Drug Database
PH

PHN-021 (PCNH / PHN021)

✓ Approved

PhytoHealth · Small Molecule · Small Molecule

What is PHN-021?

PHN-021 is a small molecule developed by PhytoHealth. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesPCNH, PHN021
CompanyPhytoHealth
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, PhytoHealth

Therapeutic Indications

PHN-021 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Gastrointestinal disordersAbdominal painPhase I

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PubMedPlants (Basel, Switzerland)2026-10-16

Multi-Trait Characterization and Selection of Elite Wild Kiwifruit (Actinidia spp.) Germplasm from the Dabie Mountains of Hubei, China.

Huang Wei W, Zhao Zhiyuan Z, Zhang Hong H, Yang Jingwen J et al.

Wild kiwifruit germplasm can broaden breeding pools through complementary fruit-quality and stress-response traits. The Hubei Dabie Mountains contain heterogeneous habitats, but coordinated evaluation of their wild Actinidia resources remains limited. Taxonomy and ploidy were determined for 117 accessions from eight sites spanning 170-1730 m. Nine descriptive fruit traits and detached-leaf responses to bacterial canker and heat were assessed in 41 fruiting accessions. Bacterial canker response was assessed using Pseudomonas syringae pv. actinidiae (Psa), and heat response using maximum photosystem II quantum efficiency (Fv/Fm) after 47 °C treatment. Seven fruit-quality traits were measured in 27 accessions with normally ripened fruit. Three taxa were identified: A. chinensis, A. polygama, and A. chinensis var. deliciosa. Diploid, tetraploid, and hexaploid cytotypes were detected. Shannon-Wiener indices for descriptive traits ranged from 0.26 to 1.64. Twenty-three accessions were classified as highly or moderately resistant to Psa. Heat screening classified 23 accessions as heat tolerant, 16 as moderately heat tolerant, and two as heat sensitive. Fruit-quality coefficients of variation ranged from 12.92% to 120.41%. Fruit-quality ranking followed by Psa screening identified MC-021, MC-026, YS-031, YS-037, and YS-038 as candidate elite germplasm. These accessions are priorities for conservation and further breeding evaluation.

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PubMedPain and therapy2026-10-15

Application of Virtual Reality in Pain Management of Patients with Postherpetic Neuralgia: A Randomized Controlled Trial.

Li Huishi H, Wang Guohui G, Zhang Wenjie W, Li Yan Y et al.

Postherpetic neuralgia (PHN) is the most frequent chronic complication of herpes zoster (HZ), the incidence of PHN gradually increases with age, and the persistent pain brings a heavy burden to patients with PHN. Virtual reality (VR) is an emerging tool for relieving acute and chronic pain. However, there is currently no research on applying VR to patients with PHN. This study aimed to explore the effectiveness and safety of VR in reducing the pain levels of patients with PHN. Providing an evidence-based medical rationale for the use of VR in pain management for patients with PHN. Fifty patients with PHN were randomly divided into the experimental group and the control group, with 25 cases in each group. The control group received PHN conventional therapy. The experimental group received VR therapy plus conventional therapy, namely 10-min VR sessions twice daily for five consecutive days (T1~T5). Primary outcome measure was patients reported pain levels at the sixth day after admission (T6). We also measured anxiety, depression and self-efficacy levels, as well as inflammatory factor levels of patients in both groups. Patients reported side effects and satisfaction in the experimental group were also recorded. Significant improvements were observed for pain (2.48 ± 1.23 vs 3.28 ± 1.37, P = 0.035), anxiety (31.44 ± 3.89 vs 33.72 ± 3.80, P = 0.041), depression (34.00 ± 5.91 vs 37.64 ± 5.02, P = 0.023), self-efficacy (32.68 ± 3.60 vs 29.92 ± 5.38, P = 0.038), IL-2 (3.30 ± 0.59 vs 2.67 ± 0.27, P<0.001), IL-6 (2.94 ± 1.38 vs 4.13 ± 2.43, P = 0.038), IL-10 (6.36 ± 1.03 vs 5.26 ± 1.09, P = 0.001), TNF-α (1.76 ± 0.48 vs 2.10 ± 0.59, P = 0.033), and INF-γ (3.82 ± 1.06 vs 3.00 ± 0.48, P = 0.001). No participants complained of severe side effects and patients' satisfaction with VR reached 80%. This study suggests that VR can be efficacious and safe for patients with PHN. This clinical trial has been registered in the Chinese Clinical Trial Registry with the registration number: ChiCTR2400085999.

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PubMedAdvances in clinical and experimental medicine : official organ Wroclaw Medical University2026-10-15

Herpes zoster epidemiology during and after the COVID-19 pandemic: A 5-year retrospective study from primary care in Poland.

Oleszko Michał M, Zaręba Lech L, Łoś Aleksandra A, Król Nikola N et al.

Herpes zoster (HZ) is caused by reactivation of latent varicella-zoster virus and affects 25-30% of individuals, with the highest incidence in adults aged ≥50 years and a lifetime risk exceeding 50% after the age of 85. Its most common complication is postherpetic neuralgia (PHN), i.e., persistent neuropathic pain. Reports of increased HZ incidence during or after SARS-CoV-2 infection suggest potential epidemiological associations requiring further investigation. Our goals were to evaluate the incidence of HZ and its complications during the pandemic and the post-pandemic period in primary care settings in Poland. We conducted a retrospective multicenter study in 20 primary care clinics in Poland, covering 43,949-81,091 patients from 2020 to 2024. Incident HZ cases and complications (PHN, herpes zoster ophthalmicus (HZO), HZ oticus, and disseminated HZ) were identified, and demographic data, including place of residence, were collected. Statistical analyses included χ2 or Fisher's exact tests, Student's t-tests or nonparametric equivalents, odds ratios (ORs) with 95% confidence intervals (95% CIs), and receiver operating characteristic (ROC) analysis to assess age-related risk of prolonged symptoms. A total of 570 HZ cases were recorded from 2020 to 2024. Incidence ranged from 1.61 to 2.14 per 1,000 persons and increased with age, reaching 6.57 per 1,000 in individuals aged ≥80 years. Patients aged ≥71 years had higher odds of developing PHN (pain persisting for >90 days) than younger patients (OR = 4.47; 95% CI: 2.30-8.67; p < 0.001). Older adults were also more likely to develop HZO (p = 0.001). Rural incidence was significantly lower during the pandemic than in the post-pandemic period (p = 0.005), with no significant differences in urban or semi-urban areas. The risk of HZ, PHN, and HZO rises with age. During the pandemic (2020-2021), rural incidence was significantly lower than in the post-pandemic period (2022-2024). The study provides updated data on HZ epidemiology in Poland and highlights the impact of the COVID-19 pandemic on healthcare access and HZ reporting in rural areas.

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PubMedThe British journal of nutrition2026-10-15

Higher scores in a Refined high in sugar, salt, and fat dietary pattern are associated with excess adiposity among 54-month-olds: Growing Up in New Zealand cohort.

Ismael Fajer Baker FB, Wall Clare Rosemary CR, Lovell Amy Luisa AL, Gontijo de Castro Teresa T

Healthy dietary patterns (DP) in early life constitute an internationally recommended platform for preventing childhood obesity. New Zealand (NZ) ranks high globally for the prevalence of child obesity. Yet, national data on overall diet quality and its relationship with healthy weight remain limited. Data from 54-month-olds (n 6048) in the Growing Up in New Zealand cohort were used to examine associations between indicators of adiposity and scores on two previously identified DP. Excess adiposity was defined by body-mass ondex/age (BMI/A) >+2 z-score (WHO Growth Standards) and a waist-to-height ratio (WtHR) >90th percentile within the cohort. Adjusted associations were examined using multiple Poisson regressions with robust variance. Prevalence ratios (PR) and 95 % confidence intervals (CI) were reported. Compared with females in the lowest tertile of adherence to a DP characterised by high intake of refined foods and those high in sugar, salt and unhealthy fats, those in the middle (PR: 1·56; 95 % CI 1·07-2·28; p = 0·021) and third tertile (PR: 2·14; 95 % CI 1·48-3·10; p < 0·001) had a higher prevalence of overweight/obesity (BMI/A). Scores in this DP were not associated with BMI/A > +2z in males nor with WtHR > 90th percentile in either sex. There were no associations between the tertiles of a DP characterised by high intake of fruit, vegetables and protein foods, and the two adiposity indicators examined for both sexes. Overall, poorer diet quality was linked to obesity at 54 months, with sex-specific effects, supporting national early childhood obesity prevention strategies targeting foods high in sugar, salt and unhealthy fats.

PMID 42878151
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PubMedBulletin of the Hospital for Joint Disease (2013)2026-10-15

Feasibility of opportunistic osteoporosis screening using ankle CT Hounsfield units in older adults with ankle fractures.

Lashgari Alexander A, Bueno Brian T BT, Konda Sanjit R SR, Egol Kenneth A KA et al.

Fragility fractures reveal osteoporosis, but ankle fractures are not consistently defined as fragility fractures. CT-derived Hounsfield unit measurements may provide an opportunistic method to identify patients at risk for osteoporosis. This study investigated the relationship between Hounsfield units (HU) from ankle CT scans and bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DEXA), with the aim of determining whether sufficient signal exists between ankle HU and DEXA-derived BMD to justify a larger prospective validation study, rather than to establish a definitive diagnostic tool. Retrospective correlation study. Level III. Patients aged 55 years or older, who underwent open reduction and internal fixation for OTA/AO 44 A-C ankle fractures between 2012 and 2024 and had both a preoperative ankle CT and a DEXA scan within 1 year of injury, were reviewed. HU values of the distal tibia and fibula were measured using standardized elliptical regions of interest. Multivariate linear regression was performed with the lowest DEXA T-score as the dependent variable, with HU values, and BMI as independent variables. A total of 57 patients (87.7% female, mean age 69.67 ± 9.24 years) were included. The average ankle HU was 192.43 ± 60.04, and the mean T-score was -1.73 ± 0.96. Regression analysis demonstrated that HU values (B = 0.005, P = .021) and BMI (B = 0.064, P = .007) were positively correlated with the T-score.The regression model was lowest T-score = 0.005*Ankle HU + 0.064*BMI-4.422.Based on this equation, an HU measurement of 106.64 or less, assuming a BMI of 21.7, correlated with osteoporosis. Ankle HU values from CT scans demonstrated a positive association with DEXA-derived BMD, supporting proof-of-concept for ankle HU as a preliminary screening tool and providing methodological groundwork for future prospective validation. Given the high prevalence of osteopenia or osteoporosis in this population, ankle fractures should prompt formal bone health evaluation.

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PubMedActa medica portuguesa2026-10-14

Incidence and Management of Postherpetic Neuralgia in Primary Care: A Multicentre Retrospective Study.

Duarte Alcino A, Gonçalo Inês I, Lopes Inês I, Carneiro Santos Isabel I et al.

This study aimed to characterize postherpetic neuralgia (PHN) in herpes zoster (HZ) patients in primary care and assess its treatment. The secondary objectives included evaluating pain records and analgesic prescriptions. A multicentric observational, descriptive, longitudinal, and retrospective study was conducted in five Family Health Units, including adult patients diagnosed with HZ between January 2013, and December 2023, using the S70 code (International Classification of Primary Care - ICPC-2). Duplicate cases, pregnant women, and deceased individuals at time of data collection were excluded. We included 735 individuals with HZ, 65% of whom were female and 81.2% were aged 50 years or older. The thoracoabdominal region was the most frequently affected, accounting for 43.7% of cases. In the initial assessment antivirals were prescribed to 81.1% and analgesics to 60.7%, predominantly nonsteroidal anti-inflammatory drugs. The cumulative incidence of PHN was 8.6% and every patient was receiving pain medication. No significant association was found between antiviral therapy and PHN (p = 0.165) or between depression/anxiety and PHN (p = 0.154). Additionally, in a complete‑case analysis, the absence of an analgesic prescription in the first consultation was associated with higher odds of PHN, although this association was not statistically significant (OR = 1.60; 95% CI 0.25 - 10.05, p = 0.546). The incidence of postherpetic neuralgia appeared slightly lower than prior reports. Antiviral use showed no association with subsequent PHN, whereas the absence of an analgesic prescription in the first consultation was associated with a higher risk of diagnosis, reinforcing the need for timely pain control. Depression and anxiety were common but not linked to PHN. Despite retrospective limitations, these findings emphasize that systematic pain assessment and early analgesic intervention in primary care can lessen the PHN burden.

PMID 42874035
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