Drug Database
HY

hyoscyamine sulfate

✓ Approved

Lumara Health · CHRM1 · Small Molecule

What is hyoscyamine sulfate?

hyoscyamine sulfate is a small molecule developed by Lumara Health. It is approved for therapeutic indications via oral (po).

Drug Profile

CompanyLumara Health
Drug ClassSmall Molecule
Molecular TargetCHRM1, CHRM2, CHRM3, CHRM4
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Lumara Health

Mechanism of Action

Molecular Targets

hyoscyamine sulfate acts on 4 molecular targets:

CHRM1cholinergic receptor muscarinic 1 (M1, HM1)
CHRM2cholinergic receptor muscarinic 2 (HM2)
CHRM3cholinergic receptor muscarinic 3 (HM3, PBS)
CHRM4cholinergic receptor muscarinic 4 (HM4, M4R)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

hyoscyamine sulfate is developed for 3 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Gastrointestinal disordersColitis ulcerative✓ Approved
Gastrointestinal disordersIrritable bowel syndrome✓ Approved
Renal and urinary disordersUrinary tract inflammation✓ Approved

Related Research Articles

PubMedMaterials (Basel, Switzerland)2026-10-16

Numerical and Experimental Study of the Effects of Water-to-Cement Ratio and Temperature on Cement-Based Materials Under Sulfate Attack.

Cao Tongning T, Chen Ze Z, Yu Chenyun C, Peng Bin B et al.

The water-to-cement ratio and temperature are key factors governing ionic transport in cement-based materials. However, quantitative descriptions of their coupled effects on sulfate ion transport-reaction processes remain limited. In this study, a coupled transport-reaction model is developed to simulate sulfate ingress in cementitious materials subjected to external sulfate attack. The predictive capability of the model is validated through a series of well-designed experiments, and the distributions of sulfate ion concentration within the materials under different water-to-cement ratios and temperature conditions are systematically analyzed. The results demonstrate good agreement between model predictions and experimental measurements, indicating that increases in both water-to-cement ratio and temperature significantly accelerate sulfate diffusion and intensify chemical reactions between sulfate ions and cement hydration products, thereby promoting material degradation. These findings highlight that the coupled effects of water-to-cement ratio and temperature should be explicitly considered in durability assessment and numerical modeling of external sulfate attack in cement-based materials to improve predictive accuracy.

PMID 42882716
Read full article →
PubMedMaterials (Basel, Switzerland)2026-10-16

Correction: Zheng et al. Calcium Sulfate Whiskers Dual-Enhance Mechanical and Anti-Corrosion Properties of Magnesium Phosphate Coatings. Materials 2026, 19, 1032.

Zheng Yaxin Y, Chen Haoran H, Liu Yi Y, Gao Xiang X

Error in Figure [...].

PMID 42882760
Read full article →
PubMedMaterials (Basel, Switzerland)2026-10-16

Assessment of Deterioration Characteristics of Solid Waste-Based Binder-Stabilized Laterite Under Multiple Environmental Factors Based on Micro-Drilling Resistance.

Yue Bing B, Zhang Qiong Q, Hu Jiaxing J, Zhu Shengli S et al.

Solid waste-based binder-stabilized laterite is prone to progressive deterioration under multiple coupled environmental factors in practical engineering applications. Conventional compression and direct shear tests fail to accurately characterize the gradient deterioration pattern of stabilized laterite specimens. In this study, a multi-factor test scheme was designed using response surface methodology, with wet-dry cycle number, initial humic acid content, and magnesium sulfate solution concentration selected as environmental factors. Continuous drilling resistance-drilling depth curves of stabilized laterite specimens were obtained using a drilling resistance measurement system, thereby quantitatively determining the deterioration depth and indirectly characterizing structural integrity via the drilling resistance in the stable drilling stage. Scanning electron microscopy observations were used to reveal the microscopic deterioration mechanism of stabilized laterite under the effects of environmental factors. The results of the regression show that the micro-drilling resistance in the stable drilling stage of undeteriorated stabilized laterite has a significant linear correlation with shear strength, indicating that micro-drilling resistance, as an indirect index of specimen integrity, also has potential for application in evaluating the strength of stabilized laterite. All three environmental factors increase the deterioration depth of stabilized laterite; wet-dry cycles exert the most significant effect and exhibit a statistically significant interaction within the investigated experimental domain with humic acid content, followed by magnesium sulfate concentration. For stabilized laterite subjected to wet-dry cycles and sulfate attacks, there exists a change point depth on the drilling resistance curve. Below this depth, the average micro-drilling resistance of the interior soil is mainly governed by the initial humic acid content. Microscopically, humic acid particles form weakly cemented zones in surrounding areas, which gradually evolve into preferential flow paths under wet-dry cycles, accelerating water infiltration and expanding deterioration depth. Magnesium sulfate crystallizes within pores to generate ettringite and other products, inducing extrusion stress on the cemented structure and further aggravating soil loosening and microcrack propagation.

PMID 42882612
Read full article →
PubMedMolecular medicine reports2026-10-16

Gut microbiota in patients receiving dialysis: Mechanisms, complications and the road to personalized microbiome‑based care (Review).

Jin Chenxia C, Wang Yanping Y

Gut dysbiosis is increasingly recognized as a potential contributor to poor outcomes in patients receiving dialysis, yet its mechanistic complexity and therapeutic implications remain incompletely understood in clinical practice. The uremic environment, dietary restrictions, polypharmacy and dialysis modality‑specific factors collectively reshape the gut microbial ecology, promoting the overproduction of deleterious metabolites such as indoxyl sulfate, p‑cresyl sulfate and trimethylamine N‑oxide while depleting protective short‑chain fatty acids. These alterations compromise intestinal barrier integrity, fuel systemic inflammation through endotoxemia and NOD‑like receptor family pyrin domain containing 3 inflammasome activation and have been associated with cardiovascular disease, immune dysfunction, peritonitis, protein‑energy wasting and cognitive impairment. Although probiotic, prebiotic, synbiotic and dietary interventions show promise, heterogeneous responses across trials underscore the inadequacy of one‑size‑fits‑all strategies. Multi‑omics profiling has revealed substantial interindividual variability in microbial composition and metabolic capacity, providing a rationale for personalized approaches. The present review synthesizes current evidence on the mechanisms underlying dysbiosis and complications in patients receiving dialysis and proposes a roadmap toward personalized microbiome‑based care to improve clinical outcomes.

PMID 42885316
Read full article →
PubMedMaterials (Basel, Switzerland)2026-10-16

Durability Degradation Mechanisms and Coupled Deterioration Behaviors of Geopolymer Concrete Under Multi-Hazard Service Environments: A Critical Review.

Li Jiale J, Yang Fei F, Hai Ran R, Mi Wenhao W et al.

Geopolymer concrete (GPC), here defined primarily as concrete based on low-calcium alkali-activated aluminosilicate binders, exhibits durability responses that depend strongly on precursor chemistry, gel assemblage, pore structure and exposure conditions; high-calcium or slag-rich systems are therefore discussed separately as related alkali-activated material (AAM) systems. This critical review synthesizes representative peer-reviewed evidence on freeze-thaw cycling, drying and autogenous shrinkage, elevated-temperature/fire exposure, chloride, sulfate and acid attack, carbonation, reinforcement corrosion and coupled multi-hazard deterioration. The evidence indicates that freeze-thaw damage is governed by pore-water phase change, cracking and transport-pathway formation, while chemical attack involves ion ingress, dealkalization, dealumination/decalcification and elemental leaching. Direct coupled evidence is strongest for freeze-thaw combined with chloride/salt or sulfate exposure; shrinkage-transport interactions are mainly correlation-supported, whereas carbonation-chloride-freeze-thaw-related corrosion remains largely a mechanism-based inference. Future work should prioritize standardized sequential multi-hazard protocols, chemistry-specific parameter databases and field-calibrated transport/corrosion models to support reliable service-life prediction and engineering design.

PMID 42882551
Read full article →
PubMedMolecules (Basel, Switzerland)2026-10-16

Hierarchical Surrogate Modeling and Optimization of the SO2 Recovery-Water Loss Trade-Off in Basic Aluminum Sulfate Regeneration.

Wang Zijun Z, Wang Bo B, Li Jianmin J, Wen Junming J et al.

Vacuum regeneration can close the absorbent loop in basic aluminum sulfate (BAS) wet flue-gas desulfurization and SO2 capture, but SO2 release occurs together with energy-intensive water evaporation. This study developed a response-specific framework to predict and balance these coupled rates using existing vacuum-regeneration data. The SO2 model included absolute pressure, temperature, aluminum concentration, basicity, and sulfite concentration, whereas the H2O model used pressure and temperature. Candidate regressors were assessed by cross-validation, error statistics, and physical-trend consistency. Gaussian process regression with a Matérn-5/2 automatic-relevance-determination kernel best predicted SO2 desorption (RMSE = 0.0631; R2 = 0.9746), while an automatic-relevance-determination squared-exponential kernel best predicted H2O evaporation (RMSE = 0.0793; R2 = 0.9928). Sulfite concentration dominated the SO2 response; pressure and temperature controlled both rates. Lower pressure and higher temperature improved SO2 recovery but increased water loss. Pareto analysis identified a model-supported compromise at approximately 26-30 kPa and 340-342 K. A 120 min recursive simulation showed declining instantaneous SO2 release as sulfite was depleted, while water evaporation continued. Within the experimental domain, the framework supports joint selection of pressure, temperature, and operating time for BAS regeneration.

PMID 42883235
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about hyoscyamine sulfate