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Loxosceles Immune F(Ab)2 (Reclusmyn)

✓ Approved

Instituto Bioclon · Polyclonal Antibodies · Polyclonal Antibodies

What is Loxosceles Immune F(Ab)2?

Loxosceles Immune F(Ab)2 is a polyclonal antibodies developed by Instituto Bioclon. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesReclusmyn
CompanyInstituto Bioclon
Drug ClassPolyclonal Antibodies, Antibody
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Instituto Bioclon

Therapeutic Indications

Loxosceles Immune F(Ab)2 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Injury, poisoning and procedural complicationsVenom poisoning✓ Approved

Related Research Articles

PubMedBMC endocrine disorders2026-10-16

Effects of SGLT-2 inhibitors on thyroid-stimulating hormone and systemic immune-inflammation index in type 2 diabetes: a retrospective study.

Bayram Seyit Murat SM, Demirci Hüseyin H, Üçgül Enes E, Canlar Şule Ş et al.

This retrospective study examined whether long-term SGLT-2i use is associated with differences in thyroid-stimulating hormone (TSH) and the systemic immune-inflammation index (SII) in patients with type 2 diabetes mellitus (T2DM) without known thyroid disease. The neutrophil-to-lymphocyte ratio (NLR), renal function (eGFR), diabetes duration, and metformin use were also evaluated as potential covariates. This was a single-center, retrospective observational study. Adults with T2DM who had used empagliflozin or dapagliflozin for at least six months were compared with an age- and sex-matched control group of patients with T2DM not using SGLT-2i, drawn from the same outpatient clinics. Key exclusion criteria included known thyroid disease, known positivity for thyroid autoantibodies, active inflammatory or autoimmune processes, advanced organ failure, and immunomodulatory treatment. TSH, SII, and NLR were measured. Statistical analyses included intergroup comparisons, correlation, multivariate linear regression, post-hoc power calculation, and multicollinearity diagnostics (variance inflation factor, VIF). The study included 330 patients across the empagliflozin (n = 139), dapagliflozin (n = 85), and control (n = 106) groups. Median TSH (1.6, 1.8, and 1.9 µIU/mL; p = 0.338) and SII (481, 531, and 468.5; p = 0.509) did not differ significantly between groups. SII and NLR were significantly correlated (r = 0.467, p < 0.001). In multivariate regression, female sex (B = 0.161, p = 0.015) and eGFR (B=-0.0043, p = 0.037) were independent predictors of log-transformed TSH; SGLT-2i use, SII, NLR, age, metformin use, and diabetes duration were not. The study had 80% power to detect a Cohen's f of 0.17 or greater; observed effect sizes were substantially below this threshold (f = 0.02 for TSH, f ≈ 0.00 for SII). Long-term SGLT-2i use was not associated with significant changes in TSH or SII in patients with T2DM without known thyroid disease, and the achieved effect sizes suggest that any true effect, if present, is likely small. Renal function emerged as an independent correlate of TSH, suggesting that the relationship between the hypothalamic-pituitary-thyroid axis and renal physiology merits further attention in this population, independent of SGLT-2i exposure. Prospective, multicenter studies incorporating free thyroxine and triiodothyronine measurements are warranted to further clarify these relationships. This study is retrospective and does not involve a clinical trial registration.

PMID 42881387
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PubMedJournal of clinical medicine2026-10-16

Effect of Tartrazine Dye on Corneoscleral Rim Clarity: An Ab Externo Visualization of Cannulated Schlemm's Canal.

Gowtham Lakshminarayanan L, Chaurasia Sunita S, Krishnamurthy Rashmi R, Mohamed Gamal G et al.

The intrinsic opacity of the sclera limits ab externo visualization of deeper structures such as Schlemm's canal, thereby constraining angle-based glaucoma surgery. Tartrazine, a US FDA-approved azo dye, transiently enhances tissue optical transparency and may improve intraoperative visualization. This study evaluated whether tartrazine improves the optical clarity of human corneoscleral rim segments (CSRS) and the ab externo visibility of Schlemm's canal cannulation. In this ex vivo feasibility (proof-of-concept) study, five human corneoscleral rims from donors unsuitable for corneal transplantation were obtained from Ramayamma International Eye Bank. Two rims were each divided into four quadrants (eight segments in total) and allocated to four groups (n = 2 independent segments per group): 0.25 or 0.50 M tartrazine, each without (CSRS-1) and with 6-0 Prolene suture cannulation of Schlemm's canal (CSRS-2), for 5 min. Segments were examined microscopically at 2.5× magnification, and scleral transparency was compared before and after treatment. Scleral clarity and suture visibility were graded by four independent evaluators on a 0-10 scale, with 10 representing maximum clarity, giving eight scored observations per group from two independent segments. Three further rims (CSRS 5, 6, and 7) underwent histopathological evaluation, comparing tartrazine-treated rims (0.25 and 0.50 M) with untreated rims to assess tissue integrity. Tartrazine at both concentrations increased corneoscleral clarity from an untreated baseline (score 0), with mean clarity scores above 6 in all groups. In non-cannulated segments (CSRS-1), scores were 6.13 at both 0.25 and 0.50 M. In cannulated segments (CSRS-2), suture visibility improved to 6.63 at 0.25 M and 8.00 at 0.50 M, the latter significantly higher than the reference group (p = 0.008), although the difference between the two concentrations was not significant (interaction p = 0.168). Histopathology showed preserved histological structure with no gross structural damage on light microscopy at either concentration. In this small preliminary series, tartrazine rapidly enhanced scleral translucency and ab externo visualization of underlying structures, suggesting potential clinical utility in ophthalmic surgery pending in vivo validation. Larger studies with more independent specimens and objective optical measurements are required to confirm these findings.

PMID 42882094
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PubMedInternational journal of molecular sciences2026-10-16

Impact of Triacetin- and Tributyrin-Based Formulations on IBS Microbiome Composition and SCFA Profiles: A Preclinical Study.

Jenkins Sánchez Liam L, Poppe Jonas J, Baudot Aurélien A, Vu Lam Dai LD et al.

Irritable bowel syndrome (IBS) is a prevalent yet poorly understood functional gut disorder frequently associated with microbial dysbiosis, making microbiome-targeting interventions a promising management strategy. In this study, we evaluated the microbiome-modulating potential of three doses of triacetin (TA; ReBiome™; 100, 200 and 300 mg/day) and two finished formulations containing TA and/or tributyrin (TB): Active Biome™ (AB) and Bio Complete 3™ (BC3). Inulin served as a benchmark prebiotic. The validated ex vivo Systemic Intestinal Fermentation Research (SIFR®) technology pipeline was applied using fecal microbiota from eight adults with IBS. TA dose-dependently increased short-chain fatty acid (SCFA) levels from 100 mg/day, significantly increasing acetate and butyrate while maintaining low gas formation. In addition to acetate and butyrate, AB and BC3 also promoted propionate while BC3 induced a particularly pronounced butyrate increase. Overall, both formulations induced stronger SCFA but milder gas increases than inulin. TA, AB and BC3 enriched IBS-depleted, butyrate-associated OTUs related to Faecalibacterium and Anaerobutyricum species. AB and BC3 increased microbial diversity (community modulation score (CMS)) by promoting Bifidobacteriaceae, Lachnospiraceae and Bacteroidaceae. Overall, TA and TA/TB-containing formulations promoted butyrate production, potentially helping mitigate IBS symptom severity by inducing a favorable fermentation profile with limited gas formation.

PMID 42884152
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PubMedAnimals : an open access journal from MDPI2026-10-16

Male Green Mud Crab (Scylla paramamosain) Is More Vulnerable to Handling Stress than Female: A Comprehensive Insight into Physiological Changes and Health Status.

Esmaeili Noah N, Wu Chenyang C, Yin Cong C, Chen Peixun P et al.

The current research investigated the effects of repeated mild handling stress (RMH) and acute handling stress (AHS) in male and female green mud crabs (Scylla paramamosain) on production, hemolymph biochemistry, immune system, antioxidant defense, endoplasmic reticulum stress gene expression, stress response, energy, and ion homeostasis. Gill, hepatopancreas, hemolymph, and muscle of 4 groups (F, M, F-RMH, and M-RMH) were sampled after 60 days of farming and after 27 h of AHS. No significant difference in growth performance and survival rate after 60 days was identified among the groups. Habituation in the M-RMH groups was observed (as shown by behavior change) and resulted in reduced fighting and broken legs. The lowest survival rate (9.09%) after AHS was observed in M crabs, which coincided with lower values of total protein in the gill, lysozyme, peroxidase, total antioxidant capacity, and glucose in the hemolymph, and higher levels of total amino acid, lactate dehydrogenase, sodium, and cholesterol in the hemolymph. Habituation may mitigate stress and aggression, which are significant issues in crab aquaculture.

PMID 42883112
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PubMedMaterials (Basel, Switzerland)2026-10-16

Transition-Metal Clusters and Complexes: Ab Initio Studies on Inducing Photoexcitation and Photocatalytic Activity.

Uzunоva Ellie L EL, Georgieva Ivelina M IM, Zahariev Tsvetan T

Theoretical methods are indispensable in studying photocatalytic reaction pathways, the energy barriers of each elementary reaction step and in elucidating the active sites in catalysis. Transition metal sulfides of the 3d elements, M = Fe, Co, Ni, Cu, mimic natural reductase and carbon monoxide dehydrogenase enzymes. The exact environment of enzyme centers, which includes a protein surrounding the active site and coordinated ligands, cannot be achieved by synthesis. Careful modeling of ligands coordinated to the active site can predict whether photoactivation occurs and ways to enhance visible light absorption. For heavier transition metals, such as the f-block elements, the photophysical properties become more pronounced. From the computational results, supported by experiments, sulfur emerges as a key element in promoting photochemical and photophysical activity. Bridging sulfur in the clusters and complexes of the 3d elements (M2-S2) acts as an electron donor similar to coordinated carbonyl or nitrosyl ligands. Lanthanides also take advantage of the coordination of sulfur-containing ligands to fine-tune light absorption and light emission, producing lanthanide sulfide photocatalysts or high-intensity luminescent complexes. The excited-state energy transfer mechanism and factors responsible for the specific lanthanide emission are successfully predicted by combined DFT/TDDFT, multireference and semiempirical calculations in close correlation with the experiment.

PMID 42882547
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PubMedDiagnostics (Basel, Switzerland)2026-10-16

Clinical Performance of the Elecsys HCV Duo Immunoassay Compared with a Standard-of-Care Algorithm Using Alinity Anti-HCV Screening and HCV RNA Confirmation.

Yoo Jaeeun J, Park Hye-Sun HS, Kim JoungOk J, Cho Sang-Ik SI et al.

Background/Objectives: The Elecsys HCV Duo immunoassay simultaneously detects HCV core antigen (HCV Ag) and anti-HCV antibodies in a single sample. We evaluated its clinical performance against a standard-of-care reference algorithm of anti-HCV antibody and HCV RNA testing. Methods: We retrospectively analyzed 1332 residual serum or plasma samples tested with reference HCV RNA assays and the Alinity i Anti-HCV assay. Samples were classified as reference-positive, indicating current or past HCV infection (n = 166; 88 RNA+/Ab+ with active infection and 78 RNA-/Ab+ with resolved or treated infection), or reference-negative (n = 1166; RNA-/Ab-), including 1000 randomly selected blood donor samples. All specimens were tested with the Elecsys HCV Duo (cobas® e 801, Roche Diagnostics). Positive and negative percent agreements (PPA and NPA) were calculated against the combined reference standard. Results were further analyzed by infection status and viral load. No HCV RNA+/anti-HCV- (window-period) specimens were available. Results: Overall agreement was high (PPA 98.8% [164/166; 95% CI, 95.7-99.9%]; NPA 99.9% [1165/1166; 95% CI, 99.5-100.0%]). Agreement of the anti-HCV component with the Alinity i Anti-HCV assay was identical (PPA 98.8%, NPA 99.9%). The HCV Duo Ag component showed a PPA of 60.2% (95% CI, 49.2-70.5%) and NPA of 99.0% (95% CI, 98.3-99.5%) against HCV RNA detection. The Ag module was also reactive in 12 of 78 (15.4%) RNA-/Ab+ specimens, all from previously treated patients; thus, 53 of 65 (81.5%) dual Ag/Ab-reactive specimens had detectable HCV RNA. HCV Ag positivity was highest at HCV RNA ≥106 IU/mL (77.4%, 41/53), compared with 32.1% (9/28) at 104-106 IU/mL and 42.9% (3/7) at <104 IU/mL. Receiver operating characteristic analysis of the Ag component yielded an area under the curve of 0.920 (95% CI, 0.904-0.934). Conclusions: The Elecsys HCV Duo demonstrated high overall agreement with the reference methods, supporting its potential as a single-step screening test for HCV infection. Most, but not all, dual Ag/Ab-reactive specimens were viremic, so this result may help prioritize anti-HCV-positive individuals for linkage to care; however, the assay does not replace HCV RNA testing, which remains necessary to confirm active infection, particularly in Ag-negative or previously treated individuals. Because no window-period specimens were included, the potential of the assay for earlier detection of acute infection could not be evaluated.

PMID 42882394
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