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lercanidipine + valsartan (Levacalm / ZV Combi)

✓ Approved

LG Chem Ltd. · AGTR1 · Small Molecule

What is lercanidipine + valsartan?

lercanidipine + valsartan is a small molecule developed by LG Chem Ltd.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesLevacalm, ZV Combi
CompanyLG Chem Ltd.
Drug ClassSmall Molecule
Molecular TargetAGTR1, CACNA1C
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, LG Chem Ltd.

Mechanism of Action

Molecular Targets

lercanidipine + valsartan acts on 2 molecular targets:

AGTR1angiotensin II receptor type 1 (HAT1R, AT1)
CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CACNL1A1, CACNA1C-IT2)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

lercanidipine + valsartan is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Vascular disordersHypertension✓ Approved

Related Research Articles

PubMedJournal of clinical medicine2026-10-16

Functional Mitral Regurgitation Trajectories in CRT-Treated HFrEF During Medical Therapy Optimization: Association with Reverse Remodeling.

Pătru Oana O, Luca Silvia S, Cozma Dragoș D, Enache Bogdan B et al.

Background: Functional mitral regurgitation (MR) is common in patients with heart failure with reduced ejection fraction (HFrEF) and may persist despite cardiac resynchronization therapy (CRT). Sacubitril/valsartan is associated with reverse remodeling in HFrEF, but MR dynamics in CRT-treated patients receiving sacubitril/valsartan remain insufficiently characterized. We aimed to characterize longitudinal changes in MR severity and assess their association with ventricular reverse remodeling in CRT-treated patients with HFrEF receiving sacubitril/valsartan. Methods: This retrospective cohort study included 188 patients with HFrEF previously treated with CRT who subsequently initiated sacubitril/valsartan. Clinical and echocardiographic assessments were performed at baseline and 10-14 months. The primary endpoint was MR improvement, defined a priori as a reduction of at least one MR grade. Changes in paired MR grade distribution were assessed using Bowker's test of symmetry. Associations between MR improvement and changes in left ventricular ejection fraction (LVEF), left ventricular end-diastolic volume (LVEDV), and left atrial volume (LAV) were evaluated. Multivariable logistic regression was used to identify factors independently associated with MR improvement. Results: MR improvement occurred in 116 patients (62%), while 72 (38%) had unchanged grades; no worsening was documented in the paired assessments. A significant shift toward lower MR grades was observed between baseline and follow-up (χ2 = 116.0, df = 5, p < 0.001). The proportion meeting the endpoint increased from 0% in baseline grade I to 51.2%, 80.0%, and 100% in grades II, III, and IV, respectively. Patients with MR improvement had greater increases in LVEF (9.0 vs. 7.0 percentage points, p = 0.006) and larger reductions in LVEDV (-45.7 vs. -28.6 mL, p = 0.004) and LAV (-20.4 vs. -4.2 mL, p < 0.001). The correlation between changes in LVEDV and MR grade was statistically significant but modest (r = 0.22, p = 0.002). Non-ischemic etiology and greater baseline LVEDV were independently associated with MR improvement, whereas baseline LVEF was not. The strong association with baseline MR grade partly reflects the endpoint's inherent dependence on initial severity. Conclusions: In patients with HFrEF treated with CRT who also received sacubitril/valsartan, lower MR grades were observed at follow-up and were associated with greater longitudinal changes in LVEF, LVEDV, and LAV. These findings describe parallel longitudinal changes in MR severity and cardiac structure within a combined device- and pharmacological-treatment setting. The observed changes cannot be disentangled from ongoing CRT-mediated remodeling, concomitant GDMT, changes in loading conditions, or other time-dependent factors and cannot be attributed specifically to sacubitril/valsartan.

PMID 42882149
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PubMedMolecules (Basel, Switzerland)2026-10-16

High-Performance and Low-Power Complementary Transistors Based on Red Carbon Ribbon.

He Yelu Y, Tan Xingyi X, Xu Gang G, Xiao Huan H et al.

Due to significant progress in architecture through the vertical stacking of negative channel metal oxide semiconductor (MOS) and positive channel MOS devices, the complementary field-effect transistor (CFET) is regarded as one of the most promising technologies for the next generation beyond the gate-all-around (GAA) architecture. This study comprehensively investigated the transport characteristics of one-dimensional (1D) red carbon ribbon (RCR) field-effect transistors (1D-RCR-FETs) with GAA gate and sub 5 nm gate lengths (Lg), using ab initio methods implemented in the Atomistix ToolKit 2019 software. Based on theoretical simulation results, n- and p-type GAA 1D-RCR-FETs with Lg of 5 nm satisfied the low-power (LP) and high-performance (HP) criteria for the 2039 horizon, according to the International Roadmap for Devices and Systems (IRDS) 2024 edition, and the corresponding results with Lg of 3 nm met the HP criteria for the 2039 horizon. Notably, both LP and HP applications demonstrated excellent symmetry between n- and p-FET devices at Lg = 5 nm, with the power-delay product, delay time, and on-state current ratios often ranging between 0.59 and 2.65, facilitating the development of CFETs. This study provides important theoretical insights highlighting the potential of 1D RCRs as promising channel materials for sub 5 nm 1D CFETs with both HP and LP application requirements.

PMID 42883134
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PubMedF1000Research2026-10-16

Open Science in Spain: Influence of Personal and Contextual Factors on Deposit Patterns.

de Gracia Palomera Daniel D

This study investigates factors influencing the deposit of academic publications and research data in open access repositories by Spanish researchers. Using survey data from a sample of Spanish academics, the research examines the impact of personal attributes (e.g., gender, age, knowledge of open science) and contextual variables (e.g., academic discipline, institutional type) on deposit behaviours. Quantitative methods, including chi-square tests and regression analysis, reveal significant associations between knowledge of open science and deposit practices. Researchers familiar with open science principles were more likely to deposit multiple versions of articles and datasets, albeit with varying intensity. Key findings highlight disciplinary and institutional differences: researchers in Life Sciences and Experimental Sciences showed higher engagement with both article and data deposits, whereas Health Sciences lagged. Gender differences were also observed, with male researchers depositing articles and datasets more frequently than their female counterparts, though age showed limited impact. Public institutions exhibited lower data deposit rates despite mandates supporting open access. The study underscores the need for tailored policies, including awareness campaigns, infrastructure investment, and discipline-specific strategies, to promote equitable and widespread adoption of open science practices. Findings contribute to understanding open science implementation, emphasizing the interplay of individual, institutional, and systemic factors.

PMID 42885361
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PubMedHealthcare (Basel, Switzerland)2026-10-16

Burnout and Perceived Stress Among Female Health Sciences Faculty Members at a University in Riyadh, Saudi Arabia: A Cross-Sectional Study.

Abusabeib Zeinab A ZA

Background/Objectives: Burnout and perceived stress are important concerns among health sciences faculty, whose roles often overlap across teaching, research, administrative, and clinical responsibilities. This study assessed burnout dimensions and perceived stress among female health sciences faculty at a single university in Riyadh, Saudi Arabia. Methods: This cross-sectional study included 228 female faculty members from five health sciences colleges, yielding a 64.4% response rate. Burnout was assessed using the Maslach Burnout Inventory-Educators Survey (MBI-ES), and perceived stress using the 10-item Perceived Stress Scale (PSS-10). Bivariate analyses incorporated effect sizes and false discovery rate adjustment for multiple comparisons. Multivariable linear regression models examined associations of demographic and professional characteristics with continuous emotional exhaustion and perceived stress scores. Results: For descriptive categorization, 34.2% of participants had high emotional exhaustion, 21.1% high depersonalization, 30.3% low personal accomplishment, and 15.2% high perceived stress. Perceived stress correlated most strongly with emotional exhaustion (r = 0.54, p < 0.001). In adjusted analyses, increasing age was associated with lower emotional exhaustion (B = -0.27, p < 0.001) and perceived stress (B = -0.16, p < 0.001), whereas working >50 h/week was associated with higher emotional exhaustion (B = 6.81, p < 0.001) and perceived stress (B = 3.13, p = 0.005). Overall adjusted college effects were not statistically significant. Conclusion: Longer working hours and younger age were associated with poorer faculty well-being, although the models explained modest proportions of outcome variance. These findings support institutional assessment of workload patterns and faculty well-being while underscoring the need for longitudinal research evaluating organizational demands, resources, and targeted interventions.

PMID 42881778
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PubMedAnimals : an open access journal from MDPI2026-10-16

Innexin2 Regulates Limb Regeneration in Procambarus clarkii: Insights from Transcriptome and DNA Methylation Analyses.

Li Jian J, Wang Yude Y, Liu Shaojun S

Limb regeneration is one of the most fascinating phenomena in life sciences. Although Procambarus clarkii exhibits remarkable regenerative capabilities, the molecular mechanisms underlying its limb regeneration remain poorly understood. To address this, we investigated the transcriptome data and DNA methylation levels during the limb regeneration process in Procambarus clarkii. We employed fluorescence in situ hybridization (FISH), RNA interference (RNAi), and mTOR inhibitors to validate the impact of key genes and pathways. Our findings from the weighted gene co-expression network analysis (WGCNA) suggest that Innexin2 may be associated with limb regeneration. Whole-genome bisulfite sequencing (WGBS) analysis revealed changes in methylation levels between the 0 dpa and 15 dpa stages of limb regeneration, while KEGG enrichment analysis highlighted the mTOR signaling pathway. Furthermore, both Torin1 and Rapamycin, as mTOR inhibitors, demonstrated that this pathway is required for limb regeneration. Overall, our study provides insights into the molecular regulatory mechanisms underlying limb regeneration in the Procambarus clarkii, offering valuable data support for future research in regeneration biology.

PMID 42882977
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PubMedInternational journal of molecular sciences2026-10-16

Establishment and Validation of a Novel Microgravity Simulation Platform for Ground-Based Animal Experiments.

Gurung Chetali C, Li Junfeng J, Teng Bin B, Liang Dong D et al.

Ground-based analog models, such as the hindlimb unloading (HU) technique, have been used for several decades in simulating microgravity effects on musculoskeletal studies. However, this model has seen limited technological advancement in several aspects. Here, the design and validation of the Microgravity Simulated Platform (MSP), a refined evolution of the classic HU model, is presented. The multipurpose engineered MSP apparatus is designed to overcome key limitations of existing models by enabling simultaneous study of a larger number of mice in compact space, with fewer lesions, less inflammation, and central axis rotation control that offers potential for future hypergravity studies. This study presents a comparative analysis with the HU and normal WT (NOR) models and demonstrates that the MSP recapitulates the classic physiological markers of disuse observed during spaceflight, particularly in the musculoskeletal system. Critically, the results indicate that the MSP not only provides a comparable simulation of microgravity-induced effects but also offers enhancements in experimental consistency and animal well-being. In conclusion, the MSP represents a significant advancement in ground-based space life sciences research, providing a more refined, efficient, high-throughput, and extensible platform for elucidating the pathophysiological mechanisms of mechanical unloading and for testing prospective countermeasures.

PMID 42884050
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