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IV

IVIG (Privigen / IVIG, liquid, CSL / IgPro10)

✓ Approved

CSL Behring · Polyclonal Antibodies · Polyclonal Antibodies

What is IVIG?

IVIG is a polyclonal antibodies developed by CSL Behring. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesPrivigen, IVIG, liquid, CSL, IgPro10
CompanyCSL Behring
Drug ClassPolyclonal Antibodies, Antibody
RouteInjectable (Others), Intravenous (IV)
StatusApproved

Therapeutic Indications

IVIG is developed for 9 unique indications across 6 therapeutic areas.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersPurpura✓ Approved
Immune system disordersImmunodeficiency✓ Approved
Nervous system disordersMultifocal motor neuropathy✓ Approved
Musculoskeletal and connective tissue disordersScleroderma✓ Approved
Nervous system disordersGuillain-Barre syndrome✓ Approved

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Related Research Articles

PubMedSoft matter2026-08-30

Bottom-up coarse-grained simulations of electric-field-induced biaxiality and switching dynamics in liquid crystals of board-like molecules.

Díaz-Acosta Adrián A, Gil-Villegas Alejandro A, Patti Alessandro A

Electric fields can alter the orientational symmetry of liquid crystals, driving the emergence of biaxial order with potential relevance for next-generation electro-optical devices. Here, we present a coarse-grained (CG) model for a liquid crystal of board-like mesogens that enables a direct connection with our previous atomistic molecular dynamics simulations. The model is constructed through a particle-based mapping scheme that preserves the intrinsic anisotropy of the molecular core while enabling access to larger system sizes and longer time scales. Effective bonded and non-bonded interactions are obtained within a bottom-up force-matching framework and validated against atomistic reference data through structural and orientational correlations. A comparison with the atomistic reference allows us to assess both the capabilities and the limitations of the present CG representation, particularly in relation to the subtle balance between nematic and weak smectic-A organisation. Building on this framework, we then investigate the response of the system to externally applied electric fields. The model successfully captures field-induced reorientation dynamics and reveals a strong dependence of the ordering kinetics on field strength. Stronger fields substantially accelerate the evolution towards equilibrium, eventually leading to a rapid-alignment regime at high field strengths. After the field is removed, the system retains residual orientational memory rather than fully relaxing to its initial disordered state, suggesting persistent field-induced correlations that may affect subsequent switching processes. Most importantly, the external field promotes the formation of a biaxial nematic phase, highlighting the ability of the model to capture subtle symmetry-breaking phenomena induced under non-equilibrium conditions and relevant to electro-optical applications. The present CG model provides an efficient and physically consistent framework for exploring equilibrium structures, switching dynamics, and field-driven non-ordering in liquid-crystalline materials.

PubMedChemical communications (Cambridge, England)2026-08-30

Cation-regulated proton conduction in node-anchored ionic-liquid/MOF-808 conductors.

Hong Yanlin Y, Wang Cong C, Li Shantao S, Jin Jincheng J et al.

Node-anchored protic ionic liquids were immobilized in MOF-808 through Zr-node post-modification to construct stable proton-conducting pathways. Cationic sulfonic acid groups strengthen hydrogen-bond networks and promote Grotthuss-type proton transport. PSO3MImH2PO4@MOF-808 achieved 3.19 × 10-3 S cm-1 at 80 °C and 95% RH with excellent stability.

PubMedAdvances in colloid and interface science2026-08-30

Characterization of solids and surface modifications by surfactants and polymers.

Rosenholm Jarl B JB

Probe molecules are used to characterize Lewis-type and Brϕnsted-type surface sites of solids. The number and strength of surface sites are determined by Langmuir adsorption isotherms and by acid-base titrations. The appearance of charged surface sites is determined by dissolution experiments and the overall surface energy by immersion experiments. First-order standard thermodynamic properties (Gibbs energies, enthalpies and entropies) are used to characterize the state of probe molecules in solution and the interaction between probe molecules and surface sites. The state of surfactants in solution is characterized using regular solution model. The adsorption to surface sites is quantified by Langmuir isotherms. Their self-assembly at surface sites is initiated at somewhat lower concentration as compared to micelle formation in solution. Loosely bound surfactants and (hemi)micelles follow the prediction of Henry adsorption isotherm. Solution properties of polymers are evaluated by applying total (Scatchard-Hildebrand, Flory-Huggins) combinatory energy. A diminished solubility results in adsorption. Polymer adsorption can be characterized using Freudlich adsorption isotherm and predicted using solubility spheres. The observations are discussed in terms of preferential solid-adsorbent (probe, surfactant, polymer), adsorbent-liquid (solubility) or solid-liquid (wetting) interactions.

PubMedJournal of chromatography. A2026-08-30

Automated miniaturized LLE-GC-MS/MS for the analysis of EPA 8270 SVOCs and multi-class pesticides in water using ethyl acetate.

Feo Maria Luisa ML, Benedetti Paolo P, Zanaboni Moira M, Tofful Luca L et al.

The determination of trace-level semi-volatile organic compounds (SVOCs) following EPA Method 8270 traditionally relies on manual liquid-liquid extraction (LLE) using large volumes of dichloromethane (DCM). However, recent 2024 TSCA regulations restricting DCM due to human health risks necessitate sustainable analytical alternatives. This study presents a fully automated, miniaturized LLE (micro-LLE) method for 170 analytes including EPA 8270 targets and multi-class pesticides (organochlorine (OCPs), organophosphorus (OPPs) and organonitrogen (ONPs) pesticides and pyrethroids). The workflow utilizes a TriPlus RSH SMART autosampler to integrate standard preparation, surrogate spiking, and extraction with on-line GC-MS/MS injection. Ethyl acetate was validated as a "green" alternative to DCM, with a 1:1 NaCl:MgSO₄ salt mixture optimizing the salting-out effect. This procedure achieved a tenfold enrichment factor using only 1.5 mL of solvent for 10 mL of sample. Method validation showed excellent linearity (R2> 0.995 for 70% of analytes) and precision (RSD < 15%). Method limits of quantification (MLOQs) between 0.05 and 10 µg/L meet stringent regulatory requirements. The method's robustness was confirmed through real-world Saharan deposition samples, identifying high levels of Phenothrin (211 ppb) and Endosulfan ether (140 ppb). This robotic workflow provides a high-throughput, sustainable solution for modern environmental monitoring.

PubMedAdvances in colloid and interface science2026-08-30

From wetting mechanisms to anti-wetting membrane design: An interfacial and colloidal perspective on membrane distillation.

Omer Abduelrahman Adam AA, Wang Duo D, Wang Yong Y, Yang Chao C

Membrane distillation (MD) is a promising thermally driven desalination technology due to its high rejection of non-volatile contaminants and its ability to operate under relatively mild conditions. However, membrane wetting remains a persistent challenge that hinders its distillation efficiency and long-term application. This review presents a mechanism-based perspective on MD wetting by linking capillary pressure imbalance, surface-tension reduction, surfactant adsorption, scaling, and colloid-driven interfacial interactions to pore invasion and performance deterioration. The influence of key membrane properties, including hydrophobicity, liquid entry pressure, surface free energy, pore structure, and thermal conductivity, was discussed in relation to wetting resistance. Building on this mechanistic understanding, four anti-wetting strategies are examined, including stabilization of the Cassie-Baxter state through hierarchical structures, extension of liquid repellency using ultralow-surface-energy materials, asymmetric interfacial regulation through Janus architectures, and dynamic interfacial regulation using stimuli-responsive membranes. Furthermore, the role of engineered colloidal nanomaterials as versatile building blocks for anti-wetting interfaces is discussed across the four design strategies. Artificial intelligence and machine learning, particularly inverse design and physics-informed approaches, are highlighted as emerging tools for membrane discovery and optimization. Future perspectives are outlined toward mechanism-guided membrane fabrication, validation under realistic feed conditions, and data-driven design of durable anti-wetting MD membranes. This review proposes anti-wetting strategies as well as design principles in the separation applications.

PubMedBiosensors & bioelectronics2026-08-30

One-pot dual-toehold RCA-Cas12a biosensor driven by a preassembled three-arm toehold-gated DNA template for sequence-selective miRNA liquid biopsy.

Han Jueun J, Song Yejin Y, Ko Uk U, Son Seong Uk SU et al.

MicroRNAs (miRNAs) in blood are promising liquid biopsy biomarkers, yet their short length, low abundance, and high intra-family homology hinder sensitive and specific detection. Combining rolling circle amplification (RCA) with CRISPR-Cas12a enables isothermal detection, but existing methods typically depend on auxiliary enzymes or in-assay ligation and rarely encode sequence discrimination within the template itself. Here, we report a one-pot dual-toehold RCA (dtRCA)-Cas12a biosensor driven by a preassembled three-arm toehold-gated (3TG) DNA template for ultrasensitive and selective miRNA detection. The 3TG template adopts a three-arm dumbbell conformation, eliminating the need for a ligase during the assay, and presents two target-complementary toehold domains with a Cas12a-recognition sequence. Target binding triggers strand displacement, initiating dtRCA via a single polymerase. The resulting amplicons activate Cas12a trans-cleavage for fluorescence or lateral flow assay (LFA) readouts. Crucially, a single-base mismatch within the toehold suppressed amplification, whereas a topology-matched circular template lacking the toehold gate failed to distinguish the target, demonstrating that selectivity arises from the template structure. The one-pot dtRCA-Cas12a system achieved attomolar sensitivity, detecting miR-21, miR-375, and let-7a at 2.5, 114.9, and 8.0 aM, respectively. The paper-based LFA maintained femtomolar sensitivity and enabled an instrument-light readout. In plasma, this platform discriminated breast cancer patients (n = 17) from healthy donors (n = 10) with AUC values of 0.97-0.98. Three-marker classification demonstrated robust performance in leave-one-out cross-validation and correctly classified 30 samples in an independent validation cohort, showing performance comparable to RT-qPCR. By embedding selectivity into a preassembled template, this 3TG-driven dtRCA-Cas12a platform provides a highly sensitive and specific strategy for multi-marker miRNA analysis with simplified readout.

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