Drug Database
SU

sumatriptan succinate (Imigran Nasal Spray / Imitrex Nasal Spray / Suminant)

✓ Approved

GSK · HTR1D · Small Molecule

What is sumatriptan succinate?

sumatriptan succinate is a small molecule developed by GSK. It is approved for therapeutic indications via inhaled.

Drug Profile

Brand NamesImigran Nasal Spray, Imitrex Nasal Spray, Suminant
CompanyGSK
Drug ClassSmall Molecule
Molecular TargetHTR1D
RouteInhaled
StatusApproved
Sources: ClinicalTrials.gov, GSK

Mechanism of Action

Molecular Targets

sumatriptan succinate acts on 1 molecular target:

HTR1D5-hydroxytryptamine receptor 1D (HTR1DA, HT1DA)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

sumatriptan succinate is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Nervous system disordersMigraine✓ Approved
Nervous system disordersCluster headache✓ Approved

Related Research Articles

PubMedJournal of agricultural and food chemistry2026-07-17

Coumarin Hydrazone Derivatives as Potent Succinate Dehydrogenase Inhibitors and Effective Antifungal Agents against Rhizoctonia solani.

Chen Wang W, Fu Lixiang L, Wang Chunyan C, Mu Yalin Y et al.

Succinate dehydrogenase inhibitors (SDHIs) are widely used worldwide for their broad-spectrum antifungal activity. Structural optimization of natural products offers a viable route to novel SDHI skeletons. Herein, a series of coumarin hydrazone derivatives were designed and synthesized by a scaffold splicing strategy. Compound 3p showed 100% antifungal activity against Rhizoctonia solani at 50 μg/mL, with an EC50 of 1.16 μg/mL. On rice leaves, 3p achieved 98.4% preventive efficacy against R. solani, outperforming Boscalid (69.6%) at the same concentration. Furthermore, it caused hyphal distortion and mitochondrial damage, similar to boscalid. Enzymatic assays confirmed 3p as an SDHI with an IC50 of 8.69 μM, and molecular docking indicated stable binding within the SDH active site. ATP analysis revealed intracellular levels were reduced to 72% in 3p-treated mycelia compared to controls. Therefore, compound 3p is a promising leader for developing novel SDH inhibitors.

PMID 42464054
Read full article →
PubMedClinical linguistics & phonetics2026-07-17

Variability of oral-nasal balance characteristics in children with cleft lip and palate over time.

Bressmann Tim T, Stevens Kyle K

The accurate assessment of oral-nasal balance disorders in children with cleft lip and palate is a perennial problem in Speech-Language Pathology. Nasalance scores obtained with a nasometer can contribute to the diagnosis of oral-nasal balance disorders. The present study investigated how consistent such classifications are over time. Twenty-seven children with cleft lip and palate were recorded six times with a nasometer headset over the course of an orthodontic palatal expansion treatment. Nasalance scores were considered hypernasal when they were higher than 30% for a non-nasal sentence and hyponasal when they were below 50% for a nasal sentence. Based on the nasalance scores, normal nasalance was found in 42.6%, hyponasality in 34.0%, and hypernasality in 23.5% of 162 sound recordings. Only 7/ 27 (25.9%) of the children had the same nasalance-based classification over the six sessions. The others demonstrated variability that straddled two adjacent categories in 15/ 27 (55.6%) of cases and all three categories in 5/ 27 (18.5%) of cases. While clinicians may wish to assign a permanent oral-nasal balance classification to their patients, the study demonstrated that a subset may show unexpected variability over time. More research is needed to establish whether it would be beneficial in some cases to explore this potential for variability before long-term decisions about a patient's clinical management are made.

PMID 42464933
Read full article →
PubMedBMJ case reports2026-07-17

Sphenochoanal polyp arising from the sphenoid ostium and mimicking an antrochoanal polyp on preoperative imaging.

Onderková Anna A, Speth Marlene Maria MM, Saleh Hesham A HA

A man in his early 20s presented with an 8-month history of unilateral nasal obstruction, hyposmia and thick nasal discharge, unresponsive to topical therapy. Preoperative CT demonstrated a smooth polypoidal mass occupying the left nasal cavity and extending into the postnasal space, most consistent with a choanal polyp of presumed maxillary origin. Endoscopic sinus surgery revealed a pedicle at the sphenoid ostium, with an otherwise clear sphenoid sinus, confirming a sphenochoanal polyp. This was unusual because preoperative CT showed only minimal mucosal change in the sphenoid sinus, a finding that typically argues against a sphenochoanal origin. The lesion was excised endoscopically at its site of attachment. Histopathology showed inflammatory nasal polyp tissue without granulomata, vasculitis or atypia. This case illustrates a diagnostic pitfall in which sphenochoanal polyps may mimic antrochoanal polyps on imaging; intraoperative identification of the true sinus of origin is essential to guide appropriate surgery and minimise recurrence.

PMID 42463175
Read full article →
PubMedFacial plastic surgery : FPS2026-07-17

Age-Related Changes in Nasal Septal Composition: A CT-Based Morphometric Analysis.

Kınal Mustafa Emrah ME, Koç Niyazi Gunsu NG

The nasal septum plays an important role in craniofacial development and rhinoplasty, but age-related changes in septal composition remain incompletely understood. Objectives & Hypotheses: To evaluate age-related morphometric changes in the nasal septum and test the hypothesis that septal composition shifts from cartilage to bone dominance with aging. Retrospective cross-sectional study (STROBE-compliant). Facial CT scans from 200 patients were analyzed. Septal cartilage area(SCA), lamina perpendicularis area(LPA), vomer area(VA), total septum area(TSA), cartilage-to-bone ratio, and SCA/LPA ratio were measured and compared by age and sex. TSA increased until adolescence and remained stable thereafter. SCA declined after adolescence, whereas LPA increased until early adulthood. Cartilage dominance progressively decreased and stabilized after 30 years. Similar proportional trends were observed in both sexes. Nasal septum morphology undergoes a distinct age-related transition characterized by a shift from cartilage dominance to bony dominance, reaching equilibrium after early adulthood.

PMID 42463113
Read full article →
PubMedCurrent medical research and opinion2026-07-17

Cost-effectiveness of nasal adrenaline in the treatment of anaphylaxis.

Nasser Shuaib S, Bottazzi Luca L, Lang Andrea A, Skou Rebecca R et al.

Nasal adrenaline spray is a novel needle-free alternative for the emergency treatment of anaphylaxis. Evidence on its cost-effectiveness versus adrenaline auto-injectors (AAIs) is currently limited. This analysis evaluates the cost-effectiveness of the nasal adrenaline spray versus an AAI in individuals ≥ 30 kg (approximately 8 years of age) at risk of all-cause anaphylaxis in the United Kingdom (UK). A de novo Markov cohort model was developed for the UK setting from a societal perspective over a lifetime horizon. Four health states captured the risks and consequences of anaphylaxis. Clinical inputs included the probability of initial and recurrent anaphylactic episodes, adrenaline carriage, whether used, administration accuracy and needle-related administration errors. Costs included product acquisition, training, emergency care, hospitalization, needle-related administration errors, and productivity loss. Outcomes were quality-adjusted life years (QALYs), with costs and benefits discounted at 3.5% annually. The impact of uncertainty was assessed using deterministic and probabilistic sensitivity analyses. In the base case, the nasal adrenaline spray was dominant versus the AAI, yielding 0.26 additional QALYs at a lower cost (-£681). Cost differences were mainly driven by product acquisition, hospitalization rates and productivity loss. Results were robust across scenario analyses but were sensitive to assumptions about adrenaline carriage and use. In the UK, the nasal adrenaline spray may be a cost-effective alternative to AAIs, largely due to assumed higher carriage and greater likelihood of use during anaphylactic episodes. Further real-world evidence is needed to validate these assumptions and their impact on cost-effectiveness.

PMID 42466634
Read full article →
PubMedThe Journal of laryngology and otology2026-07-17

Navigating Biologic Treatments in Chronic Rhinosinusitis with Nasal Polyps: A Comprehensive Review of Patient Selection.

Bayar Muluk Nuray N

PMID 42464615
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about sumatriptan succinate