Drug Database
AC

acetylsalicylic acid + dipyridamole (Asasantin / Asasantin Retard / Asasantine LP)

✓ Approved

Boehringer Ingelheim International GmbH · PTGS1 · Small Molecule

What is acetylsalicylic acid + dipyridamole?

acetylsalicylic acid + dipyridamole is a small molecule developed by Boehringer Ingelheim International GmbH. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesAsasantin, Asasantin Retard, Asasantine LP
CompanyBoehringer Ingelheim International GmbH
Drug ClassSmall Molecule
Molecular TargetPTGS1
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Boehringer Ingelheim International GmbH

Mechanism of Action

Molecular Targets

acetylsalicylic acid + dipyridamole acts on 1 molecular target:

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

acetylsalicylic acid + dipyridamole is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Nervous system disordersDelayed ischaemic neurological deficit✓ Approved
Infections and infestationsCOVID-19Phase III

Related Research Articles

PubMedFoods (Basel, Switzerland)2026-10-16

Melatonin Extends the Edible Window Period of Kiwifruit by Modulating Energy Metabolism and Respiration: A Comparison with 1-Methylcyclopropene and Acetylsalicylic Acid.

Li Xiaomao X, Mei Zulin Z, Zhang Nanxin N, Liu Xianzhi X et al.

The narrow edible window period of kiwifruit poses significant challenges for the high-value fresh fruit industry. This study comparatively evaluated the effects of 1-methylcyclopropene (1-MCP), melatonin (MT), and acetylsalicylic acid (ASA) on "Guichang" kiwifruit by analyzing their physiology, energy metabolism, and transcriptomic profiles. The results indicated that 0.5 μL/L 1-MCP, 1.0 mmol/L MT, and 2.0 mmol/L ASA were the optimal concentrations, all of which significantly inhibited ethylene production and respiration intensity. These treatments effectively maintained fruit firmness, vitamin C content, and high energy status by preserving ATP levels and the activities of H+-ATPase and Ca2+-ATPase while suppressing the activities of CCO, SDH, 6-PGDH, and G-6-PDH. Transcriptomic analysis and RT-qPCR verification revealed that these preservatives re-programmed key respiratory pathways, including glycolysis, the TCA cycle, the pentose phosphate pathway, and oxidative phosphorylation. MT exhibited transcriptomic responses highly similar to 1-MCP (sharing 13 KEGG pathways) and resulted in the lowest decay rate among treatments, whereas 1-MCP showed the strongest maintenance of core firmness. Our findings suggested that MT exhibited promising performance across multiple quality- and energy-related parameters and may serve as a potential alternative treatment for maintaining kiwifruit quality during the edible window period. Future studies should functionally validate the identified candidate genes and evaluate the effects of MT on sensory and flavor attributes under commercial storage and distribution conditions.

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PubMedMolecules (Basel, Switzerland)2026-10-16

Stereochemical 2D NMR Assignment of Thietane, Synthesis and Antiplatelet Activity of Novel Thietane-Containing 1-Isobutylpurine-2,6-dione Derivatives as Potential GPIIb/IIIa Inhibitors.

Khaliullin Ferkat A FA, Mamatov Zhekshen K ZK, Shabalina Iuliia V IV, Wang Yi Y et al.

1-Isobutylpurine-2,6-diones possess a broad spectrum of pharmacological activities, highlighting their relevance in the search for new biologically active agents. In this study, we report the synthesis of a series of novel thietane-containing 1-isobutylpurine-2,6-dione derivatives. A crucial aspect of this work is the detailed stereochemical and conformational analysis of the thietanyl substituent. For the first time, the unambiguous assignment of axial and equatorial protons within the thietane ring was achieved using 2D NMR spectroscopy, exemplified by a comprehensive study of the starting substance. Furthermore, the newly synthesized compounds were evaluated for their antiplatelet activity, revealing inhibition of platelet aggregation exceeding that of acetylsalicylic acid. Based on structural analogy to an established antiplatelet agent, we hypothesize that the observed biological effect is mediated via the inhibition of the glycoprotein IIb/IIIa (GPIIb/IIIa) receptor complex. These findings demonstrate that the incorporation of a thietane fragment into the 1-isobutylxanthine scaffold yields promising candidates for the development of novel GPIIb/IIIa-targeted antiplatelet therapeutics.

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PubMedFoods (Basel, Switzerland)2026-10-16

Protein Composition and Postprandial Aminoacidemia of Biscuits Fortified with Brewer's Spent Grain and Fermented Brewer's Spent Grain in Individuals with Metabolic Syndrome.

Leong Zi Ning ZN, Xu Yujing Y, Chen Jialin J, Chang Yidan Y et al.

Brewer's spent grain (BSG), the main side-stream of beer brewing, is an abundant and low-cost source of plant protein with limited digestibility. Fermentation pre-treatment may improve protein quality by altering amino acid composition and increasing protein accessibility. This study investigated whether the solid-state fermentation of BSG with Rhizopus oligosporus could improve amino acid composition and further elicit a greater postprandial amino acid response after the consumption of BSG-incorporated biscuits in adults with metabolic syndrome (MetS). Control biscuits (100% wheat flour) and biscuits with a 30% substitution of autoclaved BSG and fermented BSG were prepared. Compositional improvements were evaluated via an analysis of total and free amino acids and the amino acid score calculated against adult indispensable amino acid requirements. Fifteen adults with MetS then consumed 90 g of each biscuit in a randomised, double-blind, crossover trial, with postprandial plasma amino acids assessed over 120 min. Incorporating BSG increased the total amino acid content in biscuits, while fermentation further increased free amino acid content. The lysine amino acid score also increased from 0.57 (Control) to 0.81 (fermented BSG). Despite these compositional improvements, postprandial total and essential amino acid responses did not differ between biscuits, indicating a disconnect between improved protein composition and postprandial amino acid responses in individuals with MetS.

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PubMedThe Journal of small animal practice2026-10-16

Urinary liver-type fatty acid-binding protein in cats with lower urinary tract disease.

Culha N N, Acar A A, Ulutas B B, Dinler Ay C C

The aim of this study was to evaluate urinary liver-type fatty acid-binding protein levels in both obstructive and non-obstructive feline lower urinary tract disease. In addition, urinary liver-type fatty acid-binding protein levels were investigated in cats experiencing short-term (<36 hours) and long-term (≥36 hours) urethral obstruction. The study included 32 cats, classified into two main groups: cats with feline lower urinary tract disease (n = 24) and healthy controls (n = 8). The feline lower urinary tract disease group was subdivided into obstructive (n = 16) and non-obstructive (n = 8) forms. The obstructive group was further divided based on urethral obstruction duration into short-term (n = 8) and long-term (n = 8) sub-subgroups. Serum creatinine, blood urea nitrogen and potassium were measured in blood samples. Urinary liver-type fatty acid-binding protein and urinary creatinine concentrations were measured in urine supernatant samples. Urinary liver-type fatty acid-binding protein concentrations were indexed to urinary creatinine and expressed as the urinary liver-type fatty acid-binding protein/creatinine ratio. The mean urinary liver-type fatty acid-binding protein/creatinine values of cats with obstructive feline lower urinary tract disease were statistically higher than those in cats with non-obstructive feline lower urinary tract disease and healthy controls. The difference between the mean urinary liver-type fatty acid-binding protein/creatinine values of cats with long-term and short-term obstruction was not statistically significant. In addition, moderately positive correlations were calculated between urinary liver-type fatty acid-binding protein/creatinine and serum creatinine (r = .646; P < .001; 95% CI = 0.264 to 0.863) and between urinary liver-type fatty acid-binding protein/creatinine and blood urea nitrogen (r = .549; P < .01; 95% CI = 0.081 to 0.791) in the study population. This study is the first to report urinary liver-type fatty acid-binding protein/creatinine in cats with feline lower urinary tract disease. The findings suggest that urinary liver-type fatty acid-binding protein/creatinine may serve as a potential biomarker for identifying post-renal acute kidney injury in cats with obstructive feline lower urinary tract disease, particularly in long-term obstructive cases.

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PubMedFoods (Basel, Switzerland)2026-10-16

Integrated Multi-Omics and Molecular Docking Analysis of Malate Degradation by Lactiplantibacillus plantarum S4 During Sea Buckthorn Juice Fermentation.

Guo Xiaogang X, Lin Menghui M, Zhuo Laifeng L, Feng Yanru Y et al.

Sea buckthorn juice (SBJ) is nutritionally valuable, but its high malic acid content contributes to excessive sourness that limits consumer acceptance. In this study, the deacidification phenotypes of two lactic acid bacterial isolates, Lactiplantibacillus plantarum S4 and Lacticaseibacillus paracasei YJ2, were compared using fermentation phenotyping, sensory evaluation, enzyme assays, untargeted metabolomics, transcriptomics, and molecular docking. After 96 h of fermentation, S4 degraded 91.98% of malic acid, compared with 69.50% for YJ2, and exhibited higher viable-cell counts and overall sensory acceptability under the tested conditions. S4 also showed higher crude-extract malate-conversion activity under MLE-favoring conditions. Molecular docking predicted more favorable interactions of malate with S4-derived MleP and MleS than with the corresponding YJ2 proteins; however, these analyses did not directly measure MleP-mediated transport or MleS-specific catalytic flux. Metabolomic profiling showed lower abundance of malic acid and several other organic acids in S4-fermented SBJ, together with increased abundance of succinic acid, 2-oxoglutaric acid, phenyllactic acid-related metabolites, D-octopine, and N-lactoyl-phenylalanine. Transcriptomic analysis revealed differences between S4 and YJ2 in carbohydrate metabolism, glycolysis, pyruvate metabolism, energy generation, and late-stage cellular maintenance. Integration of these datasets supports a working model in which malate-associated conversion, central-carbon redistribution, organic-acid remodeling, and acid-stress adaptation may contribute to the greater malate-removal phenotype of S4. Because only one isolate of each species was examined, the observed differences should be interpreted as differences between S4 and YJ2 rather than as species-level effects.

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PubMedPlants (Basel, Switzerland)2026-10-16

Salt Stress Tolerance, Antioxidant Response, and the Effectiveness of Seed-Applied Stress Attenuators in Pumpkin Cultivars.

da Rocha Daise Feitoza DF, Pereira Kleane Targino Oliveira KTO, Arruda Maria Valdiglezia de Mesquita MVM, Torres Salvador Barros SB et al.

Salinity compromises seed germination and early seedling growth, highlighting the need to identify tolerant cultivars and effective management strategies. This study aimed to evaluate tolerance to salt stress, antioxidant activity, and the effectiveness of seed-applied stress attenuators in pumpkin cultivars. The research was conducted in two stages. In the first stage, six cultivars (Tetsukabuto, Soberana, Kin, Bahiana Tropical, Sergipana, and Adele) were subjected to three levels of osmotic potential induced by NaCl (0.0, -0.2, and -0.4 MPa). Germination, growth, and biochemical variables were evaluated. In the second stage, two contrasting cultivars were subjected to six treatments: control (0.0 MPa), salt stress (-0.4 MPa), hydropriming, gibberellic acid, ascorbic acid, and salicylic acid, all under salt stress (-0.4 MPa). In addition to germination and growth variables, oxidative damage (H2O2 and lipid peroxidation) and antioxidant activity (SOD, CAT, and APX) were evaluated. Salt stress significantly reduced germination, growth, and biomass accumulation. Cultivar Adele showed greater tolerance, whereas Tetsukabuto was more sensitive. Hydropriming, gibberellic acid, ascorbic acid, and salicylic acid mitigated the effects of salinity, with hydropriming showing the greatest reduction in lipid peroxidation. It is concluded that Adele, combined with gibberellic acid, and Tetsukabuto, combined with hydropriming and gibberellic acid, showed better performance under salinity stress, highlighting the potential of physiological and biochemical traits for identifying contrasting responses to salinity.

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