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ketoprofen SR

✓ Approved

Ethypharm Corp. · PTGS1 · Small Molecule

What is ketoprofen SR?

ketoprofen SR is a small molecule developed by Ethypharm Corp.. It is approved for therapeutic indications via unknown.

Drug Profile

CompanyEthypharm Corp.
Drug ClassSmall Molecule
Molecular TargetPTGS1, PTGS2
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Ethypharm Corp.

Mechanism of Action

Molecular Targets

ketoprofen SR acts on 2 molecular targets:

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

ketoprofen SR is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Gastrointestinal disordersAbdominal pain✓ Approved
Hepatobiliary disordersHepatitis✓ Approved

Related Research Articles

PubMedJournal of clinical medicine2026-10-16

Hemodynamic and Metabolic Predictors of Unsuccessful Electrical Cardioversion or Early Atrial Fibrillation Recurrence After Electrical Cardioversion.

Skalska Paulina P, Kurpaska Małgorzata M, Uziębło-Życzkowska Beata B, Krzesiński Paweł P

Background: Rhythm control remains a cornerstone in the management of atrial fibrillation (AF). Although electrical cardioversion (ECV) effectively restores sinus rhythm (SR), its short-term durability is limited. Aims: This study aimed to evaluate the short-term rhythm outcomes after ECV and to identify predictors of failure to achieve or maintain SR within 30 days after ECV, with particular emphasis on the hemodynamic profile of patients with persistent AF. Methods: Ninety-four consecutive patients with persistent AF undergoing elective ECV were prospectively enrolled. Cardiac rhythm was assessed immediately after ECV, at ~24 h, and ~30 days. Laboratory testing, echocardiography, and impedance cardiography (ICG) were performed before ECV. Logistic regression analysis was used to identify predictors of failure to achieve or maintain SR within 30 days after ECV. Results: ECV was initially successful in 80 patients (85.1%), with SR maintained in 76 (80.8%) at 24 h. At 30 days, SR persisted in 49 patients (52.1%), while 43 patients (45.7%) failed to achieve or maintain SR, including 14 patients in whom ECV was unsuccessful and 29 patients who experienced AF recurrence after initially successful ECV; two patients were lost to follow-up. In multivariable analysis, T2DM was independently associated with higher odds of failure to achieve or maintain SR within 30 days after ECV (OR 3.26; 95% CI 1.183-8.978; p = 0.022). Higher TFC values were also independently associated with increased odds of this outcome (OR 1.15; 95% CI 1.017-1.291; p = 0.025). In contrast, the presence of hypertension was associated with lower odds of this outcome (OR 0.30; 95% CI 0.094-0.947; p = 0.040). Among hemodynamic parameters, only TFC was independently associated with the outcome, whereas echocardiographic parameters did not differ between groups. Conclusions: Even in a relatively low-risk population without advanced comorbidity burden, failure to achieve or maintain SR after ECV remains frequent. T2DM and elevated TFC were independently associated with failure to achieve or maintain SR, while hypertension was associated with a lower risk. These findings suggest that metabolic and hemodynamic abnormalities may provide prognostic information beyond that captured by conventional echocardiography.

PMID 42882130
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PubMedMolecules (Basel, Switzerland)2026-10-16

Antifungal Efficacy and Chemical Profiles of Salvia, Oregano, and Laurus Essential Oils Against Mold Species Associated with Caciocavallo Cheese Spoilage.

Akram Shazia S, Brandimarte Beatrice B, Basile Giuseppe Natale GN, De Mastro Giuseppe G et al.

Mold contamination is a major cause of spoilage in ripened cheeses. In this study, 171 fungal isolates were recovered from semi-hard Caciocavallo cheese sampled across three seasons. The number of recovered isolates showed a descriptive decrease from summer to winter. Thirty-two representatives were selected for ITS and/or β-tubulin sequencing after morphotype screening. Among these sequenced representatives, Penicillium commune was the most frequent provisional taxonomic designation (8/32; 25.0%), followed by Aspergillus flavus (3/32; 9.4%). Penicillium echinulatum, Fusarium iranicum, Paecilomyces variotii, and Cladosporium-like isolates each accounted for 2/32 (6.3%). ITS-only assignments in taxonomically difficult genera are treated as provisional closest-match designations rather than definitive species identifications. Essential oils (EOs) from three Salvia rosmarinus Spenn. chemotypes (SR-CV2-23, SR-CV3-23, and SR-CV6-23), oregano cv. Carva (Origanum vulgare L. subsp. viridulum (Martrin-Donos) Nyman × O. vulgare L. subsp. hirtum Ietswaart; Ov-C-23), and Laurus nobilis L. (Ln-23) were chemically characterized and evaluated for their antifungal activity against mold species associated with Caciocavallo cheese spoilage. GC-MS showed that the rosemary EOs were rich in camphor, α-pinene, and 1,8-cineole; Ov-C-23 contained 83.95% carvacrol; and Ln-23 contained mainly 1,8-cineole, linalool, and bornyl acetate. All EOs exhibited concentration-dependent antifungal activity, with spore germination generally more sensitive than mycelial growth. At 0.35% (v/v), SR-CV2-23 showed the broadest observed in-vitro activity, whereas Ov-C-23 produced the highest observed inhibition of A. alternata mycelial growth. CFDA/PI confocal microscopy showed the largest relative shift toward reduced metabolic activity and membrane compromise after SR-CV3-23 treatment. In-vitro assays and cheese-slice experiment used different quantitative endpoints and were therefore not directly compared. Ov-C-23 produced the highest observed reduction in visible colonies in the cheese slice model. These EOs may contribute to integrated mold control strategies, but practical application requires further validation under industrial conditions.

PMID 42883201
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PubMedPlants (Basel, Switzerland)2026-10-16

Film Mulching with Straw Return and Controlled-Release and Conventional Urea Blend Alters Aggregate-Associated Nitrogen Distribution While Sustaining Grain Yield in Dryland Maize.

Zhang Fangfang F, Lv Yixuan Y, Lu Yanting Y, Song Ziyi Z et al.

Plastic film mulching (FM) improves crop productivity in dryland agriculture but risks soil quality degradation under continuous chemical fertilization. Under FM with optimized nitrogen (N) input from a controlled-release and conventional urea blend (CCU), straw return (SR) management may either contribute to grain yield or alter aggregate-associated N pools. A two-year film-mulched experiment was conducted with three treatments: no fertilization (CK), CCU alone (CU), and CCU plus SR (CS). Compared with CU, CS did not further increase grain yield despite greater total N uptake during critical growth stages. However, CS increased the proportion of large macroaggregate (LM) by an average of 10.0 percentage points and the mean weight diameter by 35.7%, and also increased N concentration in most aggregate fractions. A significant increase in N stock was detected in the LM fraction in both years. In contrast, N stock in the microaggregate (MI) was significantly lower under CS in 2020, whereas N stocks in small macroaggregate (SM), silt and clay (SC), and bulk soil were not significantly affected in either year. SM N stock was positively correlated with grain yield in the pooled dataset, but this association was attenuated after controlling for year and should therefore be considered exploratory. Overall, CS maintained grain yield comparable to CU while altering aggregate-associated N distribution, suggesting a potential decoupling between short-term yield and aggregate-associated N pools; however, the origin of the additional aggregate-associated N could not be resolved without isotopic tracing.

PMID 42884908
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PubMedMaterials (Basel, Switzerland)2026-10-16

Mechanical, Computational, and Biological Evaluation of 3D-Printed PLA-Bioactive Glass Scaffolds for Bone Tissue Regeneration.

Martelli Andrea A, Bellucci Devis D, Nobili Andrea A, Li Tian T et al.

Additive manufacturing enables the production of patient-specific biodegradable scaffolds for tissue regeneration. Polylactic acid (PLA), an FDA-approved polymer widely used in tissue engineering, suffers from hydrophobicity that limits cell adhesion, slows degradation, and may trigger inflammatory responses. To address these limitations, PLA was combined with bioactive glass (BG) particles to obtain printable composite filaments. Four BG compositions (45S5, S53P4, 45S5_MS, and S53P4_MS) were evaluated to determine whether Mg- and Sr-doped formulations improve biological performance of composites. The composites were characterized from morphological, physical, and mechanical standpoints, while scaffold wettability was further enhanced through alkaline surface treatment prior to in vitro cytocompatibility assays. BG incorporation increased brittleness and reduced compressive strength, while tensile properties remained comparable to pure PLA. Alkaline treatment effectively improved hydrophilicity and promoted cell adhesion and proliferation. Fluorescence microscopy revealed that scaffolds containing doped BG compositions supported particularly dense and well-spread cell populations. These findings demonstrate the synergistic effect of BG incorporation and surface modification in enhancing the performance of FDM-printed PLA scaffolds, supporting their potential use in bone tissue engineering.

PMID 42882580
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PubMedFoods (Basel, Switzerland)2026-10-16

Botanical and Geographical Origin Assessment of Olive Oil from Known and Lesser-Known Greek Olive Cultivars Using Mineral Content and Chemometrics.

Intzirtzi Eirini E, Mazarakioti Eleni C EC, Lazaridis Dimitrios G DG, Zotos Anastasios A et al.

Olive oil is a natural oil that preserves the flavor, aroma, vitamins, and properties of the olive. The most significant challenge in olive oil production is maintaining its stable chemical composition, as oxidation is the primary cause of its deterioration. Olive oil contains minerals in low concentrations, and the presence of high concentrations of minerals contributes to increased oxidation of the oil. The presence of heavy metals in olive oil can be attributed to natural, chemical, and environmental factors. Various analytical techniques are available to determine minerals in olive oil. This study aimed to verify the geographical and botanical origin of olive oil samples collected from various Greek regions using inductively coupled plasma mass spectrometry (ICP-MS). A total of 36 minerals were determined. Regarding geographical origin analysis of olive oil of the Koroneiki olive cultivar, the dominant minerals were Al, B, Ba, Ca, Cr, Cu, Fe, Ga, Li, Mg, Mn, Mo, Na, Ni, Pb, Rb, Se, Sr, W, Zn and Zr, while in the botanical origin analysis (Koroneiki, Ntopia Androu, Adramitiani, Ladoelia, Chondroelia, Ntopia Chalkidikis) the dominant minerals were Al, Cu, Fe, Mn, Na, Ni, Rb, Se, Ti. Significant (p < 0.05) variations in mineral content were observed among the samples, suggesting differences owed to geographical and botanical origins. Multivariate statistics, based on multivariate analysis of variance, linear discriminant analysis, and factor analysis, classified samples and provided correlations between minerals and the geographical and botanical origin of olive oil. Classification results based on linear discriminant analysis and using two prior probabilities (all groups are equal or compute from group sizes) during linear discriminant analysis in relation to the cross-validation method showed that mineral content analysis can be used more effectively for the determination of olive oil geographical origin (correct classification rate of 76.9% and 74.4%, respectively), whereas its botanical origin (correct classification rate of 50-56.8%) can be affected by intrinsic or extrinsic factors.

PMID 42883642
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PubMedEnvironmental research2026-10-15

Field trial of all-solid-waste stabilized soda residue for roadway subgrades: mechanical performance and environmental behavior.

Xu Yang Y, Wan Jialei J, Jin Fei F, Liu Dexing D et al.

Soda residue (SR), a highly alkaline and saline by-product of the ammonia-soda process, remains difficult to reuse at high dosage because of its high water content and soluble-salt release. Here, an all-solid-waste stabilized soda residue (S-SR) containing 70 wt.% SR was validated in a full-scale roadway subgrade to assess field constructability, engineering performance, and environmental behavior under natural exposure. Under low-temperature natural curing, mean California bearing ratio (CBR) increased from 38.6% at 1 d to 164.6% at 28 d, resilient modulus from 260.8 to 388.6 MPa, and dynamic deformation modulus from 65.6 to 199.9 MPa, while rebound deflection decreased from 0.374 to 0.190 mm. Degree of compaction and initial water content jointly controlled spatial variability. Leached Cl- decreased from 3028 mg/L at 1 d to 268 mg/L at 60 d and SO42- from 286 to 15 mg/L. Over five months, lysimeter leachate pH decreased from 10.87 to 8.32 and electrical conductivity from 15,469 to 4,236 μS/cm (a 72.6% reduction), indicating gradual decreases in leachate alkalinity and overall dissolved-ion level during the middle-to-late monitoring period. The dynamic cone penetration index (DCPI) showed strong power-law relationships with field mechanical indices (R2 = 0.94-0.99) and evolved consistently with anion leaching. Compared with reported SR-based systems, S-SR achieved higher SR utilization and 7-d CBR, together with lower material-related cost and production-stage carbon emissions. The study provides field-scale evidence for high-content SR reuse while documenting age-dependent leaching attenuation and field environmental responses under natural exposure.

PMID 42880470
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