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erythromycin (Erymin / erythromycin, Elan)

✓ Approved

Takeda · Small Molecule · Small Molecule

What is erythromycin?

erythromycin is a small molecule developed by Takeda. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesErymin, erythromycin, Elan
CompanyTakeda
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Takeda

Therapeutic Indications

erythromycin is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsSalmonellosis✓ Approved

Related Research Articles

PubMedInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2026-08-28

Streptococcus pneumoniae Invasive and Bronchoalveolar Lavage Isolates in Adult Patients in Türkiye (2019-2025): Serotype Distribution, Antibiotic Resistance, and Serotype Coverage of Pneumococcal Vaccine.

Hascelik Gülsen G, Ozakin Cuneyt C, Hazirolan Gulsen G, Hasdemir Ufuk U et al.

To determine the serotype distribution, antibiotic susceptibility, and vaccine serotype coverage of Streptococcus pneumoniae isolates from adult patients in Türkiye. This laboratory study included pneumococcal isolates collected during routine procedures between 2019-2025 in 27 tertiary hospitals across 17 cities in Türkiye. Identification was performed using the optochin test and bile lysis test. Serotyping was performed by the Quellung test. Antibiotic susceptibilities were tested according to the Clinical Laboratory Standards Institute (CLSI) criteria. Among 462 pneumococcal isolates, 72.7% were from male patients, and 43.9% were from patients aged ≥65 years. The most common diagnosis was bacteremia (55.8%), followed by pneumonia (24%) and meningitis (10.6%). The most frequent serotypes were serotype 3 (17.3%), 9N (9.1%), and 19F (5.4%). Vaccine serotype coverage rates were 34.6%, 35.9%, 47.8%, and 59.5% for PCV13, PCV15, PCV20, and PPSV23, respectively; with significantly higher coverage among patients aged ≥65 years. Most isolates were susceptible to penicillin (96.3%) and cefotaxime (97.8%) using non-meningitis breakpoints. Moxifloxacin susceptibility was 99.1%. Erythromycin resistance increased from 33.3% in 2019 to 57.5% in 2025. Serotype 3 was the predominant serotype. PCV20 may provide broader coverage than PCV13, particularly in older adults. Ongoing pneumococcal surveillance and rational antibiotic use remain essential.

PMID 42660407
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PubMedJournal of infection and public health2026-08-28

Genomic epidemiology of Streptococcus pyogenes across multiple centres in China.

Liu Minglei M, Cai Yihua Y, Xu Qiaoli Q, Dong Zihao Z et al.

Streptococcus pyogenes causes a broad spectrum of invasive and non-invasive infections globally, associated with high morbidity and mortality. In mainland China, distribution of the emm genotype has shifted markedly over recent decades, with emm12 emerging as the dominant type. Meanwhile, resistance to macrolides, lincosamides, and tetracyclines has reached extremely high levels, severely limiting clinical treatment options and leading to the designation of S. pyogenes as a medium-priority pathogen by the World Health Organization. A total of 133 non-duplicate S. pyogenes isolates were collected from seven hospitals in northern and southern China, covering five provinces and one municipality, between 2022 and 2024. All isolates underwent whole-genome sequencing, emm typing, multi-locus sequence typing, resistance gene detection, virulence gene analysis, and mobile genetic element identification. All isolates were fully susceptible to penicillin, cefotaxime, levofloxacin, linezolid, vancomycin, and chloramphenicol. Resistance rates were 93.98% for erythromycin, 92.48% for clindamycin, and 81.95% for tetracycline, with erm(B) and tet(M) identified as the main resistance genes. emm12 (81.95%) and ST36 (81.20%) were the predominant types. The emm12-ST36 lineage was strongly associated with pharyngeal infections and acute suppurative tonsillitis. No M1UK lineage was detected. Distinct virulence and mobile genetic element profiles were observed between emm12 and emm1 isolates. S. pyogenes isolates analysed in this study showed extremely high resistance to macrolides, lincosamides, and tetracyclines. Penicillin remains the first-line therapy. For patients with penicillin allergy, alternative therapy should be guided by allergy severity, local susceptibility data, clinical guidelines, and antimicrobial susceptibility testing. The emm12-ST36 type was predominant among pharyngeal isolates and showed strong association with acute suppurative tonsillitis. Continuous genomic surveillance is critical for clinical treatment and infection control.

PMID 42664882
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PubMedVeterinary medicine international2026-08-28

Multidrug-Resistant Salmonella Spp. Isolated From Cloacal Swab of Healthy Layer Chickens and Egg Surface at Selected Farms in Bangladesh.

Akter Most Rafiya MR, Kallol Md Arefin MA, Alam Shanzida Binte SB, Alam Md Mahmudul MM et al.

Multidrug-resistant (MDR) Salmonella spp. is regarded as a perilous menace of public health significance. This research finding was carried out to investigate the prevalence of MDR Salmonella spp. in cloacal swabs of healthy layer birds and egg surface washing along with their resistance patterns and some associated resistance gene detection. In total, 120 samples consisting of 60 cloacal swabs and 60 eggs were collected from three different layer farms located at Mymensingh, Bangladesh, and subjected to various classical and molecular approaches. Antibiotic resistance patterns were investigated phenotypically using the Kirby-Bauer disk diffusion method and genotypically by detection of respective resistance genes. The overall prevalence rate of Salmonella spp. was 29% (95% CI: 18.077%-33.255%) and sample-wise prevalence was 23% (95% CI: 14.415%-26.918%) in cloacal swab and 35% (95% CI: 22.043%-39.956%) in egg surface washing, respectively. Antibiotic susceptibility test revealed that the highest resistance was found to ampicillin 94.29% (95% CI: 86.65%-99.96%) followed by oxytetracycline 80.00%, (95% CI: 65.23%-98.03%), and erythromycin 65.72% (95% CI: 56.73%-75.41%), 45.71%, (95% CI: 33.039%-58.08%) to streptomycin, whereas the highest sensitivity was observed against florfenicol 74.29% (95% CI: 62.91%-85.28%), followed by ciprofloxacin (68.57%, 95% CI: 62.80%-73.66%), and sulphamethoxazole (68.57%, 95% CI: 53.48%-78.97%). The isolates were also found to be MDR as 80% (28/35) isolates (95% CI: 75.80%-86.69%) possessed a MAR index ranging between 0.33 and 0.89. On average, 19 isolates (54.28%; 95% CI: 26.90%-85.17%) were resistant to 5 - 8 antibiotics of seven classes, which is really alarming for public health significance. Based on PCR results, different resistant genes blaTEM, tetA, aadA1, cat1, and flo-R were amplified from 100%, 85.71%, 77.14%, 62.86%, and 37.14% of the isolates. Due to increased drug resistance, antibiotics and other antimicrobial drugs are becoming ineffective for the medication of both human and animal infections. Further investigations are also suggested to cope with antimicrobial resistance through this research study.

PMID 42662130
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PubMedJournal of clinical medicine2026-08-27

Prevalence, Serotype Distribution, and Antimicrobial Resistance of Streptococcus agalactiae Among Pregnant Women in Greece: A Retrospective Study.

Chasiakou Anthia A, Kaparos George G, Chasiakou Stamatia S, Demeridou Stiliani S et al.

Background:Streptococcus agalactiae (group B Streptococcus, GBS) remains a leading cause of invasive infections in pregnant women, fetuses, and neonates. Universal screening at 36-37 weeks of gestation and intrapartum antimicrobial prophylaxis are essential to prevent adverse outcomes. This study aimed to determine the prevalence, serotype distribution, and antimicrobial susceptibility of GBS isolates among pregnant women in Greece. Methods: Vaginal and rectal swabs were collected from pregnant women undergoing GBS screening between January 2021 and December 2025. Samples were processed using Todd-Hewitt broth with colistin and nalidixic acid, and cultured on blood agar and chromogenic media. The VITEK2 system was used for GBS identification and antimicrobial susceptibility testing against penicillin, erythromycin, clindamycin, tetracycline, levofloxacin, and vancomycin, according to EUCAST guidelines. The double-disk diffusion test was used for macrolide-lincosamide-streptogramin B (MLSB) phenotyping. Serotyping for all ten serotypes was conducted using a commercial latex agglutination assay. Results: Among 941 women screened, 118 (12.5%) were colonized with GBS. The most prevalent serotypes were III (29.7%), V (18.6%), Ib (14.4%), IX (10.2%), Ia (9.3%), and II (9.3%). All isolates were susceptible to penicillin. Resistance to erythromycin and/or clindamycin was detected in 37 isolates. In these isolates, the predominant MLSB phenotype was constitutive (cMLSB, 78.4%), followed by inducible (iMLSB, 13.5%), L (5.4%), and M (2.7%) phenotypes. Conclusions: GBS colonization was detected in 12.5% of pregnant women, with serotype III predominating, underscoring its clinical relevance due to its association with invasive neonatal disease. Although penicillin remains fully effective, the observed resistance to macrolides and lincosamides, primarily mediated by the cMLSB phenotype, raises concerns regarding alternative therapies.

PMID 42652862
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PubMedAntibiotics (Basel, Switzerland)2026-08-27

Resistance to Human-Reserved Antimicrobials in Clinical and Commensal Enterococcus faecalis and Enterococcus faecium from Dogs and Cats.

Iamone Giulia G, Bellato Alessandro A, Prandi Ilaria I, Stella Maria Cristina MC et al.

Background/Objectives: Although companion animals are recognized as reservoirs of antimicrobial resistant enterococci, it remains unclear whether antimicrobial resistance differs between clinical and commensal isolates, particularly for antimicrobials reserved for human medicine. This study compared antimicrobial susceptibility profiles of clinical and commensal E. faecalis and E. faecium isolates from dogs and cats, focusing on antimicrobials reserved for human medicine under European regulation and EMA/AMEG classification. Methods: A total of 99 isolates (49 E. faecalis and 50 E. faecium) collected between 2022 and 2025 were analysed by broth microdilution, gradient diffusion, and disk diffusion methods. Antimicrobial resistance patterns were compared according to bacterial species and isolate origin. Results:E. faecium exhibited significantly higher resistance rates than E. faecalis, particularly to ampicillin, fluoroquinolones, erythromycin, nitrofurantoin, and vancomycin. Multidrug resistance was widespread, affecting all clinical E. faecium isolates and 72.2% of commensal E. faecium, whereas corresponding proportions in E. faecalis were 64.1% and 40.0%, respectively. Clinical E. faecium isolates showed significantly higher resistance than commensal isolates to antimicrobials commonly used in veterinary medicine, including ampicillin, fluoroquinolones, erythromycin, gentamicin, streptomycin, and tetracycline. Conversely, no significant differences were observed for antimicrobials reserved for human medicine, including linezolid, vancomycin, teicoplanin, tigecycline, daptomycin, rifampicin, and quinupristin/dalfopristin. Conclusions: The higher resistance observed in clinical isolates to veterinary antimicrobials is consistent with the selective pressure exerted by antimicrobial use in veterinary clinical settings, whereas resistance to human-reserved agents may reflect epidemiological processes that are independent of antimicrobial exposure in veterinary clinical settings. Continuous integrated One Health surveillance is essential to monitor the emergence and dissemination of these resistance phenotypes. The AMR profiles observed in companion animals further support the need for integrated One Health surveillance, combining veterinary, human, and environmental data to better understand the emergence and dissemination of resistant enterococci.

PMID 42650657
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PubMedMicroorganisms2026-08-27

Lineage-Associated Genomic and Phenotypic Features of Bovine Mastitis-Associated Staphylococcus aureus from Northwestern China.

Zhou Ting T, Tao Xinying X, Xue Zhiying Z, Huang Yongwang Y et al.

Staphylococcus aureus is a major contagious pathogen causing bovine mastitis, with persistence and antimicrobial resistance posing ongoing challenges in dairy herds. From July 2022 to July 2023, 942 mastitis milk samples (267 clinical, 675 subclinical) from 10 farms in northwestern China yielded 98 S. aureus isolates (10.4%), which were characterized by whole-genome sequencing, antimicrobial susceptibility testing, biofilm assays, and virulence profiling. Ten sequence types, seven clonal complexes, and 16 spa types were identified, dominated by ST1 (42.9%) and ST97 (24.5%). ST1 was mainly associated with subclinical mastitis, whereas ST97 was enriched in clinical cases; a novel ST9955 (13.3%) was exclusively detected in subclinical isolates. No methicillin-resistant S. aureus was detected. Resistance was most frequently observed to penicillin (42.9%), erythromycin (28.6%), clindamycin (22.4%), and tetracycline (10.2%), with higher rates in clinical isolates. 65.3% of isolates exhibited strong biofilm-forming ability, which was significantly more frequent in subclinical cases (70.3% vs. 55.9%, p < 0.05). Virulence genes showed conserved adhesion/biofilm determinants but lineage-dependent distribution of immune evasion and toxin genes, with stable co-occurrence among capsule, biofilm, T7SS, iron acquisition, and immune evasion loci. Overall, the population was diverse but strongly lineage-structured, dominated by a few successful clones, highlighting the value of lineage-resolved surveillance for understanding and controlling bovine mastitis.

PMID 42655043
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