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amphotericin B (Amphotec / Amphocil / ABCD)

✓ Approved

Therametrics · Small Molecule · Small Molecule

What is amphotericin B?

amphotericin B is a small molecule developed by Therametrics. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesAmphotec, Amphocil, ABCD
CompanyTherametrics
Drug ClassSmall Molecule
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Therametrics

Therapeutic Indications

amphotericin B is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsWound infection fungal✓ Approved

Related Research Articles

PubMedAnimals : an open access journal from MDPI2026-10-16

An Exploratory Analysis of Genetic Structure and Introgression in Salmo trutta Populations from Campania Rivers.

Montone Angela Michela Immacolata AMI, Fulgione Andrea A, Cutarelli Anna A, Gentile Alberto A et al.

The Salmo trutta complex exhibits high genetic and phenotypic diversity due also to the historical climatic events and colonization processes. In Europe, several evolutionary lineages have been identified, including the Atlantic and Mediterranean. In Italy, native Mediterranean trout populations have been threatened by restocking practices involving hatchery-reared fish of Atlantic origin, thus resulting in widespread hybridization and genetic introgression. This study aimed to genetically characterize trout populations from selected river basins of the Campania region (southern Italy) and to assess whether the observed morphological characteristics, consistent with standard morphological descriptions of Mediterranean trout, were supported by genetic evidence (i.e., LDH-C1* locus and microsatellite markers analyses). The results revealed a complex genetic structure of Salmo trutta populations in Campania, with evidence of Atlantic introgression in several river systems. Differences between LDH-C1* genotyping and microsatellite data highlighted the importance of using multiple genetic markers to accurately detect hybridization and identify lineage composition. These explorative results have also evidenced that specific populations (i.e., those from Imperatore, Sava, and Volturno rivers), showed genetic features consistent with Mediterranean ancestry. The findings highlight the importance of genetic analyses not only for accurate species identification beyond morphology but also for supporting conservation strategies to protect native Mediterranean trout and guide restocking based on local genetic resources.

PMID 42883030
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PubMedOrganic & biomolecular chemistry2026-10-16

Visible-light-driven three-component cascade synthesis of perfluoroalkylated pyrimido[1,2-b]indazoles via EDA complexes.

Liu Peng-Lu PL, Li Dan-Dan DD, Zhao Qin-Hu QH, Xi Zi-Wei ZW et al.

We report a photocatalyst-free, visible-light-driven three-component synthesis of perfluoroalkylated pyrimido[1,2-b]indazoles. Enabled by an in situ electron donor-acceptor complex between DABCO and perfluoroalkyl iodides, this scalable, transition-metal-free approach provides an efficient pathway to access and modify biologically important nitrogen-fused heterocycles.

PMID 42886202
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PubMedCancers2026-10-16

Mapping Integrative Decision-Making Frameworks in Advanced Cancer Care: A Scoping Review of Diagnostic, Supportive-Care, and Therapeutic Integration.

Murase Kazuyuki K, Sugama Yusuke Y, Arihara Yohei Y, Takada Kohichi K et al.

Decision-making in advanced cancer care is intertwined with diagnostic profiling, prognostic communication, supportive care, and anticancer treatment selection. An author-developed D-S-T × B/C/E conceptual mapping scaffold-three decision/action domains (Diagnosis, Supportive care, Therapy) and three evaluative dimensions (Biological, Clinical, Existential)-was used to organise the literature, to identify coverage gaps and recurring framework categories, and, as a secondary conceptual synthesis objective, to derive a candidate integrative framework. The review was conducted according to the Joanna Briggs Institute (JBI) methodology for scoping reviews, pre-registered on OSF, and reported per PRISMA-ScR. PubMed was searched on 21 June 2026, and the final evidence set was derived solely from this search. Eligible records concerning adults with advanced cancer were dual-screened and charted using a structured form. Eighty-two records (2010-2026) were included. Under the strict D-S-T × B/C/E matrix, Supportive care showed the highest joint coverage, particularly S × C (59/82, 72.0%), whereas D × B and D × E were the least represented cells (13/82 each, 15.9%). Eight recurring framework categories were inductively derived from the charted framework descriptors, led by early integrated palliative care (30/82) and prognosis-informed shared decision-making (27/82). Twenty-two records met an emergence-candidate screen defined at the synthesis stage, of which three received the maximum cross-axis coupling score of 6/6 from both reviewers. The advanced-cancer decision-framework literature clusters around a small number of architectures with uneven D-S-T × B/C/E coverage. Diagnosis-centred frameworks coupled with biological or existential dimensions were relatively under-represented within our mapping and represent priority targets for future primary research; the proposed Adaptive framework provides one structure in which this research could be conducted.

PMID 42882939
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PubMedMaterials (Basel, Switzerland)2026-10-16

Thermal Performance of Masonry Walls Strengthened with Glazed-Hollow-Bead-Modified ECC.

Yang Xintian X, Wang Fa F, Liu Hui H, Wu Tianao T et al.

Existing masonry buildings in severe-cold regions face the dual challenges of structural vulnerability and high heating demand. This study develops a glazed-hollow-bead-modified engineered cementitious composite (B-ECC) and evaluates its thermal performance at the material, wall-component, and building levels within an integrated retrofit strategy. At 50% volumetric sand replacement and 1.5% PVA-fiber content, a B-ECC achieved a thermal conductivity of 0.244 W/(m·K) (52% reduction) while retaining a compressive strength of 43.9 MPa. Wall-level finite-element analysis, validated by hot-box experiments (±5% error), showed that 20 mm overlays per face provide balanced thermal improvement. A whole-building case study of a three-story masonry teaching building in Changchun demonstrated that combining B-ECC overlays with insulation, window replacement, and heat-recovery ventilation reduced annual heating demand from 70,685 to 17,229 kWh/a, achieving a 75.6% energy-saving rate. The primary value of a B-ECC lies in enabling a coordinated structural-thermal retrofit.

PMID 42882697
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PubMedPlants (Basel, Switzerland)2026-10-16

Intraspecific Karyotypic Differentiation in the Lycoris aurea Complex Revealed by Fluorochrome Banding and rDNA Fluorescence In Situ Hybridization.

She Chaowen C, Jiang Xianghui X, Quan Miaohua M, Kong Weizheng W et al.

The Lycoris aurea (L'Hér.) Herb. complex-valued for its medicinal properties and horticultural applications-is characterized by extensive intraspecific dysploidy. However, a comprehensive molecular cytogenetic framework elucidating intraspecific karyotypic differentiation and the underlying evolutionary mechanisms has yet to be established. By integrating fluorochrome banding with 5S and 45S rDNA fluorescence in situ hybridization (FISH), we performed a comparative molecular cytogenetic karyotyping of 20 natural populations and synthesized these results with previously published cytogenetic data to conduct a rigorous cytogeographic analysis of this species complex. Three distinct cytotypes were identified: cytotype A (2n = 14), cytotype B (2n = 15), and cytotype C (2n = 16). Both multivariate karyomorphometric analyses and comparison of DAPI banding and rDNA FISH patterns revealed high inter-population karyotypic uniformity in cytotype A, yet pronounced intra-cytotypic karyotypic polymorphism in cytotype C. Integrated cytogenetic evidence supports a working hypothesis wherein cytotype C likely represents the ancestral karyotype, while cytotypes A and B appear to have originated from cytotype C through two and one Robertsonian fusion events, respectively-thereby implying two independent, parallel evolutionary pathways: C → A and C → B. The evolutionary biogeographic framework for this species complex-derived from hypothesis-generating integrative inference-proposes that Quaternary climate oscillations, topographic barriers, and ecological niche divergence may have acted synergistically to shape the current parapatric distribution pattern of the three cytotypes.

PMID 42884857
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PubMedDiagnostics (Basel, Switzerland)2026-10-16

A Two-Tier Patient-Based Real-Time Quality Control Program Integrating K-Means Department Stratification and Inter-Instrument Ratios Improves Detection of Small Systematic Errors in Creatinine Testing.

Wei Xuemei X, Jiang Ziqing Z, Nan Jingzhu J, Yan Zefeng Z et al.

Background/Objectives: Patient-based real-time quality control (PBRTQC) complements traditional internal quality control. This study validates a ratio-based PBRTQC integrating department clustering with inter-instrument ratio monitoring. Methods: Creatinine data (384,730 cases, 2025) from three measuring systems (A, B, C) were analyzed; conventional PBRTQC on unstratified Instrument A data served as comparator. Departments were stratified by K-means clustering of annual mean/SD, keeping the low-mean cluster (124 departments). The data of each measuring system were split chronologically: first-layer PBRTQC was trained on the first part, the second trained the ratio programs, and the third provided independent validation. Three systematic errors (fixed additive offsets of +5.28 and +10.56 μmol/L, and a progressive offset rising to +10.56 μmol/L, corresponding to 6% and 12% of the first-layer action limit) were simulated to assess the true positive rate (TPR), false positive rate (FPR), median samples to detection (MNPed), detection time and diagnostic odds ratio (DOR). Results: Under the fixed +5.28 μmol/L (6%) offset, A-B TPR was 28.83% versus 6.77% for traditional PBRTQC, with MNPed reduced from 34 to 20. Under the progressive offset rising to +10.56 μmol/L (12%), A-B TPR was 29.00% versus 8.35%, and detection time fell from 20 to 14 min. Under the fixed +10.56 μmol/L (12%) offset, A-B and A-C TPR reached 70.15% and 74.72% (MNPed 8 and 5; detection time 2 and 1 min). Across all scenarios the ratio programs achieved higher DOR. A stratified single-instrument comparator showed complementary contributions of stratification and ratio monitoring (TPR at the +5.28 μmol/L offset: 6.77%, 15.61% and 28.83%). Conclusions: Integrating department stratification with ratio-based PBRTQC markedly improves detection of small systematic errors in creatinine testing, albeit with more false positives, offering a transferable framework for laboratories using multiple same-platform measuring systems.

PMID 42882393
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