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(S

(S)-atenolol (Atpure)

✓ Approved

Emcure Pharmaceuticals · ADRB1 · Small Molecule

What is (S)-atenolol?

(S)-atenolol is a small molecule developed by Emcure Pharmaceuticals. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesAtpure
CompanyEmcure Pharmaceuticals
Drug ClassSmall Molecule
Molecular TargetADRB1
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Emcure Pharmaceuticals

Mechanism of Action

Molecular Targets

(S)-atenolol acts on 1 molecular target:

ADRB1adrenoceptor beta 1 (B1AR, RHR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

(S)-atenolol is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Cardiac disordersAngina pectoris✓ Approved
Vascular disordersHypertension✓ Approved

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The role of BDNF promoter VI in mediating protective effects of prophylactic (R,S)-ketamine.

Chen Briana K BK, Williams Brenna L BL, Darling Anna A, Bath Kevin K et al.

Brain-derived neurotrophic factor (BDNF) exon VI promoter is implicated in mediating activity-induced synthesis of hippocampal BDNF. BDNF is implicated in (R,S)-ketamine's antidepressant effects, but its role in (R,S)-ketamine-mediated prophylaxis is unknown. Using BDNF-e6 mice, in which promoter VI-driven BDNF production is disrupted, we tested its necessity for (R,S)-ketamine's prophylactic effects.

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Ahmed Ashraf Fawzy Mosa AFM, Ali Hala Shehata HS, Alhussainy Nabeel H NH, El-Wahsh Hany M HM et al.

Co-infections with Schistosoma mansoni and Helicobacter pylori are frequently reported in low-resource endemic settings; however, their combined systemic and hematological effects in true co-endemic populations remain incompletely characterized. While S. mansoni transmission is primarily driven by exposure to agricultural water, H. pylori reflects persistent household and sanitation-related transmission, highlighting distinct yet overlapping epidemiological pathways. This study aimed to assess the association between occupational freshwater exposure and S. mansoni infection and to evaluate the clinical, hematological, and biochemical profiles associated with S. mansoni and H. pylori mono- and co-infections in a rural Egyptian population. A community-based, cross-sectional study was conducted in a rural agricultural village in Egypt. Participants were stratified into four groups: S. mansoni mono-infection (Gp1), S. mansoni-H. pylori co-infection (Gp2), H. pylori mono-infection (Gp3), and uninfected controls (Gp4). Clinical assessment, stool microscopy using the Kato-Katz thick smear technique, H. pylori coproantigen ELISA, complete blood counts, and serum biochemical analyses were performed. Comparative statistical analyses were used to evaluate group differences and associated risk factors. Occupational exposure (farm work) was strongly associated with S. mansoni infection (P < 0.001), reinforcing its role as a key transmission driver in rural endemic settings. Gastrointestinal symptoms were largely non-specific, although hematochezia occurred exclusively among individuals infected with S. mansoni. Co-infection did not significantly influence H. pylori antigen levels (P = 0.190), indicating limited biological interaction between the pathogens. Systemic alterations were predominantly driven by S. mansoni, including thrombocytopenia and marked eosinophilia (P < 0.001), alongside elevated serum globulin levels (P = 0.037), suggesting sustained immune activation. Other biochemical parameters showed no significant differences. In endemic rural settings, co-infection with S. mansoni and H. pylori does not demonstrate synergistic systemic effects but rather reflects overlapping transmission pathways with distinct epidemiological determinants. These findings suggest that integrated screening strategies may offer limited additional clinical benefit beyond pathogen-specific management, while still supporting coordinated control efforts targeting shared risk environments.

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PubMedVideo journal of sports medicine2026-08-30

Open Excision of Snapping Scapula.

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Snapping scapula syndrome is characterized as an audible crepitus or snapping sensation during scapular motion that can cause pain or discomfort. It is initially treated nonoperatively, but after failed conservative treatment, it can be treated with open or arthroscopic resection of the symptomatic portion of the scapula. The technique in this video is the open resection of the symptomatic superomedial angle of the scapula for treatment of snapping scapula syndrome. The expected result of this procedure is complete resolution of pain and elimination of the snapping or crepitus with scapular motion. Open excision for snapping scapula syndrome is a safe and easy procedure to perform with good clinical outcomes for persistent symptomatic patients who have failed conservative treatment. The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.

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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-08-30

Atomistic Kinetics of Dislocation-Mediated Grain Growth in Monolayer MoS2.

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Grain boundaries (GBs) in 2D materials are arrays of dislocations that strongly influence electronic, optical, mechanical, and transport properties. In monolayer MoS2, Mo 5|7 and S 5|7 dislocation cores are structurally established, yet how their distinct mobilities govern GB migration and grain growth has remained unresolved. Here, we directly image and quantify GB mobility in polycrystalline monolayer MoS2 at the level of individual dislocation cores. An atomic-scale in-situ heating study reveals that mobile GBs consist solely of Mo 5|7 dislocations, whereas immobile GBs contain S 5|7 kink sites that suppress GB motion. Dark-field TEM grain-growth measurements show that mobile GBs drive rapid coarsening, while S 5|7-pinned immobile GBs arrest microstructural evolution. Molecular dynamics simulations correlate this mobility contrast with distinct local mechanical and energetic environments around Mo 5|7 and S 5|7 cores, providing an atomistic origin for their different migration kinetics. These findings establish a direct structure-kinetics-growth relationship for GB evolution in monolayer MoS2 and demonstrate a broadly applicable in-situ electron-microscopy platform for probing defect-driven microstructural dynamics in 2D materials.

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Elucidating the electronic origins of a halide-dependent inversion of magnetic anisotropy in tetravalent uranium amidinate complexes.

Näder Adrian A, Hong Boseok B, Fichter Sebastian S, Patzschke Michael M et al.

Recent synthesis and characterization of tetravalent U and Np complexes [AnIVX((S)-PEBA)3] and [AnIVX(iPr2BA)3] (X = F, Cl) bearing the (S,S)-N,N'-bis(1-phenylethyl)benzamidinate ((S)-PEBA) and the N,N'-bis(isopropyl)benzamidinate (iPr2BA) ligands, respectively, have revealed a characteristic inversion of paramagnetic 1H NMR shifts for both [UF(L)3] representatives compared to the [UCl(L)3] compounds. The same effect is not observed for [NpF(L)3] and [NpCl(L)3], with currently no satisfactory explanation for these observations. Using straightforward CASSCF-SOC-NEVPT2 calculations and point-group-optimized geometries, in combination with the Kuprov model approach [G. T. P. Charnock and I. Kuprov, Phys. Chem. Chem. Phys., 2014, 16] for the calculation of pseudo-contact shifts (PCS), the experimentally derived 1H paramagnetic shifts could be reproduced qualitatively and in most cases also quantitatively. The good agreement for most signals allowed for a first evaluation of the contribution of Fermi-contact shifts (FCS) for more strongly deviating data points, which could be supported by unrestricted DFT spin densities and spin populations. To finally gain a deeper understanding as to where the differing magnetic anisotropy for the [UF(L)3] compounds stems from, the magnetic sublevels of the ground atomic multiplet |J,mJ〉 were investigated for all complexes. These revealed that only for the [UF(L)3] compounds a high |mJ〉 (pseudo) doublet showing sufficient isolation is stabilized in the ground state, whose high axiality in the end enables the realization of a prolate χ tensor responsible for the inverse PCS field.

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Fan Yinuo Y, Liu Kaihua K, Wang Chunxiao C, Zhang Xinyu X et al.

Uncontrolled bleeding and bacterial infections are major impediments to wound healing. Developing a wound dressing for the skin that possesses both antimicrobial properties and effective hemostatic capabilities is crucial. In this study, a marine polysaccharide-based multifunctional composite sponge was fabricated via chemical cross-linking approach and freeze-drying process. We structurally blended chitosan (CS) with hematite nanotubes (HNT) possessing hemostatic activity. HNT not only effectively promotes blood coagulation by activating coagulation factors but also significantly enhances the structural stability and mechanical properties of the chitosan matrix as a nano-reinforcing agent. Inspired by marine mussel adhesion, polydopamine (PDA) was employed to convert silver ions (Ag+) into silver nanoparticles (PDA@Ag). They were uniformly embedded and stabilized in CS sponges to enhance sustained antimicrobial effects and mitigate cytotoxicity. Compared with gauze, the CS/HNT/PDA@Ag sponge demonstrated excellent hemostatic performance. In rat tail injury experiments, the time to hemostasis was reduced from 89.3 s to 18 s, and blood loss was reduced from 898 to 260 mg. In rat liver injury experiments, the time to hemostasis was reduced from 121 s to 28.7 s, and blood loss was reduced from 1037 to 159 mg. The addition of Ag NPs and the subsequent release of ions significantly reduced bacterial survival rates (> 95%). In a rat full-thickness skin defect infection model, the healing rate of CS/HNT/PDA@Ag sponge reached 99.8% at 14 days of implantation, which effectively promoted collagen deposition, neovascularization and wound healing. By combining the natural biocompatibility of marine-derived CS with the synergistic effects of HNT and mussel-inspired PDA@Ag, the composite sponges offer a highly effective solution for hemostasis and infected wound healing. The online version contains supplementary material available at https://doi.org/10.1007/s42995-026-00413-1.

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