Drug Database
AS

AS0-3B (AS03B1 / AS03B)

✓ Approved

GSK · therapeutic agent

What is AS0-3B?

AS0-3B is a therapeutic agent developed by GSK. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

Brand NamesAS03B1, AS03B
CompanyGSK
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, GSK

Therapeutic Indications

AS0-3B is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

Related Research Articles

PubMedChemistry & biodiversity2026-10-15

Integrated Biological Evaluation of Benzimidazolium-Chalcone Derivatives: Antioxidant, Anti-AChE, Anticancer, and Anti-MRSA Activities With Docking Insights.

Çimentepe Mehmet M, Ünver Hakan H, Necip Adem A, Ersatir Mehmet M et al.

Four new benzimidazolium-chalcone salt derivatives were synthesized and successfully characterized using 1H NMR, 13C NMR, and FT-IR spectroscopy. Their antioxidant activity, acetylcholinesterase (AChE) inhibitory potential, antibacterial and antibiofilm activities against MRSA and MSSA strains, as well as their anticancer and apoptosis-inducing properties in human colon adenocarcinoma (HT-29) cells, were comprehensively evaluated. Among the synthesized compounds, 3a exhibited the strongest antioxidant activity, with IC50 values of 10.13 ± 0.30 µg/mL in the ABTS assay and 79.40 µg/mL in the DPPH assay, and demonstrated the highest AChE inhibitory effect. Molecular docking analysis further supported these findings, revealing a favorable binding affinity of compound 3a toward the 4EY7 target protein, with a docking score of -8.619 kcal/mol. Antibacterial evaluation using the agar well diffusion method showed that compound 3b produced the largest inhibition zone (19.2 ± 0.6 mm). Consistently, MIC analysis confirmed that 3b displayed potent antibacterial activity against MRSA (MIC: 1 µg/mL) and exhibited the most pronounced antibiofilm effect among the tested derivatives. In cytotoxicity assays, compound 3c demonstrated the highest anticancer activity against HT-29 cells, with an IC50 value of 16.7 ± 2.09 µM. Apoptosis analysis revealed that 3c predominantly induced early-stage apoptosis.

PMID 42878283
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PubMedSignal transduction and targeted therapy2026-10-15

Epigenetic regulation of humoral immunity: molecular mechanisms, diseases and therapeutic targets.

Zhang Shaocun S, Wang Yu Y, Min Xin X, Wu Yuzhang Y et al.

Humoral immunity, a fundamental branch of adaptive immunity, relies on B lymphocytes and the antibodies they produce to eliminate extracellular pathogens and neutralize toxins. The development, activation, and differentiation of B cells are tightly regulated by epigenetic mechanisms-including DNA methylation, histone modifications, chromatin dynamics, RNA modifications, and noncoding RNAs-that modulate gene expression without altering the DNA sequence, orchestrating key events such as V(D)J recombination, class switch recombination, somatic hypermutation, germinal center reactions, and the generation of memory B cells and plasma cells. In this review, we summarize how these five categories of epigenetic regulators-together with their respective writers, erasers, readers, and effectors-including DNMT3A/3B and TET enzymes, histone-modifying enzymes, SWI/SNF and INO80 remodeling complexes, N6-methyladenosine and 5-methylcytosine machineries, and microRNAs and long noncoding RNAs-collectively govern B-cell fate decisions, from early lineage commitment in the bone marrow, through germinal center dynamics, to terminal differentiation into plasma cells or memory B cells. We further examine how aberrant epigenetic programs in B cells contribute to pathogenesis across four major disease categories: B-cell malignancies, metabolic and cardiovascular diseases, autoimmune disorders, and infectious diseases. We also discuss sex-biased epigenetic mechanisms, particularly escape from X-chromosome inactivation, that may underlie the female predominance of autoimmune diseases. Finally, we discuss the therapeutic implications of targeting epigenetic regulators and assess the potential of epigenetic signatures as biomarkers.

PMID 42875430
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PubMedPlant physiology and biochemistry : PPB2026-10-15

Identification of heat-tolerant germplasm and elucidation of heat tolerance mechanisms in polyploid rice.

Cao Lichong L, Sun Lixia L, Yin Jianmin J, Guo Haibin H et al.

Heat stress has become one of the major abiotic stresses limiting rice growth and development. Polyploid rice represents an important approach in rice breeding and may contribute to heat tolerance improvement; however, the processes by which polyploid rice responds to heat stress remain mainly ambiguous. In this study, we evaluated the heat tolerance of 40 neo-tetraploid rice lines at the seedling stage. Among them, six lines displayed high heat tolerance (HD441-HD446), and 16 lines showed low heat tolerance (HD465-HD480). Cytological observations of the two lines, HD441 and HD477, which exhibited marked differences in survival rate, indicated that HD441 maintained a more stable root structure. Physiological investigations indicated that HD441 exhibited more stable antioxidant enzyme activities and accumulated less reactive oxygen species (ROS) under heat stress. Transcriptomic analysis revealed that the expression levels of heat shock protein genes (e.g., OsHSP18.2 and OsHSP60-3B) under both physiological and heat stress conditions differed significantly between the two lines. Temporal differential expression analysis further demonstrated that the expression levels of photosynthesis-related genes (e.g., OsRBCS2 and OsRBCS5) were significantly upregulated in HD441 under heat stress, and that the chloroplast structure of HD441 remained more stable than that of HD477. Integrated metabolo-transcriptomic analysis revealed that flavonoid biosynthesis was a key pathway in the heat stress response of HD441. These findings collectively offer significant insights into the regulatory processes governing high-temperature responses in polyploid rice.

PMID 42880015
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PubMedFrontiers in public health2026-10-15

Mental health literacy in maintenance hemodialysis: a qualitative study on recognition, knowledge fragmentation, and stigma-related help-seeking barriers.

Xiao Wenyi W, Xue Chendong C, Che Yingying Y, Ma Long L et al.

Psychological distress is highly prevalent among patients undergoing maintenance hemodialysis (MHD), yet qualitative evidence on their mental health literacy (MHL) remains scarce. To explore the actual level of mental health literacy, existing challenges, and needs for psychological services among patients on maintenance hemodialysis; to identify the constituent dimensions of mental health literacy in this population; and to provide qualitative evidence for developing a localized, specialized mental health literacy scale for this group and implementing targeted psychological interventions. Using purposive sampling, semi-structured in-depth interviews were conducted with MHD patients meeting the inclusion criteria at the Hemodialysis Center of a Grade III-A hospital in Ningxia from December 2023 to February 2024. The principle of maximum diversity was applied to ensure sample diversity, and the number of interviews was determined based on data saturation; a total of 11 patients were interviewed. Data were managed using NVivo 14.0 software and analyzed using Braun and Clarke's thematic analysis method. A total of 3 core themes and 6 subthemes were identified. Theme 1: Heterogeneity Recognizing of Mental Illness. Theme 2: Fragmented Mental Health Knowledge. This includes: 2a Polarized Approaches to Health Information; 2b Superficial Attribution Patterns; 2c Polarization of Self-Regulation Strategies; 2d Uneven Awareness of Mental Health Resources. Theme 3: Ambivalent attitudes toward mental illness and seeking help. This includes: 3a Cognitive Attitudes: Coexistence of Stigma and Normalization; 3b Behavioral Attitudes: The Gap between Intention and Action. MHL among MHD patients is characterized by insufficient illness recognition, fragmented knowledge, and pronounced stigma-related help-seeking barriers. Targeted, tiered psychoeducation and a culturally adapted MHL assessment tool are urgently needed for this population.

PMID 42877207
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PubMedDalton transactions (Cambridge, England : 2003)2026-10-15

Nitric oxide release from half-sandwich Ru(II)-p-cymene acylthiourea nitrite complexes: antiproliferative activities and vasorelaxant properties.

Karim Amir A, Eshaghi Malekshah Rahime R, Tseng Miao-Chu MC, Huang Shang-En SE et al.

In half-sandwich Ru(II)-p-cymene frameworks, the labile chlorido ligand can readily undergo substitution by various donor groups such as triphenylphosphine, azide, or a nitro group. In the present study, we report for the first time the incorporation of a nitrito (NO2-) ligand into an acylthiourea-based Ru(II)-p-cymene system. The six Ru(II)-p-cymene complexes comprising chlorido derivatives L1RuCl-L3RuCl (1a-3a) and nitrite-bound analogues L1RuNO2-L3RuNO2 (1b-3b) were synthesized under distinct reaction conditions and fully characterized. The molecular structures of complexes 1b and 2b were established by single-crystal X-ray diffraction analysis, while FT-IR, UV-Vis, and 1H/13C NMR spectroscopic studies clearly differentiated the coordination of the two co-ligands. A nitric oxide release study was performed chemically using (TPP)Co as an NO trapping agent, showing >70% NO release in an acidic environment for 1b and 2b. The antiproliferative activity of Ru-nitro complexes was greater than that of precursor Ru-chloride complexes in both TNBC (HCC1937) and non-TNBC (SKBR-3) cells. In the TNBC line, complexes 1b and 2b showed the lowest IC50 values (8.55 ± 1.00 and 7.47 ± 0.95 μM) and induced higher caspase-3/7 apoptotic activity than L1 and L2, which themselves produced greater activity than 1a and 2a. In vasorelaxation studies, 1b and 2b showed pronounced relaxation, achieving 85.48 ± 7.47% and 77.18 ± 4.97%, which are significantly greater than their chlorido complexes. DFT-D3 calculations were also performed to evaluate NO and OH release for all complexes, revealing that complex 2b exhibited higher NO-release, consistent with its observed anticancer activity.

PMID 42878869
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PubMedHeart and vessels2026-10-14

Clinical impact of admission estimated glomerular filtration rate categories in patients with acute myocardial infarction.

Mori Hiroyoshi H, Fukui Kazuki K, Tamura Kouichi K, Maeda Atsuo A et al.

Chronic kidney disease (CKD) is a well-established risk factor in acute myocardial infarction (AMI); however, the clinical relevance of admission estimated glomerular filtration rate (eGFR)-based categories remains unclear. We analyzed 10,870 patients from a prospective multicenter AMI registry in Japan. Patients were stratified into stages 1 (≥ 90), 2 (60-89), 3a (45-59), 3b (30-44), 4 (15-29), and 5 (< 15 mL/min/1.73 m2) based on the admission eGFR. The primary endpoint was 30-day major adverse cardiovascular events (MACE), defined as cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke. Bleeding was defined as BARC type 3 or 5. More advanced admission eGFR stages were associated with a higher risk of adverse events. After multivariable adjustment, stages 4 and 5 were associated with a significantly higher risk of MACE compared with the reference group of stages 1 and 2 (stage 4: HR 2.12, 95% CI 1.03-4.33; stage 5: HR 4.14, 95% CI 1.54-11.09), whereas stages 3a and 3b were not significantly associated with MACE. In patients with AMI, clinical outcomes varied across admission eGFR categories, with more advanced renal dysfunction, particularly stages 4 and 5, associated with a higher risk of short-term MACE. Detailed categorization of admission eGFR may provide additional prognostic information for early risk assessment.

PMID 42870066
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