Drug Database
DE

delivery technology (CEFORM EA / CEFORM RA / CEFORM)

✓ Approved

Bausch Health Companies Inc. · therapeutic agent

What is delivery technology?

delivery technology is a therapeutic agent developed by Bausch Health Companies Inc.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesCEFORM EA, CEFORM RA, CEFORM
CompanyBausch Health Companies Inc.
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Bausch Health Companies Inc.

Therapeutic Indications

delivery technology is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

Related Research Articles

PubMedMicrobial cell factories2026-10-16

Effective bio-activities of the metal nanoparticles mycosynthesized by the plants' fungal endophytes.

Madbouly Adel K AK, Rashad Younes M YM

Fungal endophytes act as bio-nano factories and are favored over bacteria and plant extracts, as they secrete large quantities of proteins and enzymes, facilitating stable, efficient, and economic nanoparticle synthesis. This review highlights the advantages of plant-associated fungal endophytes as bio-factories for metal nanoparticles (MNPs) synthesis and critically examines the biological activities and potential applications of these MNPs in human health, food technology, and agriculture. Compared to chemical synthesis, biogenic MNPs are more resistant to aggregation due to the involvement of different biomolecules, including secondary metabolites, enzymes, and proteins, reducing the metal ions to form MNPs. Biosynthesis of MNPs by several fungal genera, such as Fusarium spp., Penicillium spp., and Aspergillus spp., enables alleviation of the undesirable cytotoxicity and increased stability. In the food industry, MNPs play substantial roles in inhibiting browning and preventing food contamination. In agriculture, they act as herbicides, fungicides, pesticides, and plant growth promoters. Field application trials of these MNPs are recommended before their manipulation as a control strategy. In medicine, MNPs behave as antimicrobials, drug-delivery, antioxidants, and anticancer agents. They are applied in ophthalmology to facilitate drug delivery onto the site of infection via the improvement of targeted delivery. MNPs have demonstrated anticancer potency against cancer cell lines; however, they may also display cytotoxicity against the normal cells, especially at small sizes. However, at low pH, release of Ag+‏ ions from AgNPs increases, where such information may aid in reducing the toxicity of the AgNPs. Conjugation of MNPs and antimicrobials has shown synergistic efficacy against the microbial resistance compared to the antimicrobials alone, reducing the development of antimicrobial resistance and decreasing the duration and the dose requirements of antimicrobial treatments. Nevertheless, comprehensive toxicological, pharmacokinetic, environmental, field, and in vivo studies are required before widespread application. The novelty of this review lies in spotting the light on the useful role of fungal endophytes as bio-factories for MNPs biosynthesis and emphasizing the promising applications of these MNPs in human health, food technology, and sustainable agricultural disease management, while highlighting the challenges and research priorities required for their safe and effective translation from laboratory studies to practical applications.

PMID 42881411
Read full article →
PubMedPolymers2026-10-16

Polyvinyl Alcohol-Coated Polycaprolactone Microneedles as Polymeric Microdevices for Transdermal Antigen Delivery and Immune Activation.

Teixeira Aline F AF, Kochi Leandro T LT, De La Via Reis Ana Carola AC, Rojas Jose E JE et al.

Conventional needle-and-syringe vaccination is associated with pain, needle-related anxiety, the need for trained personnel, and logistical challenges related to vaccine distribution and storage. Microneedle (MN) technology has emerged as a minimally invasive strategy for transdermal delivery and as a platform for functional polymeric microdevices. In this study, polycaprolactone (PCL) microneedles coated with hydrophilic polymers were evaluated as a model platform for antigen delivery. Ex vivo assays using porcine ear skin were explored as a preliminary approach to assess antigen transport from polymer-coated PCL microneedles. However, antigen-specific quantification in the receptor compartment was limited by the lack of specificity of absorbance-based measurements in this biological matrix. Scanning electron microscopy (SEM) showed that PVA coating partially altered microneedle tip morphology, whereas optical coherence tomography (OCT) and optical microscopy confirmed that PVA20%-PCL-MNs maintained the ability to insert into porcine skin and generate visible insertion sites. Mechanical compression testing further showed that polymer-coated PCL-MNs maintained resistance to axial deformation under the tested conditions. PVA20%-PCL-MNs were also non-toxic and maintained high HEK293T cell viability after 24 h. Based on their preserved insertion capacity, mechanical robustness, ability to support DNP-KLH permeation, and preliminary cytocompatibility, PVA20%-PCL-MNs were evaluated in BALB/c mice using a two-dose prime-boost regimen. Although intraperitoneal immunization induced higher IgG levels, transdermal immunization with PVA20%-PCL-MNs promoted booster-dependent antigen-specific IgG responses. IgG2a/IgG1 ratio analysis indicated a predominantly IgG1-biased humoral profile, and splenocytes from mice immunized with PVA20%-PCL-MNs produced detectable levels of IFN-γ and IL-10 after in vitro stimulation. Together, these findings support PVA-coated PCL microneedles as a proof-of-concept polymeric microdevice platform for minimally invasive antigen delivery and immunogenicity assessment.

PMID 42884958
Read full article →
PubMedInternational journal of molecular sciences2026-10-16

Microneedles for Chronic Refractory Wounds: A Review of Dynamic Regulation Strategies and Therapeutic Applications.

Liu Quanying Q, Xu Yang Y, Li Wenfeng W, Shi Chunmeng C

Chronic refractory wounds (CRWs), characterized by delayed healing due to disrupted phases of hemostasis, inflammation, proliferation, and remodeling, pose significant clinical challenges with diverse etiologies such as diabetic ulcers and radiation-induced ulcers. Traditional therapies like debridement and skin flap transplantation face limitations. Microneedle technology has emerged as a promising approach, enabling painless transdermal drug delivery to the dermis while enhancing bioavailability and enabling microenvironment-responsive interventions. In this context, this review highlights advancements in microneedle design, emphasizing material selection and structural innovations tailored for CRW management, and systematically elucidates the mechanisms of action and applications of microneedles for phased regulation of CRW healing in response to the pathologic characteristics of wounds-hemostatic, inflammation regulation, angiogenesis and remodeling stage-in terms of prevention, intervention, and wound monitoring, thereby providing significant reference value for the design and clinical application of microneedles in chronic refractory wounds.

PMID 42883766
Read full article →
PubMedHealthcare (Basel, Switzerland)2026-10-16

Designing a Standardized and Sustainable Training Framework for Healthcare Workforce Capacity Building in Punjab, Pakistan.

Zakar Rubeena R, Shah Gulzar G, Momina Ain Ul AU, Shah Bushra B et al.

Background: A well-trained healthcare workforce is crucial for effective health service delivery and policy implementation. Despite the Primary and Secondary Healthcare Department's (P&SHD) efforts to improve physical infrastructure, critical gaps persist in the training system. This study aims to develop a standardized, effective, and sustainable training framework for healthcare professionals. Methods: The study was conducted from September 2024 to July 2025 using a convergent mixed-methods design. Responses were received from 26 DHDCs, representing an 83.9% response rate, with the DHDC serving as the unit of analysis. The qualitative component included 33 focus group discussions involving 270 participants, as well as 20 key informant interviews. Findings informed the development of the training framework using Kern's six-step approach and the Hennessy-Hicks Training Needs Analysis Model. Results: Of the reporting DHDCs, 96.2% had a dedicated training hall, 96.2% reported internet access, and 80.8% employed information and communication technology in training delivery. In contrast, institutional and governance capacity was markedly weaker: 16 of 26 centers lacked a documented definition of roles and responsibilities. Qualitative findings further revealed that trainings were frequently not needs-based, participant selection was perceived as influenced by favoritism and political considerations, standardized curricula and trainer criteria were absent, and evaluation was limited to attendance and satisfaction metrics. Thus, physical capacity and system functionality diverged substantially: the binding constraints were governance, coordination, staffing continuity, and financing rather than infrastructure. Conclusions: This study underscores the critical need for a standardized, sustainable training framework to strengthen the capacity and performance of healthcare providers.

PMID 42881626
Read full article →
PubMedHealthcare (Basel, Switzerland)2026-10-16

Understanding Technology Anxiety Among Older Adults with Chronic Diseases: The Roles of Perceived Ease of Use and Perceived Usefulness.

Chen Ting T, Li Meiling M, Sun Didi D, Gao Renlan R et al.

Purpose: To examine the associations of individual-level factors (eHealth literacy, chronic disease management self-efficacy, and coping style) and social-level factors (social support) with technology anxiety among older adults with chronic diseases, and to explore the potential indirect associations involving perceived ease of use and perceived usefulness. Method: A cross-sectional observational study was conducted among older adults with chronic diseases, in which 470 participants were surveyed and 456 valid responses were obtained. Measures included the eHealth Literacy Scale, Self-Efficacy for Managing Chronic Disease Scale, Simplified Coping Style Questionnaire, Social Support Rating Scale, Scale of Perceived Ease of Use, Perceived Usefulness Scale and Technology Anxiety Scale. Structural equation modelling was applied to examine the direct and indirect associations among individual- and social-level factors, technology perceptions, and technology anxiety. Results: Higher eHealth literacy, chronic disease management self-efficacy, positive coping, and social support were positively associated with perceived ease of use and perceived usefulness, whereas negative coping was negatively associated with both. Perceived ease of use and perceived usefulness were negatively associated with technology anxiety. eHealth literacy, chronic disease management self-efficacy, and positive coping were negatively associated with technology anxiety, whereas negative coping was positively associated; social support showed no significant direct association. All five antecedent factors showed significant indirect associations with technology anxiety through perceived ease of use, perceived usefulness, and the sequential pathway from perceived ease of use to perceived usefulness. Conclusions: Individual- and social-level factors were associated with technology anxiety among older adults with chronic diseases, with perceived ease of use and perceived usefulness involved in these indirect associations. These findings may provide insights for understanding technology anxiety and support future research on digital health adaptation.

PMID 42881599
Read full article →
PubMedSensors (Basel, Switzerland)2026-10-16

Closing Editorial: Editorial Board Members' Collection Series: Optical Measurements and Sensing Technology.

Norgia Michele M, Lewis Elfed E, Vallan Alberto A

This editorial provides closing remarks for the Special Issue on "Optical Measurements and Sensing Technology" published in Sensors [...].

PMID 42884240
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about delivery technology