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ior-t3 (IORt3)

✓ Approved

Center of Molecular Immunology · CD3E · Monoclonal Antibodies

What is ior-t3?

ior-t3 is a monoclonal antibodies developed by Center of Molecular Immunology. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesIORt3
CompanyCenter of Molecular Immunology
Drug ClassMonoclonal Antibodies, Antibody
Molecular TargetCD3E
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Center of Molecular Immunology

Mechanism of Action

Molecular Targets

ior-t3 acts on 1 molecular target:

CD3ECD3 epsilon subunit of T-cell receptor complex (TCRE, CD3epsilon)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

ior-t3 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Immune system disordersSolid organ transplant rejection✓ Approved

Related Research Articles

PubMedAutophagy2026-08-30

Thyroid hormone promotes lipid droplet remodeling and lipophagy through KAT2B/PCAF-dependent histone acetylation in preimplantation embryos.

Lee Song-Hee SH, Zhan Cheng-Lin CL, Cui Xiang-Shun XS

Thyroid hormones are central regulators of metabolic homeostasis and developmental programming. The active hormone triiodothyronine (T3) modulates transcription through nuclear receptors that recruit epigenetic cofactors to remodel chromatin and regulate metabolic gene networks. Although thyroid hormone signaling is known to influence lipid metabolism, whether it coordinates lipid droplet turnover with autophagy-related pathways during early embryonic development remains largely unknown. Here, transcriptomic profiling revealed distinct metabolic signatures between in vivo and in vitro embryos, with marked differences in fatty acid metabolism. Supplementation with 50 nM T3 enhanced blastocyst formation, particularly when applied from the 4-cell to blastocyst stages, coinciding with elevated thyroid hormone receptor expression. T3 induced robust lipid droplet remodeling, characterized by reduced droplet size, together with increased lipid-mitochondria colocalization and activation of lysosomal and mitochondrial pathways, consistent with enhanced lipid catabolism and organelle coupling. Mechanistically, inhibition of the histone acetyltransferase KAT2B/PCAF abolished T3-mediated developmental gains, reduced H3K9ac and H3K27ac, and resulted in nonselective autophagic stress rather than lipophagy. By contrast, T3 required KAT2B to stimulate cytosolic lipolysis, channel fatty acids into mitochondria, and enhance mitochondrial membrane potential. T3 also upregulated prostaglandin biosynthesis genes and improved outgrowth performance. These findings identify a thyroid hormone-KAT2B epigenetic axis that coordinates lipid droplet remodeling through lipolytic and lipophagic pathways, linking endocrine signaling to organelle crosstalk and mitochondrial activation during early embryogenesis.

PMID 42669119
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PubMedAsia-Pacific journal of oncology nursing2026-08-30

Changes in postoperative symptom communities and network structure in patients with oral squamous cell carcinoma: A four-time-point study.

Nie Shumin S, Liu Chunqin C, Zhang Yuqing Y, Zhao Ting T et al.

To describe changes in symptom communities and contemporaneous symptom network structure across four postoperative time points in patients with oral squamous cell carcinoma (OSCC) undergoing flap reconstruction. This prospective longitudinal study included 251 participants with complete data. Symptoms were assessed on postoperative days 1 (T1), 3 (T2), 7 (T3), and 30 (T4) using the Chinese version of the MD Anderson Symptom Inventory-Head and Neck Module. Gaussian graphical models with EBICglasso regularization were estimated separately at each time point. Symptom communities were identified using principal component analysis (PCA), with exploratory graph analysis (EGA) performed as a sensitivity analysis. Node strength and bridge strength were summarized. Paired Network Comparison Tests with 2000 permutations compared networks across time points; global-strength comparisons were Bonferroni-adjusted. In the PCA solution, three, three, four, and five symptom communities were identified at T1, T2, T3, and T4, respectively; the sensitivity analysis yielded four, three, three, and six communities, indicating methodological sensitivity. Choking cough, somnolence, problems with mucus, and vomiting had the highest node strength at T1, T2, T3, and T4, respectively. Problems with mucus had the highest bridge strength at T1 and T2, lack of appetite at T3, and distress at T4. Global strength differed between T2 and T3 and between T2 and T4 after Bonferroni correction. These descriptive, hypothesis-generating findings provide a complementary view of postoperative symptom interrelationships and may support stage-specific symptom assessment. They do not establish causal mechanisms or validated intervention targets.

PMID 42668521
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PubMedFood chemistry: X2026-08-30

Comprehensive analysis of the effects of foliar application of the synthetic strigolactone analog GR24 during the growth period on postharvest quality and metabolic indicators of pak choi.

Ma Yufeng Y, Cai Qitong Q, Wang Cheng C, Liu Yang Y et al.

Strigolactones (SLs) regulate plant growth and metabolism, but their concentration-dependent effects on leafy vegetable quality remain unclear. We investigated how the synthetic SL analog GR24 affects physiological and metabolic processes in pak choi (Brassica rapa subsp. chinensis). Mantel correlation analysis and partial least squares structural equation modeling (PLS-SEM) revealed distinct response patterns. The 1 μmol·L-1 treatment (T2) enhanced photosynthesis, carbon‑nitrogen assimilation, mineral accumulation, and GA3, ZT, ABA, and JA levels, whereas the 10 μmol·L-1 treatment (T3) promoted carotenoid and phenolic accumulation, including rutin, ferulic acid, and caffeic acid. Multivariate analysis linked phenolic acid accumulation mainly to nitrogen and amino acid metabolism, with additional associations with P status. Overall, T2 broadly enhanced primary metabolism and nutrition, whereas T3 favored secondary and antioxidant-related metabolism, providing a framework for optimizing GR24 application in high-quality leafy vegetable production.

PMID 42668560
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PubMedTrials2026-08-30

Process evaluation of the randomized trial-"Care management for older people with cognitive impairment during and after hospitalisation in Germany (intersec-CM)".

Chikhradze N N, Hannich A A, Otte I C IC, Busse T S TS et al.

Effective care of people with cognitive impairment and their families depends, among other things, on the cooperation of the professionals involved in their care. An effective dementia care management support model for people with dementia and their families for the outpatient sector has been further developed for ambulatory and hospital settings. The intersec-CM randomized controlled trial (RCT) implemented this intersectoral care management (iCM) model into routine care in three hospitals in Bielefeld and Greifswald (Germany). Care managers (CMs) trained in advance for the study used a computer-based information management system (IMS) to assess patients' health and care needs and to develop individualized care plans. The iCM aimed to improve hospital-to-primary-care transitions and ensure cross-sectoral care. This was accompanied by a process evaluation to complement the data collected in the RCT. The aim was to understand how the complex intervention works in the selected real-world setting. This paper presents the results of this process evaluation. For the process evaluation, a mixed-method design was chosen and applied. The evaluation was based on the guidelines of the British Medical Research Council for the implementation and process evaluation of complex interventions (MRC framework). A method triangulation was conducted consisting of several successive phases (t1: qualitative, t2: quantitative, t3: qualitative). The sample (t1: individual interviews n = 30, t2: survey n = 177, t3: individual interviews n = 33) consisted of patients and their relatives, clinical physicians, social workers, carers, general practitioners, care managers (CMs), and project management. The process evaluation showed that intersectoral iCM could be implemented in the hospitals. The CMs were partially successful in assessing needs, developing individual treatment plans, and coordinating and monitoring the needs of people with cognitive impairment and their families. They found it difficult to work with the different actors in the healthcare system because of the rigid daily routines and lack of time in the clinics. Overall, the results show that (1) people with cognitive impairment and their families can benefit from the intervention and (2) iCM can help with the flow of information between health professionals. The present process evaluation underlines the necessity and meaningfulness of process evaluations to understand the functionality and procedural feasibility of an RCT. Through the study, significant insights into the "black box" of the implementation of the iCM intervention could be gained. ClinicalTrials.gov NCT03359408. The trial was registered on December 2, 2017.

PMID 42668367
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PubMedCaspian journal of internal medicine2026-08-30

Papillary thyroid carcinoma in a hyperfunctioning autonomous nodule : A diagnostic paradox challenging clinical guidelines.

Paz-Ibarra José J, Concepción-Zavaleta Marcio M, Fuentes-Mendoza Jenyfer J, Herrera-Silvestre Hilder H et al.

Papillary thyroid carcinoma (PTC) is rarely found within hyperfunctioning (hot) thyroid nodules, which are typically considered benign. This case challenges the prevailing notion that functional autonomy excludes malignancy and underscores the need for a nuanced diagnostic approach. We report the case of a 63-year-old woman with clinical hyperthyroidism and a palpable right thyroid nodule. Biochemical tests confirmed thyrotoxicosis (TSH <0.005 µIU/mL, free T4 25.55 pmol/L and T3 7.69 pmol/L). Despite the hyperfunctioning profile, thyroid ultrasound showed high-risk features, including hypoechogenicity, microcalcifications, irregular margins, and elevated stiffness on shear wave elastography, classifying the lesion as ACR-TIRADS 5. A 99mTc scan confirmed a hyperfunctioning nodule. Fine-needle aspiration cytology (FNAC) revealed PTC. She subsequently underwent total thyroidectomy. FNAC revealed PTC. Histopathology confirmed a 13 mm intrathyroidal papillary carcinoma with mixed classic (40%) and oncocytic (60%) subtypes, without capsular or extrathyroidal extension. The background thyroid tissue showed macrofollicular hyperplasia. The patient recovered uneventfully and did not require radioactive iodine ablation. Genetic testing was unavailable. This case illustrates that malignancy can coexist with hyperfunctioning thyroid nodules. Suspicious sonographic features should not be dismissed due to functional status. Cytological evaluation remains essential when ultrasound findings raise concern, supporting a shift toward integrated diagnostic decision-making in thyroid nodule assessment.

PMID 42668887
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PubMedCureus2026-08-30

Prevalence of Thyroid Dysfunction in Patients With Chronic Spontaneous Urticaria Attending a Tertiary Care Urticaria Clinic: A Cross-Sectional Study.

Srinivasan Varsha V, Kannan Rajkumar R, Vadivelu Sampath S

Background and objectives Existing studies have primarily focused on autoimmune thyroid disorders in patients with chronic spontaneous urticaria (CSU); fewer studies have assessed thyroid function using routine thyroid function tests alone. The purpose of this study was to estimate the prevalence and pattern of common thyroid disorders among CSU patients at a tertiary care center. Methods A descriptive cross-sectional study was conducted among 123 patients aged above 18 years with CSU visiting the Urticaria OPD at Rajiv Gandhi Government General Hospital. After obtaining written informed consent, patients were assessed using a validated, interviewer-administered questionnaire and examined clinically. All patients underwent serum thyroid function testing, including free T3, free T4, and thyroid-stimulating hormone estimation by chemiluminescence Immunoassay. Data were entered into Microsoft Excel and analyzed using IBM SPSS Statistics for Windows, Version 26 (Released 2018; IBM Corp., Armonk, New York, United States) to determine the prevalence and pattern of thyroid disorders among CSU patients. Chi-square, Fisher's exact test, Mann-Whitney U test, and odds ratios with 95% confidence intervals were used for inferential analysis. Results The prevalence of thyroid abnormalities among patients with CSU was 29 of 123 patients (23.5%; 95% CI: 16.9-31.8%). Hypothyroidism was observed in 28 (22.8%) patients and constituted the majority of abnormalities, while hyperthyroidism was observed in one patient (0.8%). Thyroid dysfunction was observed in 16 (28.0%) patients aged <45 years and 13 (19.6%) patients aged ≥45 years (p=0.339). Female patients showed higher rates of thyroid dysfunction (27.1%) compared to male patients (15.8%), though this difference was not statistically significant (p=0.174). Conclusion The relatively high prevalence of thyroid dysfunction observed in this cohort suggests that thyroid function assessment may be considered in selected CSU patients, particularly where clinical suspicion exists.

PMID 42668794
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