Drug Database
AP

aP vaccine (aP vaccine, NAVA)

✓ Approved

Baxter International, Inc. · Vaccine · Vaccine

What is aP vaccine?

aP vaccine is a vaccine developed by Baxter International, Inc.. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

Brand NamesaP vaccine, NAVA
CompanyBaxter International, Inc.
Drug ClassVaccine
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, Baxter International, Inc.

Therapeutic Indications

aP vaccine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsPertussis✓ Approved

Related Research Articles

PubMedFoods (Basel, Switzerland)2026-10-16

Postprandial Satiety, Glycemia, and Antioxidant Capacity of Apparently Healthy Adults After Consuming Corn Chips with Avocado Paste Byproduct.

Zuñiga-Martínez B Shain BS, Domínguez-Avila J Abraham JA, Robles-Sánchez Rosario Maribel RM, Ayala-Zavala J Fernando JF et al.

Avocado paste (AP) is the main byproduct of industrial avocado processing. It has been recently studied as a source of potentially bioactive compounds with demonstrated in vivo satiety-related actions; however, these have not been explored in human consumers. The present study analyzed the effects of consuming AP-supplemented corn chips (AP-10%) on postprandial glycemia (0, 15, 30, 60, 90, and 120 min post-consumption). Subjective satiety was also analyzed during the aforementioned times, while serum satiety mediators (insulin, glucagon-like peptide-1 [GLP-1], and cholecystokinin [CCK]) and antioxidant capacity were quantified (0 and 120 min post-consumption) in eighteen apparently healthy adult consumers. Maximum glycemia occurred 15 min after consuming the chips (137 mg/dL), which the AP-supplemented samples were able to significantly decrease (118 mg/dL). Subjective satiety was positively affected, as determined by visual analogue scales, which showed that AP-supplemented samples increased the participants' sensations of satiety and fullness by approximately 28 and 29%, respectively; trends were observed on the concentration of serum satiety mediators, although they were not significant. AP supplementation also mitigated a decrease in postprandial antioxidant capacity, as compared to the control, which showed a significantly lower value, according to the ORAC assay. We conclude that AP-supplemented corn chips may have an impact on postprandial glycemia, subjective satiety, and antioxidant capacity of apparently healthy adult consumers. Further studies are required to determine and/or complement the health effects of prolonged consumption of AP or AP-supplemented products.

PMID 42883466
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PubMedJournal of clinical medicine2026-10-16

Nutritional Screening in Hospitalized Patients with Acute Pancreatitis: A Comparative Study in Mexico.

Chávez-Tostado Mariana M, Cervantes-Guevara Gabino G, Álvarez-López Francisco F, Hernández-Corona Diana Mercedes DM et al.

Background: Acute pancreatitis (AP) is an acute inflammatory condition with high metabolic demands; however, early detection of nutritional risk is underestimated and there is no universal consensus on which is most effective for predicting nutritional risk. Objectives: To compare the level of agreement of nutritional screening methods with subjective global assessment (SGA) in identifying nutritional risk in patients with AP. Methods: This study was conducted as a prospective observational cohort in hospitalized patients diagnosed with mild or moderate AP. Screening tools: nutritional risk screening-2002 (NRS-2002), malnutrition universal screening tool (MUST), short nutritional assessment questionnaire (SNAQ), malnutrition screening tool (MST) and clinical assessment via SGA were performed. Results: Nutritional risk was found in 55.3% patients via SGA assessment, 43.2% in MST, and 38.6% in NRS-2002 and SNAQ and 10.6% in MUST scales. Patients without nutritional risk exhibited a significantly higher mean BMI than at-risk patients (p = 0.026). Patients with moderate AP exhibited a 3.93 increased risk of nutritional risk compared to those with mil AP (p = 0.02). The NRS-2002 and SNAQ scales achieved the highest agreement compared with SGA. Conclusions: Nutritional risk is highly prevalent in patients with mild and moderate AP, showing a significant increase as clinical severity progresses. The NRS-2002 and SNAQ scales had more agreement and better performance when compared with SGA.

PMID 42882136
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PubMedJournal of travel medicine2026-10-16

Atovaquone-proguanil chemoprophylaxis during pregnancy: a case series and a systematic review and meta-analysis.

Condé Juliette J, Coulm Bénédicte B, Tubach Florence F, Beghin Delphine D et al.

Pregnant women travelling to malaria endemic areas require effective chemoprophylaxis, with limited options including atovaquone-proguanil (AP) for which safety data remain limited. Our objective was to describe the prevalences of pregnancy outcomes and major congenital anomaly (MCA) following AP chemoprophylaxis during pregnancy. We combined a case series from the French national Teratology Information Service (CRAT) and a systematic review and meta-analysis (SRMA), including prospective pregnancies exposed to AP for chemoprophylaxis. Outcomes were prevalence of pregnancy outcomes and MCA. The case series included all pregnancies referred to the CRAT with an expected date of delivery between 2009-2025, and known outcome. The SRMA searched Medline, Embase, Cochrane databases and grey literature up to 16/09/2025. Study selection and data extraction were performed using an independent dual review process. Risk of bias was assessed with ROBINS-I. Pooled prevalences were estimated using random-effects models. GRADE was used to assess certainty of evidence. Our case series included 191 AP-exposed pregnancies (133 during first-trimester (T1) and 75 during second/third trimester) resulting in 85.9% livebirths (n=164), 10.0% miscarriages (n=19), 1.0% medical abortions (n=2), 1.0% stillbirth (n=2) and 2.1% elective termination (n=4). The prevalence of MCA among T1-exposed pregnancies with documented MCA status (n=110) was 3.6% (95%CI[1.0;9.0]). The SRMA included four studies, which when combined with our case series (555 AP-exposed pregnancies, 457 during T1) produced a pooled prevalence of livebirths of 80.3% (95%CI[72.3;87.2], I2=67.2%, Phet=0,047), 14.6% miscarriages (95%CI[7.3;23.9], I2=73.2%, Phet=0,024) and 2.7% for MCA (95%CI[1.2;4.8], I2=0.0%, Phet=0,45). Level of evidence was low. Our findings suggest that pregnancy outcomes and MCA following AP chemoprophylaxis exposure are similar to the general population prevalences, with a low level of evidence. These data strengthen the evidence supporting a reassuring safety profile, and AP may represent a reasonable option for pregnant women requiring malaria chemoprophylaxis after risk-benefit assessment.

PMID 42886019
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PubMedPhysiological reports2026-10-16

The effects of TMS stimulus direction on corticospinal and cortico-cortical excitability of the lower limb in healthy adults.

Hall M C MC, Zoghi M M, Perraton L L, Jaberzadeh S S

Transcranial magnetic stimulation (TMS) studies in upper limb muscles have shown that stimulus direction can influence corticospinal and intracortical excitability; however, limited evidence exists for lower limb muscles. This study investigated the effect of TMS stimulus direction on corticospinal and intracortical excitability of the tibialis anterior (TA) muscle using paired-pulse TMS. Nineteen healthy adults (10 males, 9 females; mean age 41.8 ± 23 years) participated. Single- and paired-pulse TMS was delivered using a figure-of-eight coil oriented to induce anterior-to-posterior (AP) or posterior-to-anterior (PA) current flow in the left motor cortex while recording motor evoked potentials (MEPs) from the right TA. Resting motor threshold (RMT), short-interval intracortical inhibition (SICI), long-interval intracortical inhibition (LICI), and intracortical facilitation (ICF) were assessed under both stimulus directions in a single session. No significant differences were identified between AP and PA stimulation for RMT, SICI, or LICI (p > 0.05). However, AP stimulation produced significantly greater ICF responses compared with PA stimulation (p = 0.027). AP and PA stimulus directions produced comparable RMT, SICI, and LICI measures in the TA muscle, although AP stimulation elicited greater ICF. These findings suggest facilitatory intracortical circuits may be more sensitive to stimulus direction than inhibitory pathways.

PMID 42885435
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PubMedCell research2026-10-16

The cargo bridge - how cargo binding triggers AP-1 oligomerization.

Stockhammer Alexander A, Ungermann Christian C

PMID 42881260
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PubMedAnimals : an open access journal from MDPI2026-10-16

Single-Step Genomic Reaction Norm and ssGWAS Reveal Heat-Load-Dependent Genetic Architecture of Age at Puberty in Yorkshire Gilts.

Zhang Chong C, Si Jinglei J, Song Xiaoxiao X, Xiao Youen Y et al.

Heat stress adversely affects porcine reproduction, but genetic variation in the response of age at puberty (AP) to heat exposure remains poorly characterized in gilts. We analyzed 4438 AP records from Yorkshire gilts using adjusted meteorological data and compared three heat-exposure gradients across five prepubertal windows. Pedigree- and single-step genomic reaction-norm models were fitted, followed by single-step genome-wide association analyses of the intercept and slope. Among the 15 exposure scenarios, the best-fitting model used the proportion of sustained heat-stress days in the 14-day window before first observed estrus; a one-standard-deviation increase in this measure was associated with a 7.64-day increase in AP. Both reaction-norm models detected significant genetic variance for environmental sensitivity (p < 0.001). The genomic intercept-slope genetic correlation was -0.524, and genetic variances and correlations varied across the exposure gradient. GEBVs rankings at the 10th and 90th percentiles of the exposure gradient were negatively correlated (Spearman's ρ = -0.742), and the most favorable 10% of gilts did not overlap between these two exposure levels. Intercept and slope window contributions were strongly correlated (Spearman's ρ = 0.822), although component-specific regions were also detected. Functional annotation highlighted candidate genes and biological processes related to neuroendocrine regulation, ovarian development, mitochondrial and redox homeostasis, and cellular stress responses. These findings reveal genetically heterogeneous heat sensitivity in AP, supporting environment-specific genomic evaluation for reproductive robustness in gilts.

PMID 42883054
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