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atorvastatin strontium (Newvast)

✓ Approved

Hanmi Pharmaceutical · HMGCR · Small Molecule

What is atorvastatin strontium?

atorvastatin strontium is a small molecule developed by Hanmi Pharmaceutical. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesNewvast
CompanyHanmi Pharmaceutical
Drug ClassSmall Molecule
Molecular TargetHMGCR
RouteOral (PO)
StatusApproved

Mechanism of Action

Molecular Targets

atorvastatin strontium acts on 1 molecular target:

HMGCR3-hydroxy-3-methylglutaryl-CoA reductase (LDLCQ3, LGMDR28)
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Therapeutic Indications

atorvastatin strontium is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersHypercholesterolaemia✓ Approved
Metabolism and nutrition disordersHyperlipidaemia✓ Approved

Related Research Articles

PubMedJournal of environmental management2026-08-30

Rare earth elements as emerging contaminants: Multi-source release, geochemical tracing, and implications for environmental monitoring and management.

Han Yong-He YH, Zou Ming-Zhu MZ, Guan Dong-Xing DX, Li Yi-Xi YX et al.

Rare earth elements (REEs) are increasingly vital to green and high-tech industries, but their expanding use has led to widespread environmental contamination. This review evaluates REE release pathways, tracing methodologies, and knowledge gaps that limit effective environmental management. We synthesize REE inputs across mining, agricultural, industrial, and medical sectors. In mixed-source environments, overlapping geochemical signatures complicate source identification, a challenge exacerbated by global REE recycling rates below 1% and dissipation rates exceeding 90%. Against this backdrop, we systematically compare a suite of source-tracing approaches, including REE anomaly calculation, isotopic tracing (e.g., strontium, neodymium, and lead isotopes), receptor modeling (e.g., positive matrix factorization and chemical mass balance), and speciation analysis (e.g., high-performance liquid chromatography coupled with inductively coupled plasma-mass spectrometry and diffusive gradients in thin films). We identify two major methodological bottlenecks. First, the proliferation of over seven normalization systems and more than 30 anomaly equations yields results that are not readily comparable across studies. This is further complicated by region-specific baselines, particularly for gadolinium. Second, the predominant reliance on total concentrations obscures REE speciation and bioavailable fractions. To address these limitations, we propose a tiered monitoring framework that couples screening-level anomaly detection with quantitative source apportionment. This framework prioritizes standardized calculations, local baseline mapping, and bioavailability-based risk assessment. Advancing REE governance requires a shift from passive monitoring to a proactive framework that links environmental occurrence, geochemical tracing, and bioavailability-informed risk assessment.

PubMedNeurochemical research2026-08-29

Atorvastatin Exerts Context-Dependent Metabolic and Beneficial Effects on Behavior and Apoptotic Signaling in a Cafeteria Diet-Induced Metabolic Dysfunction Model.

Diogo Ítalo Leonardo ÍL, Maia Grazielle Aparecida Silva GAS, Garcia Israel José Pereira IJP, de Lima Santos Herica H et al.

The growing prevalence of obesity has been associated with metabolic and neurobiological alterations that compromise brain integrity and behavior. Diet-induced obesity, often accompanied by hypercholesterolemia, activates apoptotic signaling pathways in the central nervous system, contributing to cognitive and behavioral impairments. This study evaluated the effects of atorvastatin on behavioral performance and apoptotic signaling pathways in the hippocampus and cerebral cortex of rats subjected to a hypercaloric cafeteria diet. Male Wistar rats were assigned to four groups: control diet (CTR), control diet plus atorvastatin (ATOR), cafeteria diet (CAF), and cafeteria diet plus atorvastatin (CAF+ATOR), and exposed to the diets for 24 days. Body weight, adiposity, and circulating cholesterol levels were measured to validate the metabolic model. Behavioral assessments included locomotor activity, immobility time, and recognition memory. The expression of pro-caspase-8, pro-caspase-9, and apoptosis-inducing factor (AIF) was quantified in frontal cortex and hippocampus. The cafeteria diet increased adiposity and circulating cholesterol levels, confirming metabolic dysfunction, whereas atorvastatin reduced cholesterol levels and prevented retroperitoneal fat accumulation. In addition, the cafeteria diet altered the expression of apoptosis-related proteins in the hippocampus and cortex, whereas atorvastatin attenuated these changes. Cafeteria-fed rats showed reduced exploratory activity and increased immobility. Spatial memory was impaired by both atorvastatin and the cafeteria diet but preserved in the CAF+ATOR group. Novel object recognition was impaired only in the ATOR group. These findings indicate that atorvastatin exerts context-dependent effects under conditions of diet-induced metabolic dysfunction.

PubMedLuminescence : the journal of biological and chemical luminescence2026-08-29

Sol-Gel-Synthesized Mn4+-Doped Sr9Gd2W4O24 Red Phosphor: Structural, Optical, and EPR Studies for Deep-Red LEDs and Plant Growth Lighting Applications.

Singh Vijay V, Kaur Sumandeep S, Devi Ch B Annapurna CBA, Nande Amol A et al.

Double perovskite materials, such as strontium-gadolinium tetra tungstate (Sr9Gd2W4O24), offer tunable luminescence by adjusting composition and structure, making them ideal for LED and display applications. In this study, Sr9Gd2W4O24 phosphors doped with various concentrations of Mn4+ ions were synthesized using the sol-gel method and systematically investigated to elucidate their structural, optical, and luminescent properties. The XRD and FTIR confirmed the crystal structure and phase purity, while the DRS studies revealed a suitable band gap for optoelectronic applications. Under the excitation of 343 nm, the phosphors exhibit intense red emission at 681 nm, attributed to 2Eg → 4A2g transition of Mn4+. The photoluminescence color photometry analysis revealed emission in the red region with a color purity of 96.21%. Crystal field analysis helps to estimate factors such as Racah parameters and nephelauxetic parameters. These parameters suggest that Mn4+ experience a strong crystal field within the Sr9Gd2W4O24 matrix and a moderate degree of covalency between Mn4+-O2- bonds. Electron paramagnetic resonance studies were also performed on the current phosphor to investigate the dopant's coordination in the host. The results suggest potential application in deep-red LEDs for plant growth and advanced ceramics for optoelectronics.

PubMedPreventive nutrition and food science2026-08-29

Mineral Profiling of Preterm, Term Breast Milk, and Commercial Infant Formula: Evaluating Nutritional Adequacy for Premature Neonates.

Latif Samreen S, Shafique Munib Ahmed MA, Khalid Nauman N

This study assessed the mineral adequacy of mothers' own milk, term milk, and preterm formula for premature neonates, evaluated toxic element contents using Inductively Coupled Plasma-Optical Emission Spectrometry, and audited formula labels. Preterm and term milk were inadequate in meeting European Society for Paediatric Gastroenterology Hepatology and Nutrition-modeled mineral requirements for preterm infants at an assumed enteral intake of 165 mL/kg/d, particularly for calcium, chromium, phosphorus, magnesium, zinc, sodium, and selenium. Preterm formula met or even exceeded the requirements for calcium, magnesium, phosphorus, and zinc more frequently than human milk (P<0.05), though these findings should be interpreted cautiously given the small number of formula samples (n=5). Mineral composition was similar between preterm and term milk, except for higher phosphorus in term milk (P<0.05). Aluminum concentrations were greater in human milk-preterm and term: 16.2 and 5.9 µg/mL, respectively-than in preterm formula at 1.16 µg/mL (P<0.05). Labeled and measured formula values for calcium, sodium, sulfur, strontium, titanium, and zinc varied significantly (P<0.05). Despite lower mineral content, mothers' milk with individualized fortification is recommended for its immune benefits. These findings underline the need for improved formula labeling and monitoring of toxic elements.

PubMedCureus2026-08-29

Splenic Vein Thrombosis Complicating Hypertriglyceridemia-Induced Acute Pancreatitis in Diabetic Ketoacidosis: A Rare Clinical Tetrad.

Adetiloye Adebola O AO, Asif Anim A, Salih Mohamed M, Ismail Moustafa M et al.

Diabetic ketoacidosis (DKA) is a life-threatening metabolic emergency that may be accompanied by severe hypertriglyceridemia (HTG), particularly in patients with poorly controlled type 1 or 2 diabetes mellitus. Marked HTG is a well-recognized cause of acute pancreatitis, while splenic vein thrombosis (SVT) is an uncommon vascular complication of pancreatic inflammation. The coexistence of these four conditions represents an exceptionally rare clinical presentation. SVT is clinically significant, as it may cause sinistral portal hypertension, gastric varices, and gastrointestinal bleeding. A 34-year-old man with type 2 diabetes mellitus presented with abdominal pain, nausea, vomiting, and DKA. Initial evaluation revealed severe HTG and HTG-induced acute pancreatitis (HTG-AP), with CT showing a bulky, ill-defined pancreas, peripancreatic fluid, and fat stranding. He was initially treated with intravenous insulin, aggressive fluid resuscitation, and electrolyte replacement. Persistent abdominal pain prompted repeat CT on hospital day 3, which demonstrated isolated SVT with perigastric collaterals and no portal or superior mesenteric vein involvement. Therapeutic intravenous heparin was initiated, followed by transition to oral apixaban. He was discharged in stable condition on basal-bolus insulin, atorvastatin, fenofibrate, and omega-3 acid ethyl esters with multidisciplinary follow-up. This case describes a rare clinical tetrad linking DKA, severe HTG, HTG-AP, and SVT. It highlights the importance of early recognition and prompt multidisciplinary management of both the metabolic and thrombotic complications associated with this uncommon presentation.

PubMedBritish journal of clinical pharmacology2026-08-29

Clinical relevance of pharmacogenomic information for improving prescribing practices in acutely admitted older medical patients.

Christensen Louise Westberg Strejby LWS, Boas Anne Kirstine AK, Clausen Emilie E, Koch Nicoline Elers NE et al.

Safe prescribing and effective medication review during acute hospitalization depends on accurate information about liver and kidney function because these organs are responsible for the elimination of most medications. While estimates for kidney function are widely used, comparable markers of hepatic drug-metabolizing capacity are not routinely available. We evaluated the clinical relevance of pharmacogenomic (PGx) information for key pharmacogenes implicated in medication elimination in older adults presenting to the emergency department. Fourteen pharmacogenes were analysed using the Personal Medicine Profile™ test. GeneYouIn PillCheck™ software performed genotype-to-phenotype translations, identified drug-gene interactions (DGIs) and generated a clinical decision report based on each patient's actual medication use. Among 125 acutely admitted older medical patients (median age 78.3 years; 10 medications; 7 chronic diseases), PGx testing identified 88 DGIs across 63 patients (50.4%). Of these, 46.5% were considered by clinical experts to be clinically relevant for the individual patient, affecting 33 patients (26.4%) in the total study population. Frequently implicated pharmacogenes included CYP2C19 (25.0%), SLCO1B1 (25.0%), CYP2D6 (20.5%), CYP2C9 (14.8%) and OPRM1 (6.8%), and frequently implicated medications included losartan (13.6%), pantoprazole (12.5%), simvastatin (12.5%), atorvastatin (11.4%) and metoprolol (11.4%). With more than one-quarter of acutely admitted older medical patients having one or more clinically relevant DGIs, these findings suggest that PGx information may have meaningful clinical utility for improving prescribing practices in acute care. However, interpretation in this population requires careful consideration of other factors such as nutritional status and inflammation that may modify pharmacogene activity.

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