Drug Database
TH

thiamine-cobaltichlorophyllate (Midoriamin)

✓ Approved

Nisshin Pharma · Small Molecule · Small Molecule

What is thiamine-cobaltichlorophyllate?

thiamine-cobaltichlorophyllate is a small molecule developed by Nisshin Pharma. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesMidoriamin
CompanyNisshin Pharma
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Nisshin Pharma

Therapeutic Indications

thiamine-cobaltichlorophyllate is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Gastrointestinal disordersDuodenal ulcer✓ Approved
Gastrointestinal disordersGastric ulcer✓ Approved

Related Research Articles

PubMedFrontiers in nutrition2026-08-29

Sex-specific associations between dietary nutrient intake and cardiometabolic biomarkers in older adults with diet-related chronic diseases.

Plyassovskaya Svetlana S, Zhamantayev Olzhas O, Zhanalina Gulmira G, Kosherova Bakhyt B et al.

Older adults presenting with concurrent type 2 diabetes mellitus (T2DM), arterial hypertension (AH), and obesity face a considerable cardiometabolic challenge. There were no recent studies examining the association between their habitual nutrient consumption and circulating biomarkers in Central Asian populations. We aimed to examine sex-stratified associations between daily nutrient consumption and cardiometabolic biomarkers in community-dwelling older adults aged 60-90 years with concurrent T2DM, AH, and obesity in Central Kazakhstan. We enrolled 351 community-dwelling adults aged 60-90 years (80 men, 271 women) from four primary care facilities. Fasting glucose, total cholesterol, creatinine, urea, and triglycerides were assessed. Nutrient adequacy was expressed as percentage of Kazakhstani reference value. Spearman rank correlation, multiple linear regression, and binary logistic regression assessed dietary-biomarker relationships, stratified by sex. We identified the widespread micronutrient inadequacies in both sexes. Median potassium intake reached 34.3% of the reference value in men and 32.9% in women; calcium 33.6 and 38.1%; vitamin C 22.3 and 30.5%; vitamin E 43.7 and 38.9%; thiamine 48.1 and 49.5%. Sodium intake exceeded the reference value in both sexes, more than twofold in men and close to twofold in women. In men, total fat and saturated fat intake correlated with creatinine (rs = 0.242 and 0.250, respectively; p < 0.05), and total fat also correlated with triglycerides (rs = 0.243, p = 0.030). BMI was the leading independent triglyceride predictor (β = 0.572, p < 0.01, R 2 = 0.333). In women, most dietary-biomarker associations were absent, and calcium and riboflavin showed inverse correlations with triglycerides (rs = -0.237, p < 0.001 and rs = -0.164, p = 0.007). Older Kazakhstani adults with T2DM, AH, and obesity showed near-universal shortfalls in potassium, calcium, vitamins C and E, and thiamine alongside sodium excess. Dietary-biomarker associations were sex-specific, driven primarily by adiposity in men. Correcting these micronutrient gaps and reducing sodium intake are priorities for chronic disease management in this population.

PMID 42666241
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PubMedInternational journal of molecular sciences2026-08-27

Genetically Determined Loss-of-Function of the Organic Cation Transporter OCT1 Is Associated with Lower Liver Fat Content in Humans.

Scheurer-Böhme Anna K AK, Moritz Eileen E, Weiss Stefan S, Bülow Robin R et al.

Fatty liver is associated with increased all-cause mortality. Organic cation transporter 1 (OCT1) is a polyspecific hepatic uptake transporter. OCT1 mediates hepatic uptake of vitamin B1 (thiamine); thus, OCT1 deficiency may impair thiamine availability and consequently reduce glucose-derived energy. Consequently, OCT1-knockout mice exhibit significantly reduced liver fat. In 2% of Europeans and White Americans, common genetic variants markedly reduce OCT1 function. In this study, we used these naturally occurring variants to investigate the influences of reduced OCT1 function on liver fat in humans. We analyzed 2512 whole-body MRI datasets from the Study of Health in Pomerania (SHIP) and validated the findings using 31,594 datasets from the UK Biobank. In both cohorts, OCT1 deficiency was associated with lower fat content in the liver (p = 0.027 in SHIP; p = 2.9 × 10-6 in the UK Biobank), but not in other body compartments. OCT1 deficiency remained an independent predictor after adjustment for age, BMI, daily alcohol consumption, and biological sex. To investigate underlying mechanisms, we used Seahorse assays to show that OCT1-overexpressing cells exhibited increased mitochondrial metabolic activity when glucose was the sole energy source. Our findings warrant further investigation of OCT1 as a potential contributor to the pathogenesis of fatty liver.

PMID 42653422
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PubMedBiomolecules2026-08-27

Chondroitin Sulfate Supplementation Is Associated with Body Weight Control in Ovariectomized Rats: A Multi-Omics Study of Gut Microbiota and Metabolite Profiles.

Shen Qingshan Q, Ma Yanli Y, Zhang Chunhui C, Guo Yujie Y et al.

The prevalence of obesity among elderly women is increasing, particularly in postmenopausal populations. This exploratory study investigated the associations between chondroitin sulfate (CS) supplementation and body weight control in ovariectomized (OVX) rats, a preclinical model for postmenopausal physiology. CS supplementation was associated with significantly reduced body weight gain and preserved adipocyte morphology. CS-treated OVX rats exhibited decreased gut microbiota diversity, with reduced abundance of Photobacterium and Rhodococcus and increased abundance of Turicibacter. Metabolomic analysis revealed elevated levels of carbohydrates, fatty acids, and their conjugates, some of which correlated with body weight parameters. Bioinformatic analysis identified enriched KEGG pathways including tyrosine metabolism, glucosinolate biosynthesis and thiamine metabolism. Collectively, these findings provide preliminary correlational evidence in an OVX rat model supporting the potential of CS as a food supplement for body weight control, although causal relationships and clinical applicability warrant further investigation in postmenopausal populations.

PMID 42650763
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PubMedFood chemistry: X2026-08-27

Metabolomics-based analysis of key nutritional quality, volatile profiling and key odor-active compounds in representative foxtail millet varieties from Shanxi Province.

Wang Mengyao M, Yang Jing J, Zhang Aiying A, Liu Sichen S et al.

To reveal the regulatory mechanisms between nutritional components and aroma formation in foxtail millet, five representative varieties from Shanxi were analyzed via multiple metabolomic approaches. CNQX showed the highest carotenoid content; ZGQX had the highest thiamine, while ZGFY exhibited the most balanced B vitamin profile; JGFY was prominent in riboflavin and unsaturated fatty acids. A total of 866 volatile metabolites were putatively identified, and nine key compounds with high theoretical odor potential were screened (rOAV≥1, VIP ≥ 1). Ecological correlation analysis revealed that soil pH and available potassium positively correlated with VB1 and VB2, whereas temperature negatively correlated with C22:1n9 (p ≤ 0.05), with major nutrients primarily genotype-dependent. PCA ranked comprehensive PCA-based chemotype score as JG > CN > JF > ZG > ZZ, with distinct chemical patterns across regions. This study provides a theoretical chemical basis for aroma-oriented breeding and production area planning.

PMID 42656670
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PubMedDiseases (Basel, Switzerland)2026-08-26

Thiamine Deficiency in Hospitalized Veterans Without Alcohol Use Disorder: Prevalence, Biomarker Assessment, and Clinical Characteristics.

Mates Elisabeth A EA, Kilgore-Gomez Alexandrea A, Phibbs Claire C

Thiamine deficiency (TD) causes thiamine deficiency disorders (TDDs) which are frequently overlooked in food-secure countries such as the United States (U.S.). Lack of awareness and the absence of validated, rapidly available biomarkers perpetuate underdiagnosis. Our objective was to determine prevalence of TD in hospitalized U.S. veterans without alcohol use disorder (AUD) and describe clinical characteristics of TDDs. A secondary objective was to evaluate the utility of plasma and whole-blood thiamine biomarkers in identifying thiamine-responsive disorders (TRDs). Newly hospitalized veterans without AUD were recruited. Fasting plasma and whole-blood thiamine were obtained. Interview, physical exam, and chart review were completed to assess clinical signs of TD. Participants were invited to return after thiamine repletion and changes in symptoms and exam findings were noted. A total of 286 participants were enrolled: 261 had plasma thiamine results, 259 had whole-blood thiamine results, 179 completed interviews, 164 completed initial examination, and 60 returned for reexamination after repletion. A majority (86.59%) had potential signs or symptoms of TDDs, 26.44% had low plasma thiamine, 2.70% had low whole-blood thiamine, and 97.92% with low plasma thiamine had clinical signs of TDDs and many experienced multiple TD syndromes. Those with low plasma thiamine who returned after repletion showed improvements in cognitive scores (p = 0.0093) and motor strength (p = 0.0417), and most reported symptom improvement. Whole-blood thiamine missed many cases of TRDs. TD affects one quarter of hospitalized veterans without AUD. Low plasma thiamine identifies TRDs more frequently than low whole-blood thiamine. Using clinical criteria alone to diagnose TDDs overestimates cases and biomarker confirmation appears necessary.

PMID 42645083
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PubMedPhytopathology2026-08-26

Ecogenomic Diversity of Clavibacter nebraskensis in North America.

Flores-Lopez Luis Fernando LF, Callejas Dante M DM, Vidaver Anne K AK, Khokhani Devanshi D et al.

Goss's wilt and leaf blight of maize is caused by Clavibacter nebraskensis and has reemerged as an important disease in North America. Despite its epidemiological relevance, this species remains poorly characterized in terms of population structure, functional diversity, and ecological differentiation, particularly among strains reported from Mexico. In this study, long-read whole-genome sequencing and phenotypic assays were used to characterize genomic diversity, virulence, and fitness-associated traits in C. nebraskensis. We generated 24 long-read genomes, including 20 contemporary Mexican isolates and four historical United States strains collected between 1969 and 1996, and compared them with publicly available genomes from North America and South Africa. Phylogenomic analyses confirmed that all strains cluster within the C. nebraskensis clade, and gene accumulation curves supported a closed pangenome with accessory gene variation linked to geographic origin and isolation period. Functional assays showed strain-level variation in virulence, enzymatic activity, bacteriocin antagonism, polysaccharide production, biofilm formation, and pigmentation. Cellulolytic activity was associated with disease severity, whereas pigment-related traits were linked to thiamine metabolism. Overall, these results indicate that C. nebraskensis populations are ecologically diverse, potentially reflecting the use of alternative strategies for survival and competition. Integrating genome-wide comparisons with functional characterization of fitness-related traits provides a framework for understanding the biological factors underlying Goss's wilt dynamics.

PMID 42647157
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