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Factor VIIa (AryoSeven)

✓ Approved

AryoGen Pharmed · F7 · Recombinant Proteins

What is Factor VIIa?

Factor VIIa is a recombinant proteins developed by AryoGen Pharmed. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesAryoSeven
CompanyAryoGen Pharmed
Drug ClassRecombinant Proteins, Cell-based Therapies
Molecular TargetF7
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, AryoGen Pharmed

Mechanism of Action

Molecular Targets

Factor VIIa acts on 1 molecular target:

F7coagulation factor VII (SPCA)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

Factor VIIa is developed for 4 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Vascular disordersExtravasation blood✓ Approved
Congenital, familial and genetic disordersFactor IX deficiency✓ Approved
Congenital, familial and genetic disordersFactor VIII deficiency✓ Approved
Vascular disordersHaemorrhage✓ Approved

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Factor XIII (FXIII) deficiency is a rare bleeding disorder that can be easily missed because routine coagulation tests remain normal. We report a 32-year-old Nicaraguan man who carried a childhood diagnosis of von Willebrand disease and was inadvertently managed with cryoprecipitate for 25 years, a treatment that incidentally corrected his true underlying deficiency due to its high FXIII content. After immigrating and transitioning to von Willebrand factor/Factor VIII concentrate, he developed recurrent life-threatening intracranial hemorrhages. FXIII activity testing ultimately revealed a level of less than 5%, confirming severe FXIII deficiency. He was started on FXIII concentrate prophylaxis with no further bleeding events. This case highlights how diagnostic anchoring and inadvertent treatment with cryoprecipitate can mask FXIII deficiency for decades. Furthermore, it underscores the importance of considering FXIII testing in patients with severe or recurrent bleeding and normal standard coagulation studies.

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Kartal Özcan Ahsen A, Çiprut Ayça A, Aktaş Selman S

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Authentic leadership has been associated with work-related well-being, job satisfaction, and quality of nursing care. However, psychometric evidence supporting instruments used to assess this construct remains limited across Latin American nursing contexts, highlighting the need for further validation studies. To evaluate evidence of validity for the Authentic Leadership Questionnaire (ALQ) among nursing staff in a Latin American context. This cross-sectional methodological study included 418 nursing staff members-registered nurses and nursing assistants-selected through proportional stratified sampling from a public high-complexity hospital in Cali, Colombia, between May and October 2025. SELF and RATER versions of the ALQ were evaluated using confirmatory factor analysis. Four measurement models were compared for each version: unidimensional, correlated four-factor, second-order, and bifactor models. The final model was assessed through standardized loadings, internal consistency (McDonald's omega, ordinal alpha, composite reliability), measurement invariance (configural, metric, scalar) between nursing staff members, and correlations with job satisfaction. The revised correlated four-factor model (excluding item 9) showed the best fit (ALQ-RATER: CFI= 0.998, TLI= 0.997, SRMR= 0.045, RMSEA= 0.079; ALQ-SELF: CFI= 0.996, TLI= 0.995, SRMR= 0.047, RMSEA= 0.050). Factor loadings were significant (RATER λ = 0.661-0.945; SELF λ = 0.671-0.897). Reliability was adequate (ALQ-RATER: ω = 0.883-0.938, ordinal α = 0.887-0.952, CR = 0.899-0.957; ALQ-SELF: ω = 0.801-0.847, ordinal α = 0.846-0.880, CR = 0.850-0.880). Configural, metric, and scalar invariance were supported. Registered nurses demonstrated significantly higher latent means across all authentic leadership dimensions than nursing assistants. All ALQ dimensions were positively associated with intrinsic job satisfaction (r = 0.287-0.550) and satisfaction with supervision (r = 0.336-0.633). The ALQ demonstrated evidence of structural validity, reliability, measurement invariance, and external validity among Colombian nursing staff. The instrument can be used to assess authentic leadership in healthcare settings, support leadership development initiatives, and facilitate research examining its relationship with job satisfaction.

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The primary duties of emergency healthcare professionals (EHPs) are to provide emergency patient care to acutely ill and injured individuals. Due to the nature of their work, EHPs operate under constant stress, often requiring rapid decision-making, swift action, and the delivery of necessary medical care in life-or-death situations, sometimes under inadequately safe conditions. Therefore, the aim of this study is to determine the validity and reliability of the Emergency Healthcare Professional Stress Factors and Symptoms (SEHP:SFMS) Scale in Turkish for identifying stress factors and symptoms in emergency medical care professionals providing emergency patient care services. A methodological study design was used in this study. The study was conducted with the participation of 211 EHPs from employees working in emergency care institutions affiliated with the Muğla Provincial Health Directorate between November 2023 and June 2024. Data were collected via a face-to-face survey. Data were analysed using Lawshe content validity ratio, Kaiser-Meyer-Olkin coefficient, Bartlett test, exploratory factor analysis, principal component analysis, Varimax factor rotation method, confirmatory factor analysis, Cronbach's α internal consistency coefficient, convergent validity, discriminant validity, test-retest, and Spearman correlation coefficient tests. The linguistic translation and cultural adaptation of the SEHP:SFMS showed strong performance. The scope validity index of the scale is 0.83. The item-total correlation values of the scale were found to be between 0.486 and 0.794, and the factor loadings were between 0.474 and 0.816. Confirmatory factor analysis fit indices: χ2 = 248.727; df = 101; n = 211; p = 0.000; χ2/df = 2.463; RMSEA = 0.083; CFI = 0.914, SRMR = 0.052, which was found to be compatible and acceptable with the proposed 3-factor model. The Cronbach's α reliability coefficient of the scale was 0.931, and the total variance was 61.97%. SEHP:SFMS is a valid and reliable tool to assess stress factors and symptoms of Turkish emergency healthcare professionals. Its use improves the quality of emergency care. These study findings have been used to create a tool with Turkish validity and reliability that allows for the examination of stress factors among healthcare professionals working in emergency and critical services. Identifying and reducing stress factors among healthcare professionals is crucial for the delivery of quality healthcare services. It can also be used to develop targeted interventions and ongoing strategies to facilitate improved clinical supervision and mentoring. Nurses in emergency departments, which are among the most stressful, dynamic, intense, life-saving, and critical environments in healthcare institutions, and where life-saving treatment is administered, are at high risk of experiencing psychological trauma. Trauma experienced in the work environment is a significant problem for nursing. The consequences of trauma negatively affect nurses and institutions. Studies show that post-traumatic stress, anxiety, depression, and burnout are commonly observed in emergency department nurses. In this sense, understanding the stress and stress factors experienced by nurses can guide future interventions. The results of this study are considered important in making visible the stress and stress factors experienced by nurses in the emergency department, and also in guiding managers and nurses working in this field in terms of preventive and protective measures.

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