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CH

chlorhexidine gluconate (PerioChip)

✓ Approved

Dexcel Pharma Ltd. · Small Molecule · Small Molecule

What is chlorhexidine gluconate?

chlorhexidine gluconate is a small molecule developed by Dexcel Pharma Ltd.. It is approved for therapeutic indications via surgical implantation.

Drug Profile

Brand NamesPerioChip
CompanyDexcel Pharma Ltd.
Drug ClassSmall Molecule
RouteSurgical Implantation
StatusApproved
Sources: ClinicalTrials.gov, Dexcel Pharma Ltd.

Therapeutic Indications

chlorhexidine gluconate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsPeriodontitis✓ Approved

Related Research Articles

PubMedPediatric research2026-09-20

Exit site management: neonatal european vascular access team - ESPR recommendation 7.

Piersigilli Fiammetta F, Romitti Maria Grazia MG, Van Eenoo Suzy S, van der Lee Robin R et al.

Neonatal skin immaturity, increased transepidermal water loss, prolonged catheter dwell times, and repeated dressing manipulation expose neonates to a high risk of catheter-related infection, skin injury, dressing failure, and device dislodgement. Standardized exit site management is therefore a fundamental component of neonatal vascular access care. This article is part of a special series of ten recommendations for the management of neonatal vascular access, developed through a structured multidisciplinary consensus process integrating literature appraisal and expert deliberation. This recommendation provides evidence-based guidance for the management of exit sites of peripheral venous access devices, central venous access devices, and intra-arterial catheters in neonates. Key components include standardized assessment of the exit site and skin condition, risk-based application of Standard-ANTT® or Surgical-ANTT®, skin antisepsis adapted to gestational age, use of chlorhexidine-based solutions, securement with sutureless devices, application of octyl-butyl-cyanoacrylate glue, and use of semipermeable transparent dressings with high moisture vapor transmission rate (MVTR). Recommendations for dressing changes, complication monitoring, and catheter removal are also provided. Standardized exit site management may reduce catheter-related infections, medical adhesive-related skin injury, dressing failure, and device dislodgement, while improving consistency of care and patient safety across neonatal units. This recommendation provides evidence-based strategies for neonatal vascular access exit site management, including dressing selection, antisepsis, securement, and skin protection. Standardized exit site care may reduce catheter-related infections, dressing failure, skin injury, and device dislodgement in neonates. The recommendation promotes consistent use of aseptic non-touch technique (ANTT®), securement systems, and high MVTR dressings to preserve skin integrity and improve catheter stability. Implementing standardized exit site management practices enhances patient safety and reduces practice variation across neonatal centers.

PMID 42763318
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PubMedDental materials : official publication of the Academy of Dental Materials2026-09-19

Citric acid promotes effective in vitro decontamination of titanium while supporting surface, electrochemical, and biological properties compared with conventional chemical agents.

Corrêa Mirtes Maria Ferreira MMF, Santos Mariana Alves MA, Celles Cícero Andrade Sigilião CAS, Silva João Pedro Dos Santos JPDS et al.

This in vitro study evaluated the antimicrobial, physicochemical, electrochemical, and biological effects of chemical agents used for titanium (Ti) surface decontamination, with emphasis on identifying an optimal citric acid (CA) concentration for peri-implant disease management. Surface integrity, electrochemical behavior, and protein adsorption were analyzed after 1-min immersion in phosphate-buffered saline (PBS; control), 0.2% chlorhexidine (CHX), 3% hydrogen peroxide (HP), 1% sodium hypochlorite (SH), and CA (10, 20, 30, and 40%). Antimicrobial activity was assessed using a two-phase polymicrobial biofilm model under aerobic and anaerobic conditions. Biological effects of chemicals were evaluated by fibroblast viability. Pre-osteoblast viability and mineralization were performed on biofilm-treated surfaces. SH and CA40 induced morphological damage, whereas CA10-30 preserved surface integrity and showed nobler electrochemical behavior. Regarding antimicrobial activity, SH, CA30, and CA40 significantly reduced biofilm (≈6 log; p < 0.05), demonstrating a concentration-dependent CA effect, whereas CHX and HP performed similarly to PBS. Biologically, protein adsorption was comparable across groups, and CHX reduced early viability (24 h) (p < 0.05). However, after 14 days, CHX- and CA30-treated surfaces promoted greater mineralized nodule formation (p < 0.05). CHX and HP did not reduce biofilm after 1-min immersion, highlighting limitations of these short exposure protocols. In contrast, CA30 demonstrated a favorable balance between antimicrobial efficacy, controlled surface alterations, and biological effects, supporting its potential as an adjuvant chemical strategy for peri-implantitis treatment.

PMID 42763229
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PubMedPhotodiagnosis and photodynamic therapy2026-09-18

In vitro evaluation of photodynamic therapy associated with irrigation protocols in the control of multispecies endodontic biofilm.

Cardozo Bianca B, Pereira Ana Carolina Cambuí ACC, Mita Daniela D, Nunes Erica Miyazima EM et al.

To evaluate the antimicrobial efficacy of antimicrobial photodynamic therapy (aPDT), either alone or in combination with various irrigation protocols, against mature multispecies biofilms. Multispecies biofilms consisting of nine bacterial species were cultivated on 72 bovine dentin discs and randomly assigned to six groups (n = 12 each): saline (control), saline + aPDT, 2.5% sodium hypochlorite (NaOCl) + 17% EDTA, NaOCl + EDTA + aPDT, 2% chlorhexidine (CHX) + EDTA, and CHX + EDTA + aPDT. aPDT was performed using 0.005% methylene blue and a red diode laser (660 nm, 100 mW, 9 J, 90 s). The antimicrobial efficacy was assessed through colony-forming unit (CFU) counts and confocal laser scanning microscopy (CLSM). The data were analyzed using a significance level of 5%. The saline control exhibited the highest microbial load, which was significantly reduced when combined with aPDT (p < 0.05). Both NaOCl and CHX, in the absence of aPDT, significantly decreased microbial levels compared to saline (p < 0.05). When used alongside aPDT, NaOCl resulted in the lowest CFU values; however, no additional antimicrobial benefit from light activation was observed. The antimicrobial reduction achieved with saline + aPDT was comparable to 2% CHX. CLSM analysis corroborated these findings. aPDT enhanced the antimicrobial efficacy of physiological saline, resulting in an antimicrobial effect comparable to that observed with 2% liquid chlorhexidine. Among the irrigation protocols evaluated, 2.5% sodium hypochlorite showed the greatest antimicrobial efficacy, with no significant additional benefit following the application of aPDT.

PMID 42759825
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PubMedMedeniyet medical journal2026-09-18

In Vitro Antifungal Activity of Commonly Used Antiseptics and Disinfectants Against Candida auris Isolates.

Habip Zafer Z, Koçoğlu Mücahide Esra ME, Güneysu Yarar Büşra B, Özmen Merve M et al.

Candida auris (C. auris) has emerged as a multidrug-resistant nosocomial pathogen associated with outbreaks in healthcare settings and high mortality rates. Its ability to persist in the hospital environment highlights the importance of effective disinfection strategies. This study aimed to evaluate the in vitro susceptibility of clinical C. auris isolates to commonly used antiseptics and disinfectants under conditions reflecting routine clinical practice. Ten clinical C. auris isolates, along with reference strains of C. krusei (ATCC 6258) and C. parapsilosis (ATCC 22019), were tested. Sodium hypochlorite (5%, 1%, 0.5%), hydrogen peroxide (6%, 3%), povidone-iodine (10%, 5%, 2.5%), a chlorhexidine/n-propanol-containing liquid soap, and an ethanol/isopropyl alcohol-based hand disinfectant were evaluated by a qualitative suspension test at contact times of 1, 2, 5, 10, and 30 minutes. Growth inhibition was assessed after incubation. Povidone-iodine at all concentrations, chlorhexidine/n-propanol-containing liquid soap, alcohol-based hand disinfectant, and sodium hypochlorite at 5% and 1% achieved complete growth inhibition of all isolates within the first minute. In contrast, 0.5% sodium hypochlorite and hydrogen peroxide showed reduced efficacy at early contact times. Growth was observed in some C. auris isolates after 1 minute of exposure to 6% hydrogen peroxide, and in a larger proportion of isolates after 1-2 minutes of exposure to 3% hydrogen peroxide. Similar variability was observed in reference strains, particularly with hydrogen peroxide. Commonly used antiseptics and disinfectants are effective against C. auris when applied at appropriate concentrations and contact times. However, reduced efficacy at lower concentrations and with shorter exposure times underscores the importance of proper disinfectant use in preventing environmental persistence and transmission in healthcare settings.

PMID 42756048
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PubMedBMC cardiovascular disorders2026-09-18

The effect of antibacterial mouthwash on blood pressure in humans: a scoping review.

Singh Bhavik B, North Parker P, Rushetsky Zoë M ZM, Brito Richard C RC et al.

Oral hygiene is a key component of health. Practices for oral hygiene include brushing teeth with toothpaste, flossing, and mouth washing. It has been reported that 36% of United States adults use mouthwash daily. However, antibacterial mouthwashes kill oral nitrate-reducing bacteria, thus impairing nitric oxide production. Nitric oxide is a key molecule in vasodilation and blood pressure regulation, often acting as a mediator, so there is a potential for antibacterial mouthwashes to cause elevated blood pressure. Therefore, we conducted a scoping review to address the question: Does antibacterial mouthwash use significantly increase blood pressure in humans? A scoping review was conducted utilizing the databases PubMed and Scopus. Our search terms included "mouthwash," "chlorhexidine," "antibacterial," "salivary nitrite," "nitrate," and MeSH terms like "blood pressure" and "hypertension." Inclusion criteria required primary research articles since 2014 that analyzed changes in blood pressure in human adults after using antibacterial mouthwash. Studies with pediatric participants, animal studies, reviews, or studies that did not measure blood pressure changes were excluded. 51 studies were retrieved from the search, and after independent screening by two reviewers, nine studies were included in the scoping review. Reviewers extracted data on study methodology, sample size, participant characteristics, type of mouthwash, mouthwash regimen, and study results. Reviewers also appraised study quality using a modified Downs and Black assessment checklist. Nine studies were included: four randomized crossover trials, three nonrandomized crossover trials, one active-controlled trial, and one observational study. The studies were of good quality (mean modified Downs and Black score was 21.9 ± 2.9 out of 28 points). Five studies found significant blood pressure elevations after mouthwash usage, while four studies found no significant relationship. Heterogeneity in intervention lengths, mouthwash composition, participant characteristics, and blood-pressure assessment schedules, in addition to methodological weaknesses (such as inadequate washout periods and lack of randomization) in some studies make the pooled evidence inconclusive. Consequently, no firm conclusions can be drawn regarding the effect of antibacterial mouthwash on blood pressure at this time. Future research should utilize larger, randomized trials with standard washout periods and long-term monitoring to further clarify the relationship between antibacterial mouthwash usage and blood pressure.

PMID 42754848
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PubMedRevue medicale de Liege2026-09-17

[Anaphylaxis to MMR vaccine gelatin : practical recommendations].

Iordachescu Mihai M, El Abd Kamal K

This article reports two pediatric cases of anaphylaxis to the M-M-RVaxPro® vaccine, attributable to porcine gelatin used as a stabilizer (14.5 mg/dose). Both patients developed severe reactions after the booster dose, with positive skin and blood tests for gelatin. The first case had hereditary alpha-tryptasemia as an aggravating factor. Investigations ruled out the responsibility of neomycin, latex, and chlorhexidine. Key recommendations include avoidance of gelatin-containing vaccines and medications, substitution with gelatin-free alternatives (Priorix®), evaluation of food tolerance through an oral challenge test, and provision of an emergency kit with epinephrine. Hospital monitoring is recommended for future vaccinations in patients with mast cell disorders. The study highlights gelatin as the primary culprit in vaccine anaphylaxis, emphasizing the importance of systematic testing for vaccine components and proper management of sensitized patients.

PMID 42751843
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