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(S

(S)-atenolol (Atpure)

✓ Approved

Emcure Pharmaceuticals · ADRB1 · Small Molecule

What is (S)-atenolol?

(S)-atenolol is a small molecule developed by Emcure Pharmaceuticals. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesAtpure
CompanyEmcure Pharmaceuticals
Drug ClassSmall Molecule
Molecular TargetADRB1
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Emcure Pharmaceuticals

Mechanism of Action

Molecular Targets

(S)-atenolol acts on 1 molecular target:

ADRB1adrenoceptor beta 1 (B1AR, RHR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

(S)-atenolol is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Cardiac disordersAngina pectoris✓ Approved
Vascular disordersHypertension✓ Approved

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Smilax sinovietnamensis, a New Quadrangular Stem Species of Smilacaceae Identified Through Integrative Taxonomy.

Wang Jiamin J, Xu Haoran H, Zhang Tongtong T, Zhang Shenglu S et al.

A new species, Smilax sinovietnamensis P. Li & X.J. Jin, sp. nov. (Smilacaceae), from the Sino-Vietnamese Border, is described and illustrated. Using nuclear ribosomal DNA (nrDNA), chloroplast DNA (cpDNA), and orthologous nuclear genes (ONGs), we examined the phylogenetic position of this species within the family Smilacaceae. Furthermore, phylogenetic analyses of concatenated sequences of nrITS, five cpDNA (ndhA, ndhF, rpl16, matK, and rbcL), and two ONGs (At103 and Agt1) from 37 Smilacaceae species all strongly supported that S. sinovietnamensis is sister to S. cocculoides. Further comparative morphological analysis showed that S. sinovietnamensis can be clearly distinguished morphologically from its closely related species S. cocculoides. It has quadrangular stems and an abscission zone at one-third of the petioles' length. Combining detailed morphological comparisons and molecular evidence, we confirm the novelty of S. sinovietnamensis. Additionally, we report the plastome characteristics of S. sinovietnamensis, enriching our understanding of the evolutionary relationships within Smilacaceae. Collectively, integrating diagnostic morphological traits with nrITS, cpDNA, ONGs, and the newly assembled plastome not only confirms S. sinovietnamensis as a new species but also offers practical tools for resolving taxonomic challenges in Smilacaceae. Additionally, the species' unique quadrangular stem-an evolutionary morphology-provides significant reference value for understanding angiosperm evolution.

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PubMedInternational journal of molecular sciences2026-10-16

Synthesis of 2-Substituted Thiazolines via Efficient Tandem C-X/C-S Bond Formation.

Zhang Xuehui X, Wang Shuo S, Liu Wenjie W, Fu Yajie Y et al.

Five-membered N,S-heterocyclic 2-thiazolines are important scaffolds in natural products, pharmaceuticals, food flavors, and chiral ligands. Due to their extensive applications, the synthesis of these valuable molecules has been widely investigated in recent years. Despite advances, efficient methods that avoid expensive/toxic reagents and harsh conditions, while delivering high yields, are still needed. In this study, we developed an efficient synthetic route to two kinds of 2-substituted thiazolines via a tandem reaction that constructs both exocyclic C-X (X = S or P) and endocyclic C-S bonds. A relatively diverse range of 2-(organothio)thiazolines and 2-phosphorylthiazolines were obtained in moderate to high yields under mild conditions from commercially available S/P-nucleophiles and 2-chloroethyl isothiocyanate in the presence of a common base. This tandem C-X/C-S bond formation methodology features generally high output, rapid conversion, and good substrate scope under mild and operationally simple conditions.

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PubMedChemical communications (Cambridge, England)2026-10-16

Synergistic S-scheme heterojunction and ligand-to-metal charge transfer in Ni-MOF/CdS for bifunctional photoredox catalysis.

Zhan Ruoning R, Zhang Tongzheng T, Huang Zhaohui Z, Zhang Senlin S et al.

S-scheme heterojunctions favor efficient charge separation while preserving strong redox capabilities. Here, we report a Ni-MOF/CdS S-scheme heterojunction synthesized via in situ growth of CdS nanoparticles on a lamellar Ni-MOF. The synergy between the ligand-to-metal charge transfer (LMCT) state of Ni-MOF and the S-scheme charge transfer mechanism broadens light absorption and enhances charge separation. The optimal Ni-MOF/CdS achieves H2 evolution of 20.7 mmol g-1 h-1 and a benzaldehyde yield of 20.0 mmol g-1 h-1 without a co-catalyst, outperforming pristine Ni-MOF and CdS by 20-fold and 2.6-fold, respectively.

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Insecticidal Activity of Essential Oils from Syzygium aromaticum and Foeniculum vulgare Var. dulce and Their Major Compounds Against Spodoptera frugiperda and Physiological Selectivity for Trichogramma pretiosum.

Braga Brenda C F BCF, Venâncio Maria G MG, Oliveira Júlia A C JAC, Figueiredo Karolina G KG et al.

Spodoptera frugiperda (Lepidoptera: Noctuidae) causes significant losses in major crops and is mainly controlled with chemical insecticides and genetically modified plants; however, improper use of these strategies has led to the development of resistant populations. We evaluated the insecticidal activity of essential oils (EOs) and major compounds of Syzygium aromaticum (Myrtaceae) and Foeniculum vulgare var. dulce (Apiaceae) against S. frugiperda, and their selectivity toward Trichogramma pretiosum (Hymenoptera: Trichogrammatidae). EOs and major compounds were topically applied to caterpillars using a microsyringe. Chromatographic analysis revealed that the major compounds of S. aromaticum were eugenol (76.2%) and (E)-caryophyllene (19.9%), while (E)-anethole (83.35%) was the major compound of F. vulgare var. dulce. The EOs of S. aromaticum and F. vulgare var. dulce were toxic to S. frugiperda (LD50 = 54.2 and 41 µg/caterpillar, respectively), compared with 0.03 µg a.i./caterpillar for chlorpyrifos, with (E)-anethole accounting for most of its insecticidal activity. The EOs also adversely affected larval development, fecundity, and life table parameters. Additionally, the EO of S. aromaticum was harmful to adult T. pretiosum females, whereas F. vulgare var. dulce EO and (E)-anethole were harmless to slightly harmful to the parasitoid's immature stages, highlighting their potential for selective control of S. frugiperda.

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PubMedSoft matter2026-10-16

A multiscale mechanical model for flexible spike protein-mediated SARS-CoV-2 viral entry into host cells.

Zhong Chu-Han CH, Xin Feng-Xian FX, Xu Guang-Kui GK

The COVID-19 pandemic has so far been sustained by recurrent outbreaks, largely owing to the strong contagiousness of SARS-CoV-2 (SARS2). Here, to explain its high infectivity from a mechanical viewpoint, we propose a multiscale mechanical model that links molecular-scale binding with cell-scale endocytosis in the initial stage of viral entry mediated by flexible spike (S) proteins. With three hinges in the stalk domain, SARS2-S has unanticipated orientational freedom, giving rise to a high binding affinity up to 10 times that of SARS-S binding with ACE2. Interestingly, when SARS2-S is in the "RBD-down" conformation, the affinity decreases dramatically to only one thousandth of that of SARS-S binding with ACE2, suggesting that the conformational hiding of the receptor-binding site in this flexible state could reduce its exposure to the host immune system and therapeutic antibodies. Therefore, the mechanical properties of S proteins can be exploited by the virus to enhance its recognition of host ACE2 and attachment to host cells. As S proteins bind to ACE2 receptors, the resulting S-ACE2 complexes bridge the viral and host-cell membranes and progressively accumulate at the virus-cell interface, while their deformation and loading states evolve continuously during subsequent membrane wrapping. Increasing molecular stiffness enhances the interfacial pulling force, and the resulting increase in complex stiffness further amplifies this effect. It should be noted that excessively high molecular or complex stiffness, a higher membrane bending modulus, and a larger viral size all increase the mechanical resistance to late-stage membrane wrapping. Together, these results shed light on the pivotal role of molecular flexibility in the initial stage of viral entry, showing how spike flexibility regulates both ACE2 recognition and the mechanical progression of membrane wrapping, and may provide guidance for vaccine development and drug design.

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PubMedInternational journal of molecular sciences2026-10-16

In Vitro Screening of Sargassum spp. Ethanolic Extracts for Antioxidant Activity and Inhibition of Disease-Associated Enzymatic Targets Related to Diabetes, Alzheimer's Disease, and Parkinson's Disease.

Ali Md Yousof MY, Park Se Eun SE, Jung Hyun Ah HA, Choi Jae Sue JS

Sargassum is a large and diversified genus of marine brown algae that is distributed widely in tropical and subtropical areas. They have been used for centuries in Asian countries, and have demonstrated a variety of health advantages, including anti-cardiovascular disease, anti-osteoarthritis, anti-cancer, anti-inflammatory, antioxidant, and hypopigmentation effects. However, the putative anti-diabetic, anti-Alzheimer's, and anti-Parkinson's diseases activities of various Sargassum spp. have not been investigated and compared thoroughly. Thus, the purpose of this study was to examine the anti-diabetic, anti-Alzheimer's, and anti-Parkinson's diseases' activities of ten Sargassum and one myagroides species collected off the Korean coast. In this study, we examined the inhibitory activity of 70% ethanolic extract of the Sargassum and myagroides species against protein tyrosine phosphatase 1B (PTP1B), α-glucosidase, peroxynitrite (ONOO-), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), BACE1, MAO-A, and MAO-B. Among the Sargassum and myagroides species tested, S. hemiphyllum, S. filicinum, and S. miyabei showed potent PTP1B inhibitory activity (IC50 values of 2.11, 1.87, and 6.49 μg/mL, respectively), α-glucosidase inhibitory activity (IC50 values of 3.67, 2.30, and 11.12 μg/mL, respectively), and ONOO- scavenging activity, with IC50 values of 2.07, 4.49, and 2.46 μg/mL, respectively. Moreover, S. miyabei exhibited the highest BACE1 and BChE inhibitory activity, with IC50 values of 3.38 and 39.76 μg/mL, respectively. The highest MAO-A inhibitory activity was seen in S. miyabei, S. serratifolium, and S. macrocarpum, with IC50 values of 16.91, 12.46, and 14.02 μg/mL, respectively. Therefore, our findings showed that Sargassum species have health benefits and may be useful in treating diabetes and neurological disorders.

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