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MV

MV-130 (Bactek / MV130)

✓ Approved

Inmunotek · Cell-based Therapies · Cell-based Therapies

What is MV-130?

MV-130 is a cell-based therapies developed by Inmunotek. It is approved for therapeutic indications via oral (po) or sublingual (sl)/oral transmucosal.

Drug Profile

Brand NamesBactek, MV130
CompanyInmunotek
Drug ClassCell-based Therapies, Vaccine
RouteOral (PO), Sublingual (SL)/Oral Transmucosal
StatusApproved
Sources: ClinicalTrials.gov, Inmunotek

Therapeutic Indications

MV-130 is developed for 11 unique indications across 4 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsViral upper respiratory tract infection✓ Approved
Infections and infestationsLower respiratory tract infectionPhase III
Infections and infestationsOtitis mediaPhase II
Infections and infestationsPneumoniaPhase II
Infections and infestationsSinusitisPhase II

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Related Research Articles

PubMedMolecules (Basel, Switzerland)2026-10-16

Screening Endophytic Fungi of Australian Indigenous Plants for Biosynthesis of Silver Nanoparticles and Evaluation of Their Antibacterial Properties.

Sawalha Hanadi H, Moulton Simon E SE, Zaferanloo Bita B

The increasing emergence of bacterial resistance to conventional antimicrobial agents underscores the urgent need for alternative therapeutics. In this context, the present study investigated the antibacterial potential of silver nanoparticles (AgNPs) biosynthesised from extracellular extracts of four endophytic fungal species isolated from Eucalyptus globulus and Eucalyptus citriodora. The AgNPs were comprehensively characterised using UV-visible spectroscopy, Fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and zeta potential analysis. UV-vis spectra confirmed nanoparticle formation through characteristic absorption peaks between 400 and 500 nm. TEM imaging revealed predominantly spherical nanoparticles, with size ranges of 52-98 nm for EG 5 AgNPs, 86-197 nm for EG 6 AgNPs, 56-171 nm for EG 8 AgNPs, and 50-130 nm for EC 2 AgNPs. High negative zeta potential values (-19.3 to -31.7 mV) indicated moderate colloidal stability. FTIR analysis identified functional groups associated with the reduction and stabilisation of AgNPs. All AgNPs samples exhibited notable antibacterial activity against both Staphylococcus aureus and Pseudomonas aeruginosa, and growth-kill curve analysis demonstrated a marked reduction in bacterial proliferation over 24 h. Collectively, these findings highlight the potential of endophytic fungus-derived AgNPs as effective antibacterial agents.

PMID 42883268
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PubMedInternational journal of molecular sciences2026-10-16

Lumikine Attenuates Ventilation-Induced Lung Injury in Mice with Lipopolysaccharide-Induced Lung Fibrosis.

Li Li-Fu LF, Chu Pao-Hsien PH, Kao Winston W-Y WW, Yu Chung-Chieh CC et al.

Lipopolysaccharide (LPS) induces pulmonary fibrosis by increasing microvascular permeability and inducing severe inflammation and extracellular matrix accumulation. Mechanical ventilation (MV), although life-sustaining, can increase inflammatory cytokine production, oxidative stress, and alveolar-capillary membrane permeability, leading to ventilator-induced lung injury and pulmonary fibrosis. Lumican is essential for extracellular matrix signaling and wound fibrogenesis in the lungs, cornea, and heart. Lumikine, a peptide corresponding to the 13 C-terminal amino acids of lumican, binds to transforming growth factor-β receptor I/activin receptor-like kinase 5 and promotes wound healing. How the lumican pathway contributes to MV-induced lung inflammation and fibrosis remains unclear. We hypothesized that MV with or without LPS pretreatment would exacerbate lung injury, oxidative stress, and lung fibrosis through the lumican pathway. C57BL/6 mice (wild-type and lumican-deficient) were injected with LPS (intratracheal; 7 days) to induce lung fibrosis and then subjected to MV (10 mL/kg; room air; 8 h). Nonventilated mice served as controls. MV with LPS pretreatment reduced lumican expression and increased microvascular permeability, matrix metalloproteinase-9 level, transforming growth factor-β1 level, α-smooth muscle actin staining intensity, and Masson's trichrome staining intensity. Lumikine substantially mitigated these fibrotic changes. In conclusion, lumikine attenuates MV-induced exacerbation of pulmonary fibrosis after LPS-induced acute lung injury, partially by modulating the lumican pathway.

PMID 42883762
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PubMedSensors (Basel, Switzerland)2026-10-16

Enhanced Cadmium Detection in Real Water Sources Using a Custom Nanocomposite-Modified Carbon Electrode and Optimized Square Wave Voltammetry.

Basnet Dipen D, Boddu Rohit R, Liu Xiyuan X, Arumugam Prabhu U PU et al.

Monitoring toxic heavy metals in complex, real water sources is essential for safe water supplies. Current sensors lack the sensitivity, selectivity, and limits of detection (LOD) needed to detect heavy metals such as cadmium (Cd2+) in real water samples with minimal preparation. Here, we demonstrate a novel ternary nanocomposite-coated carbon electrochemical sensor that detects Cd2+ with the highest sensitivity (14.71 ± 0.3, 6.94 ± 0.8 μA·ppb-1·cm-2) and the lowest LODs (0.06 ± 0.02, 0.61 ± 0.10 ppb) in spiked deionized and lake waters, respectively. Sensor fabrication optimization included electrochemical polishing of carbon screen-printed electrodes, surface modification with a 1 mg/mL bismuth-reduced graphene-molybdenum disulfide nanocomposite ink, and rapid heating and cooling at 75 °C for 3 min. These steps, along with square wave anodic stripping voltammetry (SWASV) deposition potential identification, produced distinct detection peaks and high reproducibility (8% RSD). We further investigated the SWASV parameters, specifically frequency (5 to 50 Hz), amplitude (1 to 100 mV), and step potential (5 to 70 mV), using a fast causal inference algorithm, which resulted in a 233-fold increase in Cd2+ sensitivity. We found that the LOD and the full width at half maximum of the Cd2+ peak are dependent on frequency, while sensitivity and peak resolution depend on amplitude and step potential. Under optimal detection conditions of 35 Hz, 60 mV amplitude, and a 10 mV step potential, the sensor showed adequate sensitivity and LODs, even in the presence of 10-fold concentrations of Zn2+, As3+, and Cu2+ as interferents, confirming its suitability for real-world water-quality field testing.

PMID 42884312
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PubMedArchiv der Pharmazie2026-10-16

K+ Channels in Membrane Potential Dynamics and Migration of Neutrophil Granulocytes.

Ulu Tahir T, Siemer Henrik H, Heuer Alexa A, Schimmelpfennig Sandra S et al.

Neutrophil granulocytes exhibit dynamic changes in membrane potential upon stimulation with the complement component C5a. It is not well-defined which ion channels are responsible for membrane potential dynamics in neutrophils, although ion channel signaling has been linked to neutrophil behavior. Here, we investigated the contribution of K+ channels that are important players in different immune cells: KCa3.1, Kir2.1, and KV1.3. We studied their roles in membrane potential regulation, chemotaxis, and LTB4 secretion using live-cell imaging, analytical methods, and mathematical modeling. We identify membrane potential dynamics as an important regulatory axis in neutrophil migration. Kir2.1 is a key regulator of resting membrane potential. Kir2.1 blockade depolarizes the membrane potential of neutrophils by ~30 mV to -41.9 mV, and it delays and attenuates the C5a-induced depolarization. In contrast, KCa3.1 and KV1.3 inhibition neither modifies the resting membrane potential nor the C5a-induced depolarization. Nonetheless, the inhibition of all three K+ channels impairs chemotaxis toward C5a, in part by a reduced LTB4 secretion and/or possibly by non-conductive properties related to the interactome of the three K+ channels. Together, these findings demonstrate that KCa3.1, KV1.3 and Kir2.1 channels play distinct but critical roles in neutrophil function and inflammatory signalling.

PMID 42885434
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PubMedPolymers2026-10-16

Gamma-Irradiated Starch/Chitosan Composite Particles for the Adsorption of Neospora caninum Membrane Proteins as a Potential Vaccine Delivery Platform.

Palma-Calvo María Paula MP, Rodríguez-Quesada Laria L, Chacón-Cerdas Randall R, Vilanova Manuel M et al.

Gamma irradiation offers a simple and reagent-free strategy for tailoring the physicochemical properties of starch for the development of functional biomaterials, although its application in protein delivery systems remains largely unexplored. In this study, starch was irradiated at doses between 50 and 500 kGy and combined with chitosan to produce composite particles for the adsorption of Neospora caninum membrane proteins (NcMP), with the aim of developing a potential intranasal vaccine delivery platform. Irradiation induced progressive oxidation and depolymerization of starch, as evidenced by Fourier transform infrared (FTIR) analysis, increased apparent amylose content, reduced molecular weight and hydrodynamic diameter, and shifted the zeta potential to -13.4 mV, leading to the selection of starch irradiated at 300 kGy for particle preparation. The resulting starch-chitosan particles exhibited spherical morphology and, following protein adsorption, formed a protein-associated nanosystem with a hydrodynamic diameter of 105.7 nm and a zeta potential of -18.8 mV. Protein association was confirmed by fluorescence co-localization and an adsorption efficiency of 34%. These findings demonstrate that gamma irradiation is an effective approach for engineering starch-based composite particles with physicochemical characteristics suitable for protein association and intranasal delivery, supporting their potential as a versatile platform for protein subunit vaccine formulations.

PMID 42885077
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PubMedSensors (Basel, Switzerland)2026-10-16

Mask- and Coverage-Aware Traffic-State Assessment Under Sparse Probe-Vehicle Sensing.

Wu Dingxin D, Xu Zheng Z, Wang Zhiyuan Z, Huang Kai K et al.

Probe-vehicle sensing can extend traffic observation beyond fixed detectors, but its sparse and uneven coverage complicates the interpretation of predicted traffic states. This study develops a mask- and coverage-aware framework for regional traffic-state assessment from sparse probe-vehicle speed observations. Segment-level data from Xuzhou, China, were aggregated into 32 regions at 15 min resolution; only 0.157% of segment-time cells were observed. A regional target was observable whenever at least one segment in its region was observed, and the observed-target ratio across the controlled test conditions ranged from 12.1% to 23.9%. Nine controlled-missingness conditions were used to evaluate one-step speed prediction, followed by deterministic evidence-fusion assessment using predicted speed, observation masks, coverage history, and neighboring-region evidence. Reference labels for 130 stratified region-time cases were independently assigned and adjudicated by two annotators. Among the evaluated deterministic variants on this cohort, the speed-plus-mask rule achieved the strongest overall classification performance, with 69.2% accuracy and 63.7% Macro-F1. Because 69.2% equals the majority-class share of the cohort by construction (90 of 130 cases are low severity), the rule's advantage is its cross-class discrimination (Macro-F1) rather than overall accuracy alone. Adding coverage reduced the false-severe rate from 5.6% to 2.8%, but also reduced overall classification performance, demonstrating an over-escalation-control-classification trade-off. On a limited 16-case protocol, a fixed, schema-constrained large language model achieved 97.5% modal-label repeatability across five repetitions but only 32.0% Macro-F1; its limited and imbalanced support precludes any full-cohort effectiveness claim. The findings show that sensing support should be retained as traffic-state assessment evidence and reported alongside prediction and traffic-state alert performance. On the same 130 cases, a balanced RBF-SVM reached 75.0% mean grouped out-of-fold accuracy and 64.6% Macro-F1, but all four headline-metric paired intervals versus speed plus mask crossed zero and its false-severe rate was higher (9.7% versus 5.6%); no method was uniformly superior.

PMID 42884480
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