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triamcinolone acetonide + moxifloxicin + vancomycin

✓ Approved

Harrow Health, Inc. · NR3C1 · Small Molecule

What is triamcinolone acetonide + moxifloxicin + vancomycin?

triamcinolone acetonide + moxifloxicin + vancomycin is a small molecule developed by Harrow Health, Inc.. It is approved for therapeutic indications via injectable (others) or intraocular injection.

Drug Profile

CompanyHarrow Health, Inc.
Drug ClassSmall Molecule
Molecular TargetNR3C1, ,
RouteInjectable (Others), Intraocular Injection
StatusApproved
Sources: ClinicalTrials.gov, Harrow Health, Inc.

Mechanism of Action

Molecular Targets

triamcinolone acetonide + moxifloxicin + vancomycin acts on 3 molecular targets:

NR3C1nuclear receptor subfamily 3 group C member 1 (GR, GCCR)
()
DNA gyrase subunit A, Staphylococcus aureus MRSA ()
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Therapeutic Indications

triamcinolone acetonide + moxifloxicin + vancomycin is developed for 3 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Eye disordersCataract✓ Approved
Infections and infestationsEye infection✓ Approved
Eye disordersGlaucoma✓ Approved

Related Research Articles

PubMedCureus2026-08-30

Optical Coherence Tomography Biomarkers in Diabetic Macular Edema and Their Role in Predicting Visual Outcome After Ranibizumab or Triamcinolone Injection.

Palanisamy Shanmugasundaram S, Mishra Priyadarshini P, Nayak Bhagabat B, Moharana Bruttendu B et al.

Background Diabetic macular edema (DME) is the most common cause of defective vision in patients with diabetic retinopathy. With intravitreal injection being a treatment option, different forms of anti-vascular endothelial growth factor (anti-VEGF) and steroid injections are available. In order to choose the effective intravitreal injection based on the retinal changes in optical coherence tomography (OCT) biomarkers, analysis is crucial. Aim This study aimed to investigate the changes in OCT biomarkers after intravitreal injection of anti-VEGF (ranibizumab) or steroid (triamcinolone) in DME and to correlate them with visual outcome. Methods This prospective observational study included patients diagnosed with diabetic retinopathy with clinically significant macular edema (CSME). Best corrected visual acuity (BCVA) and OCT biomarkers were measured at baseline and after one month of intravitreal injection. Results A total of 58 eyes were included. There was a significant change in OCT parameters, central macular thickness (CMT), subretinal fluid (SRF) height, intraretinal cyst height, and hyperreflective foci (HRF), one month after a single intravitreal injection (p<0.05). There was a significant change in BCVA after one injection (p=0.046). Also, a significant correlation was noted between BCVA and CMT (r=-0.455; p<0.001), SRF height (r=-0.438; p=0.001), and intraretinal cyst height (r=-0.540; p<0.001). Conclusion OCT biomarkers can be used to monitor therapeutic response and to predict visual outcome after intravitreal injection in DME. The presence of more HRF at baseline might be considered for steroid injection.

PMID 42668895
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PubMedDiagnostic microbiology and infectious disease2026-08-30

Rectal carriage with carbapenem-resistant organisms, vancomycin-resistant enterococci, and Clostridioides difficile: insights from a point-prevalence survey in a high-endemic setting.

Karakosta Polyxeni P, Kalogeropoulou Eleni E, Damianidou Sofia S, Georgiou Panagiota Christina PC et al.

Rectal carriage of multidrug-resistant organisms (MDROs) and Clostridioides difficile contributes to hospital transmission, yet data from high-endemic settings remain limited. We conducted a point-prevalence survey in October 2024 among 424 adult inpatients at a Greek university hospital. Rectal swabs were screened for carbapenem-resistant organisms (CROs), vancomycin-resistant enterococci (VRE), and C. difficile using molecular and culture methods. Participants were followed until discharge or death to assess clinical outcomes. Associations were evaluated using multivariable regression. Prevalence was 19.8% for CROs, 35.6% for VRE, and 9.9% for asymptomatic C. difficile. Among CRO carriers, Enterobacterales predominated (13.4%), followed by Pseudomonas aeruginosa (6.1%) and Acinetobacter baumannii (5.4%), with KPC- and NDM-type carbapenemases most frequently detected. Twenty patients carried multiple carbapenemase genes. VRE isolates were almost exclusively Enterococcus faecium with VanA phenotype. CRO and VRE carriage were associated with prolonged hospitalization (CRO: β-coef: 21.52 days, 95% CI: 8.82-34.22; VRE: β-coef: 21.37, 95% CI: 10.57-32.18). CRO carriage was associated with higher in-hospital mortality (OR: 2.50, 95% CI: 1.22-5.11) and CRO bloodstream infection (OR: 9.77, 95% CI: 1.60-58.03). Asymptomatic C. difficile carriage was linked to higher in-hospital mortality (OR: 3.77, 95% CI: 1.40-10.17). Rectal MDRO and C. difficile carriage is common in high-endemic hospital settings and associated with adverse clinical outcomes, highlighting the need for targeted surveillance, infection control, and antimicrobial stewardship.

PMID 42669275
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PubMedArthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association2026-08-30

Editorial Commentary: Playing With the Odds: Long-Term Joint Preservation Strategies Are Critical Following Postoperative Infection After Anterior Cruciate Ligament Reconstruction.

Lykos Alexandros A, Paschos Nikolaos K NK

Even though rare, infection after anterior cruciate ligament reconstruction can have a devastating long-term effect, leading to knee arthritis for these patients. Three major strategies exist in the management of perioperative infection after anterior cruciate ligament reconstruction: infection prevention, eradication of the infection in the acute setting, and long-term management of these patients. Infection prevention can be possible with soaked grafts in vancomycin and proper patient, graft, and technique selection. Aggressive management toward eradication of the microorganism, but without compromising the biomechanical environment of the knee, can be a delicate balance. After the acute phase, focusing on restoring anatomy, enhancing healing, and improving the microenvironment may be the solution for longevity of the knee joint.

PMID 42669169
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PubMedThe Kurume medical journal2026-08-30

Necrotizing Fasciitis After Cesarean Section: A Case Report.

Morishita Yushi Y, Shimomura Takuya T, Tetsuo Aki A, Sugiyama Riko R et al.

Necrotizing fasciitis (NF) is a rapidly progressive, life-threatening soft-tissue infection requiring prompt diagnosis and aggressive surgical intervention. Although approximately 20% of NF cases arise from postoperative infections, its occurrence after cesarean delivery is extremely rare, with an estimated incidence of 0.18%. We report a case of a 35-year-old primigravida with no significant medical history who underwent emergency cesarean section for non-reassuring fetal status. On postoperative day (POD) 6, she developed fever, elevated inflammatory markers, and uterine tenderness consistent with intrauterine infection. Subsequently, erythema and induration developed at the surgical site, and despite antibiotic therapy, her condition progressed to blistering and skin necrosis. Imaging revealed gas formation and fluid collection at the incision site. Emergency surgical debridement confirmed NF involving tissues from the epidermis to the rectus fascia. Methicillin-resistant Staphylococcus aureus was isolated from wound cultures, and intravenous meropenem and vancomycin were administered. Hyperbaric oxygen therapy and negative-pressure wound therapy were applied sequentially, followed by delayed wound closure. The patient recovered well and was discharged on POD51. Although rare in obstetric practice, NF should be considered when cesarean wound infections fail to respond to standard therapy.

PMID 42669471
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PubMedThe Lancet regional health. Western Pacific2026-08-30

Priority assessment of antimicrobial-resistant pathogens in the Republic of Korea: a multicriteria decision analysis.

Kim Jeong Yeon JY, Yu Su-Yeon SY, Bae Eun Young EY, Yoon Jong Hyun JH et al.

Priority assessment of antimicrobial-resistant pathogens is essential for resource allocation and national risk management. This study aims to establish a priority list of antimicrobial-resistant pathogens to strengthen the national response to antimicrobial resistance (AMR) in the Republic of Korea (ROK). Antimicrobial-resistant pathogens were ranked throughout a multicriteria decision analysis using a preference-based survey based on PAPRIKA (Potentially All Pairwise Rankings of all possible Alternatives) method. This process involved identifying relevant criteria to evaluate pathogen priority and collecting data on disease burden for each antimicrobial-resistant pathogen. A literature review was conducted to develop a candidate list of antimicrobial-resistant pathogens (n = 56) and risk assessment criteria (n = 14). Seventeen pathogens and eight criteria were selected via a Delphi survey of experts (n = 31). Incidence, case fatality, five-year trend of AMR, and nonfatal health burden was set as quantitative indicators, while transmissibility, preventability, treatability, and antibiotic development pipeline were qualitative indicators. The pathogens were ranked using 56 expert responses from the PAPRIKA survey, and categorized them into three priority groups: emergency response, preferred management, and monitoring. The emergency response group included carbapenem-resistant (CR) Klebsiella pneumoniae, CR Acinetobacter baumannii, and vancomycin-resistant Enterococcus faecium. This priority list represents the first comprehensive assessment of AMR pathogens of greatest concern to the Korean healthcare system. Our findings may inform country-specific policy decisions, particularly regarding infection prevention and control and AMR research and development. This work was supported by a fund (Grant No. 2024ER220500) provided by the Korea National Institute of Health.

PMID 42668452
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PubMedPakistan journal of medical sciences2026-08-30

Multidrug resistant bacterial infection in liver transplant recipients: A Deterrent and obstacle.

Misbah Nazish N, Haider Jahanzaib J, Hassan Muhammad M, Fatima Mehreen M

To determine the microbiological spectrum of multi-drug resistant (MDR) bacterial infections within the first 30 days post-living donor liver transplantation (LDLT) and identify the associated risk factors contributing to their emergence. This retrospective cohort study reviewed the medical records of patients who underwent LDLT from January 2020 to December 2024 at the Liver Transplant and Hepatopancreatobiliary Surgery Unit of Dow University Hospital, Karachi. Patients were categorized into MDR and no-MDR groups based on culture-confirmed MDR bacterial infection with clinical features of sepsis. Types of MDR bacterial infections were noted. Baseline, pre-transplant, intraoperative, and post-transplant variables were recorded. Pearson Chi-square test, Mann-Whitney U test, and univariate and multivariate logistic regression analyses were performed for statistical inference. Of 151 LDLT recipients, 75 (49.7%) developed MDR bacterial infections within 30 days. Among these, gram negative MDR organisms were predominated, with carbapenem-resistant Enterobacteriaceae (21.2%) and carbapenem-resistant Acinetobacter baumannii (20.5%) most frequent, followed by vancomycin-resistant Enterococci (13.2%). On univariate analysis, MDR infection was associated with pre-transplant ICU admission, renal dysfunction, prolonged postoperative ICU stay, mechanical ventilation >48 h, hemodialysis and/or sustained low-efficiency dialysis (SLED), postoperative complications, longer invasive device duration, prolonged hospital stay, central line-associated blood stream infection (CLABSI), and intra-abdominal infections. On multivariate analysis, only CLABSI [Wald χ²=17.696 (OR 0.021; 95% CI: 0.003-0.127; p<0.001)] and intra-abdominal infections [Wald χ²=25.567 (OR 0.008; 95% CI: 0.001-0.050; p<0.001)] remained independently associated with MDR infection. Nearly half of LDLT recipients developed MDR infections, predominantly due to gram-negative organisms. CLABSI and intra-abdominal infections emerged as the key predictors of MDR bacterial infections.

PMID 42668754
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