Drug Database
AM

amoxicillin (Moxacin / amoxicillin, CSL)

✓ Approved

CSL Limited · Small Molecule · Small Molecule

What is amoxicillin?

amoxicillin is a small molecule developed by CSL Limited. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesMoxacin, amoxicillin, CSL
CompanyCSL Limited
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, CSL Limited

Therapeutic Indications

amoxicillin is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsSalmonellosis✓ Approved

Related Research Articles

PubMedHealthcare (Basel, Switzerland)2026-10-16

Antibiotic Prescribing Patterns and Antimicrobial Stewardship Among Indian Periodontists: A Cross-Sectional Survey.

Chhabrani Ankita A, D'Albis Giuseppe G, Shivamallu Avinash Bettahalli AB, Capodiferro Saverio S

Background: Antimicrobial resistance is a growing concern, and inappropriate prescribing may contribute to its rise. Variability among periodontists highlights the need to understand prescribing patterns and factors influencing antibiotic selection. We aim to assess antibiotic prescribing patterns and perceptions of resistance among Indian periodontists and evaluate factors associated with prescribing practices and selection of the antibiotic regimen perceived by respondents as most effective. Methods: A cross-sectional questionnaire survey was conducted among Indian periodontists (January-April 2024), distributed via institutional email and LinkedIn. Descriptive statistics summarized responses; chi-square/Fisher's tests assessed associations with experience. Logistic regression was performed to identify factors associated with respondents' selection of the antibiotic regimen perceived as most effective for periodontal therapy. Results: Of 500 invited, 328 responded (65.6%). Respondents were mostly female (67.7%), with a mean age of 32.25 ± 6.05 years; 50.3% had <5 years' experience and 98.6% held an MDS in Periodontology. Amoxicillin plus metronidazole was the regimen most frequently perceived as effective by respondents (37.8%), followed by amoxicillin-clavulanic acid (35.4%) and amoxicillin alone (15.9%). Oral administration was preferred (89.0%). Prophylactic antibiotics were prescribed for infective endocarditis/CABG indications by 89.6%, while 48.2% did not prescribe after laser-assisted surgery. Experience was significantly associated with prescribing frequency and post-laser prescribing (p < 0.05); associations with crown lengthening and flap surgery lost significance after Bonferroni correction. Academic practice was associated with regimen selection univariably (OR = 0.56, 95% CI 0.34-0.93) but not after multivariable adjustment (aOR = 0.65, 95% CI 0.37-1.13). Most respondents (98.5%) viewed resistance as a growing concern. Conclusions: Prescribing practices varied with experience and practice setting. Amoxicillin plus metronidazole was most frequently considered effective, though no factor independently predicted selection. High awareness of resistance underscores the need for stronger antimicrobial stewardship in periodontal care.

PMID 42881671
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PubMedAnimals : an open access journal from MDPI2026-10-16

Candida albicans Urinary Tract Infection with Suspected Fungal Hepatobiliary Disease in an Immunosuppressed Dog: A Case Report.

Norman Amy A, Walton-Clark Michelle M

Fungal urinary tract infections (UTIs) are uncommon in dogs and are typically associated with immunocompromised patients or those with other predisposing factors. Fungal hepatobiliary disease is rarely reported in the veterinary literature. This case report describes a dog on dual immunosuppressive therapy for suspected immune-mediated polyarthritis that developed a hepatopathy suspected to represent bacterial hepatobiliary disease and was subsequently treated with prolonged amoxicillin-clavulanate therapy. Following treatment, the dog developed marked hepatocellular enzyme elevations together with a Candida albicans UTI. Given the patient's progressive hepatocellular injury, clinical signs, history of immunosuppression and antibiotic therapy, concurrent fungal hepatobiliary involvement was suspected. Following initiation of oral fluconazole, the fungal UTI resolved, and there was marked improvement, with subsequent normalisation of ALT and ALP activities. Although the temporal association between antifungal treatment and clinical and biochemical improvement raised suspicion of concurrent fungal hepatobiliary involvement, simultaneous discontinuation of amoxicillin-clavulanate, substantial reduction in prednisolone dose, and continuation of hepatoprotective therapy precluded attribution of the improvement specifically to antifungal treatment. This case highlights the potential for opportunistic fungal disease in immunosuppressed dogs, particularly following prolonged antimicrobial exposure, and illustrates the diagnostic challenges associated with suspected hepatobiliary involvement.

PMID 42883105
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PubMedPoultry science2026-10-15

Longitudinal study assessing antimicrobial usage in broiler production cycles in northern Vietnam in 2022 to 2023.

Xin Chen C, Nguyen Trang T, Nguyen Quoc Hung QH, Butt Saira S et al.

Antimicrobial drugs (AMDs) are commonly used in chicken production in Vietnam for both preventive (prophylactic) and therapeutic purposes. Characterizing how the frequency of antimicrobial usage (AMU) changes from flock placement to harvest, varies by purpose, and may be influenced by production stage and mortality levels, can guide antimicrobial stewardship interventions to mitigate the risk of antimicrobial resistance (AMR) in broiler production. We investigated daily AMU and mortality patterns in production cycles of slow-growing broiler chicken flocks raised on 60 farms in two provinces (Ha Noi and Bac Ninh) in northern Vietnam at the end of 2022 and the beginning of 2023. The association between the daily probability of AMU and mortality risk was evaluated using generalized additive mixed models (GAMMs). The dynamic process of initiating a new treatment, and the expected duration of that episode, were further assessed using a two-state semi-Markov process (SMP) within a Bayesian framework. A total of 569 treatment events (70.5% preventive vs. 29.5% therapeutic) were recorded across all 60 monitored cycles. A median value of 186.1 mg/Population Correction Unit (PCU) AMDs was used for prophylaxis, while 116.7 mg/PCU was used for therapeutic treatment per production cycle. The most frequently administered AMDs for preventive treatments were colistin (23.2%), amoxicillin (19.2%), and doxycycline (11.7%). Therapeutic treatments mostly involved doxycycline (26.8%), florfenicol (17.9%), and amoxicillin (13.7%). The main effect of within-flock mortality was not significant, but the interaction between mortality and broiler age was associated with AMU both in the case of preventive and therapeutic AMU (p-value <0.05), suggesting that the effect of mortality on AMU may have varied depending on the broiler age. Broiler age was strongly and non-linearly associated with AMU (p<0.05), with distinct temporal patterns for preventive and therapeutic use. At the start of a production cycle, initiation of preventive treatment was substantially more likely than initiation of therapeutic treatment (day 0: risk ratio [RR] = 8.6), and prophylactic treatment remained dominant during the early cycle (RR > 2 before day 22). These findings indicate that preventive treatment is the primary driver of AMU during the early cycle, highlighting the need for stewardship interventions at this stage, focused on reducing non-essential prophylactic use and promoting lower-risk alternatives.

PMID 42880092
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PubMedJournal of veterinary research2026-10-15

Occurrence of Serratia marcescens in bovine intramammary infections: identification and antimicrobial susceptibility in a dairy herd.

Targońska-Karasek Małgorzata M, Ospałek Wojciech W, Krukowski Henryk H

Mastitis is one of the most economically significant diseases in dairy cattle, and its causation by atypical environmental pathogens is gaining attention. The study investigated the involvement of Serratia marcescens in intramammary infections occurring in a dairy herd and evaluated the bacterium's antimicrobial resistance profile. Between February 2024 and June 2025, 481 quarter-milk samples collected from cows on a dairy farm in eastern Poland were subjected to routine bacteriological examination. Isolates were identified by biochemical, proteomic and molecular methods and tested for antimicrobial susceptibility by automated biochemical analysis. Serratia marcescens was isolated from the milk samples of 10 cows during different sampling periods. All isolates were consistently identified as S. marcescens, confirming the reliability of the applied comprehensive approach. Molecular analyses demonstrated high sequence similarity with reference strains. Antimicrobial susceptibility testing revealed uniform resistance to amoxicillin/clavulanic acid, cefuroxime, colistin and tigecycline. Serratia marcescens should be considered a relevant opportunistic pathogen in dairies, capable of causing sporadic or epidemic mastitis episodes. The findings are consistent with previous reports linking S. marcescens mastitis to environmental reservoirs and milking equipment contamination. Comprehensive diagnostic strategies, strict hygiene practices and targeted herd management measures are important to prevent and control mastitis caused by uncommon environmental pathogens.

PMID 42877314
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PubMedCureus2026-10-15

Pancreatic Ascites Complicated by Salmonella Enteritidis Peritonitis: A Diagnostic Challenge and the Role of Surgical Source Control.

Sylla Moussa M, Bamogo Samuel S, Pappalardo Eric E

Pancreatic ascites is an uncommon complication of pancreatic disorders resulting from persistent leakage of pancreatic juice into the peritoneal cavity, most commonly due to disruption of the main pancreatic duct or rupture of a pancreatic fluid collection. Bacterial peritonitis complicating pancreatic ascites is rarely reported. We report the case of a 40-year-old man who presented with massive pancreatic ascites associated with a marked elevation of serum lipase. Analysis of the ascitic fluid strongly supported its pancreatic origin, and conservative management with enteral nutrition and a somatostatin analogue was initiated. One week after biliopancreatic magnetic resonance imaging, the patient developed sudden deterioration with septic shock, tense ascites, acute kidney injury, and purulent ascitic fluid. Emergency laparoscopy was performed because of concern for secondary peritonitis from an occult gastrointestinal perforation. Approximately 9 L of purulent ascites were evacuated, followed by extensive peritoneal lavage and drainage. No gastrointestinal perforation or other intra-abdominal source of contamination was identified. Peritoneal fluid cultures isolated a fully susceptible Salmonella enterica serovar Enteritidis, while blood cultures remained negative. Antibiotic therapy was subsequently de-escalated to amoxicillin-clavulanic acid based on antimicrobial susceptibility testing, and a full seven-day course was completed. The postoperative course was favorable. Six weeks later, MRI showed complete resolution of the ascites and a 5-cm organized pancreatic collection communicating with the distal main pancreatic duct. This case highlights an unusual occurrence of Salmonella Enteritidis peritonitis complicating pancreatic ascites in the absence of gastrointestinal perforation or documented bacteremia. Sudden clinical deterioration in patients with pancreatic ascites should prompt immediate reassessment for infectious complications and, when indicated, urgent surgical exploration for source control. Definitive management of the pancreatic ductal leak may be deferred in selected patients when the infectious complication has been controlled and clinical evolution is favorable.

PMID 42877422
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PubMedLuminescence : the journal of biological and chemical luminescence2026-10-14

Engineering PEG-Modified Fe2O3 Nanostructures for Enhanced Photocatalytic Degradation of Pesticide and Antibiotic Pollutants in Water.

Nesrat Hocine Sadam HS, Mosbahi Dalila Saidane DS, Laouini Salah Eddine SE, Aouadi Abdelatif A et al.

Pesticide and pharmaceutical contaminants in water have become an important environmental challenge because of their persistence, toxicity, and limited removal by conventional treatment methods. In this work, iron oxide nanoparticles (Fe2O3NPs) and polyethylene glycol-coated iron oxide nanoparticles (Fe2O3@PEG NPs) were synthesized and tested for photocatalytic degradation of organic pollutants in aqueous media. The obtained materials were characterized using XRD, FTIR, UV-Vis spectroscopy, and SEM analyses. The XRD patterns confirmed the formation of crystalline hematite (α-Fe2O3), with average crystallite sizes of 21.26 nm for Fe2O3 and 19.02 nm for Fe2O3@PEG. FTIR spectra indicated successful PEG coating, whereas UV-Vis analysis revealed direct band-gap energies of 2.09 and 2.00 eV, respectively. Photocatalytic performance was investigated through the degradation of chlorpyrifos and amoxicillin under UV light. The Fe2O3@PEG material showed better activity, reaching 95.84% degradation of chlorpyrifos after 120 min and 95.03% removal of amoxicillin within 60 min. Kinetic results were consistent with a pseudo-first-order model. The improved efficiency of the modified material was mainly related to better dispersion, enhanced surface interaction, and lower charge recombination.

PMID 42870510
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