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isosorbide mononitrate (Mono Mack 50D / Mono Mack)

✓ Approved

Novartis AG · Small Molecule · Small Molecule

What is isosorbide mononitrate?

isosorbide mononitrate is a small molecule developed by Novartis AG. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesMono Mack 50D, Mono Mack
CompanyNovartis AG
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Novartis AG

Therapeutic Indications

isosorbide mononitrate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Cardiac disordersAngina pectoris✓ Approved

Related Research Articles

PubMedMaterials today. Bio2026-10-05

A bio-based superhydrophobic pit and fissure sealant for enhanced stability and anticaries application.

Chen Xu X, Zhang Xiaolei X, Wang Xin X, Zhang Chen C et al.

Dental caries is one of the most prevalent chronic diseases worldwide, with most lesions occurring in occlusal pits and fissures. To prevent occlusal caries, pit and fissure sealants are considered one of the most effective measures. However, their anticaries effect are often compromised by secondary caries resulting from biofilm accumulation. Furthermore, traditional sealants based on bisphenol A glycidyl methacrylate (Bis-GMA) may release bisphenol A (BPA), raising concerns about potential endocrine disruption. In this study, we developed a bio-based superhydrophobic pit and fissure sealant by utilizing isosorbide dimethacrylate (IM) as a bio-based resin matrix, fluorinated methacrylate (FMA) as a low-surface-energy component, and a combination of micro- and nano-sized SiO2 to construct a micro-nano hierarchical surface architecture, after light curing treatment. The bio-based micro-nano structured superhydrophobic pit and fissure sealant (m-n SUP) retained superhydrophobicity after immersion in artificial saliva for 5 days, thermocycling for 5000 cycles, pH cycling for 5000 cycles, tape peeling for 100 cycles, and sandpaper abrasion for 40 cycles. m-n SUP also exhibited favorable mechanical properties and enamel bonding comparable to those of the commercial sealant, together with favorable marginal sealing performance. Moreover, m-n SUP exhibited good cytocompatibility, and markedly reduced salivary mucin adsorption and provided sustained inhibition of the initial adhesion and biofilm formation for five representative oral cariogenic bacteria over 72 h. In a rat model, m-n SUP effectively reduced the incidence and severity of occlusal carie. Overall, this bio-based superhydrophobic pit and fissure sealant can provide a promising bio-based material strategy for pit and fissure caries prevention.

PMID 42831082
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PubMedBiomolecules2026-09-26

Advancing Epidermal Barrier Resilience in Atopic Dermatitis with Isosorbide Di-Fatty Acid Esters: From Disruption to Restoration.

Chaudhuri Ratan K RK, Sivamani Raja K RK

Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease characterized by epidermal barrier dysfunction, immune dysregulation, microbial imbalance, and severe pruritus. Emerging evidence establishes that barrier disruption is a central pathogenic driver capable of initiating inflammatory signaling, neuroimmune activation, and chronic disease instability. This understanding has shifted therapeutic paradigms toward barrier-directed strategies aimed at restoring epidermal resilience. This narrative review evaluates the mechanistic and clinical evidence surrounding isosorbide fatty acid diester molecules-specifically isosorbide dicaprylate (IDC) and isosorbide di-(linoleate/oleate) (IDL)-as a barrier-first approach for AD management. Early in vitro and ex vivo investigations demonstrated that IDC significantly improves epidermal hydration, transepidermal water loss, and the expression of barrier-associated genes linked to epidermal integrity. Subsequent studies showed that IDL expands these effects through coordinated regulation of keratinocyte differentiation, lipid homeostasis, and inflammatory stress pathways. Furthermore, recent mechanistic data highlight synergistic anti-inflammatory and pruritus-modulating effects involving TRPA1-, TRPV3-, and TSLP-associated pathways, while preserving tissue integrity under cytokine-induced stress. Clinically, these findings are supported by randomized studies in pediatric and adult cohorts demonstrating significant reductions in pruritus, favorable Eczema Area and Severity Index (EASI) responses, decreased topical corticosteroid dependence, and a reduction in the relative abundance of Staphylococcus aureus. Collectively, these findings support a barrier-first therapeutic framework in which restoration of epidermal resilience may beneficially influence multiple interconnected pathways involved in atopic dermatitis.

PMID 42793078
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PubMedPolymers2026-09-26

Robust Polyimide/Graphene Composites as Electrically Functional Materials for Space-Compatible Biomedical Applications.

Campanella Martina M, Blondelli Francesca F, Toto Elisa E, Laurenzi Susanna S et al.

Polyimide-based composites with graphene nanoplatelet (GNP) fillers are investigated as multifunctional materials for potential space-compatible biomedical monitoring. These composites are designed to combine the intrinsic high thermal and chemical stability of polyimides, as well as their well-established radiation resistance reported in the literature, with the electrical functionality of graphene. PI/GNP membranes are fabricated by casting dispersions of graphene nanoplatelets within the polyimide solution, using a green and bio-based solvent (dimethyl isosorbide), followed by thermal treatment in vacuum. The effect of UV-C irradiation is investigated as a sterilization-relevant stress condition, showing that the PI/GNP composites retain their main chemical and surface characteristics after exposure. In addition, irradiation is associated with an improvement in the electrical response, suggesting that the conductive network formed by graphene nanoplatelets remains effective after treatment. Overall, this study highlights the PI/GNP composites as robust and electrically functional candidate materials for dry electrode applications in harsh environments. By combining chemical stability, thermal resistance, a stable surface and electrical conductivity, these membranes emerge as promising candidates for future health monitoring applications on Earth and during long-term missions in space.

PMID 42797130
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PubMedJTCVS open2026-09-24

Twenty-five years of the Journal of Thoracic and Cardiovascular Surgery (2000-2024): Bibliometric insights.

Yi Jiangfeng J, Zeng Guiqiang G, Li Litao L, Liu Lulin L et al.

To analyze research trends and key contributors in The Journal of Thoracic and Cardiovascular Surgery over 25 years (2000-2024) using bibliometric methods. A total of 9190 articles from Web of Science were analyzed using CiteSpace, VOSviewer, and Bibliometrix to assess publication trends, citation metrics, author/institution/country contributions, co-citation networks, and keyword co-occurrence. Annual publications increased from 329 (2000) to 659 (2014), then stabilized at an average of 319 ± 32 (2015-2024). Impact factor peaked at 6.44 in 2021. The United States led with 4695 publications, followed by Japan and Canada. Harvard University topped institutional output (662 publications), whereas Blackstone EH was the most influential author (h-index: 65). The 20 most-cited articles were predominantly clinical studies focused on surgical techniques and outcomes. Co-citation analysis identified aortic surgery, cardiac valve surgery, and coronary artery surgery as major domains. Citation burst analysis revealed transcatheter aortic valve replacement as the most dynamic recent frontier, with Mack MJ and Popma JJ showing strongest citation bursts. Cardiac surgery was the most frequent key word (300 occurrences), followed by non-small cell lung cancer and coronary artery bypass. Recent emerging terms include acute kidney injury, coronavirus disease, and surgical aortic valve replacement. This 25-year bibliometric analysis reveals The Journal of Thoracic and Cardiovascular Surgery as a leading platform for cardiothoracic surgery research with sustained growth and increasing scholarly impact. The field demonstrates strong North American institutional dominance, with transcatheter aortic valve replacement emerging as the primary research frontier. Future directions should emphasize international collaboration, research in low- and middle-income regions, transcatheter technologies, and translational research integration.

PMID 42781353
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PubMedThe International journal of pharmacy practice2026-09-23

Use of drug information resources, knowledge, and competence for managing medication related problems: results of a community pharmacy survey in Egypt.

Abozahra Dalia Yehia DY, El-Maradny Yousra A YA, Ashmawy Rasha R, Taman Rana Ahmed RA

Community pharmacists provide reliable healthcare information, over-the-counter services, and help prevent medication errors. This study aimed to assess the drug information (DI) resources commonly used in community pharmacy practice in Egypt, and the perceived barriers to their use. It also evaluates the pharmacists and students/trainees' knowledge and competence in addressing various medication-related problems. A cross-sectional study was conducted among community pharmacists and pharmacy students/trainees in Egypt. A structured, self-administered questionnaire collected demographic data, patterns of DI resource use, perceived barriers, and responses to medication-related clinical scenarios designed to assess knowledge and competence. Descriptive statistics and multivariable linear regression were performed to identify factors associated with knowledge scores. A total of 248 participants (mean age: 31.4 ± 11.5 years) completed the survey. Most respondents (89.9%) reported using professional DI resources and 78.6% used mobile DI applications or websites designed for healthcare professionals. The mean knowledge score was 4.33 ± 0.90 (range: 0-8). Formal training was associated with higher scores (β = 0.857, P = .003), whereas students/trainees scored lower than community pharmacists (β = -1.156, P = .013). The highest correct response rate (74.5%) was for identifying the interaction between sildenafil and isosorbide mononitrate. Community pharmacists and pharmacy students/trainees in Egypt reported frequent use of digital DI resources; however, their knowledge and performance remained moderate. Formal training was associated with better performance, highlighting the need to strengthen education and continuing professional development through collaboration between educational institutions and professional bodies.

PMID 42775790
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PubMedChemSusChem2026-09-16

Highly Efficient Vapor-Phase Dehydration of Bio-Derived Sorbitol Over a Sulfur-Intercalated Two-Dimensional Vanadium Phosphate Catalyst.

Dhiman Neha N, Kumar Arvind A, Acharya Dolan D, Jeyakumar Karthikeyan K et al.

Biorefinery technologies that convert sorbitol into platform chemicals like isosorbide without the use of inorganic acids are essential for sustainability and environmentally friendly green chemicals. Here, we investigate mineral acid-free vapor-phase dehydration of sorbitol over a sulfur-intercalated vanadium phosphate (VPO) catalyst. The roles of Brønsted and Lewis acid sites were studied to understand their effect on sorbitol dehydration and adsorption energy. Intercalating sulfur enhances the relative concentration of Brønsted acid sites on the lamellar VPO surface. Density functional theory results indicate that sorbitol adsorption is thermodynamically favorable on VPO catalysts. However, sulfur-intercalated VPO catalysts exhibit a reduced adsorption energy (Ead) of -0.64 eV, which is approximately 1.5 times lower than that of regular VPO catalysts, as corroborated by kinetic analysis. Notably, the resulting improvement in catalytic performance results in ≥99% bio-derived sorbitol conversion with ≥94% isosorbide selectivity, limiting other anhydrohexitol intermediate.

PMID 42745410
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