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iontophoretic system (Smart patch / Actyve)

✓ Approved

Vyteris · therapeutic agent

What is iontophoretic system?

iontophoretic system is a therapeutic agent developed by Vyteris. It is approved for therapeutic indications via transdermal.

Drug Profile

Brand NamesSmart patch, Actyve
CompanyVyteris
RouteTransdermal
StatusApproved
Sources: ClinicalTrials.gov, Vyteris

Therapeutic Indications

iontophoretic system is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

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Supervisory monitoring and control systems require prompt access to process data and information. The systems described in the literature utilize Mixed Reality (MR) technology and have different system architectures and communication methods. Some systems require the presence of intermediary elements for data exchange between the MR environment and the industrial control system. In this article, we suggest and develop an MR-based system for the supervisory monitoring and control of an industrial assembly line. The uniqueness of the suggested system consists of bidirectional communication between the MR system and the main PLC using the OPC UA protocol without intermediary elements in the MR-PLC communication chain. The Modbus TCP protocol is used for obtaining parameters from the network analyzer. The system allows us to monitor some process parameters and sensors on the assembly line and transfer supervisory commands from the MR interface to the main PLC using virtual controls on physical elements. The system was built using the MRTK library inside the Unity environment. To experimentally evaluate the system, experiments were conducted on the industrial assembly line, where the process parameters and communication performance were recorded under experimental conditions.

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Vigneshwaran Sivakumar S, Wang Shi-Cheng SC, Pan Qinhe Q

The pervasive prevalence of organic pollutants in water bodies presents major obstacles to traditional uranic recovery methods. Herein, a novel self-powered catalytic system has been developed, featuring a TGCNM heterojunction cathode paired with a carbon/chitin nanofilm nanoarray (CNF) and a silicon PVC photovoltaic (Si PVC) photoanode. This advanced assembly enables the concurrent reduction of U(VI), degradation of pollutants, and generation of electricity. The synergy between the functional groups and redox-active sites on the TGCNM heterojunction promotes efficient adsorption and stepwise reduction of U(VI), granting the system remarkable cycling stability and promising real-world applicability. When exposed to simulated sunlight, the system demonstrates impressive removal rates: 96.7% for UO22+ and 97.7% for bisphenol A (BPA). Additionally, U(VI) removal remains above 90.2% in various organic environments, illustrating strong resistance to interference. Even after five consecutive cycles, the system retains high performance (>93.9% for U(VI) and >94.3% for BPA). Under actual solar irradiation, removal efficiencies exceed 95.8% for both contaminants, underscoring its practical value. This study offers innovative perspectives on resource-focused strategies for remediating radioactive and organic-contaminated waters by integrating energy production and water treatment.

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PET-Fe-BDC Composite Geotextiles for Groundwater Remediation: In Situ Synthesis and Dynamic Retention of Pb(II) and Cd(II).

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Remediating heavy-metal pollution in flowing groundwater is challenging because powder adsorbents may agglomerate or wash away, while static tests do not represent dynamic transport. To address these limitations, a PET-Fe-BDC composite geotextile was prepared by in situ synthesis following PAM pretreatment and evaluated for Pb(II) and Cd(II) retention in continuous soil-column seepage experiments. Compared with unamended soil, the composite-geotextile-amended system markedly retarded the downward migration of both ions. In the 0-5 cm retardation layer, cumulative removal efficiencies exceeded 80% up to te', and the breakthrough times of Pb(II) and Cd(II) increased to approximately 6.9 and 6.4 times those in the unamended system, respectively. Thomas, Yan, Clark, and Yoon-Nelson models were used to describe the observed breakthrough behavior. The Yan model provided the most consistent empirical description across the tested curves. The Thomas model closely described the unamended-soil curves and the composite-system Cd(II) curve but showed weaker agreement for composite-system Pb(II), whereas the Clark and Yoon-Nelson models showed lower fitting performance. Because complete saturation was not reached, model-derived parameters were interpreted comparatively. Overall, the integrated PET-Fe-BDC composite-geotextile-amended soil system substantially delayed Pb(II) and Cd(II) breakthrough under continuous seepage, demonstrating its potential for groundwater-remediation barriers.

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