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celecoxib + tramadol HCl (MR308 / Velyntra / Seglentis)

✓ Approved

Kowa · OPRM1 · Small Molecule

What is celecoxib + tramadol HCl?

celecoxib + tramadol HCl is a small molecule developed by Kowa. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesMR308, Velyntra, Seglentis
CompanyKowa
Drug ClassSmall Molecule
Molecular TargetOPRM1, PTGS2, SLC6A2, SLC6A4
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Kowa

Mechanism of Action

Molecular Targets

celecoxib + tramadol HCl acts on 4 molecular targets:

OPRM1opioid receptor mu 1 (MOP, M-OR-1)
PTGS2prostaglandin-endoperoxide synthase 2 (PHS-2, PGG/HS)
SLC6A2solute carrier family 6 member 2 (NAT1, NET)
SLC6A4solute carrier family 6 member 4 (SERT1, 5-HTTLPR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

celecoxib + tramadol HCl is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Gastrointestinal disordersAbdominal pain✓ Approved
Injury, poisoning and procedural complicationsProcedural painPhase III

Related Research Articles

PubMedMolecules (Basel, Switzerland)2026-10-16

Comparative Analysis of Heavy Metal Leaching from Metallurgical Slag Using Different Types of Leaching Agents: A Kinetic Models Approach.

Barbusiński Krzysztof K, Nocoń Milena M, Piotrowski Krzysztof K, Loska Krzysztof K et al.

In accordance with the Circular Economy, the metallurgical solid wastes are considered secondary resources of many heavy metals, such as lead, zinc, iron, cadmium, thallium, and others. To separate valuable and toxic metals, numerous processes, among them solid-liquid extraction, have been studied in recent years. In line with this trend, the objective of this study was to investigate the possibility of leaching selected heavy metals (Pb, Zn, Cu, and Fe) from slag generated by the zinc and lead metallurgical industry. The effect of the leaching agent type (HCl, NaOH, and Na2NTA) and concentration, pH, solid-to-liquid (S/L) ratio, and interphase contact time on process efficiency was evaluated experimentally. The slag was comprehensively characterized using atomic absorption spectrometry (AAS), scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM-EDS), X-ray diffraction (XRD), and BCR (Community Bureau of Reference) sequential extraction to determine the total metal concentration, element and phase composition, as well as chemical speciation of the investigated metals. To determine the kinetic mechanisms the Weber-Morris and shrinking-core models were used. The efficiency of metal separation from slag strongly depended on the process parameters. HCl was highly effective for simultaneous metal leaching, particularly Pb, Zn, and Cu (up to over 80%), while NaOH and Na2NTA allowed for the selective separation of Pb with leaching efficiencies of up to 80% and 90%, respectively. Sequential BCR analysis confirmed the different forms of metal occurrence, with predominating highly mobile Pb fractions and stable, residual Cu and Fe fractions. Comparative analyses using SEM and sequential BCR extraction revealed significant changes in slag morphology and metal speciation following leaching with the HCl solution. The Weber and Morris model indicated the kinetic contribution of the intraparticle diffusion within the slag's porous structure, especially under HCl-based leaching. An analysis using shrinking-core models revealed different predominant mechanisms for specific metal-leaching agent systems.

PMID 42883154
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PubMedPolymers2026-10-16

In-Situ Catalytic Pyrolysis of Polystyrene with Sewage Sludge-Derived Catalysts: Sewage Sludge Ash, Sewage Sludge Char, and Fe-Impregnated Acid-Leached Sewage Sludge Char.

Pogorov Fedor F, Tokmurzin Diyar D, Vitoshnova Yelena Y, Zabara Nazar N et al.

Sewage sludge (SS)-derived materials were investigated as low-cost heterogeneous catalytic materials for polystyrene (PS) pyrolysis, focusing on the effects of thermal treatment, HCl leaching, and Fe impregnation. Sewage sludge ash (SSA), sewage sludge char (SSC), and HCl-leached Fe-impregnated sewage sludge char (Fe-LSSC) were evaluated as in-situ catalytic materials. Catalyst-to-PS ratios of 1:1-1:10 were investigated in a horizontal semi-batch tubular reactor operated in an in-situ catalyst-polymer contact mode at 800 °C. Thermal pyrolysis produced 63.9 wt.% PyOil and 12.6 wt.% PyGas. SSA increased the PyOil yield to 78.0 wt.% at 1:10 and promoted lighter aromatics; at 1:1, light aromatics increased to 66.8 wt.%, BTEX from 5.8 to 24.58 wt.%, and PAHs decreased to 11.8 wt.%. SSC showed a weaker, non-monotonic effect, with PyOil decreasing to 54.4 wt.% and PyChar increasing to 4.7 wt.% at 1:2. Fe-LSSC produced the strongest changes, increasing PyGas to 28.0 wt.% at 1:1 and H2 to 75.3 vol.% at 1:2. The gasoline-range fraction reached 82.1 wt.% at 1:2, while PAHs decreased to 8.79 wt.% at 1:1. Catalyst reuse altered gas composition, whereas thermal regeneration partially restored catalytic behavior. Overall, SS-derived materials exhibited distinct, loading-dependent catalytic functions, while HCl leaching and Fe impregnation enhanced the conversion of PS pyrolysis vapors toward lighter aromatic and gaseous products.

PMID 42885004
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-16

Toward Sustainable Separation and Recovery of Critical Metals From Discarded Industrial Perovskite Solar Modules.

Hu Guang G, Li Zhaoyang Z, Zhou Shifa S, Qin Jie J et al.

The rapid deployment of perovskite solar modules (PSMs) raises an urgent need for recycling strategies that can selectively recover critical metals from their complex multilayer architectures. Here, an architecture-guided sequential recycling strategy is developed by coupling interfacial accessibility with calcination-induced phase transformation. Ultrasonic water leaching removes >99.8% of Pb from the perovskite layer without detectable dissolution of other target metals. During subsequent HCl leaching, the polymer encapsulant functions as a physical barrier, enabling >99.9% In leaching while protecting the Sn-coated Cu ribbon from acid attack. Air calcination then removes the encapsulant and promotes the formation of CuO and chemically stable SnO2, creating a strong contrast in leaching behavior that enables selective Cu dissolution in an acetic acid-hydrogen peroxide system. Overall, recovery ratios of In and Cu exceed 99.7% and 96.1%, respectively, while most of the initial Sn is retained in a Sn-rich residue. The process further achieves a net economic benefit of about 4.735 USD/m2 module, demonstrating an economically promising and architecture-enabled route for selective multi-metal recovery from discarded industrial PSMs.

PMID 42885164
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PubMedPolymers2026-10-16

Preparation of Customizable Ligand-Functionalized Chitin Biopolymer Adsorbents Utilizing the Azide-Alkyne "Click" Reaction for the Adsorption of Aqueous Cu(II).

Berrington Blaine M BM, Williams Reyla R, LaDouceur Richard R

Chitin is an abundant biopolymer, with 1-3 million tons potentially available annually from shellfish-processing waste, but remains underutilized because its insolubility in conventional solvents makes it difficult to process and functionalize. Herein, a three-step route to chitin adsorbents with interchangeable ligands is reported. Highly acetylated chitin was tosylated and converted to the C-6 azide, and amine- and hydroxyl-terminated ligands were attached to this common intermediate by the copper-catalyzed azide-alkyne cycloaddition (CuAAC) "click" reaction, yielding water-insoluble derivatives. Cu(II) adsorption to the adsorbents was evaluated using inductively coupled plasma optical emission spectrometry (ICP-OES analysis). Under standard conditions (pH 6.0, 4 h contact), amine- and alcohol-chitin adsorbed 30.1 ± 1.3 and 22.3 ± 1.9 mg Cu g-1, respectively, approximately 4.9- and 3.6-fold more than unmodified chitin. Isotherm data were well described by the Langmuir model, with apparent capacities of 37.4 and 25.7 mg g-1 at 4 h contact. The adsorbents could be regenerated with 7% (v/v) HCl, retaining 46% and 42% of their initial uptake after four cycles. The differences in derivatives' uptakes are attributable to the identity of the grafted ligand, illustrating how the click route allows chitin adsorbents to be tailored through the choice of alkyne.

PMID 42885080
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PubMedMaterials (Basel, Switzerland)2026-10-16

Selective Adsorption Separation of Sc(III) and Zr(IV) from Acidic Solutions via Zr-SBA-15 with Rich Oxygen-Vacancy Defective.

Zhang Chuanxin C, Shi Lei L, Zhang Zhonghao Z, Li Xinsheng X

Aiming at the challenging selective separation of zirconium (Zr) and scandium (Sc) in hydrochloric acid systems, this study designed a Zr-SBA-15-30 adsorbent featuring abundant surface oxygen vacancy defects. The as-synthesized material possesses an ordered mesoporous structure, a high specific surface area of 477.606 m2/g, and a high density of surface oxygen vacancies. In a strongly acidic binary HCl solution containing both Zr and Sc, Zr-SBA-15-30 exhibited exceptional separation performance, achieving an adsorption capacity of 128 mg/g for Zr and an outstanding separation factor (SFSc/Zr) as high as 3480. Fitting results from adsorption isotherms and kinetic models revealed that the adsorption process is predominantly governed by chemisorption and proceeds mainly via monolayer adsorption. The higher ionic character of the Zr-O bond relative to the Si-O bond, Zr doping induces a redistribution of the local electron cloud density on the framework surface, thereby forming electron-rich centers with higher polarizability and stronger coordination activity. Meanwhile, the oxygen vacancy defects introduced by plasma treatment create defect energy levels within the band gap. This synergistic effect of Zr doping and oxygen vacancies can significantly enhance the separation of Zr/Sc. This work provides a viable material design strategy for the efficient separation of Zr and Sc under strongly acidic conditions.

PMID 42882608
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PubMedMaterials (Basel, Switzerland)2026-10-16

Effect of Etching Temperature and Time on In Situ HF-Generating (NH4F) Synthesis of Ti3C2Tx MXene.

Muldash Dias D, Alipuly Mukhtar M, Kazhmuratov Aidyn A, Sultakhan Shynggyskhan S et al.

MXenes are a family of two-dimensional transition-metal carbides and nitrides, produced by selectively etching the "A" layer from a layered MAX-phase ceramic precursor. Ti3C2Tx MXene was synthesised from Ti3AlC2 via microwave-assisted, in situ HF-generating etching using NH4F/HCl as a safer alternative to concentrated HF. The etching temperature was first varied (40-100 °C, 30 min), and then the duration (30-90 min) was varied at the most favourable temperature. Samples were characterised by SEM, EDS, XRD, and Raman spectroscopy. SEM showed a non-monotonic relationship between temperature and morphology, with the most uniform accordion-like layering at 80 °C before fragmentation and edge erosion at 100 °C; duration showed a similar pattern, with 30 min at 80 °C being most uniform and heterogeneity increasing at 60 and 90 min. XRD, using a composite residual-MAX-phase index, placed the MAX-to-MXene crossover between 60 and 80 °C, consistent with SEM. EDS showed fluorine content and aluminium removal decoupling with etching time, with fluorine declining sharply beyond 30 min without a corresponding recovery in aluminium removal. Raman confirmed the characteristic Ti3C2Tx fingerprint at every condition. Thus, 80 °C/30 min was identified as the most favourable processing window; however, given the coarseness of the parameter grid, the true optimum may lie within intermediate, untested conditions.

PMID 42882671
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