino acids (threonine, leucine, valine/isoleucine, lysine) and B-vitamins (thiamine, riboflavin, biotin), whereas the gut metagenome encoded complete or near-complete modules for these pathways. Sequences assigned to Bartonella-like, Acinetobacter and Enterococcus lineages contributed most. These observations indicate that the gut microbiome encodes biosynthetic potential the host genome lacks, although demonstrating a nutritional benefit to the host will require experimental manipulation.

PMID 42885240
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PubMedAnimals : an open access journal from MDPI2026-10-16

Rumen Microbiota and Metabolome Reveal the Effects of Yucca schidigera Extract on Growth Performance and Serum Immune Parameters in Fattening Goats.

Wang Hongna H, Zhao Hui H, Pan Chenchong C, A Jiaoyang J et al.

This study aimed to investigate the effects of Yucca schidigera extract (YSE) on growth performance, serum immune parameters, rumen microbiota, and metabolites of fattening goats. For this purpose, thirty-two healthy male Boer goats with similar initial body weights (36.91 ± 3.05 kg) were randomly assigned to four groups. Goats in the control group (Group A) were fed a basal pelleted diet, whereas the experimental groups (Groups B, C, and D) received 200, 400, and 600 mg of YSE per kg of basal diet, respectively. The results reveal that dietary supplementation with 600 mg/kg YSE significantly elevated average daily gain (ADG) and decreased feed-to-gain ratio (F/G) (p < 0.05). The 400 mg/kg YSE addition significantly increased serum IgM concentration and reduced the TNF-α concentration (p < 0.05). Meanwhile, 400 mg/kg dietary YSE supplementation significantly elevated Ace and Chao-1 indices of ruminal microbiota (p < 0.05). Differential ruminal metabolites were predominantly enriched in pathways involving pantothenate and CoA biosynthesis, regulation of lipolysis in adipocytes, thermogenesis, and lysine degradation. Prevotellaceae_UCG-001 was negatively correlated with average daily feed intake (ADFI) and immunoglobulin M (IgM) (p < 0.05), and ascorbate radical and ureidoperacrylic acid showed significant correlations with ADFI, IgM, and Prevotellaceae_UCG-001 (p < 0.05). Both Anaerobispirillum and Quinella were negatively correlated with TNF-α (p < 0.05), whereas thiamine and zeatin showed positive correlations with TNF-α and Quinella (p < 0.05). Under the present experimental conditions, the optimal supplemental level of YSE was 400 mg/kg diet.

PMID 42882989
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PubMedNutrients2026-10-16

Synbiotic HQP08 Supplementation for Hair Loss and Depressive Symptoms: An Open-Label Pilot Study of Clinical Outcomes and Gut Microbiome Changes.

Xu Zhilu Z, Lau Raphaela I RI, Qi Haoyu H, Wong Martin C S MCS et al.

Background: Gut microbiota dysregulation has been implicated in hair loss via the gut-skin axis, but human interventional data are limited. We previously showed that Bifidobacterium longum HK003 reverses alopecia-like phenotypes in mice. Methods: We conducted an open-label, single-arm pilot study to evaluate an HK003-containing synbiotic (HQP08) in 32 adults with self-reported hair loss over 8 weeks. The primary endpoint was the proportion of participants reporting improvement on the Patient Global Impression of Change (PGI-C) scale at week 8. Secondary outcomes included changes in hair loss severity, 60 s hair count, depressive symptoms (PHQ-9), safety, and gut microbiome composition (Chinese Clinical Trial Registry ChiCTR2500112698). Results: At week 8, 62.5% (20/32) of participants reported PGI-C improvement. Significant reductions were observed in hair loss severity (p = 0.0008), 60 s hair count (p = 0.0048), and PHQ-9 scores (p = 0.002). Younger age was associated with PGI-C response (OR per year 0.86, 95% CI: 0.73-0.98, p = 0.037). Metagenomic analysis identified engraftment of B. longum HK003-like profiles in a subset of participants at week 12. Changes in microbial pathways related to thiamine metabolism, vitamin B12 salvage, and lipopolysaccharide biosynthesis were associated with ΔPHQ-9 (FDR-adjusted p < 0.05), but not with hair-related endpoints. No serious adverse events occurred. Conclusions: This first-in-human pilot study suggests that HQP08 was well tolerated and was associated with within-participant changes in hair-loss measurements and PHQ-9 scores. Randomized controlled trials are warranted to confirm efficacy and further elucidate mechanisms within the gut-brain-skin axis.

PMID 42884562
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PubMedNutrients2026-10-16

Nutritional and Metabolic Trajectories up to 10 Years After Metabolic and Bariatric Surgery: A Tertiary-Centre Retrospective Longitudinal Cohort Study.

Mitchell Sebastian S, Bhandari Priyanka P, Houston Margaret M, Wardani Titisari T et al.

Metabolic and bariatric surgery (MBS) is the most effective durable treatment for severe obesity but predisposes to micronutrient deficiency. Long-term, broad-panel biochemical data are scarce. We examined nutritional and metabolic trajectories over up to 10 years and compared sleeve gastrectomy (SG) with Roux-en-Y gastric bypass (RYGB). Retrospective single-centre cohort undergoing MBS (NHS Lothian, 2011-2025). Twenty-five biochemical markers were captured at baseline, 6 months, 1, 5 and 10 years, and analysed using linear mixed-effects models adjusted for procedure, sex, age, baseline BMI, diabetes and deprivation, with Benjamini-Hochberg correction. Of 458 patients, 426 were analysed (82.4% female; median age 49 years; median baseline BMI 44.2 kg/m2; SG 55.2%, RYGB 41.1%; median follow-up 7.0 years). Median total and excess weight loss were 21.6% and 49.2%. Pre-operative type 2 diabetes affected 99/422 (23.5%), resolving in 41 (41.4%). Adjusted calcium fell (p < 0.001) and parathyroid hormone (PTH) rose (+0.22 pmol/L/year [95% CI 0.11, 0.33], p < 0.001) despite vitamin D increasing (+1.20 nmol/L/year, p < 0.001); elevated PTH persisted in ~33%. Haemoglobin declined (-0.32 g/L/year, p = 0.026), below-range values rising from 26.3% (109/415) to 38.5% (84/218). Serum iron and transferrin saturation rose (p = 0.034; p = 0.002). B-vitamins increased (all p < 0.001) except thiamine. Selenium, red-cell selenium and zinc fell (all p < 0.05); albumin declined (p < 0.001); cholesterol was stable. Folate and vitamin E trajectories differed between SG and RYGB; other markers did not. The PTH rise was steeper with proton pump inhibitor use (p = 0.002) and baseline BMI ≥ 50 kg/m2 (p = 0.003). Within a structured service with high supplement compliance, frank deficiency was uncommon for most markers. Nonetheless, progressive biochemical changes emerged and persisted, most consistently falling calcium with rising PTH and declining haemoglobin. These findings support indefinite, systematic nutritional surveillance after MBS.

PMID 42884716
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PubMedThe British journal of nutrition2026-10-15

Nutritional intakes and their association with symptom severity among women with Hyperemesis Gravidarum.

Sandberg Maja M, Kelly Laura L, Cunningham Alexandra A, Augustin Hanna H et al.

Hyperemesis Gravidarum (HG) is characterised by severe nausea and vomiting in pregnancy. Despite the critical role of nutrition during pregnancy and risk of malnutrition in this cohort, few studies have reported dietary intakes of women with HG. The aim was to assess the nutritional intakes of women with HG compared with dietary recommendations and to explore the association between nutritional intakes and symptom severity. In this cross-sectional study, women with a diagnosis of HG attending a day assessment unit in a large maternity hospital in Dublin, Ireland, were invited (March 2021-January 2022) to participate. Nutritional intake was assessed using 24-h food and fluid diaries. Median intakes were compared with requirements using Wilcoxon signed-rank tests. The median (interquartile range) energy and fluid intake of the thirty-six women included was 1050 (481-1461) kcal and 1196 (778-2081) mL compared with estimated requirements of 2057 (1978-2332) kcal and 2300 mL (p < 0·001 for both). The median intakes of studied nutrients and fluid were significantly below estimated requirements. Spearman's correlations between nutritional intakes and symptom severity (24-h Pregnancy-Unique Quantification of Emesis and Nausea score) were calculated for twenty-nine participants. Several nutrient intakes, including energy, macronutrients, Na, potassium, Ca, Fe, iodine, vitamin D, thiamine and vitamin B12, were significantly negatively correlated with nausea and/or vomiting scores. In conclusion, women with HG consume inadequate energy, fluid and essential nutrients, with poorer intake associated with more severe nausea and vomiting. These findings highlight the need for routine nutrition assessments and tailored interventions to improve nutritional status in women with HG.

PMID 42876064
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PubMedFrontiers in pediatrics2026-10-14

Serum metabolomics identifies ganglioside dysregulation and pyruvate dehydrogenase complex-related metabolic disturbances in pediatric drug-resistant epilepsy.

Abu-Rish Eman Y EY, AlMalki Reem H RH, Masri Amira A, Dahabiyeh Lina A LA et al.

Despite advances in epilepsy management, the exact causes of epilepsy remain unclear, and diagnostic biomarkers are still lacking. Besides, about one-third of cases involve drug-resistant epilepsy (DRE). This study employed untargeted metabolomics to identify potential metabolic signatures in the sera of pediatric patients with epilepsy using liquid chromatography-high-resolution mass spectrometry. Our results revealed several disrupted energetic pathways and metabolites indicative of oxidative stress and mitochondrial dysfunction in both controlled epilepsy (CE) and DRE groups. Seventy-five metabolites were significantly elevated in CE compared to healthy controls (HC), including ethenoadenosine, 6-methyladenine, and fatty acyl-carnitine conjugates and intermediates. Additionally, 144 metabolites were decreased in CE relative to HC, including various fatty acyl-CoA intermediates, GM3 ganglioside, and amino acids. Key disrupted pathways in CE included pyrimidine and purine metabolism, phenylalanine, tyrosine, and tryptophan biosynthesis, pyruvate metabolism, and glycolysis/gluconeogenesis. In DRE, 25 metabolites were significantly reduced compared to non-DRE (NDRE), notably S-acetyldihydrolipoamide, 2-(alpha-hydroxyethyl)-thiamine diphosphate (HE-TDP), and S-adenosylmethionine (SAM). Metabolites involved in glycerophospholipid biosynthesis were decreased, along with lower levels of GM2 ganglioside. The most affected pathways in DRE included the tricarboxylic acid (TCA) cycle, pyruvate metabolism, glycolysis/gluconeogenesis, and cysteine and methionine metabolism. The observed alterations in S-acetyldihydrolipoamide, HE-TDP, and SAM support their further investigation as candidate monitoring biomarkers and as metabolites potentially involved in therapeutically relevant pathways in DRE. The alterations observed in HE-TDP, SAM, GM2, PS, and PE generate the hypothesis that pathways involving thiamine-dependent energy metabolism, methylation, ganglioside metabolism, and mitochondrial membrane function may be relevant to DRE. However, the present observational study did not evaluate supplementation, causality, efficacy, or safety. Consequently, any therapeutic application remains speculative and would require mechanistic validation, preclinical assessment, and appropriately designed clinical trials.

PMID 42871072
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