Drug Database
OF

ofloxacin (Floxin Otic)

✓ Approved

Daiichi Sankyo Company Limited · Small Molecule · Small Molecule

What is ofloxacin?

ofloxacin is a small molecule developed by Daiichi Sankyo Company Limited. It is approved for therapeutic indications via others or topical.

Drug Profile

Brand NamesFloxin Otic
CompanyDaiichi Sankyo Company Limited
Drug ClassSmall Molecule
RouteOthers, Topical
StatusApproved
Sources: ClinicalTrials.gov, Daiichi Sankyo Company Limited

Therapeutic Indications

ofloxacin is developed for 4 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsOtitis externa✓ Approved
Infections and infestationsOtitis media✓ Approved
Ear and labyrinth disordersExternal ear inflammation✓ Approved
Ear and labyrinth disordersMiddle ear inflammation✓ Approved

Related Research Articles

PubMedInternational journal of molecular sciences2026-10-16

Photobiomodulation as a Potential Regenerative Signal in the Inner Ear: Linking Mitochondrial Redox Signaling to Cell-Fate Regulation.

Lee Min Young MY

Photobiomodulation (PBM) is a non-thermal therapeutic modality in which low-intensity red or near-infrared light is used to modulate biological activity. Experimental inner-ear studies report preservation of auditory neurons, attenuation of vestibular injury, improved survival of transplanted stem cells, and changes in otic organoid differentiation. These observations raise the possibility that PBM may influence differentiation-associated cellular states in addition to providing cytoprotection. The classical mechanistic model proposes that photons interact with mitochondrial chromophores, particularly cytochrome c oxidase, leading to changes in respiration, ATP, reactive oxygen species (ROS), nitric oxide, calcium, and downstream signaling; however, a universal primary photoreceptor has not been established. In a 2020 mouse embryonic-stem-cell-derived otic-organoid study, PBM was associated with more organoid-like structures, increased hair-cell-associated markers, increased ROS, and lower Hes5 expression. The RNA-sequencing comparison pooled five embryoid bodies into one sample per condition, limiting biological replication and statistical inference. Accordingly, the Hes5 result should be regarded as exploratory and does not demonstrate direct Notch inhibition. Studies in other regenerative tissues show that PBM can engage ROS-dependent PI3K/AKT/GSK3β/β-catenin signaling, providing a mechanistic precedent rather than proof for the inner ear. This review therefore presents a testable working model in which PBM may connect mitochondrial and redox responses to Wnt/β-catenin and Notch/HES5 pathways during otic differentiation, while emphasizing that mature hair-cell regeneration, new SGN generation, and hearing restoration have not yet been established.

PMID 42883688
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PubMedMaterials (Basel, Switzerland)2026-10-16

Study on the Performance and Efficiency of MgO/CuFeO2 Composite Catalyst in Degradation of Organic Pollutants.

Li Xuanhao X, You Junhua J, Zhang Jie J

With the acceleration of industrialization and increasing human activities, antibiotic pollutants enter aquatic environments through various pathways and pose serious threats to ecological safety and human health. Ofloxacin (OFX), a typical fluoroquinolone antibiotic, is persistent in water media owing to its high chemical stability and poor biodegradability. In this study, MgO/CuFeO2-based Fenton-type composite catalysts were prepared to investigate their efficiency in removing OFX from water. Among the as-prepared materials, MgO/CuFeO2-20 wt% exhibited the optimum catalytic activity: under the conditions of 20 mg L-1 initial OFX concentration, 0.5 g L-1 catalyst dosage and 20 mM H2O2 at natural pH, it achieved approximately 95% ofloxacin removal within 120 min, with a pseudo-first-order kinetic rate constant k1 of 0.0461 min-1. Benefiting from MgO modification, the catalyst maintained high degradation efficiency over a broad pH range of 5-9 and retained satisfactory catalytic performance after five consecutive cyclic runs with only minor activity decay. Characterizations including XRD, SEM-TEM, XPS, BET, LSV-EIS and ESR-DMPO verified that the construction of tight MgO-CuFeO2 heterointerfaces accelerated interfacial electron transfer and promoted the regeneration of Cu+/Cu2+ and Fe2+/Fe3+ redox couples. Hydroxyl radicals (·OH) were identified as the dominant reactive oxygen species for pollutant oxidation. This work provides a facile modification strategy to alleviate particle aggregation and metal-ion leaching drawbacks of bare CuFeO2, offering experimental support for designing high-efficiency delafossite-based heterogeneous Fenton-like catalysts for antibiotic-containing wastewater remediation.

PMID 42882746
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PubMedEClinicalMedicine2026-10-14

Prognostic value of hormone receptor expression in patients with HR+/HER2- advanced BC treated with first-line ET+CDK4/6i: results from the multicentre observational, real-world PALMARES-2 study.

Ligorio Francesca F, Provenzano Leonardo L, Caputo Roberta R, Vigneri Paolo P et al.

Endocrine therapy (ET) plus Cyclin Dependent Kinase 4/6 inhibitors (CDK4/6i) is the recommended first-line treatment for patients with Hormone Receptor-positive, Human Epidermal growth factor Receptor 2-negative advanced Breast Cancer (HR+/HER2- aBC). The prognostic value of the spectrum of Oestrogen Receptor (ERα) and Progesterone receptor (PgR) expression remains poorly investigated in this setting. We used updated data from the largest annotated dataset from the multicentre, real-world, Italian study PALMARES-2 (NCT06805812) to evaluate the association between ERα expression and real-world Progression-Free Survival (rwPFS), or time-to-chemotherapy (rwTTC), in patients with HR+/HER2- aBC treated with first-line ET plus CDK4/6/i. ERα expression was classified as low-intermediate (LI: 1-49%), high (H: 50-89%) or very-high (VH: 90-100%). We also assessed the prognostic value of combining PgR (<20% vs. ≥20%) and ERα expression. Multivariable Cox regression models were used to adjust associations for clinically relevant covariates. Among 4115 patients with available ERα assessment, 157 (3.8%) had ER-LI, 967 (23.5%) had ER-H and 2991 (72.7%) had ER-VH tumours. Median rwPFS and rwTTC increased progressively with increasing ERα expression (ER-LI: 10.6 and 14.3 months; ER-H: 20.5 and 29.9 months; ER-VH: 28.5 and 40.7 months, respectively; p < 0.001). PgR expression provided additional prognostic stratification, with patients with ER-VH/PgR-high tumours showing the longest median rwPFS (32.4 months, 95% CI 30.2-34.9), while those with ER-LI/PgR-low tumours had the shortest (8.3 months; 95% CI 6.9-12). Effectiveness of first-line ET plus CDK4/6i in patients with HR+/HER2- aBC worsens progressively with decreasing ERα expression, and PgR expression adds further prognostic discrimination, with low ERα and PgR expression identifying a subgroup of patients with particularly poor outcomes. Our findings, if confirmed by future studies, can help clinicians in personalising treatment choices and follow-up strategies in this clinical context. PALMARES-2 is an academic investigator-initiated study partially supported by AstraZeneca/Daiichi Sankyo.

PMID 42872060
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PubMedFukushima journal of medical science2026-10-13

Non-communicable diseases among subcontract and primary workers involved in decontamination after the fukushima daiichi nuclear power plant accident: an observational study.

Oguro Fumiya F, Nishikawa Yoshitaka Y, Sawano Toyoaki T, Kobashi Yurie Y et al.

Evidence on the population-level burden of major non-communicable diseases (NCDs) among Fukushima decontamination workers is limited, and it remains unclear whether subcontracted employment, a potential marker of employment-related vulnerability, is associated with NCD prevalence and health risk awareness. We therefore compared the prevalence of NCDs by employment status. We conducted a cross-sectional study using health checkup data from 2,790 workers (2011-2017). Data concerning hypertension, diabetes mellitus, and dyslipidemia were evaluated, along with the workers' self-reported awareness of diagnosis or treatment. Employment status was categorized as subcontracted worker or prime contractor worker. Group differences were assessed using Welch's t-tests and chi-squared tests, and quantile regression adjusted for age and sex. The study included a total of 2,790 decontamination workers, of whom 1,716 were subcontracted workers (median age, 51 years; range, 18-82). The subcontracted workers had higher mean systolic blood pressure, a lower prevalence of self-reported hypertension, and higher blood glucose levels in extreme cases. The subcontracted workers had higher systolic blood pressure despite lower self-reported hypertension. Future studies should investigate factors contributing to differences in NCD prevalence between subcontracted and prime contractor workers, such as lower self-awareness and barriers to healthcare access among subcontracted workers.

PMID 42864033
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PubMedJournal of environmental radioactivity2026-10-13

Particle-tracking assessment of potential groundwater pathways for radionuclide transport across the Futaba Fault, coastal Fukushima, Japan.

Zhang Fengrui F, Takeuchi Shinji S

Radiocesium deposited after the Fukushima Daiichi Nuclear Power Plant accident remains a long-term environmental concern, but its groundwater pathways toward inhabited coastal lowlands are poorly constrained. This study evaluates conservative groundwater pathways potentially relevant to radionuclide transport near the Futaba Fault in coastal Fukushima by coupling a steady-state MODFLOW-2005 model with MODPATH 7. One thousand realizations varied hydraulic conductivity and the porosity components used to derive effective porosity for the fault zone, granitic basement, mudstone, and three sandstone units using bounded PERT and log-PERT distributions. Fixed particles were released separately on each side of the fault. Of 2,000,000 western endpoint records, 93.24% terminated west of the fault, 6.33% reached eastern non-ocean cells, and 0.43% reached the ocean boundary. Western paths were concentrated in local circulation cells and valley-directed discharge zones. Eastern non-ocean outcomes originated from 465 of 2000 western release locations and were spatially clustered rather than controlled by fault distance alone. Of 6,000,000 eastern endpoint records, 89.02% remained within the eastern sedimentary domain and 10.98% reached the ocean boundary; none returned to the western block. Within the adopted barrier-dominated conceptual model and specified hydraulic-property distributions, endpoint maps, travel-time-distance densities, ensemble cross sections, and representative-realization visualizations show that the limited west-to-east pathways remain spatially restricted. Because sorption and decay were omitted, the results represent a conservative, retardation-free pathway assessment rather than a concentration forecast. Even under this formulation, west-derived pathways into the eastern lowland were spatially restricted, indicating limited potential for widespread groundwater-mediated radionuclide transport under the modeled conditions.

PMID 42868642
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PubMedJournal of colloid and interface science2026-10-13

Boundary unsaturated Iron coordination engineering on S-scheme heterojunctions steering selective H2O2 homolysis for enhanced Fenton-like catalysis.

Sun Zeyang Z, Wang Yan Y, Qian Kun K, Meng Suci S et al.

Redirecting photocatalytic H2O2 activation from inefficient heterolytic cleavage toward the homolytic generation of hydroxyl radicals (•OH) is paramount for maximizing oxidant utilization in photo-Fenton-like water purification. Herein, we propose a selective H2O2 homolytic activation strategy enabled by a SrFe12O19/C3N4 (SCN-50) S-scheme heterojunction synthesized via urea-assisted thermal polymerization. The engineered coordinatively unsaturated Fe sites, characterized by an upshifted d-band center, effectively diminish the thermodynamic barrier for *OH intermediate formation, thereby steering H2O2 dissociation toward the homolytic •OH pathway. Consequently, the integrated SCN-50 architecture delivers an exceptional •OH generation selectivity of 86.3%. Driven by the S-scheme internal electric field, the synergistic preservation of strongly oxidizing holes (h+) at the oxidative terminus establishes a highly efficient relay degradation network for ofloxacin (OFX). Mechanistically, initial mild oxidation initiates preliminary side-chain dismantling, whereas the abundant •OH and preserved h+ cooperatively drive subsequent ring-opening and deep degradation. SCN-50 exhibits a rapid OFX degradation rate of 0.10 min-1, surpassing pristine C3N4 and SrFe12O19 by 2.5 and 16.7 times, respectively, alongside robust stability across four batch cycles and a 100-min continuous-flow operation. This work provides profound insights into tailoring H2O2 homolysis and engineering S-scheme-driven multi-species relay degradation for environmental remediation.

PMID 42863351
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