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IV

IVIG (Privigen / IVIG, liquid, CSL / IgPro10)

✓ Approved

CSL Behring · Polyclonal Antibodies · Polyclonal Antibodies

What is IVIG?

IVIG is a polyclonal antibodies developed by CSL Behring. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesPrivigen, IVIG, liquid, CSL, IgPro10
CompanyCSL Behring
Drug ClassPolyclonal Antibodies, Antibody
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, CSL Behring

Therapeutic Indications

IVIG is developed for 9 unique indications across 6 therapeutic areas.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersPurpura✓ Approved
Immune system disordersImmunodeficiency✓ Approved
Nervous system disordersMultifocal motor neuropathy✓ Approved
Musculoskeletal and connective tissue disordersScleroderma✓ Approved
Nervous system disordersGuillain-Barre syndrome✓ Approved

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Related Research Articles

PubMedNeurology and therapy2026-10-16

Real-World Health Care Resource Utilization, Adherence, and Persistence Following Subcutaneous IgPro20 Initiation Among US Patients with Chronic Inflammatory Demyelinating Polyneuropathy.

Kuatov Batyrkhan B, Weng Shicheng S, Hubsch Alphonse A, Undreiner Laurence L et al.

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare, inflammatory peripheral nervous system disorder. Intravenous immunoglobulin (IVIG) has been the standard maintenance therapy, but since 2018, Immune Globulin Subcutaneous (Human), 20% liquid (IgPro20), a subcutaneous immunoglobulin (SCIG) therapy, has offered an alternative, demonstrating benefit in maintaining CIDP improvement and remission. This study aimed to evaluate real-world healthcare resource utilization (HCRU), adherence, and persistence following IgPro20 initiation in patients with CIDP, given limited real-world evidence on these SCIG-related outcomes. This observational, descriptive study used Optum's de-identified Clinformatics® Data Mart Database (Optum® CDM) data to examine adults with CIDP initiating IgPro20 (index date). Adult patients with ≥ 2 CIDP diagnosis claims at least 14 days apart and ≥ 6 months of enrollment pre- and post-index between January 1, 2014 and December 31, 2024 were included. Those on other SCIG products were excluded. Patients with CIDP initiating IgPro20 (N = 207) were 53.6% male, with a median age of 60.00 and few comorbidities. Acute care utilization was low at baseline and decreased further following IgPro20 initiation, with inpatient and emergency department visits per patient per year (PPPY) decreasing from 0.52 to 0.42 and from 1.00 to 0.85, respectively. Overall, outpatient (OP) visits increased from 60.62 PPPY pre-initiation to 92.61 PPPY in month 1 post-initiation, driven by visits for CIDP-related home administration, notably for nursing/home-care for self-administration training. OP visits subsequently declined to 67.43 PPPY by month 6 (n = 141). Most patients (69.1%) were highly adherent, and 63.8% remained persistent at 6 months. Patients on IgPro20 administration demonstrated therapy adherence and decreased utilization of resource-intensive settings. While initial increases in outpatient and home care visits likely reflect training for at-home therapy, other outpatient healthcare utilization decreased. High persistence and adherence indicate sustained, uninterrupted therapy.

PMID 42881325
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PubMedAdvanced materials (Deerfield Beach, Fla.)2026-10-16

Achieving High Spatial Resolution Transmission Electron Microscopy Studies in Closed Liquid Cells.

Guo Siqi S, Sun Hongyu H, Shu Le L, Ge Xuejin X et al.

Liquid cell transmission electron microscopy (LCTEM) is a rising technique for probing dynamic processes and structural transformations in liquid environments at the nanoscale. However, its broader application is largely constrained by limited spatial resolution, which arises from electron scattering by the encapsulating membranes and the liquid layer. Recent advances in instrument design, micro-electro-mechanical system (MEMS)-based cells, and ultrathin window materials have substantially improved imaging quality, yet achieving atomic-scale resolution in liquids remains a formidable challenge. This review provides a comprehensive overview of such strategies developed to enhance the spatial resolution of LCTEM, emphasizing the roles of liquid layer thickness, MEMS design, and cell configuration. We highlight representative approaches, such as reducing liquid and membrane thicknesses, optimizing MEMS architectures, and employing grid-based liquid cells, and discuss their underlying mechanisms and recent progress. Finally, we outline current challenges and future opportunities for achieving high-resolution, multifunctional LCTEM systems capable of capturing dynamic processes in realistic liquid environments.

PMID 42885387
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PubMedCancers2026-10-16

Refining Lung Cancer Care: The Emerging Role of Liquid Biopsy in Screening, Diagnosis, and Precision Oncology.

Mansour Hicham H, Mazouji Omayma O, El Hammouti Ayman A, Alloubi Ihasane I et al.

Lung cancer (LC) remains the leading cause of cancer-related mortality worldwide, representing a major public health challenge. Although low-dose computed tomography is currently the standard screening method for high-risk individuals to reduce mortality, its clinical performance is limited by false-positive findings and restricted accessibility. Emerging biomarker-based liquid biopsy offers a promising non-invasive approach for cancer detection. This narrative review provides a critical overview and evaluation of clinically endorsed liquid biopsy applications for guiding treatment in advanced-stage lung cancer, as well as investigational advances in liquid biopsy for early cancer detection. We also address challenges of current liquid biopsy technologies, the integration of artificial intelligence, implementation improvements, and future perspectives for their adoption into routine clinical practice. To complement this narrative review, a structured search of the ClinicalTrials.gov registry was performed to identify clinical trials evaluating liquid biopsy in lung cancer. Current evidence supports the clinical use of liquid biopsy for molecular profiling and treatment selection in advanced non-small cell lung cancer (NSCLC), whereas its application in early detection, screening, and minimal residual disease (MRD)-guided management remains investigational and requires further prospective validation. Overall, liquid biopsy represents a promising complementary approach to advance precision oncology and improve lung cancer management.

PMID 42882836
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PubMedChemical Society reviews2026-10-16

Liquid hydrocarbon separation membranes: mechanistic insight, material design and microenvironment engineering.

Ji Zhengxuan Z, Wang Boya B, Jiang Zhongyi Z, Yang Hao H

Liquid hydrocarbon separation is in great demand in the modern petrochemical industry. Membrane-based liquid hydrocarbon separation has emerged as a next-generation technology with great potential to address energy and environmental challenges, representing one of the most rapidly evolving and demanding frontiers. Despite its promise to revolutionize energy-intensive processes, practical application remains hindered by the complexity of liquid hydrocarbon mixtures and the stringent requirements on membrane materials. In this review, microenvironment engineering is employed as the central concept to establish an integrated chain linking molecular transport mechanisms, material design, and industrial applications of liquid hydrocarbon separation membranes (LHSMs). Based on the molecular transmembrane transport mechanisms, we identify typical microenvironments in LHSMs and systematically classify liquid hydrocarbon separations into coarse, precise, and ultrafine regimes. This mechanism-based understanding of membrane microenvironments and separation regimes represents the first unified classification framework for LHSMs. Furthermore, we highlight membrane microenvironment engineering as a critical bridge connecting advanced membrane materials with practical separation performance. In particular, we propose the efficient management of membrane microenvironments, which enables the reproducibility and scalability of membrane fabrication while ensuring effective separation performance. Moreover, emerging techniques for microenvironment engineering are discussed, including in situ and operando monitoring techniques, as well as machine learning/artificial intelligence (AI)-assisted microenvironment engineering. Finally, future directions are outlined, including deeper mechanistic understanding, scalable membrane fabrication and process integration, LHSM-specific fouling understanding, and operando- and data-driven microenvironment engineering. Collectively, this review provides a coherent roadmap for the rational design and practical implementation of next-generation membranes for sustainable liquid hydrocarbon separations.

PMID 42886027
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PubMedPolymers2026-10-16

Temperature-Responsive Ionic Liquids: Polymer Structure, Phase Transition Behaviors and Applications.

Guo Lijun L, Ji Xiaoying X, Zhou Jian J, Liu Yanju Y et al.

Temperature-responsive ionic liquids (TRILs) represent a significant advance of smart functional materials with thermally tailorable phase transition behaviors. TRILs exhibit typical lower critical solution temperature (LCST) and upper critical solution temperature (UCST) liquid-liquid phase transitions, as well as versatile liquid-solid transition modes involving crystallization, precipitation, and liquid crystal formation, which endow TRILs with superior tunability inaccessible to conventional solvents and ordinary ILs, enabling reversible regulation of solubility, miscibility, ion transport, and interfacial properties under temperature stimuli. This review systematically elaborates the structural characteristics of TRIL cations and anions, clarifies the intrinsic mechanisms of thermally triggered phase transitions, and comprehensively summarizes state-of-the-art advances in multidisciplinary applications covering water treatment, gas separation, controlled drug delivery, switchable catalysis, and electrochemical energy storage. We fully discuss the structural advantages and working principles of TRIL-based smart systems, and analyze the current bottlenecks including high intrinsic viscosity, limited regulation range, ambiguous biocompatibility, and inadequate long-term cycling stability. Future research directions are further proposed to guide the rational molecular design, composite modification, and multi-stimuli integration of high-performance TRIL materials. This work aims to provide a comprehensive and systematic reference for the development and industrial translation of next-generation thermoresponsive functional materials with case-specific environmental advantages.

PMID 42885022
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PubMedInternational journal of molecular sciences2026-10-16

Systematic Profiling Reveals Propensity of Human Ion Channels for Liquid-Liquid Phase Separation.

Li Jiamin J, Yao Yijing Y, Yu Ran R, Cui Siyu S et al.

Liquid-liquid phase separation (LLPS), a fundamental biophysical process driven by multivalent weak interactions, regulates diverse cellular physiological functions. Ion channels are critical transmembrane protein complexes governing electrophysiological signaling, yet their phase separation characteristics remain largely uncharacterized. Here, we systematically assessed the phase-separation propensity of 140 human ion-channel proteins from the PhaSePred database, and 69 human ion channel proteins were predicted to have a high propensity for LLPS (prediction score ≥ 0.5). Based on the self-assembling phase-separating (PS-Self) and partner-dependent phase-separating (PS-Part) scores of the proteins, we classified ion channel proteins with a ratio (PS-Self/PS-Part) > 1 into the PS-Self group and those with a ratio < 1 into the PS-Part group. Ultimately, 37 proteins were predicted to tend toward PS-Self, and 32 to tend toward PS-Part. Moreover, PS-Self candidates exhibited higher hydropathy and pi-pi contact scores, whereas predicted PS-Part candidates showed higher IDR, LCR, and phosphorylation-associated scores. Experimental analyses identified intracellular regions of CaV1.2, CaV1.3, NaV1.5, and KCa2.2 that formed dynamic condensate-like assemblies when expressed in HeLa cells. Our findings elucidate the phase separation classification and core structural domains mediating LLPS in key ion channels and providing a molecular basis for understanding the pathophysiological roles of ion channel phase separation in cardiac and neurological disorders and may inform the development of phase-separation-targeted diagnostic and therapeutic strategies.

PMID 42883847
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