Drug Database
PN

pneumococcal vaccine

✓ Approved

Beijing Minhai Biotechnology · Cell-based Therapies · Cell-based Therapies

What is pneumococcal vaccine?

pneumococcal vaccine is a cell-based therapies developed by Beijing Minhai Biotechnology. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

CompanyBeijing Minhai Biotechnology
Drug ClassCell-based Therapies, Vaccine
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, Beijing Minhai Biotechnology

Therapeutic Indications

pneumococcal vaccine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsPneumococcal infection✓ Approved

Related Research Articles

PubMedAdvances in virology2026-09-20

Comparative Sequence Analysis of the Envelope Gene of Kyasanur Forest Disease Virus Vaccine Strain With Currently Circulating Field Strains.

Kaje Keerthi K, Marinaik Chandranaik B CB, Gomes Amitha Reena AR, Rizwan Apsana A et al.

The present study was undertaken with the objective of performing comparative sequence analysis of the envelope (E) gene of Kyasanur forest disease virus (KFDV) vaccine strain P9605 with the circulating field strains. The study was taken up as the currently used KFDV vaccine strain, KFDV P9605, was isolated in the 1960s. For this study, we designed two sets of primers targeting the complete amplification of the E gene of KFDV. The sequencing was performed by the Sanger method, and the deduced sequence of the vaccine virus was deposited in GenBank with accession number PX067005. This sequence obtained for the vaccine virus was aligned and compared with sequences of GenBank-deposited circulating field strains. We also performed comparative sequence analysis of the Kyasanur forest disease (KFD) vaccine seed virus having passaged twice in mouse brain with the vaccine seed virus passaged six times in mouse brain to investigate whether multiple passages in mouse brain will lead to genetic mutation in the immunologically important E gene. The phylogenetic analysis revealed seven amino acid mutations in the field strains at positions A123T, S158N, D178E, D239N, A313S, M429I, and G479A when compared with the vaccine strain. We did not find any mutations at the critical fusogenic segment (residues 98-113) in the E gene of currently circulating field strains compared to the vaccine seed virus. The study found no genetic variations in the E gene of the KFD virus passed two times and passed six times in mouse brain. We performed SWISS-MODEL homology modeling, AlphaFold protein analysis, and Ramachandran plot analysis to study the E protein structures and stability. The observations made in this study suggest slow evolutionary drift and conserved structural stability of the envelope gene of KFDV ever since its emergence 7 decades ago; however, the functional implications of these amino acid substitutions need further studies on their roles in viral infectivity, transmission, and impact on immunity.

PMID 42763584
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PubMedJournal of arrhythmia2026-09-20

Clinical Characteristics and Timing of Accessory Pathway Reconduction During Catheter Ablation of Accessory Pathways.

Sasaki Wataru W, Mori Hitoshi H, Kawano Daisuke D, Matsumoto Kei K et al.

Catheter ablation of accessory pathways has high acute success rates; however, accessory pathway (AP) recurrence remains a clinically relevant issue. Although intra-procedural AP reconduction is frequently encountered during ablation procedures, its timing, predictors, and clinical significance remain insufficiently characterized. This study aimed to investigate the timing, electrophysiologic characteristics, and clinical implications of intra-procedural AP reconduction during catheter ablation of manifest and concealed accessory pathways. We retrospectively analyzed 128 patients with manifest or concealed AP who underwent catheter ablation at our institution between May 28, 2015, and February 2025. Details of cases in which AP reconduction was observed during the 30 min waiting period after successful ablation, including clinical and procedural characteristics, were compared with those of patients without reconduction. Intra-procedural AP reconduction occurred in 23 patients (18.0%). The mean time to reconduction was 16.7 ± 7.0 min, with a maximum interval of 27 min. Compared with patients without reconduction, those with reconduction had a significantly longer time to pathway interruption, more frequent broad or oblique APs, and more complex procedural approaches requiring multiple anatomical access routes. Intra-procedural reconduction was also associated with subsequent late recurrence. Fifteen of 23 events (65.2%) occurred ≥ 15 min after AP elimination. Intra-procedural AP reconduction during catheter ablation of accessory pathways is not uncommon and appears to be associated with specific electrophysiologic and procedural characteristics as well as late recurrence. These findings may facilitate identification of patients at higher risk of reconduction and help guide intra-procedural assessment during catheter ablation.

PMID 42763562
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PubMedCureus2026-09-20

Myoepithelioma-Like Tumor of the Vulvar Region Presenting as a Painful Vulvar Nodule in a Young Woman: A Case Report.

Yoshida Mitsuaki M, Nguyen Thao T TT, Iwata Takahiro T, Shimasaki Miyako M et al.

Myoepithelioma-like tumor of the vulvar region (MELTVR) is a rare mesenchymal subcutaneous tumor of low malignant potential that occurs in adult women and has typical histological features, including loss of SMARCB1 (INI1) expression. This report describes the case of a 23-year-old woman with a painful vulvar subcutaneous nodule and a diagnosis of MELTVR and describes the challenges in the approach to definitive diagnosis. A 23-year-old woman presented with a three-month history of right pubic pain. Imaging revealed a 25-mm inguinal lesion without metastasis. Biopsy demonstrated spindle and plasmacytoid tumor cells in myxoid and hypercellular areas, suggesting myoepithelioma. Although necrosis and mitotic activity were not evaluable in the biopsy specimen, malignant potential could not be excluded. Complete surgical excision was subsequently performed. The resected tumor measured 45 × 35 × 15 mm and showed multilocular solid and gelatinous areas. Histologically, lobulated growth, marked atypia, necrosis, and mitotic activity (9/10 HPF) were identified. Immunohistochemically, tumor cells showed positivity for estrogen receptor (ER) and progesterone receptor (PgR), along with loss of SMARCB1 (INI1) expression. Other markers, such as neural and myoepithelial markers, were negative. Fluorescence in situ hybridization (FISH) analysis showed no Ewing sarcoma breakpoint region 1 (EWSR1) rearrangement. MELTVR was diagnosed based on integrated clinicopathological and molecular findings. Biopsy specimens may fail to capture key diagnostic features of MELTVR because of intratumoral heterogeneity. Definitive diagnosis requires comprehensive evaluation of resection specimens with immunohistochemical and molecular analyses. This case may contribute to establishing diagnostic criteria for this rare entity.

PMID 42763470
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PubMedJournal of the American Academy of Audiology2026-09-20

Vestibular Function in Judo Athletes: Evidence of Subclinical Vestibular Dysfunction.

Avcı Nizamettin Burak NB, Kaplan Simay S, Puşulu Ayşegül Eymen AE, Tosun Nurhan N et al.

Judo is a dynamic combat sport demanding high levels of balance, agility, postural control, and kinesthetic awareness. The vestibular system plays a vital role in maintaining balance and spatial orientation, integrating sensory inputs essential for judo performance. However, few studies have directly examined vestibular function in judo athletes, despite their frequent exposure to head impacts and rapid rotational movements that may affect vestibular integrity. This study aimed to compare the vestibular functions of active judo athletes with those of healthy controls. A cross-sectional comparative design was employed. The study included 26 professional judo athletes (aged 18-23 years, ≥5 years of training experience) and 23 age- and sex-matched healthy controls. Vestibular function was assessed using the video head impulse test for semicircular canal function and cervical and ocular vestibular evoked myogenic potentials (cVEMP and oVEMP) for otolith organ function. The Post-Concussion Symptom Scale (PCSS) was administered to athletes to assess potential symptoms related to prior minor head impacts. Group comparisons were analyzed using independent-samples t tests, and Pearson correlation analysis examined relationships between vestibular outcomes, PCSS scores, and years of training. Judo athletes demonstrated significantly reduced vestibulo-ocular reflex (VOR) gains across all semicircular canals compared with controls (p < 0.05). No significant differences were observed between groups in cVEMP and oVEMP parameters (p > 0.05). PCSS scores were not correlated with vestibular test outcomes or training duration (p > 0.05). These findings suggest that judo-induced microtraumas may selectively affect semicircular canal function while sparing otolith organ responses. The subclinical decrease in VOR gains in athletes suggests that repeated head accelerations and rotational movements may lead to subclinical VOR alterations even in the absence of overt symptoms. Subclinical vestibular alterations in athletes may contribute to balance instability and increase injury risk. Routine vestibular screening in contact-sport athletes could support early detection, targeted rehabilitation, and improved long-term postural control.

PMID 42763614
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PubMedCureus2026-09-20

Noncanonical Splice Site Disruption: +4 Intronic Variant in Phosphate-Regulating Endopeptidase Homolog, X-linked (PHEX Gene) Supported by In Silico Analysis in X-linked Hypophosphatemic Rickets.

Panqueba Arias Carlos F CF, Rojas Rodriguez Ingry K IK, Quero Rossi I RI, Baez Cielo C CC

X-linked hypophosphatemic rickets (XLH) is the most common inherited cause of renal phosphate wasting. It is typically caused by pathogenic variants in the phosphate-regulating endopeptidase homolog, X-linked (PHEX gene), which lead to increased levels of fibroblast growth factor 23 (FGF23). However, noncanonical intronic variants represent a significant diagnostic challenge, as they may not be detected by conventional genetic studies and require interpretation supported by bioinformatic tools. We present the case of a pediatric patient with postnatal short stature and progressive genu varum. Biochemical studies revealed hypophosphatemia with reduced tubular reabsorption of phosphate, while calcium, parathyroid hormone (PTH), and vitamin D levels were within normal ranges. Radiological findings were consistent with rickets. Initial clinical exome sequencing was negative. Subsequently, a targeted gene panel identified a previously unreported intronic variant in the PHEX gene (c.1768+4dup; chrX:22,219,105 T>TA). In silico analysis using SpliceAI demonstrated a high probability of donor splice site loss (DS_DL = 0.80), while Pangolin predicted a splice-disrupting effect (score = 0.72); collectively, these findings support a deleterious effect on mRNA splicing. This case highlights the importance of integrating clinical, biochemical, genetic, and computational data for the interpretation of noncanonical intronic variants, expanding the mutational spectrum described for PHEX in XLH.

PMID 42763725
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PubMedOsteoarthritis and cartilage open2026-09-20

Patient and healthcare professional perceptions of weight reduction in the treatment of knee osteoarthritis: A systematic literature review.

Conaghan Philip G PG, Rolland Catherine C, Frampton James J, Lavoie Louis L et al.

Weight reduction confers significant clinical benefits in knee osteoarthritis (OA) management. This systematic review examined patients' and healthcare professionals' (HCPs) perceptions of weight reduction for surgical, pharmacological and non-pharmacological interventions, with emphasis on barriers to implementation. The review was conducted across Embase, MEDLINE, Cochrane, and PsycInfo for eligible studies using the Population, Intervention, Comparator, Outcome, Timeframe, and Study type framework. The search identified 2134 publications; of these, 203 had full-text screening, with 46 studies included: 23 qualitative studies, 15 cross-sectional studies, 6 randomized-controlled trials, one quasi-experimental and one observational cohort study. Four main themes of barriers to weight reduction were identified, including limited knowledge, lack of access to interventions, OA-specific barriers to exercise, and non-OA-specific barriers to dieting and exercise. The patient-reported barriers included intrapersonal barriers (i.e., difficulty achieving weight reduction, lack of motivation), physical barriers (i.e., age, challenges with general movement), and social barriers (i.e., lack of social support). The HCP-reported barriers included knowledge barriers, communication barriers, and systemic barriers (i.e., time constraints and resource limitations). Both patients and HCPs had varying expectations and satisfaction levels regarding the impact and delivery of weight reduction interventions. Despite broad recognition of weight reduction's benefits in knee OA, substantial barriers hinder adherence and implementation. Targeted strategies addressing patient-HCP communication, alongside enhanced education and training for both groups, are critical to improving weight reduction outcomes in this population. There is currently a gap in evidence around barriers to gastric surgery and pharmacological treatment specific to patients with knee OA.

PMID 42763547
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