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celecoxib + tramadol HCl (MR308 / Velyntra / Seglentis)

✓ Approved

Kowa · OPRM1 · Small Molecule

What is celecoxib + tramadol HCl?

celecoxib + tramadol HCl is a small molecule developed by Kowa. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesMR308, Velyntra, Seglentis
CompanyKowa
Drug ClassSmall Molecule
Molecular TargetOPRM1, PTGS2, SLC6A2, SLC6A4
RouteOral (PO)
StatusApproved

Mechanism of Action

Molecular Targets

celecoxib + tramadol HCl acts on 4 molecular targets:

OPRM1opioid receptor mu 1 (MOP, M-OR-1)
PTGS2prostaglandin-endoperoxide synthase 2 (PHS-2, PGG/HS)
SLC6A2solute carrier family 6 member 2 (NAT1, NET)
SLC6A4solute carrier family 6 member 4 (SERT1, 5-HTTLPR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

celecoxib + tramadol HCl is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Gastrointestinal disordersAbdominal pain✓ Approved
Injury, poisoning and procedural complicationsProcedural painPhase III

Related Research Articles

PubMedScience and technology of advanced materials2026-07-17

HCl-based halide vapor phase epitaxy and selective-area HCl gas etching of (-112) β-Ga2O3.

Oshima Takayoshi T, Oshima Yuichi Y

We propose (-112) and crystallographically equivalent (1-1-2), (-1-12), and (11-2) planes as the fundamental crystal orientations for β-Ga2O3studies. These planes correspond to the {100} planes of the slightly distorted face-centered-cubic oxygen sublattice in β-Ga2O3and therefore represent one of the primary crystallographic planes. On this basis, we have demonstrated both homoepitaxial growth and HCl gas etching on (-112) β-Ga2O3substrates using an HCl-based halide vapor phase epitaxy system in order to clarify both the growth and etching characteristics on the (-112) plane. In homoepitaxy, the epilayer exhibited single crystallinity with tilt and twist dispersions comparable to those of the substrate and a step-and-terrace surface morphology with a root-mean-square roughness of 0.10-0.12 nm. Although slit-like pits whose sidewalls were vertically aligned (100) facets appeared on the surface, these pits were attributed to unintentional SiO2 nanomasks at the interface and are expected to be eliminated by improving pre-growth surface treatments or the initial growth process. Furthermore, the concentration of Cl impurities in the epilayer was as low as 1 × 1015 cm-3, which was significantly lower than 2 × 1016 cm-3 observed in the simultaneously grown (001)-oriented homoepitaxial layer. For HCl gas etching, selective-area etching was performed using a SiO2 mask with patterned windows. The etched structures clearly reflected the intrinsic crystal anisotropy. Side etching was minimized when the windows were aligned along the [02-1] direction due to the formation of exceptionally flat and vertical (100) facets, which possess the lowest surface energy density. Additionally, the vertical etch rate for the (-112) plane was approximately 50 times higher than the side etch rate for the (100) plane, enabling precise fabrication of high-aspect-ratio fins and trenches. These results-particularly the excellent surface smoothness achieved in homoepitaxy and the high-aspect-ratio patterning enabled by HCl-gas etching-demonstrate that the {-112} orientations are promising candidates for β-Ga2O3 studies.

PubMedLangmuir : the ACS journal of surfaces and colloids2026-07-17

Conversion of Waste Red Mud into LTA Zeolite Adsorbent for Highly Selective Cs+/Sr2+ Removal: Governing Effects of Inorganic Acid Type and Hydrothermal Temperature on Zeolite Phase Evolution.

Yoon Sunho S, Choi Minhee M, Bae Sungjun S

Sustainable utilization of industrial solid waste and the recovery of value-added resources are critical challenges in environmental engineering. Red mud, a major byproduct of the Bayer process, contains abundant silicon and aluminum species and is a promising precursor for zeolite synthesis. In this study, LTA-type zeolites were synthesized without additional Si/Al sources using red mud acid-leaching solutions prepared with various inorganic acids. Optimal synthesis conditions for LTA-type zeolite were identified by adjusting NaOH concentration and hydrothermal conditions, and the effects of coexisting anions on LTA phase transformation and the resulting Cs+ and Sr2+ adsorption performance were evaluated. At low NaOH concentrations, nonzeolitic phases were observed, whereas 3-4 N NaOH provided suitable conditions for LTA crystallization. Hydrothermal temperature also significantly influenced phase selection, with pure LTA obtained at 60-90 °C, whereas higher temperatures promoted GIS-type frameworks. Under identical alkalinity and temperature conditions, LTA initially formed in all leachate systems, regardless of anion species. However, the transformation from metastable LTA to thermodynamically stable sodalite proceeded at markedly different rates depending on anion species, in the order HNO3 > H2SO4 > HCl. This phase transformation directly affected the adsorption of Cs+ and Sr2+. The HCl-derived system maintained the LTA phase for up to 24 h, and the resulting LTA phase exhibited maximum adsorption uptakes of 1.84 mmol g-1 for Cs+ and 1.58 mmol g-1 for Sr2+. In addition, the LTA phase demonstrated selective removal of Sr2+ and Cs+ in the presence of competing cations, following the selectivity sequence Sr2+ > Cs+ ≥ Ca2+ > K+ > Na+ > Mg2+. In contrast, accelerated sodalite formation in the HNO3-derived system led to a decrease in adsorption efficiency because of its lower cation exchange capacity. These results demonstrate that coexisting anions act as kinetic modifiers governing phase transformation behavior and functional performance.

PubMedEuropean journal of clinical pharmacology2026-07-17

Precipitants and clinical features of serotonin syndrome: a systematic review with patient-level analysis of published case reports and series.

Blyzniuk Bohdan B, Danukalo Maksym M, Gastaldon Chiara C, Barbui Corrado C et al.

Serotonin syndrome (SS) is a concern for prescribers of serotonergic acting agents and mainly antidepressants, yet the implicated drug combinations and associated outcomes across clinical settings remain incompletely characterized. We performed a systematic review in PubMed/Embase, searching for SS cases in adults from the database's inception until June 2024, and conducted a patient-level and network analysis of drug co-occurrence. The quality of SS diagnoses was assessed using the Hunter Serotonin Toxicity and the Sternbach Criteria. A total of 764 cases were included; 653 (85.6%) and 496 (65.0%) met the Sternbach and the Hunter Criteria, respectively. Patients with SS following suicide attempts were more frequently admitted to intensive care units with higher mortality rates than patients with SS related to regular prescriptions (79.4% vs 35.6% and 18.0% vs 5.1%, respectively, both p < 0.001). Of 645 regular prescription cases, 92.9% were drug combinations (≥ 2 agents). Monotherapy cases were milder and often occurred after initiation of a new antidepressant in younger patients. Drug combinations involved non-antidepressants in 90.7%. Network analysis identified trazodone as the most connected antidepressant, and fentanyl and tramadol as the most connected non-antidepressant nodes. We identified five SS cases following antipsychotic discontinuation while maintaining serotonergic agents. Non-suicidal cases of SS during regular prescription were less serious than SS cases associated with intentional overdose. The emerging role of non-antidepressant agents (e.g., several opioids and antiparkinsonian drugs) as potential precipitants support tailored interprofessional medication review in poly-medicated subjects.

PubMedDrug development and industrial pharmacy2026-07-17

Dual-drug-loaded lipid-based formulation for colon cancer therapeutics: In vitro optimization and characterization.

Shewale Rushikesh Sanjay RS, Gomte Shyam Sudhakar SS, Bishlay Jyoti J, Suthar Dimpal D et al.

The current investigation aims to fabricate, optimize and characterize dual-drug-loaded liposomes for the management of colon cancer.Significance: Lipid-based nanocarriers are versatile nanocarriers that facilitate the loading of both hydrophilic and hydrophobic therapeutic agents. The simultaneous delivery of capecitabine (CAP) and celecoxib (CEL) is anticipated to enhance anticancer efficacy against colon cancer. CAP-CEL-loaded liposomes (CAP-CEL-LIPs) were designed and optimized utilizing Box-Behnken Design (BBD). The optimized LIPs were characterized for particle size, polydispersity index (PDI), entrapment efficiency and morphological studies. In vitro drug release studies were conducted under both acidic and physiological conditions. Hemocompatibility was evaluated using the hemolysis assay and the stability of the LIPs was assessed over a duration of one month. ResultsThe optimized CAP-CEL-LIPs demonstrated a mean particle size of 130 ± 2.36 nm with a PDI of 0.162 ± 0.008, showing the homogeneous particle size distribution. The encapsulation efficiency for CAP and CEL was found to be 64.96 ± 2.81% and 92.23 ± 2.22%, respectively. SEM and TEM images revealed the spherical morphology of the developed LIPs. In vitro drug release investigations revealed a controlled release profile for both drugs under both acidic and physiological conditions. The hemolysis assay showed hemolysis rate of less than 2%, thereby confirming superior blood compatibility. Stability data indicated that LIPs remained stable for one-month. The developed CAP-CEL-LIPs showed significant cytotoxic potential with enhanced cellular uptake and apoptotic activity against colon cancer cells. The engineered CAP-CEL-LIPs could be a promising platform for managing colon cancer.

PubMedFrontiers in surgery2026-07-17

Application and advantages of intrathoracic paravertebral block in uniportal video-assisted thoracoscopic surgery.

Li Zhengjun Z, Chao Siwei S, Ma Shuai S, Li Ding D et al.

Uniportal video-assisted thoracoscopic surgery (VATS) is widely used as a minimally invasive approach for pulmonary diseases. Although this technique reduces postoperative pain, acute postoperative pain remains clinically significant. This study aimed to evaluate the feasibility and advantages of thoracoscopic paravertebral block. This single-center prospective randomized comparative study included 228 consecutive patients who underwent uniportal VATS at our institution between August 2022 and June 2024. Patients were randomly assigned to Group A (122 patients; intraoperative thoracoscopic direct-vision transthoracic paravertebral block) or Group B (106 patients; preoperative ultrasound-guided thoracic paravertebral block). Perioperative data, postoperative pain scores, opioid rescue analgesic use, and postoperative complications were analyzed. Repeated-measures analysis of variance was used to assess differences in postoperative pain scores over time between the two groups. A total of 228 patients underwent uniportal VATS pulmonary resection. No significant differences were observed between the two groups in terms of age, sex, pulmonary function, arterial blood gas analysis, surgical side, incision location, nodule size, nodule position, operative time, blood loss, drainage duration, length of hospital stay, tumor stage, or postoperative complications (P > 0.05). Postoperative complications were less frequent in Group A than in Group B. No intraoperative or 30-day postoperative mortality occurred in either group. Repeated-measures ANOVA showed significant effects of group (F = 774.002, P < 0.001), time (F = 520.972, P < 0.001), and group×time interaction (F = 4.983, P = 0.001) on VAS scores. These findings indicate that thoracoscopic paravertebral block is safe and effective. Compared with ultrasound-guided approaches, it was associated with lower postoperative pain scores and reduced rescue tramadol requirements. Further validation through prospective randomized controlled trials is required.

PubMedDiabetologia2026-07-17

Relationship between participant-reported outcomes, residual beta cell function and metabolic parameters in youth with newly diagnosed type 1 diabetes.

Taylor Peter N PN, Cheung Wai-Yee WY, Lagorio Price Joe J, Boughton Charlotte C et al.

Clinical trials of interventions to preserve beta cell function in new-onset type 1 diabetes frequently employ participant-reported outcome measures (PROMs). However, the expected changes in PROMs scores immediately following diagnosis and their association with residual beta cell function, metabolic markers and continuous glucose monitoring (CGM) are unclear. Repeated PROMs including Paediatric Quality of Life Inventory diabetes module (PedsQL) and hypoglycaemia fear survey (HFS) were recorded from participants aged 10-18 years with newly diagnosed type 1 diabetes and their parents in two clinical trials: CLOuD (N=97, hybrid closed loop [HCL] vs multiple daily injections [MDI]) and USTEKID (N=72, ustekinumab immunotherapy vs placebo). Scores were compared with serial mixed meal-stimulated C-peptide levels (AUC C-peptide), HbA1c and CGM data. PedsQL and HFS scores for children/adolescents and their parents showed wide variation between individuals but did not change substantially within individuals over the first 48 months from diagnosis. Baseline scores were highly predictive of scores at 12-48 months (p<0.001). PedsQL scores were higher (better) in those reported by children/adolescents than by their parents (p<0.01). In contrast, HFS scores were higher in parents than children (p<0.001), indicating more fear. Strong correlations were observed between child and parent scores (p<0.001). No significant improvement in these scores was detected following intervention (ustekinumab or HCL). Meta-analysis revealed modest but statistically significant associations between HbA1c and PedsQL (β(std)=-0.11; 95% CI -0.20, -0.03) and HFS (β(std)=0.11; 95% CI 0.00, 0.21), and between CGM time in range and PedsQL (β(std)=0.14; 95% CI 0.03, 0.26) but not HFS (β(std)=-0.05; 95% CI -0.16, 0.06). Beta cell function (AUC C-peptide) was strongly associated with HbA1c (β(std)=-0.29; 95% CI -0.39, -0.20) and CGM time in range (β(std)=0.41; 95% CI 0.30, 0.52). Higher beta cell function showed a trend towards better PedsQL (β(std)=0.11; 95% CI -0.03, 0.25) and lower HFS (β(std)=-0.05; 95% CI -0.17, 0.07) but this did not reach statistical significance. PedsQL and HFS scores changed little during the first 48 months after diagnosis of type 1 diabetes. These scores showed modest but statistically significant associations with measures of glucose management (HbA1c and CGM time in range), whereas the relationships with residual beta cell function (C-peptide) were weaker and did not reach significance. The modest size of these effects suggests current PROMs capture only limited aspects of the clinical benefit associated with beta cell preservation. Future research should incorporate psychometric instruments that are specifically adapted for young people using modern diabetes technologies and undergoing disease-modifying therapy, to ensure outcomes are meaningfully represented in early-stage type 1 diabetes trials.

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