Drug Database
CA

carteolol (OPC1085 / Ocupress / Mikelan, ophthalmic)

✓ Approved

CSL Vifor · ADRB1 · Small Molecule

What is carteolol?

carteolol is a small molecule developed by CSL Vifor. It is approved for therapeutic indications via others or topical.

Drug Profile

Brand NamesOPC1085, Ocupress, Mikelan, ophthalmic
CompanyCSL Vifor
Drug ClassSmall Molecule
Molecular TargetADRB1, ADRB2
RouteOthers, Topical
StatusApproved
Sources: ClinicalTrials.gov, CSL Vifor

Mechanism of Action

Molecular Targets

carteolol acts on 2 molecular targets:

ADRB1adrenoceptor beta 1 (B1AR, RHR)
ADRB2adrenoceptor beta 2 (B2AR, ADRBR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

carteolol is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Eye disordersGlaucoma✓ Approved

Related Research Articles

PubMedVestnik oftalmologii2026-10-16

[Modern principles of ophthalmic surgery for combat trauma: analysis of experience from the Special Military Operation].

Kazantsev A N AN

Combat ocular trauma presents a complex medical and tactical challenge in modern armed conflicts, it is characterized by a high frequency of combined injuries and requires a specialized system of care. The experience of the Special Military Operation (SMO) provides unique clinical material for analysis and for developing modern surgical principles. This review describes the specific features of combat ocular trauma in the context of the SMO: the predominance of multiple radiolucent orbital foreign bodies, extensive lacrimal drainage system injuries, and a pronounced contusion component. The article systematizes an adaptive model of staged treatment with delayed primary surgical care and rapid evacuation to specialized centers, and demonstrates the effectiveness of a strategy of multistage combined optical reconstructive surgery, including vitrectomy, keratoplasty, and orbital reconstruction. Comparative analysis confirmed global trends (the role of blast injury and the importance of treatment timelines), and identified specific features of the SMO that require adaptation of protocols. The SMO experience confirms the evolution of military field ophthalmic surgery toward early, technology-based, anatomically targeted reconstruction. Integrating Russian experience with international data makes it possible to formulate universal principles of care aimed at maximizing preservation of visual function and improving the quality of life of the wounded. Further development of the rehabilitation system and establishment of national trauma registries are necessary.

PMID 42885635
Read full article →
PubMedJournal of pediatric ophthalmology and strabismus2026-10-16

Comparing Nasolacrimal Duct Obstruction Care Between Demographic Groups.

Sano Catherine C, Arora Shaleen S, Manrique Monica M, Akosman Sinan S et al.

To compare nasolacrimal duct obstruction (NLDO) pediatric ophthalmic care between different demographic groups in Washington, DC. A retrospective review of pediatric patients with NLDO who received care at one tertiary care institution from 2012 to 2022 was performed. Age, sex, race and ethnicity, insurance type, language interpreter use, and consultation information were analyzed. Surgical intervention, follow-up information, and reoperation rates were also collected. A total of 1,338 patients (median age: 1.3 years) were analyzed. Hispanic, Black/African American, and unreported racial and ethnic minority patients were older at the time of initial consultation when compared to White patients. Statistically significant delays in surgical intervention following the initial visit were seen among non-English-speaking and Medicaid insured patients (P = .001 and .017, respectively). Factors such as race and ethnicity, language, and Medicaid coverage are intersecting elements that may contribute to disparities in care, manifesting particularly in specialized medical care. There are systemic barriers to pediatric ophthalmic care that may disproportionately impact vulnerable populations. Although there were no clinically significant differences in outcome, it is appropriate to understand these disparities can be present in the clinical setting to avoid a negative impact on children from racial and ethnic minority groups. Future studies discerning actionable causes of health disparity are necessary to navigate toward equitable care.

PMID 42885599
Read full article →
PubMedVestnik oftalmologii2026-10-16

[Epidemiological features of primary glaucoma in the Republic of Sakha (Yakutia)].

Zakharova E K EK, Malishevskaya T N TN, Lutskan I P IP, Petrov S Yu SY

The study aimed to investigate the epidemiological features of primary glaucoma in the Republic of Sakha (Yakutia) over a 20-year period from 2005 to 2024. Based on annual statistical reports submitted by ophthalmologists from cities and districts of Yakutia, data from the Yakut Republican Ophthalmology Clinical Hospital, the Main Bureau of Medical and Social Expert Assessment for Yakutia, and the regional glaucoma patient registry, we conducted a comparative analysis of glaucoma prevalence and incidence by disease stage, gender, and age, as well as changes in glaucoma surgical activity and glaucoma-related disability over 20 years. Analysis of glaucoma prevalence revealed a 56.01% increase in the overall glaucoma prevalence rate and a 45.1% increase in the incidence rate per 100.000 adults. The rate of persons newly recognized as disabled per 10.000 adults decreased by 16%. Indicators related to the organization of surgical care showed favorable trends: the number of laser procedures increased by 90.4%, the number of glaucoma surgeries by 21.3%, including procedures involving shunt and drainage device implantation by 46.6%, while surgical activity increased to 112.9%. The use of high-technology procedures increased more than 30-fold - from 15 surgeries in 2012 to 473 in 2024. Mobile ophthalmic care is being actively implemented in the form of off-site surgical teams and the establishment of interdistrict centers throughout Yakutia. The increase in glaucoma prevalence in the Republic of Sakha is largely associated with population aging. Despite the progressive increase in both overall glaucoma prevalence and incidence during the study period, the rate of persons newly recognized as disabled decreased by 16%. This improvement was facilitated by new models of ophthalmic care delivery, mobile specialized teams, and increased surgical activity.

PMID 42885631
Read full article →
PubMedJournal of pediatric ophthalmology and strabismus2026-10-16

Structural Evaluation of Retinal and Choroidal Features in Eyes With Primary Microtropia.

Bayraktar Havvanur H, Ekinci Aslanoğlu Cansu C, Tuğcu Betül B

To investigate the structural characteristics of the macula, optic nerve head, and choroid in eyes with primary microtropia using spectral-domain optical coherence tomography (SD-OCT). This prospective case-control study included 50 pediatric patients with a diagnosis of primary microtropia. Each participant contributed data from both eyes. Eyes were categorized as microtropic, fellow, or healthy control. All patients underwent comprehensive ophthalmic evaluation, including SD-OCT imaging. Parameters assessed included central macular thickness, total macular volume, regional retinal thickness, peripapillary retinal nerve fiber layer thickness, subfoveal and regional choroidal thickness, and choroidal vascular index. No statistically significant differences were observed among microtropic, fellow, and control eyes in terms of central macular thickness, total macular volume, or peripapillary retinal nerve fiber layer thickness (P > .05). Although microtropic eyes showed a mild trend toward increased parafoveal and perifoveal retinal thickness across all quadrants, this variation did not reach statistical significance. Similarly, subfoveal, nasal, and temporal choroidal thickness measurements, as well as choroidal vascularity index, luminal area, stromal area, and total choroidal area, were comparable across all groups. Primary microtropia was not associated with measurable retinal or choroidal structural abnormalities on SD-OCT. Although reduced visual acuity was present, the lack of detectable anatomical changes warrants further investigation to determine whether functional impairment in microtropia occurs independently of structural alterations.

PMID 42885601
Read full article →
PubMedJournal of clinical medicine2026-10-16

Treatment of Mixed Dry Eye Disease with Topical Azithromycin: A Prospective Controlled Pilot Study.

Cestnik Blaž B, Dovžak Fritz Ana A, Bone Tomaž T, Stunf Pukl Spela S

Background: This study evaluated the efficacy of topical azithromycin ophthalmic solution (Azyter®, 15 mg/g) as second-line treatment for mixed dry eye disease (DED), given the drug's known non-antimicrobial anti-inflammatory and immunomodulatory properties. Methods: In this pilot, prospective, controlled, non-randomized interventional study, fifteen patients with mixed DED refractory to first-line treatment received topical azithromycin for 30 days (twice daily for 3 days, then once daily for 27 days); ten healthy individuals served as controls. Clinical evaluation was performed before and after treatment in the study group and once in controls, and included the Dry Eye Questionnaire-5 (DEQ-5), Schirmer test, non-invasive tear break-up time (NITBUT, Sirius PLUS corneal topography), tear meniscus height (TMH; Sirius PLUS corneal topography), Efron scale grading of blepharitis, meibomian gland dysfunction (MGD), and conjunctival hyperemia; Oxford-scale grading of corneal fluorescein staining, and corneal epithelial thickness (swept-source anterior segment optical coherence tomography, AS-SS-OCT). Results: After treatment, DEQ-5 scores improved significantly (p < 0.001) and no longer differed from controls. Schirmer test and NITBUT values increased significantly (p = 0.003 and p = 0.027, respectively), becoming comparable to controls. Blepharitis, MGD, and corneal fluorescein staining scores also improved significantly (p < 0.001, p < 0.001, p = 0.002), as did maximum corneal epithelial thickness (p = 0.037). Conclusions: In this pilot cohort, second-line treatment of mixed DED with topical azithromycin significantly improved disease symptoms and signs, supporting its potential as a treatment option. Larger randomized studies are needed to confirm these findings and determine the optimal treatment regimen and duration.

PMID 42882011
Read full article →
PubMedJournal of clinical medicine2026-10-16

Viscoelastic-Assisted Rescue of Unintended Free Internal Limiting Membrane Flaps During Macular Hole Surgery: A Two-Case Report.

Minami Keisuke K, Yanai Ryoji R, Mitamura Yoshinori Y

Background/Objectives: Manipulation of an internal limiting membrane (ILM) flap can be technically challenging during macular hole (MH) surgery, particularly in highly myopic eyes with fragile ILM. Although ophthalmic viscosurgical devices (OVDs) have been used to stabilize inverted ILM flaps, their use for the rescue of unintended free-floating ILM flaps has been less well described. This study aimed to describe a perfluorocarbon liquid (PFCL)-free, viscoelastic-assisted rescue technique for the capture, transfer, and stabilization of unintended free ILM flaps during MH surgery. Methods: Two highly myopic eyes with MH underwent 27-gauge pars plana vitrectomy with an ILM flap technique. When the ILM became unintentionally detached and formed a free-floating flap, a dispersive OVD was delivered through a blunt-tip cannula to capture the flap. The OVD and attached flap were manipulated as a single unit and repositioned over the MH without direct forceps grasping. An additional OVD was applied over the flap for stabilization before fluid-air exchange and 20% sulfur hexafluoride gas tamponade. Results: MH closure was confirmed via optical coherence tomography on the first postoperative day in both eyes and was maintained through the final follow-up at 5 months in Case 1 and at 1 month in Case 2. Best-corrected visual acuity was 20/33 (0.22 logMAR) at final follow-up in both eyes, compared with 20/40 (0.30 logMAR) preoperatively. No procedure-related intraoperative or postoperative complications were observed during the available follow-up periods. Conclusions: This viscoelastic-assisted technique may provide a practical rescue approach for unintended free-floating ILM flaps during MH surgery without the need for direct forceps grasping or PFCL. Larger comparative studies with longer follow-up are needed to evaluate its reproducibility, safety, and clinical utility.

PMID 42881856
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about carteolol