triamcinolone acetonide (Triesence)

Local triamcinolone acetonide injection for the prevention of pharyngeal deformity following endoscopic submucosal dissection of superficial pharyngeal neoplasms.

Suzuki Yugo Y, Oda Minoru M, Tanaka Junji J, Kikuchi Daisuke D et al.

Extensive mucosal resection following endoscopic submucosal dissection (ESD) for hypopharyngeal neoplasms can result in scar contracture and pharyngeal deformity, potentially increasing the risk of aspiration pneumonia. This study aimed to evaluate the efficacy and safety of local triamcinolone acetonide (TA) injection for preventing post-ESD pharyngeal deformity. This retrospective cohort study included 388 patients who underwent ESD for hypopharyngeal neoplasms between 2011 and 2026. Patients were divided into those who received local TA injection after ESD (TA group, n = 65) and those who did not (control group, n = 323). Post-ESD pharyngeal deformity was classified into four grades based on endoscopic findings. The piriform sinus was subdivided into three subfields according to the extent of the mucosal defect. The TA group had a significantly lower deformity severity and fewer grade ≥ 2 deformities than the control group (both p < .001). Significant preventive effects were observed only in the piriform sinus (both p < .001). Among mucosal defects involving multiple piriform sinus subfields, both outcomes were significantly lower in the TA group for mucosal defects involving two (p < .001 and p = .046, respectively) and three (both p < .001) subfields. Similar findings were observed after propensity score matching. No adverse events related to TA injection were observed. Local TA injection may be an effective and safe strategy for preventing post-ESD pharyngeal deformity, particularly in mucosal defects involving multiple piriform sinus subfields.

Transient intraocular lens opacification after intravitreal triamcinolone injection.

Cardoso-Teixeira Pedro P, Duarte Lilianne L, Costa Ferreira Cláudia C

Comment on: 'Use of intravitreal fluocinolone acetonide implant in inflammatory macular oedema'.

Kaşıkcı Murat M, Alaçamlı Göksu G

Haemorrhagic Occlusive Retinal Vasculitis Following Cataract Surgery Without Intraocular Vancomycin.

Grech Sarah S, Bezzina Alastair A, Calleja Andrea A

This paper reports a rare case of haemorrhagic occlusive retinal vasculitis (HORV) following cataract surgery in the absence of intraocular vancomycin, raising important considerations about alternative aetiologies and perioperative management. A 79-year-old male patient with a background of type 2 diabetes, benign prostatic hyperplasia and asthma experienced recurrent hypersensitivity reactions to topical mydriatics during preoperative assessments for right eye cataract surgery in the private sector. Surgery was ultimately performed without topical mydriatics; full mydriasis was achieved with the use of intracameral mydriatic agents and iris hooks. No intraocular vancomycin was administered. Postoperative care included standard antibiotic-steroid eye drops. Three days postoperatively, the patient presented with sudden, painless vision loss. Examination revealed extensive retinal haemorrhages, vasculitis, and macular ischaemia. Imaging confirmed widespread retinal vascular damage. Infectious and autoimmune screens were negative. A diagnosis of HORV was made, and the patient was treated with intravenous methylprednisolone, topical corticosteroids, and later sub-tenon triamcinolone. Partial visual improvement was observed. This case highlights the possibility of HORV in the absence of vancomycin, suggesting that other immune-mediated or hypersensitivity pathways, in response to different triggers, may contribute to its pathogenesis.