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vornorexant hydrate (TS142 / TS 142 / ORN0829)

✓ Approved

Taisho Pharmaceutical Co., Ltd. · Small Molecule · Small Molecule

What is vornorexant hydrate?

vornorexant hydrate is a small molecule developed by Taisho Pharmaceutical Co., Ltd.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesTS142, TS 142, ORN0829
CompanyTaisho Pharmaceutical Co., Ltd.
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Taisho Pharmaceutical Co., Ltd.

Therapeutic Indications

vornorexant hydrate is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Psychiatric disordersInsomnia✓ Approved
Respiratory, thoracic and mediastinal disordersApnoeaPhase I

Related Research Articles

PubMedACS omega2026-09-18

Influence of Seawater Salts on Magnesium Oxide Hydration: Implications for Carbonation.

Evans Barbara R BR, Chung Dong Youn DY, Moseley Brittany B, Dorsey Geordan G et al.

The effects of individual component salts on MgO hydration and subsequent carbonation have not been systematically investigated despite the increase in utilization of seawater and other brines in the production of MgO-containing next-generation cements, fire retardants, and sorbents for CO2. Here, we present a study of MgO hydration in the presence of individual saltwater cations at a range of concentrations, as well as binary mixtures at seawater concentrations, and subsequent carbonation. We observed that the presence of the cations increased MgO dissolution rates and that the subsequent carbonation extent of the hydrated material remained constant or even increased. Since the presence of these salts during hydration does not show negative effects on subsequent carbonation in our experimental study, the application of seawater and other brines containing high concentrations of these salts to hydrate MgO in industrial processes is likely feasible.

PMID 42757082
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PubMedActa crystallographica. Section C, Structural chemistry2026-09-18

Hydrogen bonding in cocrystals of trans-NiII(hfac)2(H2O)2.

Clemmer Grace L GL, York Caden W CW, Gray Mackenzie G MG, Fatila Elisabeth M EM et al.

Chemical vapor deposition (CVD) precursors often employ fluorinated β-diketonate ligands bonded to metal atoms; however, these are prone to the formation of hydrates under ambient conditions and form hydrogen-bond networks which hinder the CVD process. This work investigated the use of 1,2-dimethoxybenzene (DMB) as a ligand to prevent the formation of hydrogen-bonding networks. The single-crystal structures of two complexes of diaquabis(1,1,1,5,5,5-hexafluoro-4-oxopent-2-en-2-olato-κ2O,O')nickel(II), trans-NiII(hfac)2(H2O)2, were determined, one as a 4/3 hydrate, [Ni(C5HF6O2)2(H2O)2]3·4H2O, and one as a 1,2-dimethoxybenzene (DMB) pentasolvate, [Ni(C5HF6O2)2(H2O)2]·5C8H10O2. The hydrogen-bond networks of these two materials were compared to previously reported hydrogen-bond networks seen in NiII(hfac)2(H2O)2. DMB was found to disrupt the formation of an extended hydrogen-bond network without coordinating to the Ni center.

PMID 42758473
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PubMedPharmaceutical development and technology2026-09-18

Solid Modification Strategies for Active Pharmaceutical Ingredients (APIs): A Systematic Review on Approaches, Improvements, and Limitations.

Devon George Patrick GP, Ismail Dzava Prawinsyah Fairus DPF, Lagut Jenio J, Sopyan Iyan I

Poor aqueous solubility remains a major barrier in drug development, affecting approximately 40% of marketed drugs, up to 75% of drugs under development, and nearly 90% of new chemical entities. To overcome this limitation, solid modification of active pharmaceutical ingredients (APIs) emerged as a strategy to enhance drug physicochemical properties, particularly for Biopharmaceutics Classification System (BCS) II and IV drugs. This review systematically analyzes recent advancements in solid modification techniques, including salt formation, cocrystallization, polymorphs, solvate and hydrate forms, amorphous and co-amorphous systems, inclusion complexes, and nanocrystallization. A systematic literature search spanning 2020-2025 was conducted using PubMed and ScienceDirect databases, focusing on studies that improve the physicochemical properties of the APIs. By categorizing APIs, matrices, and methods of each study, this review shows the most frequently used techniques and their matrices, advantages, and limitations of each modification, providing insights for optimizing drug performance and future research in pharmaceutical development. Among the various approaches reviewed, cocrystals, amorphous systems, nanocrystals, and inclusion complexes emerged as the most frequently used techniques. Amorphous systems and inclusion complexes offer the highest median solubility enhancements by maximizing kinetic supersaturation or equilibrium solubility, respectively, while nanocrystals efficiently improve equilibrium solubility via particle size reduction, and cocrystals provide reliable, moderate gains with superior long-term thermodynamic stability.

PMID 42759591
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PubMedACS omega2026-09-18

Review of Formation Damage Assessment for CO2 Injection and Storage.

Sagandykova Dilyara D, Kakharov Islam I, Aitkazy Shynggys S, Khanjani Maral M et al.

Carbon capture and storage (CCS) has become an essential strategy for reducing CO2 emissions, with injection and storage projects increasingly implemented around the world. However, the long-term effectiveness of geological storage depends on maintaining injectivity and reservoir integrity, both of which face challenges from various formation damage mechanisms that are specific to CO2 injection. First, this review covers recent advances in understanding the physical, chemical, thermal, and biological processes that cause permeability loss, including salt precipitation from brine drying, fines migration, hydrate and ice formation due to Joule-Thomson cooling, acid-induced mineral dissolution, clay swelling, asphaltene precipitation, microbial activity, and phase trapping. The second part of this paper provides an in-depth review of assessment techniques used to diagnose and predict formation damage such as experimental methods, numerical simulations, analytical techniques, machine learning, and molecular modeling. Despite significant progress, many uncertainties remain regarding how these mechanisms interact over operational time scales and under real-world reservoir conditions. Future research should focus on integrating experimental and numerical approaches, expanding studies across different lithologies, and developing advanced in situ monitoring methods to improve the risk assessment and manage injectivity more effectively. Overcoming these challenges is crucial for enabling safe, efficient, and scalable deployment of CO2 storage technologies, with particular emphasis on conducting long-term studies that capture the coupled processes and reservoir responses over extended operational time scales.

PMID 42757200
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PubMedPlant reproduction2026-09-17

Assessing the relative contributions of different Arabidopsis thaliana stigma factors to pollen hydration.

Chadic Paula K S PKS, Liu Raymond K M RKM, Goring Daphne R DR

Following pollination, Arabidopsis pollen grains rapidly hydrate through the transfer of water from the stigma to the pollen. Several stigma regulators of pollen hydration have been identified, and the corresponding mutants generally support milder defects in wildtype Col-0 pollen hydration, signifying the involvement of other unidentified factors in this process. Here, we uncovered a role for the stigma-specific mechanosensitive channel gene, MscS-Like 7 (MSL7), in supporting pollen hydration. While the msl7 mutant stigmas were found to support reduced hydration of wildtype Col-0 pollen, the phenotype was quite mild and very similar to that observed for other published pollen hydration mutants. Thus, we conducted a detailed comparison of different pollen hydration mutants on the stigma side (receptor kinases, PIP aquaporins) and pollen (PCP-Bs, MSL8) to compare pollen hydration mutant phenotypes and look for any additive effects of combining different mutants. Overall, all combinations resulted in the same mild hydration defect with no additional reductions in pollen hydration and no impact on pollen germination. This is in contrast to that observed for self-incompatible (SI) pollen from a transgenic Arabidopsis SI Col-0 line which shows very little pollen hydration and no pollen germination as part of the SI pollen rejection response. Together, these findings suggest that the regulation of compatible pollen hydration is quite complex and that there are likely other unknown mechanisms involved.

PMID 42752706
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PubMedAngewandte Chemie (International ed. in English)2026-09-17

Syntheses, X-ray Crystal Structures, and Raman Spectra of Self-Assembled XeO3 Chain and Network Complexes of Polytopic sp2- and sp3-Nitrogen Bases.

Goettel James T JT, Mercier Hélène P A HPA, Schrobilgen Gary J GJ

Xenon trioxide was used as a template to synthesize a structurally diverse series of self-assembled network complexes. Reactions of XeO3 in aqueous or CH3CN solutions with the polytopic nitrogen bases, 2,2'-bipyridine (2,2'-bipy), 1,10-phenanthroline (1,10-phen), 4,4'-bipyridine (4,4'-bipy), hexamethylenetetramine (HMTA), and 1,4-diazabicyclo[2.2.2]octane (DABCO) yield 1-, 2-, and 3-D supramolecular XeO3 complexes. The low-temperature X-ray crystal structures of room-temperature-stable O3Xe(2,2'-bipy), O3Xe(1,10-phen), and O3Xe(4,4'-bipy), consist of Xe---O σ-hole-bonded -(-O═Xe(O2)--)-∞ chains that coordinate through Xe---N σ-hole bonds. Shock-insensitive O3Xe(HMTA)(H2O) is crosslinked by -(-Xe(O2)O---HO(H)--)-∞ chains that are Xe---N and Xe---O coordinated to HMTA and H2O to give 3-D networks, whereas highly shock-sensitive and explosive (O3Xe)2(HMTA) forms 3-D networks in which -(-O═Xe(O2)--)-∞ chains couple to form layers that are Xe---N coordinated to HMTA. Reaction of DABCO with XeO3 in HF(aq) yields stable [HDABCO]2[(μ-FXeO3)2]·H2O and [H2DABCO][F][H2F3] salts. The XeO3 moieties of [(μ-FXeO3)2]2- form crosslinked -(-HOH--[-O═Xe(O)2(μ-F)2(O2)Xe═O-]--)-∞ chains that are Xe---N coordinated to [HDABCO]+. The XeO3 complexes provide examples of Xe(VI)---N σ-hole bonds with sp2- and sp3-hybridized polytopic N-bases, where O3Xe(2,2'-bipy) and O3Xe(1,10-phen) are unique examples of chelated noble-gas centers, and O3Xe(HMTA)(H2O) is a rare example of a Xe---O σ-hole bonded noble-gas hydrate.

PMID 42750369
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