Drug Database
TJ

TJ-114 (Sai)

✓ Approved

Tsumura · IL1RN

What is TJ-114?

TJ-114 is a therapeutic agent developed by Tsumura. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesSai
CompanyTsumura
Molecular TargetIL1RN
RouteOral (PO)
StatusApproved

Mechanism of Action

Molecular Targets

TJ-114 acts on 1 molecular target:

IL1RNinterleukin 1 receptor antagonist (IL1F3, IL-1RN)
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Therapeutic Indications

TJ-114 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Renal and urinary disordersNephritis✓ Approved

Related Research Articles

PubMedAnimals : an open access journal from MDPI2026-10-16

Retrospective Analysis of the Clinical Findings of 114 Horses with Eosinophilic Keratoconjunctivitis.

Tóth József J, Buijs Lieke L, Lorenz Rike R, Bakos Zoltan Z

Eosinophilic keratoconjunctivitis (EKC) is an inflammatory eye disease of horses with an unknown cause and suspected immune-mediated pathogenesis. This single-center retrospective case series included 114 horses (163 affected eyes) examined at a German equine referral hospital from January 2012 to December 2020. Of these horses, 71 (62.3%) were Warmbloods, 77 (67.5%) were presented from July to September, and 49 (43.0%) had bilateral disease. The cornea was involved in 139 of 163 eyes (85.3%). During the study period, 114 EKC cases occurred among 5742 ophthalmology cases (2.0%), with an increasing overall trend in hospital-based relative frequency (p < 0.001). All horses received medical treatment, and 90 (78.9%) also underwent surgery. Follow-up was available for 98 of 114 horses (86.0%): 78 (79.6%) recovered, 12 (12.2%) had persistent disease, and 8 (8.2%) underwent enucleation. Among recovered horses, median recovery time was 30 days. Exploratory analyses associated surgery with longer recovery (p < 0.001) and corneal lesion morphology with adverse outcome (p = 0.020), but treatment was clinician-selected. These findings describe EKC in one referral-hospital population but do not establish population incidence, seasonal risk, breed predisposition, or comparative treatment efficacy.

PubMedInternational journal of molecular sciences2026-10-16

Immune Checkpoint Inhibitor Data in Metastatic Melanoma with Pre-Existing Autoimmune Disease: A Real World Experience.

Vitale Maria Grazia MG, Mallardo Domenico D, Sparano Francesca F, Festino Lucia L et al.

Patients with pre-existing autoimmune disease (AID) are underrepresented in trials of immune checkpoint inhibitors (ICIs). We retrospectively compared 41 patients with stage IV melanoma and pre-existing AID with 162 contemporaneous controls without AID who received ICI treatment between November 2016 and April 2023. In the AID and control cohorts, respectively, the objective response rates were 46.3% and 32.7%, and the disease control rates were 80.5% and 51.2%. Treatment interruption attributed to worsening of the baseline AID was recorded in 11/41 patients, while 13/41 interrupted treatment because of toxicity distinct from the baseline AID. The full cohort contributed 114 progression-free survival (PFS) events and 92 deaths. In models adjusted for age, sex, ICI regimen and M category, AID was associated with PFS (adjusted hazard ratio [HR] 0.48, 95% confidence interval [CI] 0.24-0.99; p = 0.046), whereas the association with overall survival (OS) was not statistically significant (adjusted HR 0.63, 95% CI 0.29-1.34; p = 0.232). These findings support the feasibility of ICI therapy in carefully selected patients with clinically stable AID, while the observational design and residual confounding require cautious interpretation of comparative outcomes.

PubMedDental traumatology : official publication of International Association for Dental Traumatology2026-10-16

Sequential Radiographic Decision-Making in Traumatic Dental Injuries Among Final-Year Dental Students: A Scenario-Based Single-Center Cross-Sectional Study.

Ozbey Furkan F, Gokkurt Yilmaz Busra Nur BN, Yilmaz Birkan Eyup BE

Radiographic decision-making is an important component of traumatic dental injury (TDI) management. It requires clinicians to select an appropriate baseline examination, determine whether complementary imaging is needed, choose the most suitable additional modality, and consider advanced imaging only when clinically justified. This study evaluated final-year dental students' sequential radiographic decision-making performance in TDI scenarios using the 2020 International Association of Dental Traumatology (IADT) guidelines and an expert-consensus scoring framework as references. This cross-sectional survey study was conducted among final-year dental students at the Faculty of Dentistry of Afyonkarahisar Health Sciences University. All 114 eligible students were invited to participate; 110 completed the survey, yielding a participation rate of 96.5%. The instrument included eight clinical trauma scenarios. Each scenario contained four scored decision-making questions addressing the preferred baseline radiographic examination, the need for complementary imaging, selection of the complementary modality, and selective CBCT consideration. The total scenario-based radiographic decision-making score ranged from 0 to 32. Four domain scores, each ranging from 0 to 8, were also calculated for the sequential decision stages. Scenario-level performance and exploratory subgroup comparisons according to gender and self-reported IADT guideline awareness were evaluated. Of the 114 eligible final-year dental students invited to participate, 110 completed the survey, corresponding to a participation rate of 96.5%. The mean total scenario-based radiographic decision-making score was 21.62 ± 2.92 out of 32 (95% CI: 21.07-22.17), equivalent to 67.6% of the maximum possible score. The lowest mean domain scores were observed for baseline examination selection (5.04 ± 1.05 out of 8) and complementary modality selection (5.05 ± 1.22), whereas selective CBCT consideration had the highest mean score (6.10 ± 1.18). Scenario-level performance was lowest for suspected root fracture and multiple-tooth displacement with segmental mobility. In the three scenarios in which CBCT could be considered selectively, correct CBCT-related responses were 54.5%, 52.7%, and 84.5% in S5, S6, and S7, respectively. Students reporting awareness of the IADT guidelines had higher total scores than those reporting no awareness (23.24 ± 2.29 vs. 19.81 ± 2.46; unadjusted mean difference: 3.43, 95% CI: 2.53-4.33; p < 0.001; Cohen's d = 1.45). No gender-related difference was detected. Final-year dental students demonstrated moderate performance in sequential radiographic decision-making for TDIs, with greater difficulty in selecting the baseline examination and complementary modality and in managing more complex trauma scenarios. Although the overall selective CBCT domain score was comparatively high, recognition of situations in which CBCT could be justified was inconsistent across the three relevant scenarios. Self-reported IADT guideline awareness was associated with higher performance, but this exploratory cross-sectional association should not be interpreted causally. The findings identify potential educational needs in guideline-based imaging selection, staged clinical reasoning, and case-specific CBCT justification.

PubMedBiology2026-10-16

DIA Quantitative Proteomic Analysis Reveals Early Proteomic Responses to Honeybee-Derived Melittin in Murine Breast Cancer Cells.

Zhu Junling J, Xu Wenhua W, Zang He H, Yang Yunzhen Y et al.

Breast cancer remains a major clinical challenge because of its molecular heterogeneity, therapeutic resistance, and disease recurrence. Melittin, the principal bioactive peptide of honeybee venom, exhibits antitumor activity in multiple experimental models; however, its early proteome-wide effects in breast cancer cells remain incompletely characterized. In this study, E0771 murine mammary carcinoma cells were exposed to melittin for 15 min. Colony formation and CCK-8 assays using 0-8 μg/mL melittin showed concentration-dependent reductions in clonogenic capacity and cell viability. For DIA-based quantitative proteomic profiling, E0771 cells were treated with 4 μg/mL melittin for 15 min. Among 9748 quantified protein entries, 339 proteins met the exploratory criteria for candidate differential abundance, including 114 up-regulated and 225 down-regulated candidates. GO and KEGG analyses associated these candidate proteins with cell junctions, cytoskeletal organization, protein kinase-related functions, metabolic processes, and cell-death-associated pathways. A STRING-derived association network containing 132 nodes and 216 edges further prioritized CASP8, RPS27A, ANXA5, and PIK3CA as relatively high-connectivity candidates. Collectively, these findings describe early proteomic responses to short-term melittin exposure and provide candidate proteins and biological processes for subsequent mechanistic validation rather than establishing causal molecular mechanisms.

PubMedMolecules (Basel, Switzerland)2026-10-16

First Application of 3,5-Dinitrocatechol and Benzalkonium Chloride in Cloud Point Extraction: Spectrophotometric Determination of Vanadium(V).

Racheva Petya P, Saravanska Antoaneta A, Gajdošová Andrea A, Stojnova Kirila K et al.

The ability of 3,5-dinitrocatechol (3,5-DNC) to form anionic species with vanadium(V) in a mildly acidic medium was exploited to develop a spectrophotometric method for vanadium determination. The method is grounded on the formation of an ion-association complex with benzalkonium chloride (BAC), which is efficiently extracted into a surfactant-rich phase formed in a mixed micellar medium consisting of Triton X-114 and BAC. The stoichiometry of the extracted complex was established as (BA+)[VO(3,5-DNC)2], and the formula of its anionic component, [VO(3,5-DNC)2]-, was verified by quantum-chemical calculations at the B3LYP/6-311G level of theory and by comparison of the experimental absorption spectrum with simulated theoretical spectra. The results indicate that the thermodynamically more stable anti isomer is preferentially formed and extracted. The developed novel centrifuge-less cloud point extraction-spectrophotometric method exhibits an absorption maximum at 426 nm, an apparent molar absorptivity of 1.6 × 106 L mol-1 cm-1, a limit of detection of 1.7 ng mL-1, and a linear range of 5.7-29.1 ng mL-1. The method was successfully applied to the determination of vanadium in spent catalysts and vanadium-based dietary supplements. Its analytical performance and sustainability were evaluated using modern assessment tools, including RGBfast.

PubMedPhlebology2026-10-16

Sex differences and prevalence of prior deep vein thrombosis among patients with incidental iliac vein compression on computed tomography.

Lakhani Zohaib Y ZY, Reisenauer Christopher J CJ, Linch Forrest B FB, Frimpong Richard G RG et al.

PurposeThe purpose of this study was to identify risk factors and evaluate clinical outcomes associated with incidental left common iliac vein compression on CT imaging.MethodsThis is a retrospective study that reviewed venous-phase abdomen and pelvis CT scans to identify patients with incidental extrinsic compression of the left common iliac vein due to an overlying right common iliac artery. A total of 726 patients were included (364 females, 362 males; mean patient age: 61.9 ± 15.9 years). Board-certified radiologists reviewed all CT scans. Significant left iliac vein compression was defined as >50% luminal narrowing.ResultsSignificant iliac vein compression was identified in 114 (15.7%) patients and was more common in females (19.5%) versus males (11.9%) (p < 0.01). Patients with iliac vein compression >50% had significantly lower BMI than those without compression (24.8 ± 6.2 vs 28.7 ± 7.2 kg/m2, p < 0.01). Patients with incidental left iliac vein compression had a higher rate of prior left lower extremity DVT (p = 0.02).ConclusionIncidental left common iliac vein compression was present in approximately 16% of patients and was more frequent among females. Compression was associated with lower BMI and more than twice the rate of ipsilateral DVT, despite no prior diagnosis of MTS. These findings suggest that incidental iliac vein compression could have more clinical significance than previously recognized.

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