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peginterferon alfa-2b (Pegstat)

✓ Approved

Nanogen Biopharmaceutical · IFNAR2 · Recombinant Proteins

What is peginterferon alfa-2b?

peginterferon alfa-2b is a recombinant proteins developed by Nanogen Biopharmaceutical. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesPegstat
CompanyNanogen Biopharmaceutical
Drug ClassRecombinant Proteins
Molecular TargetIFNAR2
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Nanogen Biopharmaceutical

Mechanism of Action

Molecular Targets

peginterferon alfa-2b acts on 1 molecular target:

IFNAR2interferon alpha and beta receptor subunit 2 (IFNARB, IFN-alpha-REC)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

peginterferon alfa-2b is developed for 3 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Hepatobiliary disordersHepatic cirrhosis✓ Approved
Infections and infestationsHepatitis B✓ Approved
Infections and infestationsHepatitis C✓ Approved

Related Research Articles

PubMedChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026-09-19

Conversion of a ventricular rickham reservoir to a subcutaneous chest port for repeated intraventricular enzyme replacement therapy: technical note and surgical considerations.

Gopalka Mahie M, Manocha Samiya S, Romanski Kathleen K, Hoeman Erin E et al.

Cerliponase alfa enzyme replacement therapy has transformed the management of neuronal ceroid lipofuscinosis type 2 (CLN2) disease but requires lifelong cerebrospinal fluid (CSF) access for repeated intraventricular infusions. Conventional scalp-based ventricular reservoirs are associated with complications including infection, mechanical deterioration, and device revision related to repeated puncture. Chest port-mediated ventricular access has emerged as a potential alternative; however, detailed operative descriptions remain limited. We describe operative considerations and stepwise technique for establishing ventricular access using a Rickham reservoir connected via shunt tubing to a subcutaneous chest port system for repeated intraventricular cerliponase alfa infusion. Illustrative clinical experience demonstrates durable long-term use of this configuration. Key technical elements include neuronavigation-guided ventricular catheter placement, creation of a subcutaneous or subfascial chest pocket depending on patient body habitus, incorporation of strain-relief loops to reduce catheter tension, and systematic testing of the completed construct. The resulting system allows reliable ventricular access via a chest port while preserving ventricular catheter integrity. Chest port-mediated ventricular access represents a feasible and durable strategy for long-term intraventricular therapy in CLN2 disease. Dissemination of operative technique may facilitate broader adoption and support reliable delivery of enzyme replacement therapy for patients requiring lifelong treatment.

PMID 42760386
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PubMedMedicine2026-09-19

Intractable hepatic hydrothorax eliminated by thoraco-peritoneal connection: A case report.

Lang Qing Q, Ben Xiaoyuan X, Wang Chengkang C, Zhang Jiebing J et al.

Hepatic hydrothorax occurs in patients with decompensated cirrhosis and has a significantly adverse prognosis. However, several treatments, including indwelling pleural catheters, trans jugular intrahepatic systemic shunts, and automatic low-flow ascites pumps (Alfa pumps), have been utilized to relieve pleural effusion, but these methods often cause severe complications. We report the first case of using thoraco-peritoneal connection to manage hepatic hydrothorax in a cirrhotic patient without an unfavorable outcome. A 55-year-old yellow-skinned female patient with alcoholic cirrhosis suffering from hepatic hydrothorax was admitted to the hospital. She presented with recurrent yellowish complexion, anorexia, chest tightness, and shortness of breath. The definitive diagnosis encompassed liver failure, alcoholic cirrhosis in a decompensated state, esophageal varices, portal hypertension, ascites, hepatic hydrothorax, hypersplenism, cholecystolithiasis accompanied by cholecystitis, pulmonary nodules, and coronary atherosclerosis. A thoracic drainage catheter and an abdominal puncture indwelling needle were connected to allow the pleural effusion to continuously flow into the abdominal cavity. The patient showed rapid improvement in nutritional status, urine output, and a decrease in pleural effusion. Subsequently, pleural effusion did not increase, and the connection was removed 1 month later. Hydrothorax and ascites were examined by color Doppler ultrasound every 2 months. Liver function and coagulation function continued to improve. The patient resumed normal daily activities after 6 months. The management of hepatic hydrothorax remains an area requiring further investigation. Thoraco - peritoneal connection might represent a medical strategy for the management of hepatic hydrothorax in cirrhotic patients with a favorable safety profile.

PMID 42760719
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PubMedActas dermo-sifiliograficas2026-09-19

Intralesional bleomycin versus cryotherapy for the treatment of common warts: a systematic review and meta-analysis of randomized controlled trials.

Lucero Calvache D A DA, Peláez Vélez L C LC, Maldonado Carrasco C L CL, Loayza E E

Cryotherapy is a well-established treatment for common warts. However, the efficacy of bleomycin in the treatment of this condition is less well established. Therefore, we conducted a meta-analysis to compare the efficacy of bleomycin versus cryotherapy for the treatment of common warts. PubMed, Scopus, and Cochrane databases were searched for randomized controlled trials that compared bleomycin with cryotherapy for the management of common warts and reported the outcomes of (1) lack of complete clinical clearance at the patient level (patients with at least 1 residual wart at the end of follow-up) and (2) proportion of warts not completely cleared at the lesion level. Heterogeneity was examined using the I² statistic. A random-effects model was used for outcomes with high heterogeneity. We included 4 randomized controlled trials (RCTs) with 489 patients, of whom 247 (50.2%) received bleomycin. Follow-up intervals ranged from 2 to 3 weeks, with a maximum follow-up of 12 weeks; therefore, only short-term outcomes were available. Lack of complete clinical clearance at the patient level (RR, 1.26; 95%CI, 1.16-1.38; P < .00001; Figure 2A) and the proportion of warts not completely cleared at the lesion level (RR, 1.13; 95%CI, 1.05-1.21; P= .0006; Figure 2B) were significantly more common in patients treated with cryotherapy than in those treated with bleomycin. In patients with common warts, intralesional bleomycin may be associated with higher short-term clearance than cryotherapy. However, these short-term findings are based on a very small number of heterogeneous randomized controlled trials with follow-up of up to 12 weeks, and recurrence and long-term cure could not be assessed. The certainty of the evidence is therefore low, and the results should be interpreted with great caution. In clinical practice, any potential gain in short-term clearance with intralesional bleomycin needs to be weighed against its greater procedure-related pain and local adverse events, as well as factors such as accessibility, clinical expertise, and individual patient preferences.

PMID 42762904
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PubMedCurrent hematologic malignancy reports2026-09-18

Molecular Response, Event-Free Survival, and Treatment-Free Remission in Myeloproliferative Neoplasms: Update and Review with Insights from MPN Asia 2026.

Abu-Zeinah Ghaith G, Hobbs Gabriela S GS, Rampal Raajit K RK, Lee Sung-Eun SE et al.

Therapeutic goals in BCR::ABL1-negative myeloproliferative neoplasms (MPNs) are evolving to include biologically anchored measures of disease modification with control of blood counts, splenomegaly, and symptoms. Disease modification endpoints and their linkage to survival in MPNs were central to the framework of MPN Asia 2026, which took place in Seoul. This review summarizes key themes from MPN Asia 2026 and relevant recent literature, examining the evolving roles of molecular response and long-term clinical benefits within a broader disease-modification framework across polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis (MF). Clinical trials with ropeginterferon alfa-2b were central to the discussions given these studies have contributed to the evolving paradigm of disease modification in MPNs, underscoring the importance of molecular response and event-free survival (EFS) in MPN management. In PV, ropeginterferon alfa-2b treatment provides a clinical model linking durable hematologic control and deep JAK2V617F variant allele frequency (VAF) reduction with improved long-term outcomes such as EFS, and prospective treatment-discontinuation strategies. Data from Europe and Asia supports the importance of early disease control, adequate interferon exposure, and longitudinal molecular monitoring. In ET, randomized data with ropeginterferon alfa-2b and emerging new treatment approaches such as lysine-specific demethylase 1 inhibition and mutant CALR-directed therapy are incorporating molecular endpoints into clinical development. However, the association between VAF reduction and thrombosis prevention, disease modification, EFS, and treatment-free remission (TFR) need to be elucidated. In MF, molecular profiling is already integral to prognostication and treatment selection, and disease modification assessment will likely require endpoints encompassing more than symptoms and spleen response, such as anemia response, bone marrow fibrosis change, clonal evolution, patient-reported outcomes, and importantly progression-free and overall survival. Molecular response, clonal suppression, prevention of vascular and progression events, survival outcomes such as EFS and TFR play increasingly important roles in MPN management.

PMID 42758401
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PubMedGenes & diseases2026-09-18

Efineptakin alfa (NT-I7) improves overall survival and induces immune niches in murine tumors.

Dinh Trang T, Lee Judong J, Islam Sidra S, Nanda Namita N et al.

Tertiary lymphoid structures (TLSs) are emerging as good predictive biomarkers of response to cancer immunotherapy. However, therapeutic strategies to induce these structures are currently limited. We evaluated the therapeutic benefit of efineptakin alfa (NT-I7), a long-acting form of IL-7, as well as its ability to remodel the tumor immune microenvironment and induce TLSs in murine lung and colorectal tumor models. NT-I7 improved overall survival in tumor-bearing mice. It also increased the abundance of T, B, dendritic cells, and stem-like CD8 T cells and promoted the formation of immune aggregates in the tumor microenvironment (TME). Stem-like CD8 T cells were preferentially located in the immune aggregates. Spatial transcriptomic analyses of the TME further demonstrated that the immune aggregates induced by NT-I7 included TLS-like structures with enrichment of Cd274 (PD-L1) transcripts and genes involved in antigen processing and presentation. Up-regulation of Cd274 in the TLS-like structures may provide opportunities for synergy between NT-I7 and PD-1-targeted immunotherapy.

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PubMedFrontiers in neurology2026-09-18

Efgartigimod-alfa therapy in acetylcholine receptor antibody myasthenia gravis: Romanian experience.

Grecu Nicolae N, Mihalache Oana Antonia OA, Davidescu Eugenia Irene EI, Bălașa Rodica R et al.

Efgartigimod alfa, the first neonatal Fc receptor inhibitor approved for the treatment of acetylcholine receptor antibody (AChR)-positive generalized myasthenia gravis (MG), has demonstrated efficacy in randomized controlled trials. However, real-world data, particularly from Eastern Europe, remain limited. This prospective, multicenter study enrolled AChR-positive generalized MG patients treated with efgartigimod across six Romanian university hospitals between March 2024 and September 2025. Outcomes were assessed using the Myasthenia Gravis Activities of Daily Living (MG-ADL) scale, the Quantitative Myasthenia Gravis (QMG) score, and the Myasthenia Gravis Quality of Life 15-item revised scale (MG-QoL15r). Clinically meaningful improvement (CMI), minimal symptom expression (MSE), patient-acceptable symptom state (PASS), subdomain response, and corticosteroid sparing were evaluated. Thirty-nine patients completed at least one treatment cycle, receiving a total of 210 cycles. In cycle 1, CMI rates were 89.7% for MG-ADL and 74.4% for QMG, with a median MG-ADL reduction of 4.0 points (p < 0.001); 69.2% achieved CMI after a single infusion. Composite PASS increased from 25.6% in cycle 1 to 54.5% in cycle 8. Subdomain analysis showed improvements across all domains for both the MG-ADL and the QMG, with the exception of QMG respiratory. Among patients on corticosteroids (n = 29), median prednisone dose decreased from 20.0 to 10.0 mg/day (p = 0.004), with 58.6% achieving reduction or discontinuation. This first Eastern European real-world efgartigimod-treated cohort confirms rapid and sustained improvement and corticosteroid sparing, consistent with prior evidence.

PMID 42756311
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