Drug Database
TJ

TJ-114 (Sai)

✓ Approved

Tsumura · IL1RN

What is TJ-114?

TJ-114 is a therapeutic agent developed by Tsumura. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesSai
CompanyTsumura
Molecular TargetIL1RN
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Tsumura

Mechanism of Action

Molecular Targets

TJ-114 acts on 1 molecular target:

IL1RNinterleukin 1 receptor antagonist (IL1F3, IL-1RN)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

TJ-114 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Renal and urinary disordersNephritis✓ Approved

Related Research Articles

PubMedJournal of ophthalmology2026-08-30

Assessing Guideline Knowledge Alignment of Large Language Models in Ophthalmology: A Preclinical Benchmarking Study on KLEx Evidence-Based Guidelines.

Lu Hongxia H, Huo Yan Y, Xie Ruisi R, Qu Zhengyuan Z et al.

To evaluate the guideline knowledge alignment of two large language models (LLMs), GPT-5.5 Instant and DeepSeek-V4, and to determine their preclinical reliability as reference tools in refractive surgery. Using the 38 evidence-based recommendations of the international keratorefractive lenticule extraction (KLEx) guidelines as the gold standard, both LLMs were evaluated in their default configurations. Two ophthalmologists independently assessed the clinical safety and medical accuracy of the model responses using a 5-point Likert scale (1-5 points). Agreement between each model's recommendation strength and the guideline was quantified by intraclass correlation coefficient (ICC), structural reliability by the DISCERN scale, and readability by the Flesch Reading Ease (FRE) and Flesch-Kincaid Grade Level (FKGL) indices. Likert ratings did not differ between GPT-5.5 Instant (4.96 ± 0.206) and DeepSeek-V4 (4.89 ± 0.385; p = 0.134). Across 114 independent generations, the ICC for agreement with the guideline was 0.884 (95% CI, 0.836-0.918) for GPT-5.5 Instant and 0.739 (0.640-0.813) for DeepSeek-V4 (both p < 0.001). DISCERN scores were 70.18 ± 5.16 and 68.05 ± 5.41 (p = 0.085); FRE, 9.93 ± 8.33 and 3.74 ± 5.24 (p < 0.001); and FKGL, 16.07 ± 2.21 and 18.95 ± 1.96 (p < 0.001). Both models aligned closely with the guidelines, with significant concordance in GRADE-based recommendation strength. They may serve as preclinical reference tools in refractive surgery but not as a substitute for specialist judgment.

PMID 42668902
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PubMedVaccine2026-08-30

Evaluating the potential lifetime health and economic impact of PCV21, an adult-specific 21-valent pneumococcal conjugate vaccine, on invasive pneumococcal disease in adults aged ≥45 years in Spain.

Simuzingili Muloongo M, Fernández-Soberón Silvia S, Yi Zinan Z, Cossrow Nicole N et al.

PCV21, a 21-valent pneumococcal conjugate vaccine (PCV), includes eight unique serotypes not covered by other currently licensed pneumococcal vaccines, and accounts for approximately 79% of IPD cases among adults aged ≥65 years in Spain, compared with 65% for PCV20. This study evaluated the potential lifetime health and economic impact of PCV21 compared with PCV20 vaccination on IPD among adults aged ≥45 years in Spain. A published Markov model estimated the lifetime IPD cases, IPD-related deaths, and associated direct medical costs (2024 Euros) for Spanish adults aged 45-64 and ≥ 65 years vaccinated with either PCV21 or PCV20. A sensitivity analysis assessed the effect of varying inputs on the direct costs averted by PCV21 compared with PCV20. For adults aged 45-64 years, PCV21 was projected to prevent 1590 IPD cases and 134 IPD-related deaths, compared with 1412 cases and 114 deaths prevented with PCV20. Compared with PCV20, PCV21 averted 13% more IPD cases and 17% more IPD-related deaths. The greater reduction in IPD burden translated into €7.3 million in direct medical costs saved with PCV21, 10% higher than the €6.6 million saved with PCV20. Among adults aged ≥65 years, PCV21 was projected to prevent 10,262 IPD cases and 2207 IPD-related deaths, compared with 8243 cases and 1772 deaths prevented with PCV20. Compared with PCV20, PCV21 averted 24% more IPD cases and 25% more IPD-related deaths. The corresponding economic impact was also higher with PCV21, with €1301 million in direct medical costs saved compared with €1044 million for PCV20, representing a 25% greater reduction in costs. In both age groups, PCV21 showed greater health and economic impact associated with IPD compared with PCV20, underscoring the potential benefits of incorporating PCV21 into adult pneumococcal vaccination strategies in Spain.

PMID 42669238
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PubMedAJPM focus2026-08-30

Beyond Proxies: Environment, Neighborhood, and Racial Disparities in Hypertensive Disorders of Pregnancy.

Singh Noreen N, Chiofalo Jacqueline M JM, Shuman Saskia Z SZ, Smith Aimee L AL

Hypertensive disorders of pregnancy are leading causes of maternal morbidity and mortality in the U.S., with persistent racial disparities. Current clinical guidelines include Black race and lower income as proxy risk factors, which lack precision and may obscure structural and environmental contributors to hypertensive disorders of pregnancy risk. This study evaluated environmental and neighborhood-level exposures as clinically accessible, structurally grounded risk factors for hypertensive disorders of pregnancy that can be feasibly implemented in practice. A retrospective cohort study was conducted among 619 pregnant patients receiving care within a Federally Qualified Health Center network. The primary outcome was hypertensive disorders of pregnancy, defined as gestational hypertension or preeclampsia diagnosed during pregnancy, intrapartum, or postpartum. Address-linked exposures included high nitrogen dioxide pollution (≥5 ppb), high neighborhood poverty (>30% of residents below the federal poverty level), and ZIP code-level racial composition (majority White and majority Black or Hispanic ZIP codes). Associations with hypertensive disorders of pregnancy were assessed in the full cohort and in race-stratified models, with and without adjustment for aspirin prescription. ORs with 95% CIs were reported. Among 619 patients, 114 (18.4%) developed hypertensive disorders of pregnancy. High nitrogen dioxide pollution was associated with the highest odds of hypertensive disorders of pregnancy (OR=3.73, 95% CI=2.43, 5.79, p<0.001), followed by high neighborhood poverty (OR=2.21, 95% CI=1.45, 3.43, p<0.001). After adjustment for aspirin prescription, high nitrogen dioxide exposure remained the strongest risk factor (OR=2.88, 95% CI=1.81, 4.61, p<0.001). Residence in majority White ZIP codes was protective for both Black (OR=0.41, 95% CI=0.20, 0.81, p=0.012) and non-Black (OR=0.37, 95% CI=0.22, 0.64, p<0.001) individuals. High nitrogen dioxide pollution exposure and high neighborhood poverty were independently associated with increased hypertensive disorders of pregnancy risk across racial groups, with nitrogen dioxide demonstrating the strongest association and effect size comparable with that of established clinical high-risk factors. Environmental and neighborhood-level measures may enhance hypertensive disorders of pregnancy risk assessment beyond race- and income-based proxies and can be derived from routinely available address-linked data.

PMID 42668660
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PubMedInternational journal of audiology2026-08-29

Navigating natural hazards with hearing devices: lived experience challenges, insights and opportunities.

Maguire Brigit B, Villeneuve Michelle M, Boisvert Isabelle I

This study explores the potential impacts of natural hazards for people who use hearing devices. A cross-sectional online survey was used, based on the Emergency Preparedness Survey of People with Disability. 124 deaf, Deaf or hard-of-hearing adults living in Australia completed the survey; of these, 114 respondents used at least one hearing device. Findings reveal significant dependence on hearing devices among some deaf, Deaf or hard-of-hearing people. One-third of respondents who could communicate effectively with their hearing device/s reported complete communication loss without their device; this also impacted abilities to make spoken emergency calls. Losing or damaging a device negatively impacted many respondents, who also relied on power for charging batteries and smartphones, which may control hearing devices. Hearing device reliance impacts how natural hazard emergencies are experienced when devices may be lost, damaged, or unable to be powered - highlighting the need for targeted emergency preparedness strategies. This study demonstrates the importance of integrating considerations for assistive devices into emergency planning and response frameworks. There are vital roles for device manufacturers and suppliers in ensuring device resilience during natural hazard emergencies, and for professionals in supporting people to develop emergency preparedness plans that reflect their reliance on and connection to their assistive devices.

PMID 42667158
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PubMedJournal of electrocardiology2026-08-29

Progressive electrocardiographic remodeling despite Tafamidis therapy in transthyretin amyloid cardiomyopathy (ATTR-CM).

Escorbiac Lilou L, Weeder Simon S, Kääb Stefan S, Massberg Steffen S et al.

Electrocardiographic (ECG) abnormalities are a hallmark of transthyretin amyloid cardiomyopathy (ATTR-CM), yet longitudinal ECG changes under disease-modifying therapy remain poorly characterized. In this retrospective multicenter study, 140 patients with confirmed ATTR-CM receiving tafamidis underwent serial 12‑lead ECG assessment at baseline and after one year. ECG parameters were analyzed in relation to biomarker-based disease stage, clinical progression, and all-cause mortality. Longitudinal ECG changes were evaluated using Wilcoxon signed rank and McNemar tests. Survival analyses were conducted using Kaplan-Meier estimates and univariable Cox regression. At baseline, PR interval, QRS duration, and QTc were significantly associated with advanced disease stage, whereas QRS voltage and heart rate were not. During follow-up, patients showed clinical progression with worsening functional status despite stable biomarker-based disease stage. Serial ECG assessment demonstrated ongoing electrical remodeling with significant QRS prolongation (109 vs. 114 ms, p < 0.001), increasing conduction disturbances, and a doubling of pacemaker stimulation. These changes occurred independently of disease stage and were confirmed in patients without pacemaker-stimulated rhythm. Longitudinal changes in QRS voltage were inconsistent and depended on the analytic approach. Baseline QRS duration ≥120 ms and markedly prolonged PR interval (>220 ms) were associated with adverse outcome, whereas longitudinal ECG changes were not independently associated with mortality. In ATTR-CM, baseline conduction abnormalities - but not longitudinal ECG changes - were associated with adverse outcomes. Despite tafamidis therapy, ECG abnormalities continued to progress, predominantly reflecting ongoing conduction system involvement independent of biomarker-based disease stage, suggesting that serial ECG assessment may complement disease monitoring rather than risk stratification.

PMID 42667731
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PubMedFrontiers in oncology2026-08-29

Investigation of clinical applicability of deep learning-based virtual contrast-enhanced MRI for nasopharyngeal carcinoma patients.

Zeng Guangping G, Li Wen W, Li Xue X, Sun Rui R et al.

There is a lack of research evaluating the clinical performance of virtual contrast-enhanced MRI (VCE-MRI). This study aims to assess the clinical utility of an established VCE-MRI technique in NPC patients and to establish patient selection criteria. We retrospectively collected data from 333 NPC patients across six institutions (2012-2023). VCE-MRI was synthesized from T1-weighted and T2-weighted MRI for each patient using the multimodality-guided synergistic neural network (MMgSN-Net), which was pre-trained on a large cohort of 1682 NPC patients from 14 institutions. Three experienced radiologists independently assessed image quality using a 5-point Likert scale, with scores below 4 deemed clinically unacceptable. The association between assessment results and patient clinical characteristics of corresponding patients (tumor diameter, T-stage, shape, gender, age) was analyzed to stratify the patients suitable for MMgSN-Net-based VCE-MRI. Clinically acceptability of VCE-MRI significantly decreased with larger tumor diameters (p=0.001), advanced T-stage (T1: 100%, T2: 95.1%, T3: 90.0%, T4: 69.6%; p<0.001), and complex tumor shape (regular: 94.8% vs. complex: 74.0%; p<0.001). Age and gender had no significant impact (p=0.327, 0.773). 13 unacceptable patients were found due to severe VCE-MRI artifacts. VCE-MRI achieved high clinical acceptability in T1/T2 patients (109/114, 95.6%) and T3/T4 patients with regular tumor shapes (115/120, 95.8%). In contrast, acceptability significantly decreased to 73.0% (65/89) for T3/T4 tumors with complex shapes. The T-staging result discordance rate between VCE-MRI and CE-MRI is 8.4%, with overstaging in 15 cases. MMgSN-Net-based VCE-MRI demonstrates favorable clinical feasibility in selected patient subgroups, T1/T2-stage NPC and T3/T4-stage NPC with regular tumor morphology, potentially reducing GBCAs administration in 67.3% of eligible patients when applying these stratification criteria.

PMID 42666204
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