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Factor VIIa (AryoSeven)

✓ Approved

AryoGen Pharmed · F7 · Recombinant Proteins

What is Factor VIIa?

Factor VIIa is a recombinant proteins developed by AryoGen Pharmed. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesAryoSeven
CompanyAryoGen Pharmed
Drug ClassRecombinant Proteins, Cell-based Therapies
Molecular TargetF7
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, AryoGen Pharmed

Mechanism of Action

Molecular Targets

Factor VIIa acts on 1 molecular target:

F7coagulation factor VII (SPCA)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

Factor VIIa is developed for 4 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Vascular disordersExtravasation blood✓ Approved
Congenital, familial and genetic disordersFactor IX deficiency✓ Approved
Congenital, familial and genetic disordersFactor VIII deficiency✓ Approved
Vascular disordersHaemorrhage✓ Approved

Related Research Articles

PubMedDiagnostics (Basel, Switzerland)2026-10-16

Thromboelastographic Assessment of the Differential Sensitivity of Three Contact Activators to Coagulation Factor Deficiencies in Hemocell Environments.

Liang Weiguo W, Xia Mao M, Li Junpo J, Li Fuyang F et al.

Background: Thromboelastography (TEG) assesses global coagulation, but its sensitivity for factor deficiencies is reportedly low and may depend on the contact activator. However, the differential TEG sensitivity of contact activators for individual factor deficiencies in whole blood containing platelets and red blood cells remains unclear. This study assessed the relative sensitivity of three contact activators for detecting single coagulation factor deficiencies in reconstituted whole-blood samples using TEG. Methods: Reconstituted whole-blood samples with graded activities of FII, FV, FVIII, FIX, FX, FXI, and FXII were prepared by mixing platelets, plasma, and red blood cells, and analyzed by TEG using kaolin-, ellagic acid-, and colloidal silica-based activators (KL, EA and CS). Relative sensitivity was assessed via: (1) the factor activity at which R time first showed a statistically significant prolongation; (2) a novel metric, Sensitivity for Detecting Factor Deficiencies (SDFD), defined as the normalized relative change in R time, enabling comparison without reference ranges. Results: KL showed the broadest and highest sensitivity, detecting significant prolongation at the mildest deficiency levels for most factors. EA showed intermediate-to-high sensitivity and the highest sensitivity for FXII. CS was the least sensitive except for FV. Notably, the activity threshold of KL for exceeding the reference range was substantially lower than that for statistical significance. Conclusions: The sensitivity of TEG to coagulation factor deficiencies is dependent on the contact activator. KL showed the highest overall sensitivity to factor deficiencies, while EA showed the highest sensitivity for FXII deficiency under the conditions of this study. R time of KL can be significantly prolonged yet still stay within the reference range. This mismatch calls for more sensitive TEG reagents and stricter ranges.

PMID 42882372
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PubMedJournal of the American Heart Association2026-10-16

Temporal Dynamics of Complement Activation and Outcome in Patients With Acute Ischemic Stroke.

Wang Yan Y, Westendorp Willeke F WF, Bijlsma Merijn W MW, Tanck Michael W T MWT et al.

Immune-mediated inflammatory responses exacerbate brain injury and affect the prognosis in acute ischemic stroke. We characterized longitudinal complement activation after acute ischemic stroke using serial plasma samples from 10 patients and 8 controls. Initial markers of classical (C1q), lectin (mannose-binding lectin), and alternative (complement factor Bb) pathways, as well as regulatory (complement factor H) and downstream markers (C3a, C5a, and C5b-9) were measured by ELISA at 9 time points. Patients with stroke showed broad complement activation, with increased C1q, mannose-binding lectin, complement factor Bb, C3a, C5a, and C5b-9, and reduced complement factor H compared with controls. Complement components showed distinct temporal patterns during follow-up. Complement factor Bb levels were lower in patients with unfavorable functional outcome and in those with moderate-to-severe stroke. C1q and C3a trajectories differed according to functional outcome, whereas C3a trajectories also differed according to stroke severity. C1q trajectories differed according to age group and infarct volume. These findings suggest dynamic, pathway-specific complement activation after acute ischemic stroke and highlight the need for larger studies to clarify its prognostic and therapeutic relevance.

PMID 42885785
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PubMedNutrients2026-10-16

Fit-Ideal Internalisation and Disordered Eating in Adolescent Girls: Psychometric Evaluation and Incremental Validity of the Fit Internalization Test.

Baceviciene Migle M, Balciuniene Vaiva V, Jankauskiene Rasa R

The present study aimed to validate the Lithuanian translation of the Fit Ideal Internalization Test (FIIT) in adolescent girls. A total of 1067 girls (mean age = 17.27, SD = 0.61; age range = 15-19 years) participated in the study. FIIT, muscular ideal internalization, body dissatisfaction (BD), disordered eating (DE), body appreciation (BA), and exercise motivation were assessed. Exploratory factor analysis (n = 534) replicated the original three-factor structure, explaining 74.43% of the total variance. Confirmatory factor analysis (n = 533) supported the three-factor model, with strong factor loadings. Composite reliability was excellent (McDonald's ω = 0.919-0.969). Measurement invariance was established across sport participation groups, and sport-involved girls reported higher Fit Drive, Fit Overvaluation, and FIIT total scores than non-sport-involved girls. All FIIT subscales were positively associated with muscular internalization, BD, and DE and negatively associated with BA, while Fit Idealisation and Fit Overvaluation showed weak negative associations with autonomous exercise motivation, consistent with the hypothesised pattern of associations. The FIIT explained significant additional variance in DE beyond body mass index, BD, and muscular ideal internalization, with Fit Idealisation showing the strongest unique association (β = 0.401, p < 0.001). The Lithuanian FIIT appears to be a psychometrically sound instrument for assessing fit ideal internalization among Lithuanian adolescent girls.

PMID 42884698
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PubMedCells2026-10-16

Placental Insulin-like Growth Factor Signaling and Neurodevelopment: Emerging Evidence from the Placenta-Brain Axis.

Carver Annemarie J AJ, Williamson Eleanor G EG, Stevens Hanna E HE

The field of neuroplacentology is a growing area that focuses on the influence of placental function on brain development. This field has expanded our understanding of the placenta's crucial role in proper neurodevelopment as well as placental anomalies that increase the risk of adverse neurodevelopmental outcomes. Neuroplacentology studies have revealed distinct roles of placentally provided hormones and nutrients in neurodevelopment whose disruption by perinatal problems, including inflammation, can increase the risk of neurodevelopmental disorders such as autism spectrum disorder and ADHD. Placental insulin-like growth factor signaling significantly influences brain growth in animal model studies and is tightly linked with human neurodevelopmental outcomes. Insulin-like growth factor signaling is well-established as a regulator of placental function and is fundamental in fetal brain cell developmental processes and plays a role in inflammation. Placental insulin-like growth factor signaling underlies the placental production and delivery of hormones and nutrients that are necessary for fetal neural cell proliferation, differentiation, and growth. It is especially important to study this pathway in the placenta due to aberrant insulin-like growth factor signaling found in conditions such as preterm birth, fetal growth restriction, gestational diabetes, and obesity. All these conditions are linked to a greater risk for neurodevelopmental disorders, neuroinflammation, and other anomalies. This research subfield has also revealed sex differences in the insulin-like growth factor signaling pathway that will contribute to understanding the etiologies of these conditions. This area of study has and will continue to identify specific mechanisms, many currently in model systems, which could eventually be leveraged in preventative and interventive care to improve neurodevelopmental outcomes.

PMID 42882457
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PubMedHealthcare (Basel, Switzerland)2026-10-16

Development and Psychometric Evaluation of the Peritoneal Dialysis Treatment Adherence Scale: A Multicenter Methodological Study.

Aydın Zehra Z, Sarıbudak Tuğba Pehlivan TP

Background/Objectives: Peritoneal dialysis (PD) requires patients to manage dialysis procedures, medications, fluid intake, and nutrition at home. Existing assessment approaches do not adequately distinguish patients' treatment-related knowledge and awareness from their self-reported adherence practices across these domains. This study aimed to develop and psychometrically evaluate the Peritoneal Dialysis Treatment Adherence Scale, a patient-reported instrument designed to assess treatment-related knowledge/awareness and self-reported adherence practices in peritoneal dialysis. Methods: This multicenter methodological study included 600 adults receiving PD at eight hospitals in Türkiye. An initial 64-item pool was evaluated by 12 experts and pilot-tested with 30 patients. The main sample was randomly divided into two independent subsamples of 300 participants for exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). EFA was conducted using principal axis factoring with direct oblimin rotation, and Horn's parallel analysis was used to determine factor retention. CFA was conducted in the independent confirmatory subsample. Internal consistency was evaluated using Cronbach's alpha and McDonald's omega, and three-week test-retest reliability was assessed in 30 participants using intraclass correlation coefficients. Results: The final instrument comprised a 32-item Knowledge Dimension, assessing self-reported treatment knowledge and awareness, and a 25-item Adherence Practices Dimension, assessing the frequency and consistency of self-reported adherence practices. Primary factor loadings ranged from 0.694 to 0.971 for Knowledge and from 0.508 to 0.951 for Adherence Practices, with no items meeting the prespecified criterion for problematic cross-loading. Separate four-factor CFA models demonstrated acceptable within-dimension fit; however, the additional integrated eight-factor CFA including all 57 items did not meet all conventional global-fit criteria, indicating that the overall measurement structure requires further independent validation. Internal consistency in the independent confirmatory subsample was high for both dimensions: Knowledge, α = 0.950 and ω = 0.984; Adherence Practices, α = 0.952 and ω = 0.986. Test-retest reliability was strong for Knowledge (ICC = 0.946) and Adherence Practices (ICC = 0.940). Conclusions: The Peritoneal Dialysis Treatment Adherence Scale demonstrated promising but provisional structural evidence, high internal consistency, and strong temporal stability. Its separately scored Knowledge and Adherence Practices dimensions may support domain-specific assessment in PD; however, the overall eight-factor measurement structure requires further independent validation before widespread clinical use.

PMID 42881777
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PubMedNutrients2026-10-16

Turkish Adaptation of the Clean Food Consumerism Scale: A Validity and Reliability Study.

Sipahi Uygur Simge S, Çakır Biçer Nihan N, Öneş Ece E, Roberts Sena S et al.

Background: Clean food consumerism reflects consumers' preferences for foods perceived as natural, authentic, transparent, and health-promoting. This study aimed to culturally adapt the Clean Food Consumerism Scale (CFCS) into Turkish and evaluate its psychometric properties. Methods: The CFCS was translated, back-translated, reviewed by experts, pilot-tested, and psychometrically evaluated. For the pilot study and factor analyses, the Turkish version was administered to 1637 adults, who were allocated to three mutually exclusive subsamples: n = 180 for the pilot study, n = 500 for EFA, and n = 957 for CFA. An additional, separate sample of 124 participants completed the CFCS twice at a three-week interval for the test-retest analysis. Internal consistency, construct validity, convergent validity, discriminant validity, criterion validity, and test-retest reliability were assessed using Cronbach's alpha, item-total correlations, EFA, CFA, composite reliability (CR), average variance extracted (AVE), the Fornell-Larcker criterion, heterotrait-monotrait (HTMT) ratios, correlations with the Sustainable and Healthy Eating Behaviors Scale (SHEBS), and test-retest correlations. Results: The 18-item CFCS demonstrated excellent internal consistency (Cronbach's α = 0.948). Sampling adequacy was supported by the KMO value (0.927) and significant Bartlett's test (χ2 = 7525.229, p < 0.001). EFA supported a five-factor structure comprising Perceived Health Benefits, Production Process Transparency, Authenticity, Perceived Ease of Use, and Familiarity, explaining 80.92% of the total variance. CFA supported the five-factor model. After adding one content-justified residual covariance between two closely related Perceived Health Benefits items, the final model showed acceptable fit (χ2 = 641.39, df = 124, p < 0.001; CFI = 0.965, TLI = 0.956, NFI = 0.957, RMSEA = 0.066 [90% CI 0.061-0.071], SRMR = 0.047, GFI = 0.926, AGFI = 0.899). Standardized factor loadings ranged from 0.748 to 0.938, composite reliability from 0.873 to 0.940, and average variance extracted from 0.697 to 0.771. HTMT ratios for all factor pairs remained below 0.685 and the Fornell-Larcker criterion was satisfied for every factor, supporting discriminant validity. Test-retest reliability over three weeks was excellent (r = 0.889, p < 0.001), and CFCS scores were positively correlated with SHEBS scores (r = 0.441, p < 0.001). Conclusions: The Turkish version of the CFCS demonstrated strong validity, reliability, and temporal stability while preserving the original five-factor structure. It provides a psychometrically sound instrument for assessing clean food consumerism among Turkish-speaking adults and may support future research in nutrition, public health, sustainability, and consumer behavior.

PMID 42884725
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