Drug Database
OF

ofloxacin (Floxin Otic)

✓ Approved

Daiichi Sankyo Company Limited · Small Molecule · Small Molecule

What is ofloxacin?

ofloxacin is a small molecule developed by Daiichi Sankyo Company Limited. It is approved for therapeutic indications via others or topical.

Drug Profile

Brand NamesFloxin Otic
CompanyDaiichi Sankyo Company Limited
Drug ClassSmall Molecule
RouteOthers, Topical
StatusApproved
Sources: ClinicalTrials.gov, Daiichi Sankyo Company Limited

Therapeutic Indications

ofloxacin is developed for 4 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsOtitis externa✓ Approved
Infections and infestationsOtitis media✓ Approved
Ear and labyrinth disordersExternal ear inflammation✓ Approved
Ear and labyrinth disordersMiddle ear inflammation✓ Approved

Related Research Articles

PubMedFood chemistry2026-08-28

A ratiometric fluorescence sensor based on Eu3+@tetrafluorosuccinic acid functionalized UiO-67: Enhancing the detection performance of ofloxacin through pre-concentration effect.

Sun Xueqin X, Fan Yan Y, Liu Jiacheng J

The excessive use of ofloxacin (OFL) has led to its persistent residues in water sources and animal-derived foods, posing a threat to human health. Therefore, it is urgent to develop fluorescent sensing materials capable of detecting ofloxacin in water environments and food matrices. Herein, a novel Eu3+@tetrafluorosuccinic acid-functionalized ratiometric fluorescent material Eu3+@UiO-67-TFSA was prepared by a two-step post-synthetic modification of UiO-67. In the concentration range of 1-15 μM, the Eu3+@UiO-67-TFSA had a limit of detection (LOD) of 0.42 μM for OFL, which was approximately 3.90 times lower than that of the non-fluorinated Eu3+@UiO-67-SA (LOD = 1.64 μM). The improved sensing performance could be attributed to the pre-concentration effect provided by the Eu3+@UiO-67-TFSA. The possible detection mechanism was systematically elucidated through relevant experiments and density functional theory (DFT) calculation. Moreover, the constructed smartphone-assisted visual sensing platform was successfully applied to detect OFL in actual food samples and real water environment samples.

PMID 42664839
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PubMedAnnals of the ICRP2026-08-27

Communicating radiation emergencies on social media.

Gruß M M

This article examines the challenges and benefits of social media use for communicating radiation emergencies and malicious events. As traditional crisis communication principles have to adapt to the evolving social media landscape, this article emphasises the need for communicators to keep pace with platforms such as X, WhatsApp, and TikTok. Challenges include inconsistent messages, conflicting information, and the risk of misinformation spreading. However, social media offers advantages such as rapid information dissemination and increased visibility for communicating authorities. The discussion draws from case studies, including the Fukushima Daiichi accident, the COVID-19 pandemic, and the lost radioactive capsule in Australia, highlighting the necessity for adaptable crisis communication strategies in response to situational contexts and changes in online communication. Future work involves analysing past incidents, developing recommendations for effective social media use, and designing social media templates for timely messaging during radiation emergencies within the framework of ICRP Task Group 120.

PMID 42658245
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PubMedAnnals of the ICRP2026-08-27

'Suetsugi Atlas' project: Lessons from implementing co-expertise process.

Ando R R

The co-expertise initiative in the Suetsugi district of Iwaki City, Fukushima Prefecture, located 27 km from the Fukushima Daiichi Nuclear Power Plant, was carried out through collaboration between the volunteer group Ethos in Fukushima and the Suetsugi community from 2011 to 2020. As the initiative neared its end in 2017, the residents expressed a desire to document their post-nuclear accident experiences. This effort led to the creation of the Suetsugi Atlas in the spring of 2022. The development of the Atlas revealed a high degree of satisfaction among residents with the co-expertise process. However, it also shed light on the challenges of building trust beyond their direct experience, suggesting that lives affected by the accident still face unresolved issues. It also revealed that for co-expertise to be successful, the full engagement of public authorities alongside affected people in the recovery process is essential. These results are valuable for refining the methods and applications of the co-expertise process.

PMID 42658222
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PubMedAnalytica chimica acta2026-08-26

Preparation and characterization of latex-poly(butadiene-maleic acid) coated open tubular silica columns for ion chromatography-A proof-of-concept study.

He Ge G, Zhang Miao M, Li Haiyan H, Wu Shuchao S et al.

Open tubular ion chromatography (OTIC) has attracted increasing attention because of its low sample and eluent consumption and potential for high separation efficiency. Fused silica capillaries have well-defined geometry and are commercially available, but their direct use with hydroxide eluents is limited by the alkaline instability of silica. Therefore, stationary-phase coatings that can provide ion-exchange functionality while reducing direct exposure of the silica surface to alkaline eluents are of interest. We describe the preparation and characterization of poly (butadiene-maleic acid) (PBMA) coated open tubular (OT) silica columns for cation-exchange (CEX) separation in OTIC. By further agglomerating anion-exchange (AEX) latex nanoparticles onto the PBMA layer through electrostatic attraction, these CEX OT silica columns were converted to AEX OT columns, which showed preliminary tolerance to hydroxide eluents up to 50 mM KOH under the tested conditions. Efficiencies of 1.10 × 104 ± 2.6 × 102 plates/m for Na+ and 4.63 × 104 ± 1.5 × 102 plates/m for Cl- were achieved for the CEX OT silica columns (PBMA coated) and AEX OT silica columns (latex-PBMA coated), respectively. Compared with representative OTIC columns, the fused-silica capillaries showed the lowest outer-diameter relative standard deviation (RSD) of 0.8%. This study demonstrates a latex-PBMA coating strategy for constructing fused silica-based AEX OTIC columns. The results provide a preliminary route for improving the hydroxide-eluent tolerance of fused silica OTIC columns while preserving their geometric uniformity, and broaden the material and stationary-phase options for future OTIC development. Further optimization of long-term stability, reproducibility, and column performance is still required.

PMID 42648808
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PubMedAnalytica chimica acta2026-08-26

A chiral electrochemical sensor based on β-CD/Ce-doped Cu-MOF/MWCNTs-COOH for enantioselective recognition and detection of levofloxacin.

Ma Nanke N, Wei Anqi A, Peng Huiling H, Xie Lixia L et al.

Chirality plays a critical role in drug efficacy and environmental safety. The antibacterial activity of ofloxacin resides almost exclusively in its S-enantiomer (levofloxacin, LEV), while the R-enantiomer contributes little to therapeutic effects but may pose unnecessary risks. Rapid and reliable methods for enantioselective determination of ofloxacin enantiomers are therefore essential for pharmaceutical quality control, food safety monitoring, and environmental analysis. However, existing electrochemical sensors often suffer from limited enantioselectivity and insufficient sensitivity. To address this challenge, a novel enantioselective electrochemical platform is developed. A β-cyclodextrin/cerium-doped copper metal-organic framework/carboxylated multi-walled carbon nanotube composite (β-CD/Ce-doped Cu-MOF/MWCNTs-COOH) was fabricated on a glassy carbon electrode. The sensor achieves discrimination of ofloxacin enantiomers with an IL/ID ratio of 3.39. DFT calculations at pH 4.0 reveal that β-CD binds LEV with higher adsorption energy (-63.8 kJ/mol) than DEX (-58.3 kJ/mol), confirming the superior response for LEV originates from stereospecific inclusion. Quantitative analysis of LEV shows two linear ranges (0.03-1 μM and 1-10 μM) with a low detection limit of 0.01 μM. The sensor also enables accurate determination of LEV percentage in enantiomer mixtures across 0-100%. Excellent selectivity against common interferents, good reproducibility (RSD = 0.98%), repeatability (RSD = 1.26%), and long-term stability (95.2% retention after 21 days) are demonstrated. Practical applicability is validated by detecting LEV in commercial eye drops, honey, and tap water with satisfactory recoveries (96.0-108.0%). This work presents the first application of Ce-doped Cu-MOF/β-CD/MWCNTs-COOH composites for the enantioselective electrochemical sensing of ofloxacin, a chiral fluoroquinolone antibiotic. The synergistic combination of high conductivity, abundant catalytic sites, and stereospecific host-guest recognition provides a generalizable strategy for high-performance enantioselective sensing, with promising applications in pharmaceutical, food, and environmental analysis.

PMID 42648840
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PubMedJournal of radiological protection : official journal of the Society for Radiological Protection2026-08-26

Bridging the gap between national policy and local implementation: analysis of sheltering-in-place policy development and stakeholder concerns in Japan.

Saito Yoshika Y, Yamamura Momoka M, Yamamoto Chika C, Matsumoto Chihiro C et al.

Preparedness for nuclear and radiological emergencies increasingly requires consideration of complex scenarios, including compound disasters, disruptions to critical infrastructure, and challenges in public communication. In Japan, following the Fukushima Daiichi Nuclear Power Station accident, sheltering-in-place has been positioned as a key protective action for residents within the Urgent Protective Action Planning Zone. However, recent experiences, including the 2024 Noto Peninsula Earthquake, have highlighted operational challenges and renewed concerns regarding the practical implementation of sheltering-in-place. This study examined the policy development process for sheltering-in-place in Japan by analyzing discussions of the Nuclear Regulation Authority's "Study Team on the Operational Use of Sheltering-in-Place" held between April 2024 and March 2025. A qualitative document analysis was conducted using publicly available meeting records, the final report, and comments submitted by local governments and members of the public during consultation and public comment procedures. The study found that the study team clarified key operational elements of sheltering-in-place, including initiation, geographic scope, continuation, termination, transition to evacuation or temporary relocation, temporary outings, and information provision. However, comments from local governments and the public revealed persistent concerns regarding legal and institutional consistency, compound-disaster response, public communication, information dissemination systems, continuity of social and business activities, support for healthcare and welfare facilities, maintenance of lifelines and essential supplies, and coordination among governmental and related organizations. These findings suggest that the successful implementation of sheltering-in-place depends not only on technical criteria such as dose assessment and protective action thresholds, but also on effective risk communication among governments, healthcare and welfare institutions, businesses, and residents. The principal challenge is translating national policy into locally understandable and actionable practices. Strengthening stakeholder engagement, public communication, and community-based preparedness during non-emergency periods may therefore be essential for enhancing the effectiveness and social acceptability of shelteringin-place as a protective action in future nuclear emergencies.

PMID 42648325
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