Drug Database
TJ

TJ-15 (OGT)

✓ Approved

Tsumura · therapeutic agent

What is TJ-15?

TJ-15 is a therapeutic agent developed by Tsumura. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesOGT
CompanyTsumura
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Tsumura

Therapeutic Indications

TJ-15 is developed for 5 unique indications across 5 therapeutic areas.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersEczema✓ Approved
Gastrointestinal disordersGastritis✓ Approved
Vascular disordersHypertension✓ Approved
Psychiatric disordersObsessive-compulsive disorder✓ Approved
Nervous system disordersCerebral cyst haemorrhage✓ Approved

Related Research Articles

PubMedCells2026-10-16

GDF-15/GFRAL Axis Dynamics and Vulnerability Windows in Bariatric Surgery: Pathophysiological, Microbiomic, and Pharmacological Perspectives.

Pînzariu Alin Constantin AC, Șerban Ionela Lăcrămioara IL, Soroceanu Radu Petru RP, Vlăsceanu Vlad Ionuț VI et al.

Bariatric surgery (BS) and new pharmacological treatments cause significant neurometabolic changes. However, the pathways linking peripheral stress to central metabolic control remain poorly understood. This review highlights the GDF-15/GFRAL/RET complex as a key integrator of multiorgan-to-brain stress signals that shape systemic metabolic adaptation after surgical and pharmacological interventions. Based on a structured search across PubMed, Embase, Scopus, Google Scholar, and Web of Science covering 2020-2026 alongside foundational studies, we integrated translational evidence from peer-reviewed human trials and mechanistic animal models to map the GDF-15/GFRAL/RET axis across bariatric and incretin domains. We examined the neurobiology of the GDF-15/GFRAL axis to clarify variability in metabolic and behavioral outcomes after BS. This axis links metabolic stress signals from the gut, liver, and adipose tissue to the hindbrain and hypothalamic regulation of energy balance. Changes in the gut microbiome and SCFA-FFAR2/FFAR3 signaling after surgery interact with GDF-15 and incretin pathways. Future studies should critically compare BS with synergistic or alternative non-invasive neurometabolic approaches such as incretin mimetics, exogenous GDF-15 therapies, and high-protein diets.

PMID 42882521
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PubMedNutrients2026-10-16

Longitudinal Changes in Left Ventricular Structure and Function During a Dietary Weight-Management Trial in Adults with Heart Failure, Type 2 Diabetes, and Obesity: A Secondary Analysis of Pro-HEART.

Evangelista Lorraine S LS, Meraz Rebecca R, Angosta Alona D AD, Nguyen Angelina P AP et al.

Background: Obesity is associated with adverse cardiac remodeling in heart failure (HF), but changes during dietary weight management are not well described. We examined longitudinal changes in left ventricular (LV) structure and systolic function during a dietary weight-management intervention. Methods: Pro-HEART participants were randomized to high-protein or standard-protein hypocaloric diets. LV end-diastolic dimension (LVEDD), ejection fraction (LVEF), and posterior wall thickness (LVPWT) were assessed at baseline, 3 months, and 15 months. Linear mixed-effects models tested time and diet effects. Results: At 15 months, LVEDD data were available for 31 of 92 participants (33.7%). Achieved protein intake was similar between randomized groups. Among 92 participants, LVEDD changed significantly over time (F(2, 51.20) = 7.45, p = 0.001), with model-estimated mean LVEDD decreasing from 59.00 mm at baseline to 54.56 mm at 15 months. LVEDD decreased from 3 to 15 months (-4.42 mm; 95% CI, -7.52 to -1.33; nominal p = 0.006; Holm-adjusted p = 0.012) and from baseline to 15 months (-4.44 mm; 95% CI, -6.86 to -2.02; nominal p < 0.001; Holm-adjusted p = 0.002). LVEF did not change significantly over time (overall p = 0.074); an exploratory baseline-to-15-month contrast was +4.11 percentage points (95% CI, 0.55-7.67; Holm-adjusted p = 0.072). LVPWT did not change significantly, and no diet group × time interactions were observed. Conclusions: LVEDD was lower at longer-term follow-up. LVEF did not change significantly over time, although an exploratory baseline-to-15-month contrast suggested an increase. Because both groups received hypocaloric diets, there was no non-dietary control group, and longitudinal HF medication data were unavailable, the observed cardiac changes cannot be attributed specifically to weight loss or the dietary intervention.

PMID 42884690
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PubMedBiology2026-10-16

Rice Bran as a Sustainable Feed Material Substitute to Improve the Meat Quality in Late-Stage Wenchang Chicken.

Liu Jie J, Wei Limin L, Guo Qiqi Q, Yuan Jingli J et al.

The growing competition between humans and livestock for corn-soybean based feed calls for sustainable alternatives like rice bran. This study assessed substituting feed with rice bran (0%, 5%, 10%, 15%, 20%) in diets for slow-growing Wenchang chickens, a prized Chinese yellow-feathered breed. Up to 15% substitution maintained final body weight and average daily gain, but 20% substitution reduced body weight. Feed intake rose significantly at 10-20% substitution. Substituting 15-20% rice bran for feed significantly reduced abdominal fat without affecting slaughter performance or serum biochemical indicators. Meat quality had trade-offs: thigh muscle redness improved at 15%, and breast muscle fibers changed, but water-holding capacity decreased with increased cooking loss. Breast muscle intramuscular fat and inosinic acid increased, while fatty acid profiles changed, reducing both beneficial (e.g., oleic acid) and undesirable trans fatty acids at ≥10%, and saturated fatty acids in thigh muscle at 15%. Moreover, in the 20% group, alanine and glycine levels in breast muscles were notably lower than in the control and 5% groups. Additionally, the 15-20% group showed a significant reduction in total amino acids, the 10-20% group showed a significant reduction in flavor amino acids, and various free amino acids in thigh muscles were also reduced compared to the control group. Rice bran affected meat quality and nutrition, with mixed effects. Notably, incorporating a 10% rice bran substitute in the diet can improve meat quality traits in slow-growing yellow-feathered broiler chickens without impacting production performance.

PMID 42883359
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PubMedBone research2026-10-16

15-PGDH inhibition in osteoarthritis: PGE2 skeletal interoception, cartilage regeneration and compartment-managed disease modification.

Chen Qiaojie Q, Zhang Haijun H, Chen Yang Y, Zhang Bo B

Osteoarthritis is a whole-joint disease in which cartilage loss, synovial inflammation, subchondral bone remodelling and pain-related neural changes co-evolve, yet structural improvement does not reliably translate into pain relief. This Review centres prostaglandin E2 (PGE2) skeletal interoception in the translational framework for 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibition. In skeletal interoception, PGE2 produced in mechanically stressed bone and osteochondral tissues is sensed by prostaglandin E receptor 4 (EP4)-positive sensory afferents, relayed to central circuits and translated into altered sympathetic norepinephrine output. Because 15-PGDH catabolises PGE2, its inhibition may prolong the persistence and spatial reach of this interoceptive cue while also acting locally on chondrocyte state. This combined local and interoceptive action offers a plausible mechanism for cartilage repair and pain modulation, but may also create compartment-specific risk when prolonged PGE2 persists in synovium or subchondral bone. We compare 15-PGDH inhibition with upstream synthesis blockade and receptor-specific strategies, and propose that development should be organised around three checkpoints: cartilage-enriched exposure, durability under mechanical load and structure-pain coherence. Current evidence supports cautious development rather than broad generalisation; clinical translation will require compartment-resolved pharmacokinetics/pharmacodynamics, EP-receptor attribution and early surveillance for synovial, osteochondral and pain-system liabilities.

PMID 42881169
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PubMedFoods (Basel, Switzerland)2026-10-16

Dynamics of Mycotoxins, Microbial Communities, and Quality of Corn When Stored at Various Temperatures.

Yuan Yixuan Y, Lyu Pengwen P, Shi Ze Z, Li Junze J et al.

Corn is a major grain crop in China; however, mycotoxin contamination during storage threatens grain quality. In this study, naturally contaminated corn was stored at 15 °C or 35 °C under 65 ± 5% relative humidity for 8 months, with monthly sampling. Mycotoxin contents and fungal communities were analyzed, and the major quality indicators of corn were evaluated. Under both storage conditions, aflatoxins and ochratoxin A remained below detection limits. At 15 °C, fumonisins B1 and B2 decreased by 3.2% and 2.5%, respectively, after 8 months of storage. FB3 reached 41.51 ± 2.10 μg/kg at month 8, representing a 17.3% decrease. Deoxynivalenol and zearalenone remained relatively stable. At 35 °C, the concentrations of FB1, FB2, and FB3 reached 414.85 ± 3.27, 59.52 ± 1.53, and 91.76 ± 2.04 μg/kg, respectively. These five toxins increased by 13.8%, 40.0%, 82.8%, 10.4%, and 26.1%, respectively. Analysis of fungal communities indicated that dominant taxa differed between storage conditions, with higher relative abundance of Fusarium at 35 °C and higher Trichoderma at 15 °C. Storage at 35 °C resulted in a significant decrease in crude fat, starch content, germination rate, and antioxidant enzyme activity compared with conditions at 15 °C, while free fatty acid content increased. Storage at 15 °C limited toxin accumulation and quality deterioration compared with 35 °C. Temperature control can therefore improve corn preservation.

PMID 42883545
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PubMedJournal of clinical medicine2026-10-16

Ketoacidosis at Hypoglycemic and Low Glucose Levels Associated with SGLT2 Inhibitor Use: A Descriptive Systematic Review of Published Cases.

Itagaki Hideya H, Endo Tomoyuki T

Background/Objectives: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are increasingly used for heart failure and chronic kidney disease beyond type 2 diabetes, increasing exposure among people without diabetes. Ketoacidosis is a recognized complication, but presentations at low blood glucose (<100 mg/dL) fall outside the familiar euglycemic diabetic ketoacidosis (DKA) alert and are easily missed. We aimed to describe the clinical phenotype of such cases; this review was not registered. Methods: We systematically searched PubMed and Web of Science (to 25 June 2026) and included only peer-reviewed case reports and case series describing ketoacidosis with a documented blood glucose <100 mg/dL at or near diagnosis during ongoing SGLT2 inhibitor use or within approximately two weeks after discontinuation. Reporting completeness was assessed with the CARE (Case Report) checklist; analyses were descriptive. Results: Fifteen cases met the criteria (median age 61 years; 6/15 nondiabetic; 6/15 receiving it for heart failure). Median glucose was 68 mg/dL (n = 15; 10/15 <70). Metabolic acidosis was frequently marked (median pH 7.17 [n = 14], anion gap 19.9 [n = 13], β-hydroxybutyrate 5.0 mmol/L [n = 11]). Fasting or poor oral intake was the commonest precipitant (11/15). Among six cases with extractable timing, three occurred within 24 h. Blood glucose was not correlated with β-hydroxybutyrate in this small exploratory sample (Spearman ρ = -0.20; n = 11; p = 0.56). One death occurred (aspiration). Conclusions: This descriptive synthesis characterizes ketoacidosis occurring at hypoglycemic and low glucose levels reported in SGLT2 inhibitor users, including nondiabetic and cardiorenal patients. The design cannot establish incidence, risk, or causality (very low certainty of evidence); clinicians should nonetheless consider ketoacidosis in exposed patients with anion-gap acidosis or ketosis even without hyperglycemia.

PMID 42882058
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