Drug Database
AM

AM-87 (Difur)

✓ Approved

Cantabria Labs · LTB4R

What is AM-87?

AM-87 is a therapeutic agent developed by Cantabria Labs. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesDifur
CompanyCantabria Labs
Molecular TargetLTB4R, IL6R
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Cantabria Labs

Mechanism of Action

Molecular Targets

AM-87 acts on 2 molecular targets:

LTB4Rleukotriene B4 receptor (GPR16, P2Y7)
IL6Rinterleukin 6 receptor (IL6RQ, IL-6R-1)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

AM-87 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersPsoriasis✓ Approved

Related Research Articles

PubMedCureus2026-09-20

3D Printing With Low-Cost and Recycled Medical-Grade Plastics: A Narrative Review of a Sustainable Pathway for Neurosurgical Tools, Training Models, and Implants in Low- and Middle-Income Countries.

Najeeb Zia-Ul-Rehman ZU, Fawad Ul Hassan Muhammad M, Khan Faiqa I FI, Farhan Muhammad M et al.

3D printing enables rapid prototyping and the customized production of functional medical devices. In neurosurgery, where precise anatomical representation is essential, 3D printing is widely utilized to fabricate patient-specific implants, surgical guides, and anatomical models for preoperative planning and training purposes. Medical 3D printing predominantly utilizes polymer-based materials. The advances in polymer science have established biomaterials as essential components in healthcare applications. Healthcare systems in low- and middle-income countries (LMICs) are burdened by financial limitations, rendering the acquisition of expensive, imported medical-grade filaments and biomaterials a significant concern. This narrative review focuses on the use of low-cost and recycled biomaterials and 3D printing in neurosurgery, particularly in LMICs. Additive manufacturing (AM) not only reduces waste concerns but also helps in designing refined products. Keeping the tensile strength, durability, and elastic modulus the same, the integration of low-cost and recycled medical-grade plastics and polymer-based biomaterials offers a practical approach to overcoming these barriers by improving affordability, accessibility, and local manufacturing capacity. 3D printing offers the potential for sustainable innovation in healthcare by utilizing locally available and recycled materials, aligning with cost-effective and environmentally conscious practices.

PMID 42763535
Read full article →
PubMedEuropean journal of neurology2026-09-19

Association of Time of Day With Functional Outcome in Intracerebral Hemorrhage.

Lieschke Franziska F, Lo Eng H EH, Mandeville Emiri T ET, Foerch Christian C et al.

The timing of ischemic stroke and intracerebral hemorrhage (ICH) onsets follow distinct daily patterns, but it remains unclear whether these patterns influence ICH outcomes. Consecutive data were obtained from the prospective stroke inpatient quality assurance registry of Hesse, Germany from 2015 to 2023. Patients with ICH were grouped according to the time of symptom onset: morning (5:00 AM to 10:59 AM), midday (11:00 AM to 4:59 PM), evening (5:00 PM to 10:59 PM), and night (11:00 PM to 4:59 AM). The primary outcome was global disability at discharge, analyzed using ordinal logistic regression. Secondary outcomes included mortality and complications during hospitalization. To account for potential confounding, the analysis incorporated both inverse probability weighting (IPW) and propensity score matching (PSM) based on baseline characteristics. After exclusions, 5665 patients underwent final analysis. Peak ICH incidences occurred around 8:30 AM and 5:00 PM with a minimum at approximately midnight. Patients experiencing ICH during the evening and particularly at night had higher discharge disability, compared to those with symptom onset in the morning or midday. Unadjusted analyses found daily variations in mortality and in-hospital complications that were no longer significant after adjustment by PSM or IPW. Our study confirms the daily pattern previously observed in ICH onset, with peak onset during daytime. Functional outcomes were worse in evening and night onset ICH patients. These findings underscore the potential for chronobiologically informed prevention and treatment strategies and the need for further research into time-dependent pathophysiology and care delivery.

PMID 42760870
Read full article →
PubMedAngewandte Chemie (International ed. in English)2026-09-19

Bio-Inspired Bidirectional Proton Regulatory Mechanisms by Anhydride-Based Hydrogel Electrolytes for High-Performance Aqueous Zinc-Ion Batteries.

Li Jingcheng J, Chu Yuanwei Y, Li Xinpeng X, Luo Tingting T et al.

Aqueous zinc-ion batteries (AZIBs) employing hydrogel electrolytes offer significant advantages in mitigating short-circuit and electrolyte leakage risks. Nevertheless, the sluggish transport kinetics of Zn2 + and severe interfacial instability of zinc anodes still severely restrict their further development. Herein, a bio-inspired hydrogel electrolyte based on poly(acrylamide-co-maleic anhydride) (P(AM-co-MA)) copolymer is fabricated to construct a dual-functional polymer network. The dynamic acid-base equilibrium between carboxyl and amide groups enables reversible bidirectional proton buffering, which effectively suppresses the hydrogen evolution reaction and anode corrosion. Meanwhile, the synergistic Zn2 + hopping sites constituted of carboxylate and amide groups optimize the ion-transport microenvironment and accelerate Zn2 + migration kinetics synchronously, realizing the coordinated regulation of proton activity and Zn2 + transport. Thus, the optimized P(AM-co-MA) hydrogel electrolyte delivers a high Zn2 + transference number of 0.66 and an ionic conductivity of 16 mS cm-1. The assembled Zn||Zn symmetric cells achieve ultra-long and stable cycling for over 2700 h at 1 mA cm-1. Furthermore, the pouch-type Zn||NaV3O8 full cells based on this hydrogel electrolyte exhibit a high specific capacity of 254 mAh g-1 at 1 A g-1, with a capacity retention of 80% after 120 cycles, verifying the great application potential of this rational design for flexible energy storage devices.

PMID 42762445
Read full article →
PubMedFrontiers in plant science2026-09-19

Cytological basis and key metabolite profiling of fresh tobacco leaves with different oiliness indices in Yunyan 87.

Hu Xianfeng X, Xu Wei W, Chen Hao H, Pan Shouhui S et al.

Tobacco oiliness index is a key chemical trait that significantly influences tobacco quality. To elucidate the cytological features and key metabolites underlying varying relative oiliness indices, fresh Yunyan 87 tobacco leaves were analyzed by microscopic and metabolomic profiling. The results indicated that leaves with high oiliness exhibited a tighter tissue architecture, characterized by closely packed mesophyll cells and reduced intercellular spaces; conversely, leaves with low oiliness showed a looser arrangement. The levels of cembratriene-diols, methyl nonanoate, and methyl palmitate in trichome exudates were markedly elevated in high-oil leaves compared with those in low-oil leaves. High-oil leaves exhibited a significantly greater abundance of starch grains and osmiophilic granules. In contrast, low-oil leaves displayed localized chloroplast swelling and mild mitochondrial vacuolation, suggesting insufficient or imbalanced accumulation of intracellular storage substances. The concurrent elevation of oleic acid, a signature lipid metabolite, exhibited a strong positive correlation with relative oiliness index and holds promise as a reliable biomarker for identifying and selecting high-oil tobacco leaves. These findings offer a theoretical reference for the targeted breeding and agronomic management of high-oil tobacco varieties.

PMID 42761252
Read full article →
PubMedFrontiers in physiology2026-09-19

Circadian rhythm in platelet: an emerging therapeutic target in human diseases.

Wang Zihui Z, Chen Zhe Z, Li Fei F, Chen Linxi L et al.

Platelet function and count display robust circadian oscillations with a period of approximately 24 hours, governed by the core molecular clock and modulated by environmental factors such as light, diet, and stress. This review elaborates on three key aspects. First, platelet surface markers peak around 8-9 AM, whereas platelet count, ATP release, and aggregability reach their maximum between 3-8 PM. Mechanistically, the nuclear receptor Rev-erbα drives the morning surge in platelet reactivity and thrombosis via the OPHN-1/RhoA/ERM signaling pathway. Second, through their circadian rhythm, platelets actively participate in the pathogenesis of cardiovascular diseases, neurological disorders, and metabolic diseases. Third, circadian-targeting drugs including tasimelteon, ramelteon, agomelatine, SR9009, VTP-43742, and PF-670462 offer novel therapeutic strategies for rhythm-related disorders. This review highlights the circadian regulation of platelets as an emerging therapeutic target in human diseases.

PMID 42761465
Read full article →
PubMedAllergologia et immunopathologia2026-09-19

Diagnostic performance of antibodies against extractable nuclear antigens detected by immunoblot in the differentiation of connective tissue diseases.

Oliva Menacho José Enrique JE, Oliva Candela José Arturo JA, Arroyo Acevedo Jorge Luis JL

Connective tissue diseases are inflammatory, autoimmune diseases that threaten the quality of life. To evaluate the differential diagnostic performance of antibodies against extractable nuclear antigens (ENAs) detected by immunoblot in patients with connective tissue diseases. An observational, descriptive, and cross-sectional study was conducted at the Immunoserology Service of the Arzobispo Loayza National Hospital and the Pharmacology Laboratory of the Faculty of Medicine at the National University of San Marcos between June 2020 and March 2021. The medical records of 300 patients with connective tissue disease were reviewed, and the immunoblot method was used to detect antibodies against ENA in the patients' serum. Final diagnoses were established according to classification criteria predefined by the EULAR/ACR (European Alliance of Associations for Rheumatology/American College of Rheumatology). Of the 300 cases with connective tissue disease, 87 (29%) cases had systemic lupus erythematosus, and 51 cases had anti-dsDNA with sensitivity of 59%, specificity of 87%, PPV of 65%, NPV of 84%, LR+ of 4.62, and LR- of 0.47 in SLE. In 81 (27%) cases of Sjögren's syndrome, 68 had anti-Ro 52 with sensitivity of 83%, specificity of 68%, PPV of 49%, NPV of 91.4%, LR+ of 2.59, and LR- of 0.25. It was demonstrated in 35 (11.7%) cases of CREST: 31 cases had anti-Cenp B with sensitivity of 88%, specificity of 96%, PPV of 77%, NPV of 98% and LR+ of 22. Selected profiles of antibodies against ENAs detected by immunoblot can support the differential diagnosis of connective tissue diseases.

PMID 42760884
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about AM-87