Drug Database
PH

PHN-021 (PCNH / PHN021)

✓ Approved

PhytoHealth · Small Molecule · Small Molecule

What is PHN-021?

PHN-021 is a small molecule developed by PhytoHealth. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesPCNH, PHN021
CompanyPhytoHealth
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, PhytoHealth

Therapeutic Indications

PHN-021 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Gastrointestinal disordersAbdominal painPhase I

Related Research Articles

PubMedPain research & management2026-08-28

Mendelian Randomization Research Examining the Effects of Insomnia on Herpes Zoster and Postherpetic Neuralgia.

Yang Xueying X, Li Xuan X, Lin Jingrun J, Chen Yuqing Y et al.

Insomnia is closely linked to herpes zoster (HZ) and postherpetic neuralgia (PHN); nonetheless, the causal relationship has not been sufficiently clarified. This research employs the Mendelian randomization (MR) method to investigate the causal relationship between insomnia and HZ, as well as PHN. Summary statistics from publicly available GWASs were utilized for four sleep traits (insomnia, sleep duration, habitual short sleep [< 7 h/day], and habitual long sleep [≥ 9 h/day]), HZ, PHN, and common risk factors (smoking, alcohol use, obesity, hypertension, and diabetes [Type 1 and Type 2]). Bidirectional univariable two-sample MR was conducted to assess causal associations between insomnia and HZ/PHN. Multivariable MR (MVMR) was performed to determine whether insomnia exerted an independent causal effect on HZ after adjusting for these risk factors. This study identified a positive causal effect of insomnia on HZ risk via inverse variance weighted (IVW) (OR = 1.97, 95% confidence interval [CI]: 1.13-3.45, p = 0.017, P-FDR = 0.034). Longer sleep duration showed a suggestive inverse association with HZ, with each additional hour associated with 34% lower odds (IVW: OR = 0.66, 95% CI: 0.43-1.00, p = 0.048; P-FDR = 0.096). Neither habitual short sleep (IVW: OR = 1.17, p = 0.206) nor habitual long sleep (IVW: OR = 1.11, p = 0.446) was causally associated with HZ. No causal relationships were observed between any sleep trait and PHN, nor evidence for reverse causation. In MVMR, insomnia remained associated with HZ after adjusting for diabetes via IVW (OR = 2.36, 95% CI: 1.12-4.93, p = 0.023), but this association disappeared after further adjustment for smoking, alcohol use, obesity, and hypertension. Genetically determined insomnia was causally associated with increased HZ risk, independent of diabetes but probably confounded by smoking, alcohol use, obesity, and hypertension, while longer sleep duration showed a suggestive protective effect.

PMID 42661494
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PubMedPublic health nursing (Boston, Mass.)2026-08-27

Public Health Nurse Preceptors in Ireland: Exploring Recognition, Preparedness, and Support for Professional Development.

Vickers Niamh N, Guinness Denise Mc DM, Conyard Karl F KF, Byrne Keighleigh K et al.

Preceptorship is a widely recognized pedagogy which positions experienced nurses as mentors, educators and assessors in the clinical environment. Public Health Nurse (PHN) preceptors are instrumental to the education and development of PHN students. This study aimed to evaluate PHN preceptors' perceived recognition, preparedness and support in their roles and to determine overall satisfaction. A cross-sectional survey included a validated instrument modified for the Irish community context and convenience sampling methods to target PHN preceptors associated with one Higher Education Institution, following low-risk ethical approval in 2024. Subscale domains included preparedness, recognition, support and satisfaction. Data were analyzed using descriptive and inferential statistics and STROBE guidelines used for reporting. A response rate of 35.8% (n = 86) was attained. The Preparedness domain demonstrated the highest consensus (M = 12.48, SD = 2.06), indicating that respondents felt prepared for their Preceptorship role. Respondents demonstrated high levels of agreement with pedagogical competencies related to making objective student assessments and supporting skills development. Barriers included insufficient time to engage with preceptorship. The results reveal a disconnect between preceptors perceiving that they were highly valued by students but that the preceptorship role was not formally acknowledged as part of their workload at an organizational level. High attendance was reported at preceptor education sessions (87.2%) and a preference for future education to be delivered online (46.4%). PHN preceptors are critical to integrating theoretical learning in the clinical practice environment. While results demonstrate high satisfaction and confidence, significant challenges exist at the systems level to balance the role and demands of preceptorship, within workloads due to time constraints. At a time when primary care settings are being prioritized for healthcare, the workforce challenges need to be understood and solutions co-created. Future research should incorporate qualitative methods to explore the experiences of preceptors and PHN students.

PMID 42658096
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PubMedNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026-08-27

Immunoinflammatory mechanisms and emerging therapies for postherpetic neuralgia.

He Shunv S, Deng Dan D, Luo Wen-Fei WF

This review examines the immunoinflammatory mechanisms underlying postherpetic neuralgia (PHN) and emerging mechanism-based therapies. PHN is increasingly recognized as a neuroimmune disorder driven by varicella-zoster virus reactivation, peripheral nerve injury, cytokine-mediated inflammation, oxidative stress, glial activation, and central sensitization. Although conventional treatments, including antidepressants, anticonvulsants, topical agents, opioids, and neuromodulation, provide symptomatic relief, they rarely modify the underlying disease process. A key scientific gap is the lack of consensus on the optimal timing, patient selection, and targets for immunomodulatory, gene-based, or RNA-based interventions to prevent the transition from acute neuroinflammation to chronic pain. Therefore, this review briefly summarizes standard-of-care therapies and focuses on emerging strategies targeting upstream mechanisms, including cytokine modulation, NLRP3 inflammasome inhibition, oxidative stress regulation, viral vector-based gene therapy, RNA interference, non-coding RNA approaches, and phenotype-guided precision medicine. We propose a stage-specific, mechanism-oriented framework for future PHN management.

PMID 42658336
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PubMedInternational journal of environmental research and public health2026-08-27

Facing Dementia in Primary Care: A Process Evaluation of a Multicomponent Practice Change Intervention to Improve Dementia Diagnosis in General Practice.

Yates Mark M, Gibson Caroline C, Pond Constance Dimity CD, Daly Stephanie S et al.

Dementia is a leading cause of disability and death worldwide, yet diagnosis in primary care remains substantially lower than expected, delaying access to treatment, support and future care planning. The Facing Dementia Together Practice Change Program was developed as a co-designed, multicomponent intervention to improve dementia diagnosis in Australian general practice. A mixed-methods process evaluation used the RE-AIM framework with the addition of Appropriateness. The intervention included Primary Health Network (PHN) engagement, GP education, clinical resources, audit and benchmarking reports, specialist support, and a dementia risk-alert tool. Data were collected through surveys, stakeholder interviews, website analytics and program documentation. Clinicians who participated reported increased confidence and changes in dementia-related clinical behaviours, while education, resources and benchmarking were perceived as valuable. However, overall reach was limited by competing clinical priorities, workforce pressures, lack of financial incentives, and PHN implementation challenges. The dementia risk-alert tool was feasible but achieved limited uptake because of software compatibility, usability concerns and incomplete electronic medical record data. Although the program was acceptable to participating clinicians, limited reach constrained its potential impact. These findings highlight organizational, workforce, digital infrastructure and policy factors that influenced implementation of multicomponent interventions in routine primary care.

PMID 42652401
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PubMedBiopsychosocial science and medicine2026-08-27

Prospective Links between Intraindividual Measures of Negative Affect and Physical Well-being among Couples Coping with Cancer.

Langer Shelby L SL, Todd Michael M, Porter Laura S LS, Koffer Rachel R

Research examining associations between intraindividual variability in affective experiences and health stems largely from non-clinical samples and individuals versus within a dyadic context. We sought to examine this linkage in couples coping with cancer. 233 patients with cancer and their spouses/partners (mean age = 52.5) completed twice-daily ecological momentary assessments for 14 days. Nine negative affect items were used to compute intraindividual negative affect means, standard deviations (SDs, capturing overall dispersion), and mean square successive differences (MSSDs, capturing occasion-to-occasion shifts). Upon study entry and 12 months later, participants completed a measure of physical well-being. Within- and across-partner associations between negative affect dynamics and 12-month change in physical well-being were examined using an Actor-Partner Interdependence Model framework. When SD was used as the indicator of negative affect intraindividual variability, higher mean negative affect predicted declines in physical well-being for caregivers (actor effect, P=.035), and greater patient variability predicted declines in caregiver physical well-being (partner effect, P=.036). When MSSD was used as the indicator of intraindividual variability, greater patient variability predicted declines in their own physical well-being more strongly among those with lower average negative affect (patient mean x patient MSSD interaction, P=.021) and for patients whose partners had greater negative affect variability (patient MSSD x caregiver MSSD interaction, P=.013). Future work could examine intervention strategies to minimize negative affect and foster equanimity in this population, potentially tailoring based on participants' own mean levels and their partner's variability.

PMID 42658670
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PubMedAnatolian journal of cardiology2026-08-27

The BREATH2 Score as an Independent Predictor of 1-Year Mortality in Patients with Heart Failure with Preserved Ejection Fraction.

Yalvaç Halit Emre HE, Babayiğit Ezgi Çamlı EÇ, Dağhan Hazal H

Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome with substantial early morbidity and mortality. The BREATH2 score was recently developed as an echocardiography-independent screening tool for HFpEF. However, its prognostic significance has not been investigated. This study aimed to evaluate the association between the BREATH2 score and 1-year all-cause mortality in patients with established HFpEF. A total of 213 patients with HFpEF were retrospectively analyzed. The primary endpoint was 1-year all-cause mortality. Discriminative performance of the BREATH2, H2FPEF, and HFA-PEFF scores was assessed using receiver operating characteristic analysis. Multiple logistic regression was performed to identify independent predictors of mortality. Kaplan-Meier survival analysis was conducted using a prespecified BREATH2 cut-off (≥6). During 12-month follow-up, 32 patients (15.0%) died. The BREATH2 score was significantly higher among non-survivors (P = .001). Receiver operating characteristic curve analysis demonstrated that BREATH2 had the highest discriminative ability for 1-year mortality (area under the curve [AUC] = 0.683, P < .001, 95% CI: 0.616-0.745), outperforming H2FPEF (AUC = 0.554, P = .324) and HFA-PEFF (AUC = 0.593, P < .001). In multiple analyses adjusting for age, creatinine, and N-terminal pro-B-type natriuretic peptide, BREATH2 remained independently associated with mortality (odds ratio = 1.658 per 1-point increase, P = .021, 95% CI: 1.078-2.551). Patients with BREATH2 ≥6 had significantly lower survival compared with those with lower scores(log-rank, P = .013). The BREATH2 score independently predicts 1-year mortality in patients with HFpEF. Beyond its diagnostic role, BREATH2 may serve as a practical early risk stratification tool at initial clinical presentation.

PMID 42656080
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