Drug Database
LY

lysine salicylate (lysine salicylate / Dolorosan)

✓ Approved

VUFB · Small Molecule · Small Molecule

What is lysine salicylate?

lysine salicylate is a small molecule developed by VUFB. It is approved for therapeutic indications via unknown.

Drug Profile

Brand Nameslysine salicylate, Dolorosan
CompanyVUFB
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, VUFB

Therapeutic Indications

lysine salicylate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Gastrointestinal disordersAbdominal pain✓ Approved

Related Research Articles

PubMedJournal of animal science2026-10-16

Effects of supplemental leucine and lysine on metabolic and inflammatory responses of neutrophils and peripheral blood mononuclear cells in growing cattle.

Garcia Miriam M, Pearl Kimberly A KA, Titgemeyer Evan C EC, Bradford Barry J BJ

This study evaluated effects of postruminal leucine and lysine supplementation on hematological variables and ex vivo neutrophil and peripheral mononuclear cell (PBMC) responses in steers. Rumen-cannulated steers (n = 7; BW = 173 kg, 5 mo) were assigned to a 6 × 6 Latin square, with one treatment sequence replicated in the seventh steer. Treatments were a factorial arrangement of leucine (0, 15, or 30 g/d) and lysine (0 or 6 g/d) administered via continuous abomasal infusion. Blood was collected on d 7 of infusion for hematological analysis and isolation of neutrophils and PBMC. Neutrophil function was assessed by phagocytosis and oxidative burst, and metabolic responses by glucose concentrations in spent media with or without lipopolysaccharide (LPS). Peripheral mononuclear cells were cultured under concanavalin A (ConA) with or without LPS to evaluate cytokine production, glucose, and mRNA expression. Data were analyzed using the MIXED procedure of SAS with period, lysine, and leucine as fixed effects and steer as a random effect, and orthogonal contrasts were used to evaluate linear and quadratic effects of leucine and their interactions with lysine and LPS. Most hematological variables were not affected by treatment. Lysine increased platelet counts and decreased lymphocyte counts (P = 0.04), whereas hemoglobin tended to increase linearly with increasing leucine (P = 0.10). Neutrophil glucose utilization was not affected by main effects; however, a linear leucine × LPS was detected (P = 0.04), with glucose decreasing as leucine increased in the absence of LPS, but not under LPS. Neutrophil phagocytosis and oxidative burst were not affected by treatment. For PBMC, glucose concentrations were lower under ConA than ConA + LPS (P < 0.001), and a lysine × quadratic leucine was detected (P = 0.01). For PBMC, leucine linearly decreased TNFA (P = 0.05), GLUT1 (P = 0.07), and GLUT3 (P = 0.05) mRNA abundance, whereas lysine tended to increase NFKB1 (P = 0.09). Production of TNF-α was greater under ConA than ConA + LPS (P < 0.001) and was not affected by treatment. In contrast, IFN-γ increased under ConA + LPS (P < 0.001), increased linearly with leucine (P = 0.02), and tended to increase with lysine (P = 0.10). These results show that leucine modulated metabolic responses in neutrophils and both metabolic and inflammatory responses in PBMC, whereas lysine primarily influenced selected hematological variables, with limited effects on PBMC inflammatory signaling.

PMID 42885583
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PubMedInternational journal of molecular sciences2026-10-16

The Catalytically Inactive KDM5B-NTT Isoform Associates with Chromatin and Increases H3K4 Trimethylation in Breast Cancer Cells.

Manzini Valeria V, Di Nisio Elena E, Piana Alessandro A, Perticaroli Valerio V et al.

Histone lysine demethylases are mainly known as transcriptional regulators for their demethylase activity, but catalysis-independent functions are increasingly recognized. This work focuses on lysine-specific demethylase 5B (KDM5B), targeting H3K4me3. The canonical functional isoform is PLU-1. A catalytically inactive N-terminally truncated isoform (NTT) was previously identified in human cell lines. NTT lacks the Jumonji N-terminal (JmjN) domain, responsible for demethylase activity, and part of the AT-Rich Interaction Domain (ARID), but retains the plant homeodomains (PHDs) involved in chromatin interaction. The study aimed to investigate NTT chromatin association, its potential regulatory role, and its phenotypic effects. NTT-FLAG was overexpressed in MCF7 cells, using PLU-1-FLAG and empty vector for comparison. Chromatin association and H3K4me3 distribution were analyzed by Cleavage Under Targets and Release Using Nuclease (CUT&RUN), while migration and invasion were assessed by wound-healing, live-imaging microscopy, and invasion assays. NTT-FLAG and PLU-1-FLAG displayed similar genomic localization, preferentially associating with active promoters enriched in H3K4me3. Both isoforms increased promoter-associated H3K4me3, suggesting that chromatin binding alone is insufficient to promote demethylation. Functionally, NTT overexpression was associated with increased directional migration and invasive capacity compared with PLU-1. Overall, these findings support a catalysis-independent regulatory role for NTT and suggest a model in which chromatin interaction is driven by PHD domains, while co-interactor availability may be required for proper PLU-1 demethylase activity.

PMID 42884018
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PubMedInternational journal of molecular sciences2026-10-16

Poly-L-Lactic Acid Attenuates Fibrotic Remodeling During Cutaneous Wound Healing.

Byun Kyung-A KA, Kim Hyoung Moon HM, Oh Seyeon S, Yu Ki Woong KW et al.

Pathological hypoxia following cutaneous injury is a critical driver of wound chronicity and fibrotic remodeling. The nuclear receptor binding SET domain protein 2 (NSD2)/lysine demethylase 2A (KDM2A)-histone H3 lysine 36 dimethylation (H3K36me2) axis is a known regulator of hypoxia-induced epithelial-to-mesenchymal transition (EMT) in malignancy; however, its role in skin repair remains largely unexplored. We investigated whether poly-L-lactic acid (PLLA) could attenuate fibrotic remodeling by modulating the NSD2/KDM2A-H3K36me2 axis and examining angiogenic signaling. We used a murine 9 mm punch-wound model for in vivo assessment and HaCaT keratinocytes and human dermal fibroblasts (HDFs) exposed to 2% O2 as in vitro hypoxia models. PLLA was administered to evaluate its impact on angiogenic signaling, collagen architecture, and the NSD2/KDM2A pathway. PLLA was associated with increased angiogenic markers and reduced expression of several hypoxia-associated epigenetic and fibrotic markers. In mice, PLLA increased vascular endothelial growth factor (VEGF)/VEGF receptor 2 expression and blood vessel abundance. In addition, PLLA decreased NSD2 and H3K36me2 levels while increasing KDM2A levels. Histological analysis showed less dense collagen staining and a change in the collagen type I/type III staining ratio, alongside a smaller photographically defined residual lesion area. Under controlled hypoxic conditions in vitro, PLLA suppressed EMT-related transcription factors, including Snail, Slug, and Twist, in keratinocytes and attenuated transforming growth factor-β1/phosphorylated mothers against decapentaplegic homolog 2/3 signaling and α-smooth muscle actin expression in fibroblasts. These findings support further study of PLLA-associated changes in vascular, epithelial, and fibrotic markers during wound remodeling.

PMID 42884118
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PubMedNature communications2026-10-16

MAP2-mediated integrin dysregulation reprograms cancer cell plasticity in hepatocellular carcinoma.

Lou Ut Kei UK, Wong Tin-Lok TL, Huang Ianto Bosheng IB, Lam Ka-Hei KH et al.

Targeting tumor cell plasticity is central to overcome drug resistance and metastasis. Through lineage-tracing and lineage-ablation studies, our team has previously shown hepatocellular carcinoma (HCC) cells marked by CD133 to represent a functional subset displaying dedifferentiated status with stemness traits, yet there are limited therapies effective for eradicating such resilient cell populations. Here, we explore the therapeutic potential of repurposing an existing drug estramustine phosphate (EMP) for targeting HCC plasticity through inhibiting MAP2, a gene uniquely enriched in CD133+ 'HCC' stemness subset but not in CD133+ 'normal' regenerative cells. MAP2 is transcriptionally activated by histone 3 lysine 27 acetylation and its upregulation correlates with aggressive clinical features. Mechanistically, MAP2 sustains tumor plasticity and transition to a mesenchymal state through inducing filamentous actin polymerization and YAP activation, which subsequently disrupts integrin expression and cell adhesions. Our research offers a promising opportunity for drug repurposing using EMP in combination with sorafenib to target HCC at its stemness roots.

PMID 42881192
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PubMedInternational journal of molecular sciences2026-10-16

In Vitro Anticancer Activity and Integrated Multi-Target Computational Analysis of Ylang-Ylang Essential Oil Against Breast Cancer.

Chebaibi Mohamed M, Elbouzidi Amine A, Taibi Mohamed M, Haddou Mounir M et al.

Ylang-ylang essential oil (YEO), obtained from Cananga odorata, contains chemically diverse constituents with potential anticancer activity that warrants further investigation. This study investigated the anti-breast-cancer potential of YEO through an integrated experimental and computational approach. The essential oil was chemically characterized by gas chromatography-mass spectrometry, and its in vitro cytotoxic activity was evaluated against ER-positive MCF-7 and triple-negative MDA-MB-231 and MDA-MB-436 breast-cancer cell lines using the MTT assay. Peripheral blood mononuclear cells were included as a preliminary model for assessing cytotoxic selectivity toward non-tumoral cells. To generate hypotheses concerning possible molecular interactions, identified constituents were evaluated against three breast-cancer-relevant targets: estrogen receptor alpha (ER-α), epidermal growth factor receptor (EGFR), and poly(ADP-ribose) polymerase 1 (PARP1). The computational workflow included a structural confidence assessment based on AlphaFold 2, together with CNN-assisted Gnina docking, Glide docking, and in silico ADMET profiling. The in vitro experiments showed that YEO had biological activity against breast-cancer cells, and the computational analyses showed that the ligand profiles were dependent on the target. Gnina identified trans-geranylgeraniol, farnesyl-decanoate and linalool as the top candidates for ER-α, EGFR and PARP1, respectively, while Glide pointed out δ-cadinene for ER-α, benzyl salicylate for EGFR and benzyl benzoate for PARP1. Both benzyl benzoate and α-cadinol also had potentially favorable multi-target binding profiles. The ADMET analysis found that several components had acceptable drug-likeness, but the high lipophilicity of some sesquiterpenes might limit their pharmacokinetic behavior. Overall, the results support the prioritization of selected YEO constituents as candidates for further investigation of potential multi-target anticancer activity. Nevertheless, the docking results remain predictive and do not demonstrate direct target inhibition or molecular synergy. Further biochemical, mechanistic, pharmacokinetic, and in vivo studies are needed to evaluate the biological relevance and translational potential of the prioritized constituents.

PMID 42883803
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PubMedAnimals : an open access journal from MDPI2026-10-16

Ileal Digestibility of Crude Protein and Amino Acids in Bakery and Biscuit Byproducts Fed to Growing Pigs.

Lim Chaibin C, Jung Hyunjung H, Kim Joeun J, Min Yejin Y et al.

This study evaluated the apparent ileal digestibility (AID) and standardized ileal digestibility (SID) of crude protein (CP) and amino acids (AAs) in three bakery and biscuit byproducts fed to growing pigs. Five crossbred barrows fitted with a T-cannula at the distal ileum were allotted to a 5 × 5 Latin square design. The AID of CP was higher in the plain bread meal (PB) and sweet bread meal (SB) than in corn (CN) and biscuit meal (BC) (p < 0.05), while the AID of most indispensable AAs was higher in CN and PB than in BC (p < 0.05), reflecting the dietary CP and total AA concentrations. After correction for basal endogenous AA losses, the SID of CP separated the ingredients more clearly, with PB and SB higher than CN, and CN higher than BC (p < 0.05). The SID of lysine, methionine, threonine, and tryptophan did not differ among the four ingredients, indicating that the digestible supply of these limiting AAs was maintained when corn was replaced with these ingredients. These SID values provide ingredient-level information for incorporating bakery and biscuit byproducts into growing pig diets as alternative feed ingredients alongside corn.

PMID 42883056
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