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dust mite vaccine (acaroid)

✓ Approved

Merck KGaA · Vaccine · Vaccine

What is dust mite vaccine?

dust mite vaccine is a vaccine developed by Merck KGaA. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand Namesacaroid
CompanyMerck KGaA
Drug ClassVaccine
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Merck KGaA

Therapeutic Indications

dust mite vaccine is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved
Respiratory, thoracic and mediastinal disordersAsthmaPhase III

Related Research Articles

PubMedExperimental & applied acarology2026-08-30

Bottom-up effects of strawberry cultivar resistance on the demographic and predatory performance of Neoseiulus californicus (Phytoseiidae) against Phytonemus pallidus (Tarsonemidae).

Ansari-Shiri Hassan H, Zalucki Myron P MP, Fathipour Yaghoub Y

The cyclamen mite, Phytonemus pallidus Banks, is a major threat to strawberries, causing significant damage. Chemical control is challenging due to its hidden feeding habits. Therefore, emphasizing host plant resistance is crucial, particularly in the tritrophic system. In the present study, the compatibility of the predatory mite Neoseiulus californicus McGregor with resistant and susceptible strawberry cultivars was evaluated for the management of the cyclamen mite, P. pallidus, under laboratory conditions. Leaves from two greenhouse-adapted cultivars, Sabrina (susceptible) and Albion (resistant), and two field-adapted cultivars, Gaviota (susceptible) and Paros (resistant), were used to assess predator performance. The fecundity, intrinsic rate of increase (r), and finite rate of increase (λ) of N. californicus were significantly greater on the susceptible greenhouse- and field-adapted cultivars than on the corresponding resistant cultivars. Predation rate did not differ significantly between the greenhouse cultivars but was significantly higher on the resistant field cultivar Paros than on the susceptible cultivar Gaviota. Although Paros reduced the predator's population growth potential by approximately 19%, this effect was compensated by a 21% increase in predation rate. In contrast, Albion caused only a slight reduction (5%) in predator population growth while substantially suppressing cyclamen mite populations (20%). These findings indicate that N. californicus remains an effective biological control agent on resistant strawberry cultivars, particularly Albion, demonstrating good compatibility between host plant resistance and biological control. The combined use of resistant cultivars and N. californicus therefore represents a promising strategy for the sustainable management of cyclamen mite in strawberry production systems.

PMID 42669094
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PubMedJournal of immunotoxicology2026-08-30

Prolonged brain cytokine elevation and microgliosis following exposure to World Trade Center dust particulate matter in male spontaneously hypertensive rats.

Jerome Kailey M KM, Gibson Brandon M BM, Gorr Matthew W MW, Schwieterman Neill A NA et al.

Exposure to World Trade Center (WTC) dust following the September 11, 2001 attacks has been linked to numerous negative health outcomes in First Responders, including cognitive impairment disproportionately impacting First Responders with aging. However, the mechanisms underlying neurocognitive decline remain poorly characterized. This investigation examined the effects of WTC dust exposure on myelin integrity and neuroinflammatory signaling in twelve-week old male spontaneously hypertensive rats. To model Ground Zero exposure in First Responders, WTC dust was intratracheally administered for two consecutive days (2.43 [± 0.78] mg/day).  It was hypothesized that WTC dust exposure would enhance neuroinflammatory signaling and promote an earlier, progressive decline of myelin abundance. Rats were euthanized at 3 and 12 mo post-exposure. Changes in myelin abundance (Black-Gold II), myelin basic protein (MBP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), and microglial responses (ionized calcium-binding protein; Iba1) were assessed through immunohistochemical staining, and cytokines were measured in brain homogenates. WTC dust exposure resulted in increased Black-Gold II staining at 3 mo despite no changes in MBP or CNPase. In contrast, microglial activation and IL-1β concentrations were elevated in dust-exposed rats at 12 mo. Collectively, these data suggest WTC dust exposure induces sustained neuroinflammatory signaling and may elicit a compensatory myelin response indicative of early neurodegeneration.

PMID 42669197
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PubMedGeoHealth2026-08-30

How Do Climatic Factors Directly Influence the Incidence and Risk of Meningococcal Meningitis Across the African Meningitis Belt? A Narrative Literature Review.

Cliff Molly M, Diallo Kanny K, Yapi Richard B RB, Tano Axelle B D ABD et al.

Globally, the highest incidence of meningococcal meningitis occurs within the African meningitis belt, spanning 26 countries across sub-Saharan Africa. Meningococcal meningitis incidence is highly seasonal in this region specifically, with outbreaks mostly occurring during the dry season, characterized by low rainfall and atmospheric humidity, high temperature, and increased dust and wind speed. The strong seasonality of meningococcal outbreaks coincides with seasonal variation in climatic factors. This multicollinearity can make it difficult to identify environmental drivers of disease and the mechanisms by which they operate. This review aims to collate existing evidence to better clarify the mechanisms by which climatic variables influence meningococcal meningitis incidence. We examined the impact of dust, wind speed, temperature, rainfall, and land cover on meningococcal meningitis outbreaks. Within the literature, atmospheric dust and wind speed had the strongest statistical association with meningococcal outbreaks and demonstrated greater predictive probability than other climatic variables. However, several climatic factors have demonstrable influences on one another, reflected in the seasonality of meningococcal meningitis. Atmospheric dust can reduce precipitation levels in part through its radiative properties. Decreased rainfall and increasing temperatures can dry out soil, increasing its availability to be uplifted as dust. Alongside, this lower atmospheric humidity increases evaporative demand, leading to faster soil moisture loss and enhanced surface drying. We argue that rainfall, temperature, and land cover variability may act as part of a broader climatic mechanism, increasing atmospheric dust. This increases the incidence and risk of meningococcal meningitis.

PMID 42668872
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PubMedEnvironment international2026-08-30

The extractive classroom: indoor school environments as reservoirs of mining legacy.

Zanetta-Colombo Nicolás C NC, Prieto Manuel M, Manzano Carlos A CA, Fleming Zoë L ZL et al.

The global energy transition is accelerating the demand for copper and other energy-transition minerals worldwide, potentially expanding the existing large-scale mining across the Global South. Sustainability assessments of mining currently focus primarily on ambient outdoor concentrations of chemicals (metals) and commonly assume that buildings can buffer human exposure. Here we test this assumption in Calama, Chile, a desert city downwind of one of the world's largest copper-mining complexes (Chuquicamata). We combined elemental, isotopic, and mineralogical analyses with oxidative potential measurements and zebrafish embryo assays to examine paired indoor and outdoor settled dust from 38 schools in Calama. Indoor concentrations of Cu, As, Pb, and Mo closely tracked outdoor levels and exceeded regional desert background by up to one order of magnitude, with minimal attenuation for As and Pb. Mineralogical and isotopic evidence indicated that the dust is not connected to fresh vehicles or combustion emissions, but rather to the mining industry. Additionally, the evidence showed enrichment in oxidized mining-derived particles, and indoor dust exhibited substantial oxidative potential. Zebrafish embryos exposed to dust extracts showed elevated heart rate under sublethal conditions. These results indicate that indoor environments in intensive mining landscapes, including classrooms, may be physically integrated into the surrounding extractive environment and should be incorporated into regular environmental monitoring, mine-closure planning, and just-transition governance.

PMID 42669219
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PubMedKidney medicine2026-08-30

COVID-19 Vaccine Knowledge, Practice, and Attitudes Among Hemodialysis Patients in Egypt, Kenya, and Cameroon: A Multicenter Study.

Elsayed Enass E, Kotb Khaled M KM, Heiba Ahmed A, Elhussini Manal Shaker MS et al.

Patients receiving hemodialysis (HD) are at increased risk of severe coronavirus disease 2019 (COVID-19) and were prioritized for vaccination, yet vaccine hesitancy remains common. We assessed COVID-19 vaccine knowledge, acceptance, and attitudes among patients receiving HD in Egypt, Kenya, and Cameroon and identified factors associated with vaccine acceptance, prior infection, willingness to receive future doses, and postvaccination complications. Multicenter cross-sectional survey study. Between March 2021 and April 2022, 765 patients receiving maintenance HD and 196 non-dialysis controls were recruited from dialysis centers in Egypt, Kenya, and Cameroon. Sociodemographic characteristics, clinical comorbidities, prior COVID-19, sources of vaccine information, and exposure to vaccinated or infected relatives. COVID-19 vaccine acceptance, willingness to receive future doses, prior infection, and post-vaccination complications. Structured questionnaires assessed knowledge, practices, and attitudes toward COVID-19 vaccination. Multivariable logistic regression identified factors independently associated with study outcomes. Vaccine acceptance was lower among patients receiving HD than nondialysis controls (58.2% vs 96.2%). Fear of side effects was the most common reason for refusal (39.3%). Postvaccination complications were less frequent among patients receiving HD (22.3% vs 44.3%). Hesitancy was more common among women, younger participants, and those with comorbidities or no prior COVID-19. Having vaccinated or previously infected relatives was associated with a greater willingness to receive future doses. Cross-sectional design limits causal inference. Nonprobability sampling and unmatched controls may limit generalizability. COVID-19 cases may have been underreported because of limited testing. COVID-19 vaccine hesitancy among patients receiving HD is driven by fear, misinformation, and sociodemographic factors. Targeted education and improved access to reliable vaccine information may help increase uptake in this population.

PMID 42668537
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PubMedEMBO molecular medicine2026-08-30

A cavity-reduced prefusion RSV F bivalent vaccine elicits durable and protective immunity.

Liu Lijie L, Yan Mengrong M, Liang Ruoxu R, Wu Qingxin Q et al.

Respiratory syncytial virus (RSV) remains a major cause of severe respiratory disease, and stabilization of the prefusion (preF) conformation of the F glycoprotein is central for vaccine development. Here, we report a structure-guided engineering strategy that enhances preF stability by reducing the hydrophobic cavity within the trimeric F protein. Targeted modifications at metastability-associated sites generated RVF-88, a disulfide-free stabilized preF immunogen that preserves key neutralizing epitopes, including antigenic site Ø, while exhibiting improved structural integrity and long-term storage stability. Formulated as an unadjuvanted bivalent vaccine, RVF-88 elicited potent neutralizing antibody responses and durable immune protection lasting up to 5 months in mice. Vaccination also protected both mice and cotton rats against RSV challenge. Structural analyses confirmed the intended cavity-reduction design, revealing a reduced apical hydrophobic cavity volume and surface area while maintaining the prefusion architecture. Together, these findings establish hydrophobic cavity reduction as a rational strategy for stabilizing prefusion RSV F and provide a promising next-generation vaccine candidate with improved stability and immunogenicity for further clinical development.

PMID 42668284
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