Drug Database
IO

ior-t3 (IORt3)

✓ Approved

Center of Molecular Immunology · CD3E · Monoclonal Antibodies

What is ior-t3?

ior-t3 is a monoclonal antibodies developed by Center of Molecular Immunology. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesIORt3
CompanyCenter of Molecular Immunology
Drug ClassMonoclonal Antibodies, Antibody
Molecular TargetCD3E
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Center of Molecular Immunology

Mechanism of Action

Molecular Targets

ior-t3 acts on 1 molecular target:

CD3ECD3 epsilon subunit of T-cell receptor complex (TCRE, CD3epsilon)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

ior-t3 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Immune system disordersSolid organ transplant rejection✓ Approved

Related Research Articles

PubMedEndokrynologia Polska2026-10-16

Exposure to hypothyroid serum alters expression of oncogenes and tumor suppressors in preneoplastic breast cells.

Hanusek Karolina K, Bornikowska Katarzyna K, Białas Alex A, Iwanicka-Nowicka Roksana R et al.

Hypothyroidism is the most prevalent thyroid disorder, whereas breast cancer (BC) is the most common malignancy inwomen. The association between hypothyroidism and BC remains unclear, and clinical studies provide conflicting data, suggesting thathypothyroidism may increase, reduce, or have no effect on BC risk. We hypothesised that exposure of mammary cells to hypothyroidserum triggers transcriptional reprogramming that may influence their future malignant potential. Serum samples were collected from female patients with hypothyroidism (group H) and healthy volunteers (control group C). The preneoplastic breast epithelial cell line MCF10AT was cultured in the presence of serum H or serum C, with or withoutsupplementation with 3,5,3'-triiodothyronine (T3). Whole‑transcriptome profiling was performed using the Clariom™ S Assay (ThermoFisher Scientific, Waltham, MA, USA), and validation was conducted using quantitative polymerase chain reaction (qPCR). Transcriptomicdata from the Cancer Genome Atlas BRCA cohort were used to evaluate gene expression patterns in breast tumors. Microarray analysis revealed altered expression of 301 genes, including 185 upregulated and 116 downregulated genes. More than half of the genes with an false discovery rate (FDR) < 0.05 showed consistent directionality of expression in both breast tumors and premalignant MCF10AT cells exposed to hypothyroid serum. Exposure of MCF10AT cells to hypothyroid serum markedly inducedexpression of well‑recognized BC oncogenes (including AGR2 and KRT14), while concurrently reducing expression of tumor suppressors(e.g. ACSL5, FBXO32 and KLF9), as well as the expression of nuclear T3 receptor THRB. T3 treatment reversed the gene expression changesinduced by hypothyroid serum, confirming that the observed effects resulted from decreased T3 concentrations in the patients' sera. A hypothyroid milieu alters the transcriptomic profile of premalignant breast cells, increasing the expression of T3‑responsive oncogenes and decreasing the expression of T3‑regulated tumor suppressors. Further studies are required to determine whether these changes promote or attenuate malignant progression.

PMID 42885589
Read full article →
PubMedBiodegradation2026-10-16

Phytoremediation of hexavalent chromium from soil via Pennisetum pedicellatum and chromium-resistant rhizospheric microflora: a synergistic approach.

Kumar Pankaj P, Sharma Apurva A, Singh Snigdha S, Maharana Dusmant D et al.

Hexavalent chromium [Cr(VI)] is a persistent, highly toxic, and bioaccumulative contaminant that poses serious risks to soil ecosystems and human health. This study investigated the phytoremediation potential of Pennisetum pedicellatum and characterized chromium-associated rhizospheric bacteria in Cr(VI)-contaminated soil. A 60-day greenhouse pot experiment was conducted using four Cr(VI) treatments: control (T0), 25 mg kg⁻1 (T1), 50 mg kg⁻1 (T2), and 100 mg kg⁻1 (T3). Plant and soil samples were collected at 15-day intervals to evaluate growth, biomass, biochemical responses, and chromium accumulation. Chromium uptake increased with both treatment concentration and exposure time, with the highest accumulation observed in T3, reaching 58.55 mg kg⁻1 in roots and 20.23 mg kg⁻1 in shoots. Chromium was preferentially retained in the root system, while prolonged exposure adversely affected root and shoot growth despite relatively higher biomass production under T3. The calculated bioaccumulation factor (BAF) and translocation factor (TF) confirmed P. pedicellatum's ability to accumulate chromium, with root sequestration indicating phytostabilisation as the predominant remediation mechanism. In addition, five chromium-associated rhizospheric bacterial isolates were identified through biochemical characterization and 16S rRNA gene sequencing as Bacillus foraminis, Bacillus wudalianchiensis, Bacillus australimaris, Bacillus licheniformis, and Bacillus paramycoides. Although these isolates were successfully identified, their functional roles in chromium resistance, Cr(VI) reduction, biosorption, and plant growth promotion were not evaluated in this study. Overall, the findings demonstrate that P. pedicellatum is a promising candidate for the phytostabilization of chromium-contaminated soils and provide a foundation for future investigations into plant-microbe-assisted phytoremediation under field conditions.

PMID 42881258
Read full article →
PubMedAnimals : an open access journal from MDPI2026-10-16

Replacement of Soybean Meal with Fermented Dried Tomato Pomace Modulates Immune Responses, Antioxidant Gene Expression, and Meat Quality in Boer Goats: Insights from Hepatic Transcriptomics.

Sangsawad Papungkorn P, Long Yong Y, Kaewda Jirawadee J, Paengkoum Pramote P et al.

This study evaluated the effects of replacing soybean meal with fermented dried tomato pomace (FDTP) on biochemical, immune, and antioxidant responses, meat quality, and hepatic transcriptomic profiles in Boer goats. Twenty-four male goats were assigned to a control diet or diets in which FDTP replaced 33.33% (T1), 66.66% (T2), or 100% (T3) of soybean meal for 60 days (n = 6). Serum biochemical parameters, total immunoglobulin, and alternative complement hemolytic activity were unaffected, whereas lysozyme activity increased linearly with FDTP replacement. FDTP increased muscular SOD1 expression and altered cytokine expression in a tissue-specific manner, including increased IL10 and reduced IL1B and TNFα expression in selected tissues. In gastrocnemius muscle (n = 3), T2 had higher collagen content and lower cooking loss than the control and T3, whereas T3 had higher drip loss than T2; selected textural properties were also altered. During refrigerated storage, lipid oxidation was affected by storage day but not by treatment or the treatment × day interaction. T2 was selected post hoc for exploratory hepatic transcriptomic comparison with the control (n = 5). Among 587 DEGs, significantly enriched KEGG pathways involved metabolism and biotransformation, including steroid hormone biosynthesis, retinol metabolism, bile secretion, xenobiotic metabolism, and pentose and glucuronate interconversions. In addition to the enriched pathways, PI3K-Akt, MAPK, NF-κB, and cytokine-cytokine receptor pathways contained DEGs related to metabolic, stress, and immune responses. Overall, FDTP replacement was associated with changes in selected immune and meat-quality traits and with hepatic transcriptional responses predominantly related to metabolic and biotransformation processes.

PMID 42883083
Read full article →
PubMedJournal of advanced nursing2026-10-16

Temporal Network of Symptoms, Physical Activity and Nutritional Status in Breast Cancer Patients Undergoing Chemotherapy: The Central Role of Fatigue.

Rouxin Wang W, Yanjun Wu W, Yanyan Lu L, Wubin He H

To examine longitudinal interrelationships among symptom burden, physical activity and nutritional status in breast cancer patients undergoing chemotherapy. A longitudinal observational study with three repeated measurements. A total of 280 breast cancer patients were recruited from two tertiary hospitals in China. Data were collected before chemotherapy (T1), after cycle 3 (T2) and after cycle 6 (T3) using the Memorial Symptom Assessment Scale-Short Form (MSAS-SF), International Physical Activity Questionnaire-Short Form (IPAQ-SF) and Patient-Generated Subjective Global Assessment (PG-SGA). Cross-lagged panel network analysis estimated contemporaneous and temporal networks, with centrality indices identifying influential nodes. Fatigue and appetite loss emerged as consistent central nodes. Higher fatigue severity at T1 predicted decreased physical activity at T2 (β = -0.17, 95% CI: -0.24 to -0.10) and higher physical activity at T2 predicted better nutritional status at T3 (β = -0.18, 95% CI: -0.25 to -0.11). Nutritional status did not predict subsequent symptoms or activity. Fatigue had the highest strength centrality. This study reveals a temporally ordered predictive pattern from fatigue to reduced physical activity and subsequent deterioration in nutritional status in breast cancer patients during chemotherapy. Early fatigue management may inform interventions aimed at mitigating this trajectory. Oncology nurses may consider prioritizing fatigue assessment and management from the start of chemotherapy and promoting physical activity during mid-treatment to help preserve nutritional status. What problem did the study address? The temporal relationships among symptoms, physical activity and nutritional status during chemotherapy were unclear What were the main findings? Fatigue predicted subsequent physical activity decline, which in turn predicted nutritional deterioration; fatigue was the most central node in the network. Where and on whom will the research have an impact? The findings will inform oncology nursing practice for breast cancer patients undergoing chemotherapy in China and internationally. STROBE guideline for observational studies. This study did not include patient or public involvement in its design, conduct, or reporting.

PMID 42885088
Read full article →
PubMedThe British journal of educational psychology2026-10-16

Reciprocal relations between teachers' relational goals, students' conflict and boredom in German and mathematics classes.

Hußner Isabell I, Raufelder Diana D, Lazarides Rebecca R

Teachers' relational goals are important prerequisites of positive teacher-student relationships, in turn shaping students' emotional experiences during the learning process. However, the reciprocal nature of these interrelations remains unclear. We tested reciprocal relations between teachers' relational goals, student-perceived conflicts with teachers, and students' boredom in German and mathematics class. N = 89 German language teachers with their n = 1573 students and n = 77 mathematics teachers with their n = 1588 students who participated across four time points (T1-T4) over two school years. We estimated two subject-specific (German/mathematics) random-intercept cross-lagged panel models (RI-CLPMs). In German classes, teachers' relational goals (T3) negatively related to students' boredom (T4). In mathematics classes, students' boredom (T1) negatively related to teachers' relational goals (T2). In both subjects, students' overall conflict with the teacher was positively related to their overall boredom. The findings suggest subject-specific transactional dynamics rather than consistent reciprocal effects by showing that German language teachers' relational goals are related to lower subsequent boredom, whereas in mathematics, higher student boredom was associated with lower subsequent teachers' relational goals. Strengthening relational classroom practices may help reduce boredom and conflict.

PMID 42881347
Read full article →
PubMedAustralian dental journal2026-10-16

From Diagnosis to Decision-Making: AI-Driven Triage of Oral Mucosal Lesions Detected on Intraoral Photographs.

Schwärzler Julia J, Tolstaya Ekaterina E, Tichy Antonin A, Yap Tami T et al.

Managing oral mucosal lesions in general dental practice is challenging, as visually similar conditions may require very different treatments. We developed an AI-based triage system connecting intraoral image analysis with guideline-based treatment recommendations, tested it externally, and compared its performance with clinicians' recommendations. YOLOv8 and YOLOv11 were trained on 4079 intraoral photographs to classify 11 oral mucosal lesion types. These were mapped into five treatment tiers defined by urgency and management aim: T1 specialist referral for malignant and high-risk lesions, T2 interdisciplinary referral for specialist-led non-cancer management, T3 risk-adapted surveillance, T4 dental treatment with reassessment, and T5 no treatment. Model performance was compared with two general dentists and four specialists on an internal test set. YOLOv11 was additionally tested on an external dataset. YOLOv11 outperformed YOLOv8 in macro-averaged precision, recall, and F1 score, achieving 0.72, 0.74, and 0.73 respectively. However, 25% of T1 high-risk cases were under-triaged. YOLOv11 significantly outperformed all clinicians, whose F1 scores ranged from 0.33 to 0.69. External performance decreased markedly (F1 score: 0.58), consistent with domain shift. Guideline-oriented AI triage is feasible but requires multicentre training for improved generalizability, as well as safety-focused optimization, and prospective user evaluation before clinical use.

PMID 42885096
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about ior-t3