Drug Database
YY

YY-3130 (YY 3130 / YY3130)

✓ Approved

YuYu Pharma · Small Molecule · Small Molecule

What is YY-3130?

YY-3130 is a small molecule developed by YuYu Pharma. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesYY 3130, YY3130
CompanyYuYu Pharma
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, YuYu Pharma

Therapeutic Indications

YY-3130 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersHypercholesterolaemia✓ Approved

Related Research Articles

PubMedDiabetes, obesity & metabolism2026-10-15

Incorporation of Carob Into a High-Fat Meal Influences Subjective Satiety, Ghrelin and PYY Regulation.

Amerikanou Charalampia C, Kleftaki Stamatia-Angeliki SA, Tzavara Chara C, Vourtsi Aikaterini A et al.

Dietary components that influence appetite-related hormones and subjective satiety may help regulate food intake. Aqueous carob (Ceratonia siliqua L.) preparations may have a role in postprandial appetite regulation. To investigate the effects of an aqueous carob preparation incorporated into a high-fat meal on postprandial appetite-related hormones and subjective satiety. An acute randomized controlled crossover trial was conducted in 20 healthy males. Participants consumed two meals of similar energy content on separate occasions: a control meal containing an orange-flavoured beverage and a test meal containing an aqueous carob preparation. Blood samples and subjective appetite ratings, assessed using visual analogue scales, were collected over a 180-minute postprandial period. Compared with the control meal, the carob meal resulted in lower subjective hunger (p = 0.011) and desire to eat (p = 0.029), and greater satisfaction (p = 0.047). Peptide YY (PYY) area under the curve (AUC) values differed between meals (p = 0.040). Following the control meal, ghrelin decreased at 30 min (p = 0.012), followed by a marked increase at 180 min (p < 0.005). The magnitude of the change in ghrelin from baseline to 180 min differed between meal conditions (p = 0.005). The findings suggest that an aqueous carob preparation may improve subjective appetite responses when consumed with a high-fat meal. Differences in PYY and ghrelin responses may contribute to these effects, although a causal relationship was not established. The acute study design and inclusion of only healthy males limit conclusions about long-term effects and applicability to other populations. Incorporating an aqueous carob preparation into a high-fat meal may favourably influence postprandial appetite and satiety regulation. Further research is needed to determine whether these effects persist over time and translate into reduced food intake.

PMID 42881118
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PubMedRSC advances2026-10-15

Strain induced phase transitions, superior optoelectronics, and photocatalytic potential of Ba2GdNbO6: promising material for solar hydrogen production.

Saeed Usman U, Sherazi S Faiza SF, Noor Rabbia R, Al-Buriahi M S MS et al.

Strain engineering provides an effective route for tuning the multifunctional features of materials, thereby enhancing their potential for spintronic and energy-conversion applications. In this work, we investigate the effects of hydrostatic ([111]) strain on the structural, mechanical, magnetic, electronic, photocatalytic, and optical aspects of the Ba2GdNbO6 structure using first-principles calculations within GGA + U (generalized gradient approximation + Hubbard parameter) and GGA + U + SOC (spin-orbit coupling) frameworks. The negative formation enthalpies, elastic constants, and ab initio molecular dynamics simulations confirm the thermodynamic, mechanical, and thermal stability of the structures. Further, vibrational free-energy calculations reveal that tensile strain becomes thermodynamically favorable at elevated temperatures due to enhanced vibrational entropy. It is predicted that unstrained compound exhibits an indirect band gap (E g) of 3.27/3.26 eV with a stable ferromagnetic (FM) ground state within the GGA + U/GGA + U + SOC scheme. Interestingly, under compressive strain, a magnetic transition from the FM to antiferromagnetic (AFM) ground state occurs, accompanied by an electronic indirect-to-direct E g transition. In contrast, tensile strains preserve the FM ground state having lower indirect E g as is found in the unstrained one. Moreover, charge-density, electron localization function, and Bader analyses reveal enhanced metal-oxygen charge transfer under compression and reduced orbital overlap under tension while preserving predominantly ionic bonding. Notably, the system exhibits near ultraviolet light-harvesting, achieving absorption coefficients as high as 1.26/1.18/1.10 × 106 cm-1 at 3.26 eV, 1.48/1.44/1.42 × 106 cm-1 3.26 eV, and 1.36/1.37/1.36 × 106 cm-1 2.87 eV along the xx-/yy-/zz-axis for the -5%, 0%, and +5% strained systems, respectively, highlighting its excellent optical response. Even more strikingly, the band-edge potentials robustly straddle the water redox couples across the entire strain window with valence/conduction band edge potentials of 2.39/-0.88, 2.39/-0.87, and 2.18/-0.67 V (vs. normal hydrogen electrode) at -5%, 0%, and +5% strain, respectively, providing sufficient overpotential for spontaneous hydrogen and oxygen evolution reactions and establishing Ba2GdNbO6 as a strain-resilient photocatalyst for solar-driven water splitting.

PMID 42877631
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PubMedZhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation2026-10-13

[Mitigation Strategies and Evaluation Methods for Lipemia Interference in In Vitro Diagnostic Products].

Ji Yurong Y, Yin Xiaofan X

Lipemia interference resistance constitutes a critical performance indicator in the design and development of in vitro diagnostic products. In this article, the causes of lipemic samples and their interference pathways are briefly introduced; currently available common strategies employed to counteract lipemia interference have been summarized, including widely accepted approaches such as ultracentrifugation and sample dilution, as well as recently implemented techniques like reagent formulation modification and measurement procedure optimization. Furthermore, based on the requirements outlined in the latest publication of the Clinical and Laboratory Standards Institute (CLSI) EP07 Interference Testing in Clinical Chemistry and the pharmaceutical industry standard of the People's Republic of China YY/T 1789.5 - 2023 Performance Evaluation Methods for In Vitro Diagnostic Test Systems - Part 5: Analytical Specificity, the standardized evaluation methods for lipemia interference are systematically discussed.

PMID 42865061
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PubMedZhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation2026-10-13

[Research on Quality Control Testing Methods for Laparoscopic Surgical Robots].

Lu Heqing H, Liao Yuan Y, Zheng Jiaxin J, Yan Hao H et al.

To address the lack of quality and safety evaluation criteria and the inconsistency of testing methods in the clinical application of laparoscopic surgical robots, this study developed a scientific and operable testing method system based on a four-dimensional framework of "device appearance and function-electrical safety-image quality-robotic arm and surgical instruments". By identifying risk points of 21 core indicators, such as leakage current and horizontal/vertical resolution, and referencing standards such as YY/T 1712-2021 to determine the testing principles, the testing tools, operation steps, and limit values for each indicator were clearly defined. Multi-center validation was conducted on seven devices of different brands in three institutions. The validation results showed that the operability of the testing methods across different devices exceeded 90%, and the qualification rate of indicators was over 77%, effectively identifying latent device quality deficiencies. This system addresses a critical gap in the applied quality evaluation of laparoscopic surgical robots, providing standardized tools for hospital acceptance, daily quality control, and health supervision, and promoting the industrialization of medical devices and the standardization of the industry.

PMID 42865048
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PubMedMicrobiological research2026-10-09

The gut-pancreas axis in chronic pancreatitis: Microbiota-endogenous GLP-1 interactions and candidate repair pathways.

Fan Zhengyang Z, Chen Yonghao Y, Li Yuan Y, Dong Yanbin Y et al.

Chronic pancreatitis (CP) is a progressive fibroinflammatory disorder with limited disease-modifying options. Human CP studies report gut microbial and intestinal-barrier alterations, predominantly in cross-sectional cohorts. This review integrates CP-specific clinical and experimental observations with mechanistic evidence from cell, rodent, and non-CP human studies. Barrier disruption can increase lipopolysaccharide exposure and engage Toll-like receptor 4-associated inflammatory and fibrogenic signaling, whereas microbial and host-derived metabolites regulate enteroendocrine L-cell secretion through defined receptor-mediated and metabolic pathways. Human glucagon-like peptide-1 (GLP-1) studies in CP show heterogeneous responses, while CP trials have not yet connected microbiota-driven GLP-1 changes to disease progression. Evidence for direct pancreatic GLP-1 receptor (GLP-1R) signaling is strongest in β cells; reported immune, stellate-cell, and exocrine effects derive largely from preclinical or pharmacological studies and should not be equated with physiological endogenous GLP-1 exposure. CP-specific animal studies reported attenuated fibrosis or improved barrier and immune endpoints after microbiota-directed interventions, whereas limited human synbiotic trials reported improvements in selected gastrointestinal or perioperative outcomes but did not assess endogenous GLP-1, microbiome engraftment, pancreatic fibrosis, or disease progression. Together, these findings support a biologically coherent and testable microbiota-metabolite-endogenous GLP-1 framework for CP, with causal direction and clinical relevance requiring longitudinal validation. Translation requires microbiome-stratified CP trials incorporating functional microbiome and metabolite profiling; basal and meal-stimulated measurements of active and total GLP-1, together with peptide YY; prespecified clinical outcomes; mediation and treatment-by-biomarker analyses; and long-term safety assessment.

PMID 42854469
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PubMedFrontiers in nutrition2026-10-09

Intermittent fasting-associated microbiome remodeling and functional modulation by Lacticaseibacillus rhamnosus HN001.

Shao Tinghui T, Liu Jin-Ming JM

The gut microbiome is a critical regulator of host metabolism, yet how intermittent fasting (IF) remodels the gut ecosystem independent of dietary composition remains unclear. This study aimed to isolate the effect of feeding rhythm on the gut microbiome and identify specific microbial taxa mediating IF-induced metabolic changes. We employed a family-based 'shared meal' model that strictly standardized dietary composition across all participants. Five healthy adults (3 males, 2 females) from a single family participated in a pilot, hypothesis-generating 4-week 16:8 IF intervention with longitudinal fecal sampling for 16S rRNA sequencing and untargeted metabolomics. To functionally test a candidate Lacticaseibacillus-associated mechanism, C57BL/6 J mice were subjected to a 1-week 16:8 IF protocol with or without daily oral supplementation of Lacticaseibacillus rhamnosus HN001. Plasma beta-hydroxybutyrate (betaOHB) and peptide YY (PYY) were measured by ELISA. IF was associated with body weight loss in humans (2.1 +/- 0.4 kg, 95% CI: 1.3 to 2.9 kg, p < 0.05) without a significant reduction in caloric intake. In the primary paired genus-level DESeq2 analysis accounting for participant identity, no genus remained significant after false-discovery-rate correction, although Lacticaseibacillus showed a directional decrease after IF, consistent in direction with the original exploratory unpaired analysis. Predicted microbial functional and fecal metabolomic changes were consistent with altered microbial energy metabolism. In mice, IF significantly elevated plasma betaOHB (p = 0.0046) and reduced body weight, whereas HN001 supplementation reversed these IF-associated effects under the conditions tested. In this pilot, hypothesis-generating human cohort, IF was associated with coordinated microbiome and metabolomic remodeling, including a directional Lacticaseibacillus signal that motivated subsequent functional testing. In mice, L. rhamnosus HN001 supplementation reversed IF-associated weight loss and ketosis, supporting the functional plausibility of a Lacticaseibacillus-associated mechanism. The human observations require confirmation in larger, independent cohorts with time-matched non-fasting controls and species-resolved microbiome measurements.

PMID 42852269
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