Drug Database
BR

bronchitis vaccine

✓ Approved

China National Pharmaceutical · Cell-based Therapies · Cell-based Therapies

What is bronchitis vaccine?

bronchitis vaccine is a cell-based therapies developed by China National Pharmaceutical. It is approved for therapeutic indications via unknown.

Drug Profile

CompanyChina National Pharmaceutical
Drug ClassCell-based Therapies, Vaccine
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, China National Pharmaceutical

Therapeutic Indications

bronchitis vaccine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersBronchitis chronic✓ Approved

Related Research Articles

PubMedNutrients2026-10-16

Persimmon By-Products: Bioactive Phytochemicals, Sustainable Valorization and Potential Food and Health Applications.

Wang Huiwen H, Hou Weishi W, Anwar Haseeb H, Arshad Muhammad Sajid MS et al.

Persimmon (Diospyros kaki L.) has gained increasing attention as a functional fruit due to its rich bioactive phytochemicals; however, a substantial proportion of its biomass, including peels, seeds, leaves, and calyx, remains underutilized. This review comprehensively examines the phytochemical composition, biological activities, and potential applications of persimmon by-products, with particular emphasis on their role in sustainable food systems and value-added product development. A comprehensive review of the literature was conducted across major databases, including Scopus, Web of Science, PubMed, and ScienceDirect, covering studies published between 2000 and 2025. The findings indicate that persimmon by-products are rich sources of phenolic acids (e.g., gallic, caffeic, and ferulic acids), flavonoids (e.g., quercetin and catechin derivatives), carotenoids, tannins, dietary fibre, and bioactive lipids. These compounds exhibit diverse biological activities, including antioxidant, anti-inflammatory, antidiabetic, hypolipidemic, and antimicrobial effects, with the available evidence being primarily derived from in vitro and in vivo studies. Additionally, recent research highlights their potential applications in food products, food supplements, nutraceutical research, and other health-related products. Despite these promising findings, limitations related to variability in extraction methods, lack of standardized assays, and limited clinical validation remain significant challenges. Overall, this review provides a comprehensive synthesis of current knowledge and identifies key research gaps to support the future evaluation and responsible utilization of persimmon by-products in food and health-related applications.

PMID 42884645
Read full article →
PubMedMolecules (Basel, Switzerland)2026-10-16

Dereplication of Natural Products from an Endophytic Fungus from Ocotea diospyrifolia with Anti-Inflammatory Potential Through Dual Modulation of PGE2 and LTB4 Release.

Oliveira Giovanni S GS, Marques Marcus V A MVA, Nascimento Ana L U ALU, Santos Valmore H P VHP et al.

Endophytic fungi are significant sources of structurally diverse natural products with promising pharmacological and biological applications. In this study, endophytic fungi isolated from Ocotea diospyrifolia leaves were investigated as potential producers of anti-inflammatory natural products using an integrated workflow combining biological screening, comparative metabolomics, and high-resolution mass spectrometry-based dereplication. Crude extracts from five endophytic fungi (designated as OD1, OD5, OD6, OD7, and OD8) were screened for their ability to inhibit prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) release. Lentinus sp. OD5 extract displayed promising dual inhibitory activity, and its UHPLC-QTOF-HRMS-based metabolomic profiling enabled the annotation of two compounds. Mass spectrometry data analysis, combined with SIRIUS annotation, putatively identified rhodojaponin, a grayanane diterpene with reported anti-inflammatory activity, and tinocordiside, an immunomodulatory diterpenoid glycoside. These findings expand the chemical diversity currently associated with endophytic fungi and provide a strong foundation for the future isolation, structural confirmation, and pharmacological evaluation of anti-inflammatory metabolites with potential therapeutic applications.

PMID 42883263
Read full article →
PubMedMolecules (Basel, Switzerland)2026-10-16

Bee-Derived Products in Neurodegenerative Diseases: Bioactive Constituents, Redox-Modulating Mechanisms, Evidence, and Translational Perspectives.

Garbarek Jakub J, Hys Oskar O, Woźniak Alina A, Szewczyk-Golec Karolina K et al.

Oxidative stress, mitochondrial dysfunction, and chronic neuroinflammation are closely interconnected processes involved in the pathogenesis and progression of neurodegenerative diseases. Bee-derived products, including honey, propolis, royal jelly, bee pollen, bee bread, and bee venom, contain diverse bioactive constituents with antioxidant, anti-inflammatory, immunomodulatory, and redox-modulating properties. This narrative review summarizes the major bioactive compounds present in bee-derived products and evaluates their potential relevance to neuroprotection. Particular attention is given to mechanisms involving activation of the Nrf2/ARE antioxidant response, inhibition of NF-κB-dependent inflammatory signaling, modulation of the NLRP3 inflammasome, mitochondrial protection, regulation of apoptosis, and maintenance of proteostasis. Available evidence from cellular and animal models, together with the limited clinical data, is discussed primarily in the context of Alzheimer's and Parkinson's diseases, with additional consideration of amyotrophic lateral sclerosis and other neurodegenerative or neuroinflammatory conditions. Although several bee-derived products and isolated constituents show promising biological effects, their therapeutic translation remains limited by variable chemical composition, insufficient standardization, low or uncertain bioavailability, limited evidence of central nervous system exposure, and safety concerns. Further mechanistic, pharmacokinetic, and well-controlled clinical studies are therefore required before their potential neuroprotective applications can be reliably established.

PMID 42883328
Read full article →
PubMedMolecules (Basel, Switzerland)2026-10-16

Cooking Oil-Derived Aldehydes: Overlooked Components of the Western Diet with the Potential to Disrupt Fetal Brain Development.

Shanahan Catherine C, Grootveld Martin M

Dietitians routinely recommend refined high polyunsaturated fatty acid (PUFA) content culinary oils such as soybean, corn, canola, rapeseed and sunflower oils to pregnant women. Unfortunately, these PUFAs readily undergo peroxidation (especially at high frying or cooking temperatures), generating toxic lipid oxidation products, including reactive aldehydes and oxidized lipid mediators with established biological activities that may negatively impact fetal brain development. This hypothesis-driven perspective paper proposes a conceptual framework linking the maternal consumption of oils contaminated with lipid oxidation products to fetal neurodevelopmental vulnerability. We also identify key research priorities, including improved exposure assessments, the development of reliable aldehyde and other oxylipin biomarkers, and controlled dietary intervention studies. Such investigations will help clarify whether these commonly consumed culinary oils meaningfully contribute to the increasing rates of adverse neurodevelopmental outcomes.

PMID 42883294
Read full article →
PubMedInternational journal of molecular sciences2026-10-16

Food-Grade By-Products as Sustainable Sources of Phytochemicals: Green Extraction Strategies, Encapsulation Technologies, and Applications in Functional Food Development.

Kruczek Marek M, Pokorski Patryk P, Drygaś Barbara B, Gumul Dorota D

Food-industry by-products, including fruit and vegetable pomace, peels, and seeds, are increasingly recognized as sustainable sources of bioactive compounds, particularly phenolic compounds and carotenoids, including anthocyanins and lycopene. These phytochemicals exhibit a range of biological activities; however, their application in food systems is often limited by poor stability, low bioavailability, and susceptibility to environmental degradation. This review summarizes recent advances in the recovery and stabilization of bioactive compounds from food-industry by-products. Particular attention is given to green extraction technologies, including ultrasound-assisted, microwave-assisted, pressurized liquid, and supercritical fluid extraction, which can improve extraction efficiency while reducing solvent consumption and environmental impact. Furthermore, conventional and emerging encapsulation approaches, such as spray drying, ionic gelation, nanoemulsions, Pickering emulsions, liposomes, and lipid nanoparticles, are discussed as strategies to improve the stability, bioaccessibility, and delivery of recovered phytochemicals. The integration of green extraction and encapsulation technologies offers a promising strategy for the valorization of food processing residues and the development of innovative functional food ingredients. Such integrated approaches may contribute to waste reduction, improved resource efficiency, and the implementation of circular economy principles in food production.

PMID 42884105
Read full article →
PubMedInternational journal of molecular sciences2026-10-16

Immune Profiles Elicited by Different HBV Vaccine Modalities and Their Associations with Serological and Intrahepatic Viral Outcomes.

Xiao Huiying H, He Jinhang J, Zhu Lili L, Wang Songmei S et al.

Therapeutic vaccination for chronic hepatitis B aims to restore HBV-specific T-cell immunity and contribute to a functional cure. We systematically compared the immune profiles and antiviral efficacy of four vaccine modalities: recombinant HBsAg (rHBsAg), antigen-antibody immune complex (IC), a DNA vaccine encoding HBsAg (DNA-HBsAg), and an HBsAg-Fc fusion DNA vaccine (DNA-HBsAg-Fc). In naïve mice, the rHBsAg vaccine predominantly induced anti-HBs IgG responses, whereas the IC vaccine elicited strong anti-HBs IgG and detectable CD4+ T-cell responses. In contrast, DNA vaccines preferentially induced HBsAg-specific CD8+ T-cell immunity, which was further enhanced by fusion to the Fc fragment of human IgG1. In the pre-immunization/AAV-HBV model, high anti-HBs titers in rHBsAg and IC groups were associated with rapid clearance of circulating HBsAg but not with comparable reductions in HBcAg+ hepatocytes, whereas stronger HBsAg-specific CD8+ T-cell responses in the DNA vaccine groups were associated with greater reductions in HBcAg+ hepatocytes. However, in the therapeutic AAV-HBV model, all vaccine monotherapies showed limited and non-sustained antiviral efficacy, with only transient reductions in serum HBsAg and limited reductions in HBcAg+ hepatocytes. These findings highlight the distinct immune profiles of different vaccine platforms and an association between stronger HBsAg-specific CD8+ T-cell responses and reduced intrahepatic HBcAg expression, while underscoring the limited efficacy of vaccine monotherapy in the AAV-HBV model.

PMID 42883747
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about bronchitis vaccine