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measles vaccine (live-attenuated)

✓ Approved

Beijing Tiantan Biological Products · Vaccine · Vaccine

What is measles vaccine (live-attenuated)?

measles vaccine (live-attenuated) is a vaccine developed by Beijing Tiantan Biological Products. It is approved for therapeutic indications via unknown.

Drug Profile

CompanyBeijing Tiantan Biological Products
Drug ClassVaccine, Large Molecules
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Beijing Tiantan Biological Products

Therapeutic Indications

measles vaccine (live-attenuated) is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsMeasles✓ Approved

Related Research Articles

PubMedActa tropica2026-08-30

Recombinant Toxoplasma gondii expressing FIPV spike protein S1 subunit: A proof-of-concept approach against toxoplasmosis and feline infectious peritonitis.

Xie Fujie F, Jiang Xinyu X, Yang Yilin Y, Xie Yuehua Y et al.

Feline infectious peritonitis virus (FIPV) is a lethal feline pathogen with no widely effective prophylactic vaccine available. To address this unmet need, we explored the feasibility of using Toxoplasma gondii (whose definitive host is felids) as a live delivery platform to develop a bivalent vector vaccine. We generated a transgenic T. gondii strain engineered to express and secrete the FIPV spike protein S1 subunit into the parasitophorous vacuole. Immunization in mice confirmed the immunogenicity of this recombinant parasite, which induced specific antibody responses targeting both the T. gondii vector and the FIPV S1 antigen. In vitro neutralization assays revealed limited FIPV-neutralizing capacity in immune sera, with only low-level inhibitory activity observed at the lowest serum dilution, which was markedly inferior to the neutralization potency induced by recombinant S1 protein vaccination. Collectively, these data preliminarily verify the potential of T. gondii as a multivalent antigen delivery vector. This work provides a proof-of-concept framework for a dual-target vaccination strategy intended to mitigate the epidemiological burden of both FIPV and T. gondii in cats, and underpins integrated One Health-oriented disease prevention and control efforts.

PMID 42669354
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PubMedKidney medicine2026-08-30

COVID-19 Vaccine Knowledge, Practice, and Attitudes Among Hemodialysis Patients in Egypt, Kenya, and Cameroon: A Multicenter Study.

Elsayed Enass E, Kotb Khaled M KM, Heiba Ahmed A, Elhussini Manal Shaker MS et al.

Patients receiving hemodialysis (HD) are at increased risk of severe coronavirus disease 2019 (COVID-19) and were prioritized for vaccination, yet vaccine hesitancy remains common. We assessed COVID-19 vaccine knowledge, acceptance, and attitudes among patients receiving HD in Egypt, Kenya, and Cameroon and identified factors associated with vaccine acceptance, prior infection, willingness to receive future doses, and postvaccination complications. Multicenter cross-sectional survey study. Between March 2021 and April 2022, 765 patients receiving maintenance HD and 196 non-dialysis controls were recruited from dialysis centers in Egypt, Kenya, and Cameroon. Sociodemographic characteristics, clinical comorbidities, prior COVID-19, sources of vaccine information, and exposure to vaccinated or infected relatives. COVID-19 vaccine acceptance, willingness to receive future doses, prior infection, and post-vaccination complications. Structured questionnaires assessed knowledge, practices, and attitudes toward COVID-19 vaccination. Multivariable logistic regression identified factors independently associated with study outcomes. Vaccine acceptance was lower among patients receiving HD than nondialysis controls (58.2% vs 96.2%). Fear of side effects was the most common reason for refusal (39.3%). Postvaccination complications were less frequent among patients receiving HD (22.3% vs 44.3%). Hesitancy was more common among women, younger participants, and those with comorbidities or no prior COVID-19. Having vaccinated or previously infected relatives was associated with a greater willingness to receive future doses. Cross-sectional design limits causal inference. Nonprobability sampling and unmatched controls may limit generalizability. COVID-19 cases may have been underreported because of limited testing. COVID-19 vaccine hesitancy among patients receiving HD is driven by fear, misinformation, and sociodemographic factors. Targeted education and improved access to reliable vaccine information may help increase uptake in this population.

PMID 42668537
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PubMedEMBO molecular medicine2026-08-30

A cavity-reduced prefusion RSV F bivalent vaccine elicits durable and protective immunity.

Liu Lijie L, Yan Mengrong M, Liang Ruoxu R, Wu Qingxin Q et al.

Respiratory syncytial virus (RSV) remains a major cause of severe respiratory disease, and stabilization of the prefusion (preF) conformation of the F glycoprotein is central for vaccine development. Here, we report a structure-guided engineering strategy that enhances preF stability by reducing the hydrophobic cavity within the trimeric F protein. Targeted modifications at metastability-associated sites generated RVF-88, a disulfide-free stabilized preF immunogen that preserves key neutralizing epitopes, including antigenic site Ø, while exhibiting improved structural integrity and long-term storage stability. Formulated as an unadjuvanted bivalent vaccine, RVF-88 elicited potent neutralizing antibody responses and durable immune protection lasting up to 5 months in mice. Vaccination also protected both mice and cotton rats against RSV challenge. Structural analyses confirmed the intended cavity-reduction design, revealing a reduced apical hydrophobic cavity volume and surface area while maintaining the prefusion architecture. Together, these findings establish hydrophobic cavity reduction as a rational strategy for stabilizing prefusion RSV F and provide a promising next-generation vaccine candidate with improved stability and immunogenicity for further clinical development.

PMID 42668284
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PubMedJapanese journal of infectious diseases2026-08-30

Immunogenicity and Safety of the 9-valent Human Papillomavirus (HPV) Vaccine Administered as 2-Dose or 3-Dose Regimens in Japanese Boys and Girls Aged 9-15 Years.

Takeuchi Yuzuru Y, Yonekawa Motoharu M, Murata Shinya S, Nakagomi Mariko M et al.

A phase III open-label study evaluated the immunogenicity and safety of the 9-valent human papillomavirus (9vHPV) vaccine in Japanese boys and girls. Japanese boys aged 9-15 years (n = 105) received a 3-dose (Day 1, Month 2, and Month 6) regimen; Japanese boys (n = 104) and girls aged 9-14 years (n = 105) received a 2-dose (Day 1 and Month 6) regimen. Antibody responses to HPV6/11/16/18/31/33/45/52/58 were assessed at Month 7, 18, and 30 using a competitive Luminex immunoassay. Injection-site adverse events (AEs; Days 1 to 5 post-dose), systemic AEs (Days 1 to 15 post-dose), and serious AEs (duration of study) were assessed. At Month 7, for HPV types targeted by the 9vHPV vaccine, seroconversion rates were 100% in all three arms, and in cross-study comparisons with efficacy studies, anti-HPV geometric mean titers in boys were noninferior to those in Japanese men aged 16-26 years, and in girls were noninferior to those in Japanese women aged 16-26 years. Most injection-site AEs were mild to moderate in intensity. No deaths or vaccine-related serious AEs were observed. These results support immunobridging of efficacy findings in Japanese men and women to Japanese boys and girls. The 9vHPV vaccine was generally well tolerated.

PMID 42669546
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PubMedVaccine2026-08-30

Ethical considerations of incentive structures in vaccine acceptance research.

Musrati Mohamed Amer MA, Shenaisheh Salem S, Elemraid Mohamed A MA

PMID 42669239
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PubMedReproductive biomedicine online2026-08-30

Impact of combining fast vitrification and fast warming protocols on live birth outcomes.

Arkfeld Christopher K CK, Vagios Stylianos S, Minis Evelyn E EE, Fitz Victoria W VW et al.

Does the combination of fast vitrification and fast warming protocols, compared with standard vitrification and standard warming protocols, result in differences in pregnancy outcomes following frozen embryo transfer (FET)? This was a retrospective comparative cohort study of unique patients undergoing either natural, medicated or programmed FET cycles of single blastocysts. The first FET following fresh cycles was included for each patient. Three groups were analysed: standard vitrification with standard warming protocol (n = 1025); standard vitrification with fast warming protocol (n = 926); and fast vitrification with fast warming protocol (n = 471). The primary outcome was live birth rate. Secondary outcomes included positive pregnancy test rate, biochemical pregnancy rate, clinical pregnancy rate and miscarriage rate. Logistic regression models were performed, controlling for day of cryopreservation (day 5 or day 6), FET preparation, body mass index and oocyte age. A subanalysis was performed on embryos that underwent preimplantation genetic testing for aneuploidy (PGT-A). Unadjusted analysis showed no difference in live birth rate (42.5% versus 41.8% versus 46.9%; P = 0.167), pregnancy rate (58.8% versus 56.3% versus 62.4%; P = 0.085), biochemical pregnancy rate (8.9% versus 8.1% versus 8.5%; P = 0.827), clinical pregnancy rate (49.6% versus 48.1% versus 53.3%; P = 0.179), and spontaneous abortion rate (6.9% versus 6.0% versus 6.2%; P = 0.704) across the standard vitrification-standard warming, standard vitrification-fast warming, and fast vitrification-fast warming groups, respectively. These findings remained unchanged in the adjusted analysis. A subanalysis of PGT-A embryos showed no difference in live birth rate (45.1% versus 46.2% versus 49.6%; P = 0.472) between the standard vitrification-standard warming (n = 548), standard vitrification-fast warming (n = 424), and fast vitrification-fast warming (n = 266) groups, respectively. The fast vitrification-fast warming protocol for vitrified and warmed blastocyst-stage embryos is as effective as the standard vitrification-standard warming protocol, demonstrating no negative impact on live birth or secondary outcomes.

PMID 42669220
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