Drug Database
AL

aluminium hydroxide (Pangramin Depot)

✓ Approved

ALK-Abello · therapeutic agent

What is aluminium hydroxide?

aluminium hydroxide is a therapeutic agent developed by ALK-Abello. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesPangramin Depot
CompanyALK-Abello
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, ALK-Abello

Therapeutic Indications

aluminium hydroxide is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved

Related Research Articles

PubMedFrontiers in oncology2026-07-17

ALK-positive Spitz nevus of the nasal dorsum in a child: a case report and literature review.

Juan Wang W, Zhai Zhifang Z

This article reports a case of Spitz nevus with ALK positive nasal cavity in a 3-year-old and 5-month-old female child. The clinical manifestation is red patches on the nose of the child, gradually increasing in size, without itching or pain. Histopathological examination showed a large proliferation of spindle shaped cells in the dermis, without any evidence of nuclear fission. Spindle shaped cells show positive reactions to markers such as S100, SOX10, ALK, P16, MelanA, etc. Pathological diagnosis of Spitz nevus with ALK positivity. Spitz nevus is a benign proliferative lesion of melanocytes, commonly found in children and adolescents, with specific clinical and pathological features. ALK gene fusion is more common in Spitz nevi and helps in differential diagnosis from malignant melanoma. Most ALK positive Spitz nevi exhibit benign biological behavior, but close follow-up is still necessary to assess potential risks. Future research should further explore the relationship between fusion genes and the biological behavior of Spitz tumors.

PMID 42465576
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PubMedRespirology case reports2026-07-17

Successful Introduction of Lorlatinib After Drug Eruption With Alectinib in ALK-Positive Lung Adenocarcinoma: A Case Report.

Omura Shunsuke S, Sunata Keeya K, Tani Tetsuo T, Uchibori Koyuru K et al.

Anaplastic lymphoma kinase (ALK) fusion genes are detected in approximately 3%-5% of non-small cell lung cancers (NSCLC). Alectinib and lorlatinib are ALK tyrosine kinase inhibitors with established efficacy; however, their adverse event profiles differ. We report a 61-year-old man with recurrent ALK-positive lung adenocarcinoma who developed a grade 2 drug eruption consistent with fixed drug eruption during alectinib therapy. The rash resolved following drug discontinuation and corticosteroid treatment. Lorlatinib was subsequently initiated without recurrence of cutaneous toxicity. Apart from Common Terminology Criteria for Adverse Events (CTCAE) Grade 2 dyslipidemia, no significant adverse events occurred, and partial response has been maintained for over 1 year. This case suggests that lorlatinib may be a feasible alternative in patients who develop cutaneous adverse reactions to alectinib, enabling continuation of targeted therapy.

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PubMedAnnales de pathologie2026-07-17

[Diagnostic approach to non-cutaneous T-cell lymphomas in 2025: What pitfalls and how should they be classified?]

Drieux Fanny F, Pirlog Radu R, Gaulard Philippe P, Poullot Elsa E

Peripheral T-cell lymphomas are a heterogeneous group of neoplasms derived from mature T or NK lymphocytes. With the exception of primary cutaneous T-cell lymphomas, these lymphomas are rare (<7% of lymphomas in France). Peripheral T-cell lymphomas derived from follicular helper T cells (TFH) account for more than 40% of cases. TFH lymphoma has numerous diagnostic pitfalls, including classical Hodgkin lymphoma, diffuse large B-cell lymphoma, and marginal zone lymphoma, which are attributable to the "follicular T helper" function of the tumor cells. Anaplastic large cell lymphomas (ALCL) are classified according to the presence or absence of an ALK gene fusion (ALCL-ALK+) and, for ALCL ALK-, according to their clinical presentation as nodal, cutaneous, or breast implant-associated disease. Among intestinal peripheral T-cell lymphomas, classifications distinguish enteropathy-associated T-cell lymphoma and monomorphic epitheliotropic intestinal T-cell lymphoma, two diseases derived from intraepithelial intestinal T lymphocytes that differ in their clinical context, immunomorphological features, and distinct mutational profiles. Assessment of Epstein-Barr virus (EBV) status is a fundamental prerequisite in peripheral T-cell lymphomas. Among extranodal peripheral T-cell lymphomas, EBV association defines extranodal NK/T-cell lymphoma. This review will address the diagnostic approach to a T-cell infiltrate, the various T cell lymphoma entities according to nodal, extranodal, or leukemic presentation, the main differential diagnoses, and the diagnosis of exclusion, peripheral T-cell lymphoma, not otherwise specified. With a few exceptions, peripheral T-cell lymphomas are aggressive diseases for which conventional chemotherapies are of limited efficacy.

PMID 42463321
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PubMedRSC advances2026-07-17

Zn-Al layered double hydroxide loaded polyurethane foam nanocomposite for photocatalytic degradation of textile effluents.

Pareek Garima G, Chandan Mohammed Rehaan MR, Razak M Zayan Abdul ZA, Shaik Aabid Hussain AH

This study introduces a novel multifunctional nanocomposite fabricated by impregnating Zinc-Aluminum Layered Double Hydroxide (Zn-Al LDH) nanoparticles into a polyurethane (PU) foam matrix at varying concentrations (0.2 g, 0.6 g, and 1.0 g) to facilitate the efficient removal of organic pollutants. The structural and morphological properties of the synthesized Zn-Al LDH were characterized using XRD, FESEM, and UV-Visible spectroscopy, while the resulting loaded PU foam was analyzed using FTIR, SEM-EDAX, bulk density, and sol fraction to confirm successful integration and stability. Performance evaluations conducted under UV irradiation revealed that while pure Zn-Al LDH nanoparticles achieved 98% degradation rates for methyl violet, the hybrid nanocomposite reached a superior degradation efficiency of approximately 99%. This enhanced performance is attributed to a potent synergistic effect wherein the porous PU foam serves as an effective adsorbent to concentrate the dye molecules, while the embedded Zn-Al LDH nanoparticles simultaneously drive photocatalytic degradation, ensuring near-complete remediation of the aqueous synthetic solution.

PMID 42466475
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PubMedJournal of photochemistry and photobiology. B, Biology2026-07-17

A hydrogen sulfide activated fluorescence probe for screening tumor cells and diagnosis of non-small cell lung carcinoma.

Si Weijie W, Guo Zhishan Z, Zhang Yuzhe Y, Meng Dan D et al.

Fluorescence probes are applied as chemical tools for the diagnosis and treatment of cancer. Despite the successful development of certain fluorescence probes, significant demand for enhancement remain in sensitive diagnosis and effective treatment. In this work, we developed a novel H2S-activable fluorescence probe, CerYT, utilizing nitrobenzoxadiazole (NBD) as the imaging fluorophore and ceritinib as a potent ALK kinase inhibitor for tumor cells. The probe exhibits good sensitivity (LOD = 121 nM) and specificity, and it can also detect H2S with precision in cells and tumor. Moreover, probe CerYT can exhibit enhanced fluorescence in tumor cells for sensitive tumor cell diagnosis, while simultaneously releasing the inhibitor ceritinib to induce significant damage to tumor cells. Consequently, the synergistic impact of ceritinib with H2S activation offers a highly efficacious diagnosis and therapeutic attribute for tumor cells and carcinoma.

PMID 42462551
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PubMedChemistry, an Asian journal2026-07-17

Amine-Functionalized CAU-10-Based Electrospun Hygroscopic Membrane for Atmospheric Water Harvesting.

Alabbad Sarah A SA, Essalhi Mohamed M, Bashanaini Rawan A RA, Baig Nadeem N et al.

Metal-organic frameworks (MOFs) are promising sorbents for atmospheric water harvesting (AWH) owing to their adjustable porosity and reversible adsorption properties. Aluminium-based CAU-10 exhibits excellent hydrothermal stability but has limited water uptake at low relative humidity (RH). Here, a bifunctional electrospun membrane integrating amine-functionalized CAU-10 (CAU-10-H/NH2) with polyacrylonitrile (PAN) fibres was developed to improve water capture over a wide RH range. Mixed-linker CAU-10 frameworks with different NH2 ratios were synthesised to adjust hydrophilicity and adsorption performance. Structural analysis confirmed that crystallinity and stability were maintained after incorporating amines and fabricating the membrane. Water adsorption studies revealed that pure CAU-10 adsorbed 452 cm3/g at P/P0 = 0.8, while amine functionalization increased low-humidity uptake to 69 cm3/g at P/P0 = 0.1. The best-performing CAU-10-(0.5 NH2)@PAN membrane combined strong low-pressure adsorption (50 cm3/g) with a high overall capacity (376 cm3/g at P/P0 = 0.8), proving it to be a durable and efficient MOF-polymer composite suitable for scalable AWH applications.

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